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Results for "

tonic

" in MedChemExpress (MCE) Product Catalog:

40

Inhibitors & Agonists

11

Natural
Products

3

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-105084A
    Lubeluzole dihydrochloride

    		Sodium Channel Neurological Disease
    Lubeluzole (dihydrochloride) is a neuroprotective agent which blockades neuronal voltage-gated sodium channels. Lubeluzole (dihydrochloride) also produces both tonic and block of cardiac sodium channels. Lubeluzole (dihydrochloride) is promising for research of antiarrhythmic agents .
    Lubeluzole dihydrochloride
  • HY-32067
    Aceclidine

    Quinuclidin-3-yl acetate

    		 mAChR Cardiovascular Disease Neurological Disease
    Aceclidine (Quinuclidin-3-yl acetate) is a modulator of M3 muscarinic acetylcholine receptor and a M1 receptor agonist (EC50: 40 μM). Aceclidine is a cycloplegic agent, a surfactant, a tonicity adjustor and optionally a viscosity enhancer and an antioxidant. Aceclidine has the potential for the research of disorders such as refractive errors of the eye, xerostomia, Sjogren's syndrome, glaucoma, conjunctivitis, lacrimal gland disease, and esotropia .
    Aceclidine
  • HY-32067A
    Aceclidine hydrochloride

    Quinuclidin-3-yl acetate hydrochloride

    		 mAChR Neurological Disease
    Aceclidine (Quinuclidin-3-yl acetate) hydrochloride is a modulator of M3 muscarinic acetylcholine receptor and a M1 receptor agonist (EC50: 40 μM). Aceclidine hydrochloride is a cycloplegic agent, a surfactant, a tonicity adjustor and optionally a viscosity enhancer and an antioxidant. Aceclidine hydrochloride has the potential for the research of disorders such as refractive errors of the eye, xerostomia, Sjogren's syndrome, glaucoma, conjunctivitis, lacrimal gland disease, and esotropia .
    Aceclidine hydrochloride
  • HY-Y0121
    Ethyl cinnamate

    		Parasite VEGFR Apoptosis Cardiovascular Disease Cancer
    Ethyl cinnamate, an orally active chemical constituent of the rhizome of Kaempferia galanga, exhibits anti-cancer, nematocidal, sedative and vasorelaxant activities. Ethyl cinnamate is a fragrance ingredient used as a food flavor and additive for cosmetic products. Ethyl cinnamate is also an excellent clearing reagent for mammalian tissues. Ethyl cinnamate suppresses tumor growth through anti-angiogenesis by attenuating VEGFR2 signal pathway in colorectal cancer. Ethyl cinnamate inhibits the tonic contractions induced by high K+ and phenylephrine (PE) with respective IC50 values of 0.30 mM and 0.38 mM in rat aorta .
    Ethyl cinnamate
  • HY-N2276
    Nodakenetin

    		Others Inflammation/Immunology
    Nodakenetin, isolated from Angelica decursiva, possesses antioxidant anti-inflammatory activities. Nodakenetin has the potential to be an antiarthritic and nerve tonic .
    Nodakenetin
  • HY-108327
    PF-05020182

    		Potassium Channel Neurological Disease
    PF-05020182 is an orally active opener for Kv7 channel, that activates human Kv7.2/7.3, Kv7.4 and Kv7.3/7.5 with EC50 of 334, 625 and 588 nM, respectively. PF-05020182 exhibits anticonvulsant activity in rats corneal electric shock-induced tonic seizure (MES) models. PF-05020182 is blood-brain barrier (BBB) penetrable .
    PF-05020182
  • HY-N11706
    β-Cedrene

    (+)-β-Cedrene

    		 Fungal Infection Inflammation/Immunology
    β-Cedrene ((+)-β-Cedrene) is a sesquiterpene compound that can be isolated from Centaurea kotschyi var. kotschyi and Centaurea kotschyi var. decumbens, exhibiting antibacterial, anti-inflammatory, antispasmodic, tonic, diuretic, sedative, insecticidal, and antifungal activities. β-Cedrene is also a potent competitive inhibitor of the CYP2B6-mediatedbupropion hydroxylase, with a Ki value of 1.6 μM .
    β-Cedrene
  • HY-119820
    Xaliproden free base

    SR57746A free base

    		 5-HT Receptor Neurological Disease
    Xaliproden free base is an orally active and selective 5-HT1A receptor agonist. Xaliproden free base shows analgesic effect against acute tonic nociceptive pain and has neuroprotective effects. Xaliproden free base has an acute inhibitory effect on paclitaxel (HY-B0015)-induced mechanical allodynia by inhibiting the excessive response of primary afferent neurons .
    Xaliproden free base
  • HY-N4295
    Bacopaside V

    		Others Neurological Disease
    Bacopaside V is a bioactive triterpenoid glycoside of Bacopa monniera, a herb having confirmed nervine tonic activity .
    Bacopaside V
  • HY-135412
    N-Methyl Duloxetine hydrochloride

    		Sodium Channel Neurological Disease
    N-Methyl Duloxetine hydrochloride is an analgesic. N-Methyl Duloxetine (hydrochloride) elicits both tonic and use-dependent block of neuronal Na + channels .
    N-Methyl Duloxetine hydrochloride
  • HY-Y0121R
    Ethyl cinnamate (Standard)

    		Parasite VEGFR Apoptosis Cardiovascular Disease Cancer
    Ethyl cinnamate (Standard) is the analytical standard of Ethyl cinnamate. This product is intended for research and analytical applications. Ethyl cinnamate, an orally active chemical constituent of the rhizome of Kaempferia galanga, exhibits anti-cancer, nematocidal, sedative and vasorelaxant activities. Ethyl cinnamate is a fragrance ingredient used as a food flavor and additive for cosmetic products. Ethyl cinnamate is also an excellent clearing reagent for mammalian tissues. Ethyl cinnamate suppresses tumor growth through anti-angiogenesis by attenuating VEGFR2 signal pathway in colorectal cancer. Ethyl cinnamate inhibits the tonic contractions induced by high K+ and phenylephrine (PE) with respective IC50 values of 0.30 mM and 0.38 mM in rat aorta .
    Ethyl cinnamate (Standard)
  • HY-108300
    Oxyfedrine hydrochloride

    		Adrenergic Receptor Cardiovascular Disease
    Oxyfedrine hydrochloride, a vasodilator, is an orally active β-adrenoreceptor agonist. Oxyfedrine decreases the tonicity of coronary vessels. Oxyfedrine hydrochloride can be used in the research of cardiovascular disease .
    Oxyfedrine hydrochloride
  • HY-112070
    Oxyfedrine

    		Adrenergic Receptor Cardiovascular Disease
    Oxyfedrine, a vasodilator, is an orally active β-adrenoreceptor agonist. Oxyfedrine decreases the tonicity of coronary vessels. Oxyfedrine can be used in the research of cardiovascular disease .
    Oxyfedrine
  • HY-B0161C
    (R)-Duloxetine

    (R)-LY248686

    		 Sodium Channel Neurological Disease
    (R)-Duloxetine is a isomer of Duloxetine (HY-B0161) that causes tonic and usage-dependent impairment of neuronal Na + channels. (R)-Duloxetine can be used in pain research .
    (R)-Duloxetine
  • HY-108011
    Naftazone
    1 Publications Verification

    		 mGluR iGluR Endogenous Metabolite Cardiovascular Disease
    Naftazone is a naphthoquinone derivative, it can be used for the research of venous insufciency. Naftazone protects blood vessels, increases venous tonicity and capillary resistance, and improves lymphatic and venous circulation .
    Naftazone
  • HY-101708
    N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea

    		Biochemical Assay Reagents Neurological Disease
    N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea is an anticonvulsant agent with potential for the treatment of generalized tonic-clonic and partial seizures.
    N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea
  • HY-W097106
    (S)-3-N-Cbz-Amino-succinimide

    		Drug Isomer Neurological Disease
    (S)-3-N-Cbz-Amino-succinimide (Compound 1d) is an antiepileptic agent that can inhibit pentylenetetrazole (PTZ) and maximal electroshock (MES)-induced tonic convulsions in mice .
    (S)-3-N-Cbz-Amino-succinimide
  • HY-120620
    BMS-195270

    		Others Others
    BMS-195270 is a small molecule that inhibits Carbachol (HY-B1208)-evoked tonicity of isolated rat bladder strips. BMS-195270 inhibits calcium flux .
    BMS-195270
  • HY-W415953
    Periplanetin

    		Sex Pheromone Others
    Periplanetin is a peptide of the insect lipomotor hormone family (AKH family) that can be isolated from the secretion of the cervical organ of Periplaneta americana L. and Blatta orientalis L. The periplanetin peptide has potential analgesic activity and lowers the threshold of tonic seizures .
    Periplanetin
  • HY-N4264
    Vinaginsenoside R3

    		Others Inflammation/Immunology
    Vinaginsenoside R3 is a saponin composition of roots of Panax ginseng. Ginsengs have been not only used as therapeutic agents with tonic, anti-fatigue, and anti-gastric ulcer effect but also marketed as dietary supplements and raw materials of health food .
    Vinaginsenoside R3
  • HY-108011R
    Naftazone (Standard)

    		iGluR Endogenous Metabolite mGluR Cardiovascular Disease
    Naftazone (Standard) is the analytical standard of Naftazone. This product is intended for research and analytical applications. Naftazone is a naphthoquinone derivative, it can be used for the research of venous insufciency. Naftazone protects blood vessels, increases venous tonicity and capillary resistance, and improves lymphatic and venous circulation .
    Naftazone (Standard)
  • HY-N2238
    Dipsanoside A

    		Others Metabolic Disease
    Dipsanoside A is a novel tetrairidoid glucoside from Dipsacus asper. Dipsacus asper Wall., a perennial plant widespread in China, has been used in traditional Chinese medicine for hundreds of years as a tonic for refreshment, as a fissiparism promoter of the osseous cells, and as an embryo security agent, etc .
    Dipsanoside A
  • HY-N2236
    Dipsanoside B

    		Others Infection
    Dipsanoside B is a novel tetrairidoid glucoside from Dipsacus asper. Dipsacus asper Wall., a perennial plant widespread in China, has been used in traditional Chinese medicine for hundreds of years as a tonic for refreshment, as a fissiparism promoter of the osseous cells, and as an embryo security agent, etc .
    Dipsanoside B
  • HY-B0161CR
    (R)-Duloxetine (Standard)

    		Sodium Channel Neurological Disease
    (R)-Duloxetine (Standard) is the analytical standard of (R)-Duloxetine. This product is intended for research and analytical applications. (R)-Duloxetine is a form of Duloxetine (HY-B0161) that causes tonic and usage-dependent impairment of neuronal Na+ channels. (R)-Duloxetine can be used in pain research .
    (R)-Duloxetine (Standard)
  • HY-171182
    D3017

    		Endogenous Metabolite Neurological Disease
    D3017 is the main metabolite of D2624, which has oral bioactivity and anti-convulsant effects. D3017 ED50 value is 1.5 mg/kg in mice, and it can be used for research on severe generalized tonic-clonic seizures (grand mal) and complex partial epilepsy .
    D3017
  • HY-16928R
    Cytochalasin B (Standard)

    		Arp2/3 Complex Cancer
    (R)-Duloxetine (Standard) is the analytical standard of (R)-Duloxetine. This product is intended for research and analytical applications. (R)-Duloxetine is a form of Duloxetine (HY-B0161) that causes tonic and usage-dependent impairment of neuronal Na+ channels. (R)-Duloxetine can be used in pain research .
    Cytochalasin B (Standard)
  • HY-100783B
    Bicuculline methobromide

    (+)-Bicuculline methobromide; d-Bicuculline methobromide

    		 GABA Receptor Neurological Disease
    Bicuculline methobromide is a selective GABAA Receptor antagonist with an IC50 value of 3 μM. Bicuculline methobromide induces clonic tonic convulsions in mammals and can also be used to block Ca 2+ activated potassium channels. Bicuculline methobromide can be used in studies of epilepsy and other related psychiatric disorders .
    Bicuculline methobromide
  • HY-137790
    Bicuculline methochloride
    Maximum Cited Publications
    26 Publications Verification

    (-)-Bicuculline methochloride; l-Bicuculline methochloride

    		 GABA Receptor Neurological Disease
    Bicuculline ((+)-Bicuculline; d-Bicuculline) methochloride is a selective GABAA receptor antagonist with an IC50 value of 3 μM. Bicuculline methochloride induces clonic tonic convulsions in mammals and can also be used to block Ca 2+ activated potassium channels. Bicuculline methochloride can be used in studies of epilepsy and other related psychiatric disorders .
    Bicuculline methochloride
  • HY-119521
    Mexiletine
    1 Publications Verification

    KOE-1173

    		 Sodium Channel Cardiovascular Disease Neurological Disease
    Mexiletine is an orally effective antiarrhythmic agent which has also been found to be effective for myotonia and neuropathic pain. Mexiletine exerts its efficacy through blocking sodium channels (IC50 : 75±8 μM for tonic block, 23.6±2.8 μM for use-dependent block), therefore can be used for cardiovascular and neurological research .
    Mexiletine
  • HY-A0093
    Mexiletine hydrochloride
    1 Publications Verification

    KOE-1173 hydrochloride

    		 Sodium Channel Cardiovascular Disease Neurological Disease
    Mexiletine is an orally effective antiarrhythmic agent which has also been found to be effective for myotonia and neuropathic pain. Mexiletine exerts its efficacy through blocking sodium channels (IC50 : 75±8 μM for tonic block, 23.6±2.8 μM for use-dependent block), therefore can be used for cardiovascular and neurological research .
    Mexiletine hydrochloride
  • HY-A0093R
    Mexiletine (hydrochloride) (Standard)

    KOE-1173 (hydrochloride) (Standard)

    		 Sodium Channel Cardiovascular Disease Neurological Disease
    Mexiletine (hydrochloride) (Standard) is the analytical standard of Mexiletine (hydrochloride). This product is intended for research and analytical applications. Mexiletine is an orally effective antiarrhythmic agent which has also been found to be effective for myotonia and neuropathic pain. Mexiletine exerts its efficacy through blocking sodium channels (IC50 : 75±8 μM for tonic block, 23.6±2.8 μM for use-dependent block), therefore can be used for cardiovascular and neurological research .
    Mexiletine (hydrochloride) (Standard)
  • HY-113350
    Thromboxane A2

    TXA2

    		 Prostaglandin Receptor Endogenous Metabolite Inflammation/Immunology Endocrinology Cancer
    Thromboxane A2 (TXA2) is a prostanoid mediator produced by the metabolism of Arachidonic acid (HY-109590) through the cyclooxygenase pathway. Thromboxane A2 activates the thromboxane-prostanoid (TP) receptors. Thromboxane A2 is a potent vasoconstrictor eicosanoid. Thromboxane A2 (TXA2) leads to potent vasoconstriction by stimulation of smooth muscle cells. Thromboxane A2 acts as s tonic immunoregulator to regulate adaptive immune responses .
    Thromboxane A2
  • HY-119521S
    Mexiletine-d3

    KOE-1173-d3

    		 Isotope-Labeled Compounds Cardiovascular Disease Neurological Disease
    Mexiletine-d3 (KOE-1173-d3) is deuterium labeled Mexiletine. Mexiletine is an orally effective antiarrhythmic agent which has also been found to be effective for myotonia and neuropathic pain. Mexiletine exerts its efficacy through blocking sodium channels (IC50 : 75±8 μM for tonic block, 23.6±2.8 μM for use-dependent block), therefore can be used for cardiovascular and neurological research .
    Mexiletine-d3
  • HY-119521S1
    Mexiletine-d6

    KOE-1173-d6

    		 Isotope-Labeled Compounds Sodium Channel Cardiovascular Disease Neurological Disease
    Mexiletine-d6 (KOE-1173-d6) is deuterium labeled Mexiletine. Mexiletine is an orally effective antiarrhythmic agent which has also been found to be effective for myotonia and neuropathic pain. Mexiletine exerts its efficacy through blocking sodium channels (IC50 : 75±8 μM for tonic block, 23.6±2.8 μM for use-dependent block), therefore can be used for cardiovascular and neurological research .
    Mexiletine-d6
  • HY-100714D
    DL-AP5 lithium

    2-APV lithium; DL-2-Amino-5-phosphonovaleric acid lithium

    		 iGluR Neurological Disease Inflammation/Immunology
    DL-AP5 (2-APV) lithium is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 lithium shows significantly antinociceptive activity. DL-AP5 lithium specifically blocks on channels in the rabbit retina .
    DL-AP5 lithium
  • HY-100714C
    DL-AP5 sodium
    1 Publications Verification

    2-APV sodium; DL-2-Amino-5-phosphonovaleric acid sodium

    		 iGluR Neurological Disease Inflammation/Immunology
    DL-AP5 (2-APV) sodium is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 sodium shows significantly antinociceptive activity. DL-AP5 sodium specifically blocks on channels in the rabbit retina .
    DL-AP5 sodium
  • HY-100714R
    DL-AP5 (Standard)

    2-APV (Standard); DL-2-Amino-5-phosphonovaleric acid (Standard)

    		 Reference Standards iGluR Neurological Disease Inflammation/Immunology
    DL-AP5 (Standard) is the analytical standard of DL-AP5. This product is intended for research and analytical applications. DL-AP5 (2-APV) is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 shows significantly antinociceptive activity. DL-AP5 specifically blocks on channels in the rabbit retina .
    DL-AP5 (Standard)
  • HY-100714
    DL-AP5
    1 Publications Verification

    2-APV; DL-2-Amino-5-phosphonovaleric acid

    		 iGluR Neurological Disease Inflammation/Immunology
    DL-AP5 (2-APV) is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 shows significantly antinociceptive activity. DL-AP5 specifically blocks on channels in the rabbit retina .
    DL-AP5
  • HY-100714CR
    DL-AP5 sodium (Standard)

    2-APV sodium (Standard); DL-2-Amino-5-phosphonovaleric acid sodium (Standard)

    		 Reference Standards iGluR Neurological Disease Inflammation/Immunology
    DL-AP5 (sodium) (Standard) is the analytical standard of DL-AP5 (sodium). This product is intended for research and analytical applications. DL-AP5 (2-APV) sodium is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 sodium shows significantly antinociceptive activity. DL-AP5 sodium specifically blocks on channels in the rabbit retina .
    DL-AP5 sodium (Standard)
  • HY-Y0121S1
    Ethyl cinnamate-d7

    		Isotope-Labeled Compounds Others
    Ethyl cinnamate-d7 is deuterated labeled Ethyl cinnamate (HY-Y0121). Ethyl cinnamate, an orally active chemical constituent of the rhizome of Kaempferia galanga, exhibits anti-cancer, nematocidal, sedative and vasorelaxant activities. Ethyl cinnamate is a fragrance ingredient used as a food flavor and additive for cosmetic products. Ethyl cinnamate is also an excellent clearing reagent for mammalian tissues. Ethyl cinnamate suppresses tumor growth through anti-angiogenesis by attenuating VEGFR2 signal pathway in colorectal cancer. Ethyl cinnamate inhibits the tonic contractions induced by high K+ and phenylephrine (PE) with respective IC50 values of 0.30 mM and 0.38 mM in rat aorta .
    Ethyl cinnamate-d7

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