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thyroid-stimulating hormone

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Thyroid Hormone Receptor (4) TSH Receptor (7) Antibiotic (1) Apoptosis (2) Bacterial (1) Endogenous Metabolite (1) Estrogen Receptor/ERR (1) Flavivirus (2) PKA (1) PKC (2) Reference Standards (1) TNF Receptor (2)
By Research Areas:	Cancer (2) Endocrinology (10) Infection (1) Inflammation/Immunology (4) Metabolic Disease (3)

13

Inhibitors & Agonists

3

Peptides

1

Natural
Products

1

Recombinant Proteins

1

Antibodies

Targets Recommended: Thyroid Hormone Receptor TSH Receptor Nuclear Hormone Receptor 4A/NR4A PTHR GHR GHSR GnRH Receptor MCHR1 (GPR24) c-Fms

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Protirelin acetate 3 Publications Verification Thyrotropin-releasing-hormone acetate; TRH acetate	Thyroid Hormone Receptor	Inflammation/Immunology Endocrinology
Protirelin Acetate is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

Protirelin 3 Publications Verification Thyrotropin-releasing-hormone; TRH	Thyroid Hormone Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology
Protirelin is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

VA-K-14 hydrochloride	TSH Receptor	Endocrinology
VA-K-14 hydrochloride is a specific thyroid-stimulating hormone receptor (TSHR) antagonist (IC₅₀= 12.3 μM) .

Org41841	TSH Receptor	Endocrinology
Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC₅₀s of 0.2 and 7.7 μM, respectively.

Thyrotropin 1 Publications Verification TSH; Pretiron	TSH Receptor PKC Apoptosis	Metabolic Disease Inflammation/Immunology Endocrinology Cancer
Thyrotropin (TSH, Pretiron) is a thyroid-stimulating hormone produced by thyrotrope cells in the anterior pituitary gland. Thyrotropin regulates the endocrine function of the thyroid. Thyrotropin induces transcriptional regulation of TH-gatekeeper genes in tanycytes through the Tshr/Gαq/PKC pathway. Thyrotropin prevents Apoptosis. Thyrotropin has an association of low levels with increased bone remodeling, reduced bone mass and a high fracture risk in mice. Thyrotropin is promising for research of skeletal remodeling, hyperthyroidism .

ADX61623	Estrogen Receptor/ERR	Endocrinology
ADX61623 is a potent *follicle stimulating hormone* (FSH) receptor (FSHR)** negative allosteric modulator (NAM). ADX61623 shows luteinizing hormone receptor (LH-R) activity and is not active on thyroid-stimulating hormone (TSH) receptors. ADX61623 can be used for the study of estrogen dependent disease .

Org 274179-0	TSH Receptor	Metabolic Disease
Org 274179-0 is a potent and allosteric antagonist of thyroid-stimulating hormone (TSH) receptor, with an IC₅₀ of nanomolar concentration. Org 274179-0 completely inhibits TSH (and TSI)-mediated TSH receptor activation with little effect on the potency of TSH. Org 274179-0 can be used for the research of Graves' disease (GD) .

PGlu-3-methyl-His-Pro-NH2 TFA A-42872 TFA	TSH Receptor	Endocrinology
PGlu-3-methyl-His-Pro-NH2 TFA (A-42872 TFA), the modified thyrotropin-releasing hormone (TRH) peptide, enhances binding to pituitary TRH receptors and increases stimulation of thyroid-stimulating hormone (TSH) release from the pituitary. The in vitro permeability of PGlu-3-methyl-His-Pro-NH2 TFA through rat skin is increased in the presence of enhancers Ethanol and Cineole .

Tiratricol 1 Publications Verification 3,3',5-Triiodothyroacetic acid	Flavivirus Thyroid Hormone Receptor TNF Receptor	Endocrinology
Tiratricol is an orally available thyroid hormone analog that inhibits pituitary thyroid-stimulating hormone secretion. Tiratricol is an intracellular toxin neutralizer that inhibits LPS and lipid A cytotoxicity with IC₅₀s of 20 μM and 32 μM, respectively. Tiratricol reduces TNF production in lipopolysaccharide-stimulated macrophages. Tiratricol also has antiviral activity and is an inhibitor of yellow fever virus (Flavivirus). It can bind to the RdRp domain of the viral NS5 protein to hinder YFV replication. .

Tiratricol (Standard) 3,3',5-Triiodothyroacetic acid (Standard)	Flavivirus Thyroid Hormone Receptor Reference Standards TNF Receptor	Endocrinology
Tiratricol (Standard) is the analytical standard of Tiratricol. This product is intended for research and analytical applications. Tiratricol is an orally available thyroid hormone analog that inhibits pituitary thyroid-stimulating hormone secretion. Tiratricol is an intracellular toxin neutralizer that inhibits LPS and lipid A cytotoxicity with IC₅₀s of 20 μM and 32 μM, respectively. Tiratricol reduces TNF production in lipopolysaccharide-stimulated macrophages. Tiratricol also has antiviral activity and is an inhibitor of yellow fever virus (Flavivirus). It can bind to the RdRp domain of the viral NS5 protein to hinder YFV replication. .

ML-109	TSH Receptor	Metabolic Disease Endocrinology
ML-109 is a potent and full thyroid stimulating hormone receptor (TSHR) agonist, with an EC₅₀ of 40 nM.

NCATS-SM4420	TSH Receptor	Cancer
NCATS-SM4420 (Compound A35) is an orally active thyroid-stimulating hormone receptor (TSHR) ligand that inhibits the proliferation of MDA-T32 and MDA-T85 cells in vitro (IC₅₀ values of 0.71 μM and 0.38 μM, respectively) and suppresses metastasis of MDA-T85F1 in mice. NCATS-SM4420 holds promise for research in the field of thyroid cancer .

KT5823 Maximum Cited Publications 8 Publications Verification	PKA PKC Bacterial Apoptosis Antibiotic	Infection Inflammation/Immunology
KT5823, a selective the cGMP-dependent protein kinase (PKG) inhibitor with an K_i value of 0.23 μM, it also inhibits PKA and PKC with K_i values of 10 μM and 4 μM, respectively. KT5823 is a Staurosporine-related protein kinase inhibitor, increases thyroid-stimulating hormone-induced (Na ⁺/I ^- symporter) NIS expression, and iodide uptake in thyroid cells. KT5823 arrests cells after the G0/G1 boundary and causes increases in the levels of apoptotic DNA fragmentation .

Cat. No.	Product Name	Target	Research Area

Protirelin acetate 3 Publications Verification Thyrotropin-releasing-hormone acetate; TRH acetate	Thyroid Hormone Receptor	Inflammation/Immunology Endocrinology
Protirelin Acetate is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

Protirelin 3 Publications Verification Thyrotropin-releasing-hormone; TRH	Thyroid Hormone Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology
Protirelin is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

PGlu-3-methyl-His-Pro-NH2 TFA A-42872 TFA	TSH Receptor	Endocrinology
PGlu-3-methyl-His-Pro-NH2 TFA (A-42872 TFA), the modified thyrotropin-releasing hormone (TRH) peptide, enhances binding to pituitary TRH receptors and increases stimulation of thyroid-stimulating hormone (TSH) release from the pituitary. The in vitro permeability of PGlu-3-methyl-His-Pro-NH2 TFA through rat skin is increased in the presence of enhancers Ethanol and Cineole .

Cat. No.	Compare	Product Name	Species	Source

	mTSH Protein, Mouse (HEK293) Glycoprotein hormones alpha chain; Anterior pituitary glycoprotein hormones common subunit alpha; Follicle-stimulating hormone alpha chain; FSH-alpha; Follitropin alpha chain; Luteinizing hormone alpha chain; LSH-alpha; Lutropin alpha chain; thyroid-stimulating hormone alpha chain; TSH-alpha; Thyrotropin alpha chain; Cga; Mus musculus; Mouse; FSH-alpha; hormone	Mouse	HEK293
	mTSH Protein, Mouse (HEK293) is the recombinant mouse-derived mTSH, expressed by HEK293 , with tag Free labeled tag. ,

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	TSH Receptor/TSH-R Antibody (YA1252) LGR3; TSHR; Thyrotropin Receptor; thyroid-stimulating hormone receptor (TSH-R)	IHC-P	Human
	TSH Receptor/TSH-R Antibody (YA1252) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TSH Receptor/TSH-R.

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