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synthesize oligonucleotides

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (2) DNA/RNA Synthesis (4) Drug Intermediate (2) Nucleoside Antimetabolite/Analog (5)
By Research Areas:	Cancer (1) Infection (1)
Oligonucleotides:	Nucleoside Phosphoramidites (2) Nucleoside Analogs (1) Nucleotide Analogs (2) Adenine (2) Uracil Nucleotide (1) Cytidine (1) Adenine Nucleotide (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Oligonucleotides

Targets Recommended: Antibody-Oligonucleotide Conjugates (AOCs)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W570888

2'-O,4'-C-Methylenecytidine LNA-C(Bz)	Nucleoside Antimetabolite/Analog	Cancer
2'-O,4'-C-Methylenecytidine (LNA-C(Bz)) is a bicyclic nucleoside analogue with fixed N-type conformation. 2'-O,4'-C-Methylenecytidine can be used to synthesize oligonucleotides. 2'-O,4'-C-Methylenecytidine forms duplexes with complementary DNA and RNA strands .

HY-21997

DMT-2'fluoro-da(bz) amidite	DNA/RNA Synthesis Drug Intermediate	Others
DMT-2'fluoro-da(bz) amidite is a key intermediate for synthesizing antisense oligonucleotides with high nuclease resistance, high RNA binding affinity, and maintained base-pair specificity .

HY-147012

GalNAc-L96	Drug Intermediate	Others
GalNAc-L96, a triantennary N-acetylgalactosamine (GalNAc), is a ligand of asialoglycoprotein receptor (ASGPR). GalNAc-L96 can be used to synthesize GalNAc-siRNA and can be used for oligonucleotide delivery .

HY-W010854

2'-Deoxyadenosine 5'-di-phos-phate disodium dADP disodium	DNA/RNA Synthesis	Others
2'-Deoxyadenosine 5'-di-phos-phate disodium (dADP disodium) is an inhibitor of bacterial poly(A) polymerase. It can be used to synthesize deoxyadenosine oligonucleotides with Escherichia coli polynucleotide phosphorylase and other enzymes .

HY-17653

Morpholino A phosphoramidite	Others	Others
Morpholino A phosphoramidite is a nucleoside group that can be used to synthesize amino phosphorus oligonucleotides .

HY-157091

Uridine, 5'-(P,P',P'',P''-tetrahydrogen imidotriphosphate)	Nucleoside Antimetabolite/Analog	Others
Uridine, 5'-(P,P',P'',P''-tetrahydrogen imidotriphosphate) is a non-hydrolyzable nucleotide that can synthesize RNA oligonucleotides .

HY-173247

GalNAc-NAG37 phosphoramidite	Biochemical Assay Reagents	Others
GalNAc-NAG37 phosphoramidite, a N-acetylgalactosamine (GalNAc) derivative, is a ligand of asialoglycoprotein receptor (ASGPR). GalNAc-NAG37 phosphoramidite can be used to synthesize GalNAc-siRNA and can be used for oligonucleotide delivery .

HY-W881466

5'(E)-VP-2'-OMe-Bz-A Phosphoramidite	DNA/RNA Synthesis	Others
5'(E)-VP-2'-OMe-Bz-A Phosphoramidite is a phosphoramidate nucleotide precursor compound, which is mainly used to synthesize stable and functionalized modified oligonucleotides and is used in the development and synthesis of nucleic acid drugs .

HY-W1119956

5’-(E)-VPG Phosphoramidite 5'(E)-VP-2'-OMe-iBu-G Phosphoramidite	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Infection
5'-(E)-VPG Phosphoramidite (5'(E)-VP-2'-OMe-iBu-GPhosphoramidite) is a structurally modified phosphoramidite reagent used to synthesize biologically stable oligonucleotides. 5'-(E)-VPG Phosphoramidite (POM) carries a VP protecting group and can be coupled to the target oligonucleotide at the 5' end via solid-phase synthesis. The modified oligonucleotide is then constructed through oxidation and deprotection steps. 5'-(E)-VPG Phosphoramidite is suitable for RNAi and viral replication research .

HY-W1119957

5'(E)-VP-2'-OMe-U Phosphoramidite	Biochemical Assay Reagents	Others
5'(E)-VP-2'-OMe-U Phosphoramidite is a phosphoramidite that contains 5’ DMT and uridine with 2’-O-methyl protection. 5'(E)-VP-2'-OMe-U Phosphoramidite can be used to synthesize oligonucleotide.

HY-78574

N-Benzoylcytidine	Nucleoside Antimetabolite/Analog	Others
N-Benzoylcytidine is a modified cytidine analogue that can be phosphorylated by uracil-cytidine kinase (UCK1 and UCK2). N-Benzoylcytidine can be used to synthesize 2-OH protective groups for solid-phase RNA synthesis, as well as synthetic oligonucleotides for UV induction and targeted gene silencing in zebrafish embryos .

HY-148503

5'-ODMT cEt N-Bz A Phosphoramidite (Amidite)	Nucleoside Antimetabolite/Analog	Others
5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is a nucleoside phosphoramidite monomer used to synthesize locked nucleic acid (LNA) analog oligonucleotides. It can be used as a building block of antisense oligonucleotides (ASOs) to target complementary RNA sequences. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) locks the furanose ring into an N-type conformation through 2',4'-constrained ethyl (cEt) modification, enhancing hybridization affinity and mismatch discrimination with RNA, while significantly improving the resistance of oligonucleotides to exonuclease digestion. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) mediates RNase H-dependent mRNA degradation or inhibits translation by forming a stable hybrid with RNA, thereby achieving gene expression regulation. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is mainly used in the development of antisense drugs, gene function research and oligonucleotide synthesis related to disease treatment .

Cat. No.	Product Name	Type

HY-21997

DMT-2'fluoro-da(bz) amidite	Gene Sequencing and Synthesis
DMT-2'fluoro-da(bz) amidite is a key intermediate for synthesizing antisense oligonucleotides with high nuclease resistance, high RNA binding affinity, and maintained base-pair specificity .

HY-W010854

2'-Deoxyadenosine 5'-di-phos-phate disodium dADP disodium	Gene Sequencing and Synthesis
2'-Deoxyadenosine 5'-di-phos-phate disodium (dADP disodium) is an inhibitor of bacterial poly(A) polymerase. It can be used to synthesize deoxyadenosine oligonucleotides with Escherichia coli polynucleotide phosphorylase and other enzymes .

HY-173247

GalNAc-NAG37 phosphoramidite	Gene Sequencing and Synthesis
GalNAc-NAG37 phosphoramidite, a N-acetylgalactosamine (GalNAc) derivative, is a ligand of asialoglycoprotein receptor (ASGPR). GalNAc-NAG37 phosphoramidite can be used to synthesize GalNAc-siRNA and can be used for oligonucleotide delivery .

Cat. No.	Product Name		Classification

HY-W570888

2'-O,4'-C-Methylenecytidine LNA-C(Bz)		Nucleoside Analogs Cytidine
2'-O,4'-C-Methylenecytidine (LNA-C(Bz)) is a bicyclic nucleoside analogue with fixed N-type conformation. 2'-O,4'-C-Methylenecytidine can be used to synthesize oligonucleotides. 2'-O,4'-C-Methylenecytidine forms duplexes with complementary DNA and RNA strands .

HY-21997

DMT-2'fluoro-da(bz) amidite		Nucleoside Phosphoramidites Adenine
DMT-2'fluoro-da(bz) amidite is a key intermediate for synthesizing antisense oligonucleotides with high nuclease resistance, high RNA binding affinity, and maintained base-pair specificity .

HY-W010854

2'-Deoxyadenosine 5'-di-phos-phate disodium dADP disodium		Nucleotide Analogs Adenine Nucleotide
2'-Deoxyadenosine 5'-di-phos-phate disodium (dADP disodium) is an inhibitor of bacterial poly(A) polymerase. It can be used to synthesize deoxyadenosine oligonucleotides with Escherichia coli polynucleotide phosphorylase and other enzymes .

HY-148503

5'-ODMT cEt N-Bz A Phosphoramidite (Amidite)		Nucleoside Phosphoramidites Adenine
5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is a nucleoside phosphoramidite monomer used to synthesize locked nucleic acid (LNA) analog oligonucleotides. It can be used as a building block of antisense oligonucleotides (ASOs) to target complementary RNA sequences. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) locks the furanose ring into an N-type conformation through 2',4'-constrained ethyl (cEt) modification, enhancing hybridization affinity and mismatch discrimination with RNA, while significantly improving the resistance of oligonucleotides to exonuclease digestion. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) mediates RNase H-dependent mRNA degradation or inhibits translation by forming a stable hybrid with RNA, thereby achieving gene expression regulation. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is mainly used in the development of antisense drugs, gene function research and oligonucleotide synthesis related to disease treatment .

HY-157091

Uridine, 5'-(P,P',P'',P''-tetrahydrogen imidotriphosphate)		Nucleotide Analogs Uracil Nucleotide
Uridine, 5'-(P,P',P'',P''-tetrahydrogen imidotriphosphate) is a non-hydrolyzable nucleotide that can synthesize RNA oligonucleotides .

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