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steroidal saponins

" in MedChemExpress (MCE) Product Catalog:

45

Inhibitors & Agonists

42

Natural
Products

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N5135
    Liriopesides B

    Nolinospiroside F

    		 Others Others
    Liriopesides B (Nolinospiroside F) is a steroidal saponin isolated from Ophiopogon japonicas. Liriopesides B has anti-oxidative and anti-aging effects .
    Liriopesides B
  • HY-N8804
    Shatavarin IV

    Asparanin B

    		 Reactive Oxygen Species (ROS) Neurological Disease Cancer
    Shatavarin IV is a steroidal saponin, that can be isolated from the roots of Asparagus racemosus (Liliaceae). Shatavarin IV shows anticancer activity. Shatavarin IV elicits lifespan extension and alleviates Parkinsonism in Caenorhabditis elegans .
    Shatavarin IV
  • HY-N6079
    Timosaponin A1

    		Lipoxygenase Dipeptidyl Peptidase COX Metabolic Disease Cancer
    Timosaponin A1, a natural steroidal saponin, is a 5-lipoxygenase (5-LO), COX-2, and dipeptidyl peptidase 4 (DPP-4) inhibitor with IC50s of 3.29 µM, 36.43 µM, and 33.25 µM, respectively .
    Timosaponin A1
  • HY-N12355
    Disporoside C

    		Others Others
    Disporoside C is a steroidal saponin can be isolated from Disporopsis pernyi .
    Disporoside C
  • HY-N12065
    Parisyunnanoside H

    		Others Others
    Parisyunnanoside H is a steroidal saponin isolated from Paris polyphylla Smith var. yunnanensis .
    Parisyunnanoside H
  • HY-N11983
    (25R)-Ruscogenin-3-yl α-L-rhamnopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→4)]-β-D-glucopyranoside

    		Others Others
    (25R)-Ruscogenin-3-yl α-L-rhamnopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→4)]-β-D-glucopyranoside (compound 1) is a steroidal saponin , can be isolated from the roots of Ophiopogon japonicus .
    (25R)-Ruscogenin-3-yl α-L-rhamnopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→4)]-β-D-glucopyranoside
  • HY-N7614
    Anemarrhenasaponin A2

    Schidigerasaponin F2; Timosaponin AII

    		 Others Cardiovascular Disease
    Anemarrhenasaponin A2 (Schidigerasaponin F2) is a steroidal saponin isolated from the rhizomes of Anemarrhena asphodeloides. Anemarrhenasaponin A2 inhibits ADP-induced platelet aggregation .
    Anemarrhenasaponin A2
  • HY-N3323
    Mannioside A

    		Others Inflammation/Immunology
    Mannioside A is a steroidal saponin. Mannioside A is a nature product that could be isolated from Dracaena mannii. Mannioside A has anti-inflammatory effect .
    Mannioside A
  • HY-N5135R
    Liriopesides B (Standard)

    Nolinospiroside F (Standard)

    		 Reference Standards Others Others
    Liriopesides B (Standard) is the analytical standard of Liriopesides B. This product is intended for research and analytical applications. Liriopesides B (Nolinospiroside F) is a steroidal saponin isolated from Ophiopogon japonicas. Liriopesides B has anti-oxidative and anti-aging effects .
    Liriopesides B (Standard)
  • HY-N12128
    Ophiopogonin R

    		Others Cancer
    Ophiopogonin R (compound 3) is a steroid saponin. Ophiopogonin R was isolated and purified from natural ophiopogonin. Ophiopogonin R was not cytotoxic to five human tumor cell lines (HepG2, HLE, BEL7402, BEL7403 and Hela) .
    Ophiopogonin R
  • HY-N12002
    Diosgenin-3-O-rhamnosyl(1→2)[glucosyl(1→6)]glucoside

    		Others Others
    Diosgenin-3-O-rhamnosyl(1→2)[glucosyl(1→6)]glucoside (compound 9) is a steroidal saponin, which can be obtained from Paris polyphylla var., Yunnan pine (yunnanensis) Isolated .
    Diosgenin-3-O-rhamnosyl(1→2)[glucosyl(1→6)]glucoside
  • HY-N4271
    Protogracillin

    		Others Cardiovascular Disease
    Protogracillin is a steroidal saponin isolated from Dioscorea zingiberensis Wright (DZW). Steroidal saponins from DZW rhizomes have the potential to reduce the risk of cardiovascular diseases by anti-thrombotic action .
    Protogracillin
  • HY-N4270
    Pseudoprotogracillin

    		Others Others
    Pseudoprotogracillin is a steroidal saponin isolated Dioscoreae species .
    Pseudoprotogracillin
  • HY-107284
    Officinalisinin I

    		Others Others
    Officinalisinin I is a steroidal saponin, isolated from Anemarrhena asphodeloides.
    Officinalisinin I
  • HY-121593
    Ruizgenin

    		Others Others
    Ruizgenin is a new steroidal saponin diol extracted from Agave lecheguilla.
    Ruizgenin
  • HY-N13104
    Dracaenoside F

    		Others Others
    Dracaenoside F is a steroidal saponin that can be isolated from Dracaena cochinchinensis .
    Dracaenoside F
  • HY-133237
    Anemarrhenasaponin III

    		Others Others
    Anemarrhenasaponin III is a steroidal saponin isolated from the rhizome of Anemarrhena asphodeloides Bunge (Liliaceae) .
    Anemarrhenasaponin III
  • HY-N12424
    Elephanoside D

    		Others Others
    Elephanoside D (compound 8) is a steroidal saponin isolated from the stems of Yucca elephantipes Regel.
    Elephanoside D
  • HY-N5078
    Terrestrosin K

    		Others Cardiovascular Disease
    Terrestrosin K, a steroidal saponin from Tribulus terrestris L., has potential to treat cardiovascular and cerebrovascular diseases .
    Terrestrosin K
  • HY-N2283
    Deltonin
    1 Publications Verification

    		 ERK Akt Endogenous Metabolite Cancer
    Deltonin, a steroidal saponin, isolated from Dioscorea zingiberensis, has antitumor activity; Deltonin inhibits ERK1/2 and AKT activation.
    Deltonin
  • HY-N13137
    Timosaponin N

    		Glycosidase Metabolic Disease
    Timosaponin N is a natural steroidal saponin that inhibits the activity of α-Glucosidase. Timosaponin N can be used in diabetes-related research .
    Timosaponin N
  • HY-N5074
    Terrestrosin D

    		Apoptosis Cancer
    Terrestrosin D, a steroidal saponin from Tribulus terrestris L., induces cell cycle arrest and cancer cells apoptosis. Terrestrosin D has antiangiogenic activities .
    Terrestrosin D
  • HY-N0706
    Gracillin
    2 Publications Verification

    		 Apoptosis Autophagy Cancer
    Gracillin is a steroidal saponin that can be extracted from the roots of the plant and has anti-tumor properties. Gracillin can induce cancer cell apoptosis and autophagy .
    Gracillin
  • HY-N0812
    Timosaponin BII

    Prototimosaponin A III

    		 Amyloid-β Neurological Disease Inflammation/Immunology Cancer
    Timosaponin BII (Prototimosaponin A III) is a steroid saponin found in the rhizomes of Anemarrhena asphodeloides. Timosaponin BII has neuronal protective, anti-inflammatory and antioxidant activities .
    Timosaponin BII
  • HY-N0799
    Protodioscin

    		Endogenous Metabolite Cardiovascular Disease Cancer
    Protodioscin, a major steroidal saponin in Trigonella foenum-graecum Linn., has been shown to exhibit multiple biological actions, such as anti-hyperlipidemia, anti-cancer, sexual effects and cardiovascular properties.
    Protodioscin
  • HY-N3584
    Paris saponin VII
    4 Publications Verification

    Chonglou Saponin VII

    		 Akt p38 MAPK P-glycoprotein Bcl-2 Family Caspase PARP Autophagy Apoptosis Cancer
    Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .
    Paris saponin VII
  • HY-N3584R
    Paris saponin VII (Standard)

    Chonglou Saponin VII (Standard)

    		 Reference Standards Akt p38 MAPK P-glycoprotein Bcl-2 Family Caspase PARP Autophagy Apoptosis Cancer
    Paris saponin VII (Standard) is the analytical standard of Paris saponin VII. This product is intended for research and analytical applications. Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .
    Paris saponin VII (Standard)
  • HY-16958R
    PD 404182 (Standard)

    		Antibiotic Dimethylargininase (DDAH) Reference Standards Inflammation/Immunology
    Paris saponin VII (Standard) is the analytical standard of Paris saponin VII. This product is intended for research and analytical applications. Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .
    PD 404182 (Standard)
  • HY-N6806
    Timosaponin B III

    		Others Neurological Disease Inflammation/Immunology
    Timosaponin B III is a major bioactive steroidal saponin isolated from Anemarrhena asphodeloides Bge, and exhibits anti-inflammatory, anti-platelet aggregative and anti-depressive effects .
    Timosaponin B III
  • HY-N1422
    Hecogenin

    		Fungal Infection Inflammation/Immunology
    Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects .
    Hecogenin
  • HY-N0706R
    Gracillin (Standard)

    		Reference Standards Apoptosis Autophagy Cancer
    Gracillin (Standard) is the analytical standard of Gracillin. This product is intended for research and analytical applications. Gracillin is a steroidal saponin that can be extracted from the roots of the plant and has anti-tumor properties. Gracillin can induce cancer cell apoptosis and autophagy .
    Gracillin (Standard)
  • HY-W046906R
    (E)-Oct-2-enoic acid (Standard)

    		Reference Standards Endogenous Metabolite Metabolic Disease
    Timosaponin BII (Standard) is the analytical standard of Timosaponin BII. This product is intended for research and analytical applications. Timosaponin BII (Prototimosaponin A III) is a steroid saponin found in the rhizomes of Anemarrhena asphodeloides. Timosaponin BII has neuronal protective, anti-inflammatory and antioxidant activities .
    (E)-Oct-2-enoic acid (Standard)
  • HY-N0799R
    Protodioscin (Standard)

    		Reference Standards Endogenous Metabolite Cancer
    Protodioscin (Standard) is the analytical standard of Protodioscin. This product is intended for research and analytical applications. Protodioscin, a major steroidal saponin in Trigonella foenum-graecum Linn., has been shown to exhibit multiple biological actions, such as anti-hyperlipidemia, anti-cancer, sexual effects and cardiovascular properties.
    Protodioscin (Standard)
  • HY-N0812R
    Timosaponin BII (Standard)

    Prototimosaponin A III (Standard)

    		 Amyloid-β Reference Standards Neurological Disease Inflammation/Immunology Cancer
    Timosaponin BII (Standard) is the analytical standard of Timosaponin BII. This product is intended for research and analytical applications. Timosaponin BII (Prototimosaponin A III) is a steroid saponin found in the rhizomes of Anemarrhena asphodeloides. Timosaponin BII has neuronal protective, anti-inflammatory and antioxidant activities .
    Timosaponin BII (Standard)
  • HY-N13136
    Timosaponin D

    		Others Cancer
    Timosaponin D, a natural steroid saponin, can be obtained from the rhizome of Anemarrhena asphodeloides. The IC50 values ​​of Timosaponin D against HepG2 and SGC7901 cells are 43.90 and 57.90 μM, respectively. Timosaponin D can be used in anticancer research .
    Timosaponin D
  • HY-N0177
    Diosgenin
    5+ Cited Publications

    		 STAT MicroRNA Metabolic Disease
    Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway . Diosgenin is an exogenous activator of Pdia3/ERp57 . Diosgenin inhibits aortic atherosclerosis progression by suppressing macrophage miR-19b expression .
    Diosgenin
  • HY-N1422R
    Hecogenin (Standard)

    		Reference Standards Fungal Infection Inflammation/Immunology
    Hecogenin (Standard) is the analytical standard of Hecogenin. This product is intended for research and analytical applications. Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects .
    Hecogenin (Standard)
  • HY-N1654
    2',3'-Dehydrosalannol

    		Bacterial Infection
    2',3'-Dehydrosalannol is a potent antibacterial agent. 2',3'-Dehydrosalannol shows antibacterial activity against K. pneumonia ATCC 13883, P. aeruginosa ATCC 27853, S. aureus ATCC 25922, E. coli ATCC 11775, and E. faecalis ATCC 10541, with MIC values of 0.78, 1.56, 1.56, 6.25, and 25 μg/mL, respectively .
    2',3'-Dehydrosalannol
  • HY-N0177R
    Diosgenin (Standard)

    		Reference Standards STAT MicroRNA Metabolic Disease
    Diosgenin (Standard) is the analytical standard of Diosgenin. This product is intended for research and analytical applications. Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway . Diosgenin is an exogenous activator of Pdia3/ERp57 . Diosgenin inhibits aortic atherosclerosis progression by suppressing macrophage miR-19b expression .
    Diosgenin (Standard)
  • HY-N0124
    Dioscin
    Maximum Cited Publications
    10 Publications Verification

    Collettiside III; CCRIS 4123

    		 Autophagy Apoptosis Cardiovascular Disease Cancer
    Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity .
    Dioscin
  • HY-16445BR
    CNDAC hydrochloride (Standard)

    		Reference Standards Nucleoside Antimetabolite/Analog Drug Metabolite Apoptosis DNA/RNA Synthesis Cancer
    Dioscin (Standard) is the analytical standard of Dioscin. This product is intended for research and analytical applications. Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity .
    CNDAC hydrochloride (Standard)
  • HY-N0124R
    Dioscin (Standard)

    Collettiside III (Standard); CCRIS 4123 (Standard)

    		 Reference Standards Autophagy Apoptosis Cardiovascular Disease Cancer
    Dioscin (Standard) is the analytical standard of Dioscin. This product is intended for research and analytical applications. Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity .
    Dioscin (Standard)
  • HY-N0811
    Anemarsaponin B

    		NO Synthase COX NF-κB MEK Inflammation/Immunology
    Anemarsaponin B is a steroidal saponin. Anemarsaponin B decreases the protein and mRNA levels of iNOS and COX-2. Anemarsaponin B reduces the expressions and productions of pro-inflammatory cytokines, including TNF-a and IL-6. Anemarsaponin B inhibits the nuclear translocation of the p65 subunit of NF-κB by blocking the phosphorylation of IκBα. Anemarsaponin B also inhibits the phosphorylation of MAP kinase kinases 3/6 (MKK3/6) and mixed lineage kinase 3 (MLK3). Anti-inflammatory effect .
    Anemarsaponin B
  • HY-N2078
    Yamogenin

    Neodiosgenin

    		 LXR Reactive Oxygen Species (ROS) Apoptosis Fatty Acid Synthase (FASN) Metabolic Disease
    Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes. Yamogenin is a steroidal saponin that can be obtained from plant species with in vitro cytotoxicity, antioxidant, and antimicrobial properties. Yamogenin induces cell death via the extrinsic and intrinsic way of apoptosis. Yamogenin inhibits protein denaturation with an IC50 of 1421.92 μg/mL. Yamogenin can be studied in research on gastric cancer .
    Yamogenin
  • HY-N2078R
    Yamogenin (Standard)

    Neodiosgenin (Standard)

    		 Reference Standards LXR Apoptosis Fatty Acid Synthase (FASN) Reactive Oxygen Species (ROS) Metabolic Disease
    Yamogenin (Standard) is the analytical standard of Yamogenin. This product is intended for research and analytical applications. Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes. Yamogenin is a steroidal saponin that can be obtained from plant species with in vitro cytotoxicity, antioxidant, and antimicrobial properties. Yamogenin induces cell death via the extrinsic and intrinsic way of apoptosis. Yamogenin inhibits protein denaturation with an IC50 of 1421.92 μg/mL. Yamogenin can be studied in research on gastric cancer .
    Yamogenin (Standard)

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