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stereoselectively

" in MedChemExpress (MCE) Product Catalog:

36

Inhibitors & Agonists

2

Biochemical Assay Reagents

8

Natural
Products

2

Isotope-Labeled Compounds

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W011024
    (2R,3S)-N-Cbz-6-oxo-2,3-diphenylmorpholine

    		Biochemical Assay Reagents Others
    (2R,3S)-N-Cbz-6-oxo-2,3-diphenylmorpholine is a chiral building block, which can be used in the stereoselective synthesis of fluorescent and non-fluorescent amino acids .
    (2R,3S)-N-Cbz-6-oxo-2,3-diphenylmorpholine
  • HY-117734
    PYD-106

    		iGluR Neurological Disease
    PYD-106 is a stereoselective pyrrolidinone (PYD) positive allosteric modulator for GluN2C-containing NMDA receptors. PYD-106 increases opening frequency and open time of single channel currents activated by maximally effective concentrations of agonist but only has modest effects on glutamate and glycine EC50. PYD-106 selectively enhances the responses of diheteromeric GluN1/GluN2C receptors but not triheteromeric GluN1/GluN2A/GluN2C receptors .
    PYD-106
  • HY-22385
    Salsolidine
    2 Publications Verification

    		 Monoamine Oxidase Neurological Disease
    Salsolidine is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor.
    Salsolidine
  • HY-105545A
    Levetimide

    		mAChR Neurological Disease
    Levetimide is a potent and stereoselective inhibitor of [ 3H](+)pentazocine binding, with a Ki of 2.2 nM .
    Levetimide
  • HY-176431
    TLCD1-IN-1

    		Endogenous Metabolite Metabolic Disease
    TLCD1-IN-1 (compound MB-4A) is a covalent TLCD1 inhibitor. TLCD1-IN-1 stereoselectively engages and inhibits TLCD1 in HepG2 cells .
    TLCD1-IN-1
  • HY-N9022
    (S)-1-(4-Hydroxy-2,2-dimethylchroman-6-yl)ethanone

    		Others Others
    (S)-1-(4-Hydroxy-2,2-dimethylchroman-6-yl)ethanone is an enantiopure chiral alcohol. Stereoselective reduction of prochiral ketones is studied by using both cell cultures and wild tissues of various endemic plant species .
    (S)-1-(4-Hydroxy-2,2-dimethylchroman-6-yl)ethanone
  • HY-10572A
    (R)-Efavirenz

    (R)-DMP 266; (R)-EFV; (R)-L-743726

    		 Reverse Transcriptase Infection
    (R)-Efavirenz ((R)-DMP 266) is a non-nucleoside reverse transcriptase inhibitor that acts by non-competitive inhibition of the viral enzyme. (R)-Efavirenz can be metabolized by CYP2B6 to 8-hydroxyefavirenz in a highly stereoselective manner. (R)-Efavirenz is promising to be a useful probe for the CYP2B6 active site and catalytic mechanisms .
    (R)-Efavirenz
  • HY-22385A
    Salsolidine hydrochloride

    		Monoamine Oxidase Neurological Disease
    Salsolidine hydrochloride, a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A (monoamine oxidase A) inhibitor.
    Salsolidine hydrochloride
  • HY-B0204B
    (-)-Pimobendan

    (-)-UD-CG115

    		 Phosphodiesterase (PDE) Cardiovascular Disease
    (-)-Pimobedan is an isomer of pimobedan. It has the property of stereoselective partitioning or distribution into erythrocytes. The clearance of (-)-pimobedan from erythrocytes is significantly lower than that of (+)-pimobedan, which is entirely due to its stereoselective distribution into erythrocytes. This stereoselective property of (-)-pimobedan may explain the phenomenon previously reported that it produces a 1.5-fold greater contractile force than the (+)-isomer in detergent-treated myocardial specimens of guinea pigs and dogs. These properties suggest that (-)-pimobedan may have unique advantages in terms of in vivo distribution and pharmacological action, which may have important implications for its clinical use.
    (-)-Pimobendan
  • HY-167662
    Sopromidine

    		Histamine Receptor Drug Isomer Others
    Sopromidine is a potent and stereoselective isomer of the achiral H2-agonist Impromidine (HY-116777) .
    Sopromidine
  • HY-W076971
    Ethyl pivaloylacetate

    		Others Others
    Ethyl pivaloylacetate is a β-ketoester. Ethyl pivaloylacetate can be uesd as the substrate to evaluate the activity and stereoselectivity of the ketoreductase tool-box .
    Ethyl pivaloylacetate
  • HY-W570890
    2'-O-MOE-5-Me-C(Bz)

    		DNA/RNA Synthesis Others
    2'-O-MOE-5-Me-C (Bz) is a nucleotide for the stereoselective synthesis of nucleoside alkyl phosphonates .
    2'-O-MOE-5-Me-C(Bz)
  • HY-158301
    MY-1B
    1 Publications Verification

    		 DNA Methyltransferase RNA MTase Others
    MY-1B is a covalent inhibitor of the RNA Methyltransferase NSUN2 (IC50: 1.3 μM). MY-1B stereoselectively ligands active-site cysteine residues (C271) of NSUN2. MY-1B can stereoselectively and covalently bind to PSME1, disrupting the proteasome regulatory complex and downregulating the presentation of specific MHC-I subtypes .
    MY-1B
  • HY-121665
    Rosaprostol

    		Others Others
    Rosaprostol is a compound with antiulcer activity, and its enantiomers can be synthesized from the corresponding building blocks via a specific synthetic route involving multistep reactions and stereoselective transformations.
    Rosaprostol
  • HY-117580
    16α-Hydroxyprednisolone

    OH-PRED

    		 Drug Metabolite Inflammation/Immunology
    16α-Hydroxyprednisolone is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid budesonide via cytochrome P450 3A (CYP3A) enzymes .
    16α-Hydroxyprednisolone
  • HY-105236
    (Rac)-Enadoline

    (Rac)-CI-977 free base

    		 Opioid Receptor Neurological Disease
    (Rac)-Enadoline ((Rac)-CI-977 free base) is a selective K-opioid receptor agonist that stereoselectively antagonizes clonic seizures induced by slow intravenous injection of N-methyl-DL-aspartate in mice .
    (Rac)-Enadoline
  • HY-N12970
    14S(15R)-EET

    		Others Others
    14S(15R)-EET is an endogenous epoxytrienoic acid derivative that mainly exists in rat organs. By studying its metabolic process, it was found that its stereoselective hydration and formation of chiral diols were significantly affected by epoxidase. Different 14,15-EET enantiomers showed different regions and stereochemistry of hydration reactions, among which 14(R),15(S)-EET showed specific hydration for C15. These findings reveal the important role of epoxidase in the metabolism of endogenous EETs, and the differences in enzyme affinity and reaction rate for individual EET enantiomers may lead to their stereoselective metabolism .
    14S(15R)-EET
  • HY-138793
    2-(2,6-Dioxopiperidin-3-yl)phthalimidine

    EM-12

    		 TNF Receptor Cancer
    2-(2,6-Dioxopiperidin-3-yl)phthalimidine (EM-12), a teratogenic Thalidomide analogue, is more active than Thalidomide and is much more stable for hydrolysis. 2-(2,6-Dioxopiperidin-3-yl)phthalimidine enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomas .
    2-(2,6-Dioxopiperidin-3-yl)phthalimidine
  • HY-117580S
    16α-Hydroxyprednisolone-d3

    OH-PRED-d3

    		 Isotope-Labeled Compounds Drug Metabolite Inflammation/Immunology
    16α-Hydroxyprednisolone-d3 is the deuterium labeled 16α-Hydroxyprednisolone. 16α-Hydroxyprednisolone is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid budesonide via cytochrome P450 3A (CYP3A) enzymes .
    16α-Hydroxyprednisolone-d3
  • HY-B0352A
    (S)-Mirtazapine

    (S)-Org3770; (S)-6-Azamianserin

    		 5-HT Receptor Neurological Disease
    (S)-Mirtazapine ((S)-Org3770) is a S(+)-enantiomer of Mirtazapine with pronociceptive properties in an animal model of acute thermal nociception. (S)-Mirtazapine is a stereoselective 5-HT2 receptor antagonist. (S)-Mirtazapine is metabolized by CYP2D6 and CYP1A2 .
    (S)-Mirtazapine
  • HY-117580R
    16α-Hydroxyprednisolone (Standard)

    		Drug Metabolite Inflammation/Immunology
    16α-Hydroxyprednisolone (Standard) is the analytical standard of 16α-Hydroxyprednisolone. This product is intended for research and analytical applications. 16α-Hydroxyprednisolone is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid budesonide via cytochrome P450 3A (CYP3A) enzymes .
    16α-Hydroxyprednisolone (Standard)
  • HY-B1127R
    Betamipron (Standard)

    		Bacterial Antibiotic Others
    16α-Hydroxyprednisolone (Standard) is the analytical standard of 16α-Hydroxyprednisolone. This product is intended for research and analytical applications. 16α-Hydroxyprednisolone is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid budesonide via cytochrome P450 3A (CYP3A) enzymes .
    Betamipron (Standard)
  • HY-106840A
    L-365260 hemihydrate
    1 Publications Verification

    		 Cholecystokinin Receptor Neurological Disease Metabolic Disease
    L-365260 hemihydrate is an orally active and selective antagonist of non-peptide gastrin and brain cholecystokinin receptor (CCK-B), with Kis of 1.9 nM and 2.0 nM, respectively. L-365260 hemihydrate interacts in a stereoselective and competitive manner with guinea pig stomach gastrin and brain CCK receptors .
    L-365260 hemihydrate
  • HY-B0352AS
    (S)-Mirtazapine-d3

    (S)-Org3770 d3; (S)-6-Azamianserin d3

    		 5-HT Receptor Neurological Disease
    (S)-Mirtazapine-d3 is a deuterium labeled (S)-Mirtazapine. (S)-Mirtazapine is a S(+)-enantiomer of Mirtazapine with pronociceptive properties in an animal model of acute thermal nociception.(S)-Mirtazapine is a stereoselective 5-HT2 receptor antagonist. (S)-Mirtazapine is metabolized by CYP2D6 and CYP1A2[1].
    (S)-Mirtazapine-d3
  • HY-N13080
    3-Oxo-bufalin

    		Others Cancer
    3-Oxo-bufalin is an active compound that can be isolated from cultured toad liver tissue. 3-Oxo-bufalin can be produced through a metabolic pathway, and it is a metabolite of Bufalin (HY-N0877) catalyzed by the stereoselective 3β-dehydrogenase. Bufalin is a Na+/K+-ATPase inhibitor and has anti-tumor activity .
    3-Oxo-bufalin
  • HY-135811R
    Desethyl chloroquine (Standard)

    		Parasite Toll-like Receptor (TLR) Autophagy Infection
    Desethyl chloroquine (Standard) is the analytical standard of Desethyl chloroquine. This product is intended for research and analytical applications. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity .
    Desethyl chloroquine (Standard)
  • HY-135811
    Desethyl chloroquine
    1 Publications Verification

    		 Parasite Toll-like Receptor (TLR) Autophagy Infection
    Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity .
    Desethyl chloroquine
  • HY-135811A
    Desethyl chloroquine diphosphate
    1 Publications Verification

    		 Parasite Toll-like Receptor (TLR) Autophagy Infection
    Desethyl chloroquine diphosphate is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine diphosphate possesses antiplasmodic activity .
    Desethyl chloroquine diphosphate
  • HY-W022362
    2-Aminotetralin

    		Serotonin Transporter Neurological Disease
    2-Aminotetralin is a potent and selective serotonin 5-HT1 agonist. 2-Aminotetralin exhibits high affinity (Ki≤25 nM) and at least 50-fold stereoselective preference at 5-HT1A, 5-HT1B, and 5-HT1D receptors .
    2-Aminotetralin
  • HY-106840
    L-365260
    1 Publications Verification

    		 Cholecystokinin Receptor Neurological Disease Metabolic Disease
    L-365260 is an orally active and selective antagonist of non-peptide gastrin and brain cholecystokinin receptor (CCK-B), with Kis of 1.9 nM and 2.0 nM, respectively. L-365260 interacts in a stereoselective and competitive manner with guinea pig stomach gastrin and brain CCK receptors. L-365260 can enhance Morphine analgesia and prevents Morphine tolerance .
    L-365260
  • HY-40228
    (R)-(+)-tert-Butylsulfinamide

    (R)-2-Methylpropane-2-sulfinamide

    		 Biochemical Assay Reagents Others
    (R)-(+)-tert-Butylsulfinamide ((R)-2-Methylpropane-2-sulfinamide) is a chiral reagent commonly used in the asymmetric synthesis of compounds such as amines, amino acids, and amino alcohols. (R)-(+)-tert-Butylsulfinamide achieves stereoselective reactions by condensing with carbonyl groups to form sulfinyl imine intermediates, and after the reaction, this group can be removed under acidic conditions to obtain the target product .
    (R)-(+)-tert-Butylsulfinamide
  • HY-169803
    L-657926

    		Prostaglandin Receptor Cardiovascular Disease
    L-657926 is a stereoselective antagonist of the thromboxane A2 (TxA2) receptor, composed of (-)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-1-yl acetic acid and (+)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-l-yl acetic acid. The IC50s of (-) and (+) configurations for TxA2 are 0.27 nM and 124 nM, respectively.
    L-657926
  • HY-N0548
    α-Angelica lactone
    2 Publications Verification

    		 Glutathione S-transferase Cancer
    α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes .
    α-Angelica lactone
  • HY-W010507
    (R)-Methyl 3-hydroxybutanoate

    Methyl (R)-(-)-3-hydroxybutyrate

    		 Biochemical Assay Reagents Others
    (R)-Methyl 3-hydroxybutanoate, (R)-Methyl 3-hydroxybutanoate is an enantiomer, from the perspective of the methyl (-CH3) group, the hydroxyl (-OH) group on the third carbon atom The group faces to the right, a colorless transparent liquid, soluble in organic solvents such as ethanol and ether, insoluble in water, (R)-Methyl 3-hydroxybutanoate is usually used to synthesize various organic compounds (including drugs, agricultural chemicals and flavoring agents) It can also be used as a chiral auxiliary in asymmetric synthetic reactions involving the formation of chemical bonds in a stereoselective manner.
    (R)-Methyl 3-hydroxybutanoate
  • HY-168382
    5R(6S)-EET

    		Prostaglandin Receptor Endogenous Metabolite Others
    5R(6S)-EET is the metabolite of Arachidonic acid (HY-109590). 5R(6S)-EET activates the synthesis of endogenous prostaglandin (PGE2), which inhibits the Na + absorption, increases the intracellular Ca 2+, and promotes the depolarization of transmembrane voltage. 5R(6S)-EET exhibits stereoselectivity with less effectness than 5S(6R)-EET (HY-168382A) .
    5R(6S)-EET
  • HY-12316
    20(S)-Hydroxycholesterol
    2 Publications Verification

    20α-Hydroxycholesterol

    		 Smo Endogenous Metabolite Cardiovascular Disease Metabolic Disease Cancer
    20(S)-Hydroxycholesterol (20α-Hydroxycholesterol) is an allosteric activator that selectively targets the Smoothened (Smo) of the Hedgehog pathway with an EC50 of ~30 μM (Hedgehog). 20(S)-Hydroxycholesterol binds to the extracellular cysteine-rich domain (CRD) of Smo in a stereoselective manner, activating downstream Gli transcription factors (without inducing transcription of receptor genes in the Wnt pathway). 20(S)-Hydroxycholesterol enhances osteogenic differentiation of bone marrow stromal cells and synergistically activates the Raf/MEK/ERK pathway with Simvastatin (HY-17502) to promote bone regeneration. 20(S)-Hydroxycholesterol can be used to study the mechanisms of developmental biology, oncology, bone, and angiogenesis .
    20(S)-Hydroxycholesterol

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