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squalene synthase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) DNA/RNA Synthesis (1) Endogenous Metabolite (4) Farnesyl Transferase (12) Ferroptosis (1) Fungal (1) HCV (2) Parasite (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (2) Infection (2) Metabolic Disease (11)

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Targets Recommended: PGE synthase Thymidylate Synthase ATP Synthase Acetolactate Synthase (ALS) Glucosylceramide Synthase (GCS) NO Synthase Fatty Acid Synthase (FASN) Cyclic GMP-AMP Synthase GSK-3

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103087

FIN56 Maximum Cited Publications 21 Publications Verification	Ferroptosis	Others
FIN56 is a specific inducer of ferroptosis. FIN56 induces ferroptosis by inducing degradation of GPX4. FIN56 also binds to and activates squalene synthase .

HY-100313A

YM-53601 4 Publications Verification	Farnesyl Transferase HCV	Infection Metabolic Disease
YM-53601, a **squalene synthase** inhibitor, reduces plasma cholesterol and triglyceride levels in vivo . YM-53601 inhibits squalene synthase derived from human hepatoma cells with an IC₅₀ of 79 nM. Lipid-lowering agent . YM-53601 is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation .

HY-16108A

Squalene synthase-IN-3 tripotassium	Farnesyl Transferase	Metabolic Disease
Squalene synthase-IN-3 tripotassium (Compound 1) is a potent **squalene synthase** inhibitor .

HY-163452

Squalene synthase-IN-2	Farnesyl Transferase	Metabolic Disease
Squalene synthase-IN-2 (comppund isomer A-(1S, 3R)-14i) is an orally active **squalene synthase inhibitor with IC₅₀** values of 3.4, 99 nM for squalene synthase and cholesterol synthesis, respectively. Squalene synthase-IN-2 reduces plasma cholesterol and triglyceride .

HY-149405

Squalene synthase-IN-1	Others	Metabolic Disease
Squalene synthase-IN-1 (compound 1) is a potent antihyperlipidemic agent acting through **Squalene Synthase** inhibition. Squalene synthase-IN-1 exhibits an outstanding antioxidant and anti-inflammatory activity. Squalene synthase-IN-1 displays a significant reduction not only of glucose but also of oxidative stress levels, while it did not cause any toxicity .

HY-125311

Zaragozic acid D	Farnesyl Transferase	Cancer
Zaragozic acid D is a **squalene synthase inhibitor. Zaragozic acid D also is a farnesyl-protein transferase (FPTase) inhibitor with an IC₅₀** value of 100 nM for bovine FPTase .

HY-100313

YM-53601 free base	Farnesyl Transferase HCV	Metabolic Disease
YM-53601 free base, a **squalene synthase** inhibitor, reduces plasma cholesterol and triglyceride levels in vivo . YM-53601 free base inhibits squalene synthase derived from human hepatoma cells with an IC₅₀ of 79 nM. Lipid-lowering agent . YM-53601 free base is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation .

HY-100299

RPR107393 free base	Farnesyl Transferase	Cardiovascular Disease Metabolic Disease
RPR107393 free base is an orally active potent selective squalene synthase (SQS) inhibitor. RPR107393 free base inhibits rat liver microsomal squalene synthase with an IC₅₀ value of 0.8 nM. RPR107393 free base reduces triglyceride biosynthesis by suppressing fatty acid biosynthesis via an increase in intracellular farnesol and its derivatives. RPR107393 free base reduces plasma cholesterol in rats and marmosets. RPR107393 free base can be used for metabolic disease research, such as hypercholesterolemia, hypertriglyceridemia and atherosclerosis ^[1][2].

HY-178158

SQS-IN-1	Farnesyl Transferase Apoptosis DNA/RNA Synthesis	Cancer
SQS-IN-1 is a squalene synthase (SQS) inhibitor. SQS-IN-1 exhibits potent and broad-spectrum anti-proliferative effects on both mouse and human lung cancer cell lines. SQS-IN-1 inhibits DNA replication and the cell cycle, causing mitochondrial hyperpolarization and inducing cell apoptosis. SQS-IN-1 inhibits cell migration and invasion. SQS-IN-1 can be used to the study of lung cancer .

HY-B2097

Incadronate disodium YM 175; Bisphonal	Farnesyl Transferase	Metabolic Disease
Incadronate disodium (YM 175) is a bisphosphonate with strong inhibitory activity on bone resorption. Incadronate disodium indirectly stimulates renal 25-hydroxyvitamin D-1-hydroxylase by increasing circulating parathyroid hormone. Incadronate disodium, a cholesterol-lowering agent, is a potent inhibitor of rat liver microsomal squalene synthase (K_i=57 nM). Incadronate disodium inhibits sterol biosynthesis in mouse macrophage J774 cells (IC₅₀=64 μM). Incadronate disodium has the potential for malignant tumors research .

HY-123405

YM-75440	Endogenous Metabolite	Others
YM-75440 is an orally active inhibitor of squalene synthase.

HY-N13888

Schizostatin	Farnesyl Transferase	Metabolic Disease
Schizostatin is a **squalene synthase inhibitor with an IC₅₀** of 0.84 μM .

HY-116290A

Zaragozic acid A trisodium Squalestatin S1 trisodium	Farnesyl Transferase Fungal Endogenous Metabolite	Others
Zaragozic acid A trisodium is a fungal metabolite that acts as a reversible competitive inhibitor of squalene synthase .

HY-125324

Squalestatin 3	Endogenous Metabolite	Cardiovascular Disease
Squalestatin 3 is a secondary metabolite, which can be isolated from Phoma. Squalestatin 3 is an inhibitor for **squalene synthase with an IC₅₀** of 6 nM .

HY-16274

Lapaquistat acetate 1 Publications Verification TAK-475	Farnesyl Transferase	Metabolic Disease
Lapaquistat acetate (TAK-475) is a **squalene synthase** inhibitor, blocking the conversion of farnesyl diphosphate (FPP) to squalene in the cholesterol biosynthesis pathway . Lapaquistat acetate is effective at lowering low-density lipoprotein cholesterol, but it might cause liver damage. Lapaquistat acetate is used for hypercholesterolemia and mevalonate kinase deficiency (MKD) research .

HY-116290

Zaragozic acid A 1 Publications Verification Squalestatin S1	Endogenous Metabolite	Metabolic Disease
Zaragozic acid A is a fungal metabolite that acts as a reversible competitive inhibitor of squalene synthase. Zaragozic acid A is an inhibitor of acute hepatic cholesterol synthesis in mouse (IC₅₀ = 6 μM) .

HY-135625

BPH-1218	Parasite	Infection
BPH-1218 is an inhibitor of squalene synthase (SQS), with the IC₅₀ of 31 nM and 64 nM for TcSQS and HsSQS, respectively, that can be used as an anti-infective agent .

HY-126871

Zaragozic acid D2	Farnesyl Transferase	Metabolic Disease Cancer
Zaragozic acid D2 is the inhibitor for **squalene synthase and Ras farnesyl-protein transferase (Ras FPTase), with IC₅₀** of 2 nM and 100 nM, respectively. Zaragozic acid D2 is potentially ameliorating hypercholesterolemia and Ras-induced cancer .

Zaragozic acid A 1 Publications Verification Squalestatin S1	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Disease Research Fields	Endogenous Metabolite
Zaragozic acid A is a fungal metabolite that acts as a reversible competitive inhibitor of squalene synthase. Zaragozic acid A is an inhibitor of acute hepatic cholesterol synthesis in mouse (IC₅₀ = 6 μM) .

Zaragozic acid D	Microorganisms Ketones, Aldehydes, Acids Source classification	Farnesyl Transferase
Zaragozic acid D is a **squalene synthase inhibitor. Zaragozic acid D also is a farnesyl-protein transferase (FPTase) inhibitor with an IC₅₀** value of 100 nM for bovine FPTase .

YM-53601 free base	Alkaloids Carbazole Alkaloids	Farnesyl Transferase HCV
YM-53601 free base, a **squalene synthase** inhibitor, reduces plasma cholesterol and triglyceride levels in vivo . YM-53601 free base inhibits squalene synthase derived from human hepatoma cells with an IC₅₀ of 79 nM. Lipid-lowering agent . YM-53601 free base is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation .

Schizostatin	Natural Products Microorganisms Source classification	Farnesyl Transferase
Schizostatin is a **squalene synthase inhibitor with an IC₅₀** of 0.84 μM .

Squalestatin 3	Natural Products Microorganisms Source classification	Endogenous Metabolite
Squalestatin 3 is a secondary metabolite, which can be isolated from Phoma. Squalestatin 3 is an inhibitor for **squalene synthase with an IC₅₀** of 6 nM .

Zaragozic acid D2	Microorganisms Ketones, Aldehydes, Acids Source classification	Farnesyl Transferase
Zaragozic acid D2 is the inhibitor for **squalene synthase and Ras farnesyl-protein transferase (Ras FPTase), with IC₅₀** of 2 nM and 100 nM, respectively. Zaragozic acid D2 is potentially ameliorating hypercholesterolemia and Ras-induced cancer .

Cat. No.	Compare	Product Name	Species	Source

HY-P72193

	FDFT1 Protein, Human (His) DGPT; ERG9; Farnesyl diphosphate farnesyltransferase; Farnesyl-diphosphate farnesyltransferase; FDFT_HUMAN; FDFT1; FPP:FPP farnesyltransferase; SQS; squalene synthase; squalene synthetase; SS	Human	E. coli
	FDFT1 is a key enzyme in cellular metabolism responsible for coordinating the condensation of two farnesyl pyrophosphate (FPP) molecules, a key step in sterol biosynthesis. The process proceeds in two distinct steps: First, two FPP molecules react to form the stable squalene diphosphate intermediate (PSQPP), releasing protons and inorganic diphosphate. FDFT1 Protein, Human (His) is the recombinant human-derived FDFT1 protein, expressed by E. coli , with N-6*His labeled tag.

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HY-P81002

	FDFT1 Antibody (YA3512) DGPT; ERG9; FDFT1; SQS; squalene synthase; SS	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	FDFT1 Antibody (YA3512) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FDFT1.

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squalene synthase

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