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single-strand breaks

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (2) Apoptosis (1) Bacterial (1) Biochemical Assay Reagents (3) COX (4) DNA/RNA Synthesis (11) Drug-Linker Conjugates for ADC (1) Isotope-Labeled Compounds (1) PARP (1) Reference Standards (1) Topoisomerase (1)
By Research Areas:	Cancer (13) Infection (1) Inflammation/Immunology (3)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W159870

N-Nitrosodibenzylamine	DNA/RNA Synthesis	Others
N-Nitrosodibenzylamine is a potent and orally activity DNA damage inducer. N-Nitrosodibenzylamine induces DNA single-strand breaks (SSBs) .

HY-13744

Rubitecan RFS 2000; 9-Nitrocamptothecin	Topoisomerase	Cancer
Rubitecan (RFS 2000), a Camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells .

HY-W076740

8-Bromoadenine 8-Bromo-9H-purin-6-amine	DNA/RNA Synthesis Biochemical Assay Reagents	Others
8-Bromoadenine (8-Bromo-9H-purin-6-amine) is a DNA radiosensitizer that inhibits DNA single-strand break repair in cells. 8-Bromoadenine is a brominated derivative of adenine, and radioactive adenine can be prepared by replacing bromine with deuterium .

HY-137457

Venadaparib 1 Publications Verification IDX-1197	PARP	Cancer
Venadaparib (IDX-1197) is a potent, selective and orally active PARP inhibitor with IC₅₀s of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively. Venadaparib does not sensitive to PARP-5. Venadaparib prevents the repair of DNA single-strand breaks (SSB) and can be used for solid tumors research .

HY-136170

MC-SN38 2 Publications Verification	Drug-Linker Conjugates for ADC	Cancer
MC-SN38 is a agent-linker conjugate composed of a potent microtubule-disrupting agent SN38 and a non-cleavable MC linker to make antibody agent conjugate (ADC). SN-38, an active metabolite of the Topoisomerase I inhibitor Irinotecan, inhibits DNA synthesis and causes frequent DNA single-strand breaks .

HY-D2353

Biotin-PEG3-benzophenone	DNA/RNA Synthesis	Cancer
Biotin-PEG3-benzophenone is biotin-labeled Benzophenone (HY-Y0546). Benzophenone is an endogenous metabolite and a photosensitizer that has been implicated in photosensitive damage to DNA. Benzophenone causes nucleobase oxidation, formation of cyclobutane-pyrimidine dimers, single-strand breaks, DNA-protein cross-links or abasic sites, different pathologies that may occur in nucleosides, oligonucleotides or DNA .

HY-126490

Phleomycin 1 Publications Verification	Bacterial Antibiotic DNA/RNA Synthesis	Infection Cancer
Phleomycin is a copper-dependent DNA damaging agent and antibiotic with antitumor activity. Phleomycin binds to DNA and produces ROS in the presence of reducing agents (such as dithiothreitol and glutathione), inducing single-strand and double-strand breaks in DNA. Phleomycin can induce cell apoptosis or mutation and is widely used in cancer inhibition, microbial genetic transformation (as a screening marker to improve fungal transformation efficiency) and DNA repair mechanism research .

HY-W159870R

N-Nitrosodibenzylamine (Standard)	DNA/RNA Synthesis	Others
N-Nitrosodibenzylamine (Standard) is the analytical standard of N-Nitrosodibenzylamine. This product is intended for research and analytical applications. N-Nitrosodibenzylamine is a potent and orally activity DNA damage inducer. N-Nitrosodibenzylamine induces DNA single-strand breaks (SSBs) .

HY-132267S

N-Nitrosodibenzylamine-d4	Isotope-Labeled Compounds DNA/RNA Synthesis	Others
N-Nitrosodibenzylamine-d₄ is deuterium labeled N-Nitrosodibenzylamine. N-Nitrosodibenzylamine is a potent and orally activity DNA damage inducer. N-Nitrosodibenzylamine induces DNA single-strand breaks (SSBs) .

HY-117818

Sapurimycin Antibiotic DC 116	Antibiotic	Cancer
Sapurimycin is an antitumor antibiotic isolated from Streptomyces DO-116 and belongs to the capramycin family. Sapurimycin exhibits potent activity against Gram-positive bacteria and exhibits significant antitumor effects against leukemia P388 and sarcoma 180 in mouse models. In vitro studies have shown that Sapurimycin can induce single-strand breaks in supercoiled plasmid DNA .

HY-Y0543

5-Methylfurfural 1 Publications Verification	Biochemical Assay Reagents COX	Inflammation/Immunology Cancer
5-Methylfurfural is a chemical that can be utilized as food additive, intermediate in the production of agrochemicals, and precursor of certain anti-cancer natural products. 5-Methylfurfural is formed during the photoexposition of ranitidine hydrochloride. 5-Methylfurfural is an organic compound. 5-Methylfurfural has a strong tendency to be further hydrogenated to 2,5-dimethylfuran (DMF). 5-Methylfurfural can predominantly evoke skin inflammation and barrier disintegration. 5-Methylfurfural degrades native DNA through the formation of single-strand breaks .

HY-W012817

Methylhydroquinone	COX	Inflammation/Immunology
Methylhydroquinone is an orally active COX inhibitor with IC₅₀s of 480.7 μM and 52.2 μM for ovine COX-1 and human recombinant COX-2, respectively. Methylhydroquinone has potential DNA damaging effects: 1) inhibiting COX-1 to reduce prostaglandin synthesis and exert anti-inflammatory activity; 2) inducing DNA single-strand breaks. Methylhydroquinone exerts its effects by competitively binding to the active sites of COX-1 (such as Tyr385, Met522) and non-covalent interactions .

HY-W012817R

Methylhydroquinone (Standard)	COX	Others
Methylhydroquinone (Standard) is the analytical standard of Methylhydroquinone. This product is intended for research and analytical applications. Methylhydroquinone is an orally active COX inhibitor with IC50s of 480.7 μM and 52.2 μM for ovine COX-1 and human recombinant COX-2, respectively. Methylhydroquinone has potential DNA damaging effects: 1) inhibiting COX-1 to reduce prostaglandin synthesis and exert anti-inflammatory activity; 2) inducing DNA single-strand breaks. Methylhydroquinone exerts its effects by competitively binding to the active sites of COX-1 (such as Tyr385, Met522) and non-covalent interactions[1][2].

HY-Y0543R

5-Methylfurfural (Standard)	Biochemical Assay Reagents Reference Standards COX	Inflammation/Immunology Cancer
5-Methylfurfural (Standard) is the analytical standard of 5-Methylfurfural. This product is intended for research and analytical applications. 5-Methylfurfural is a chemical that can be utilized as food additive, intermediate in the production of agrochemicals, and precursor of certain anti-cancer natural products. 5-Methylfurfural is formed during the photoexposition of ranitidine hydrochloride. 5-Methylfurfural is an organic compound. 5-Methylfurfural has a strong tendency to be further hydrogenated to 2,5-dimethylfuran (DMF). 5-Methylfurfural can predominantly evoke skin inflammation and barrier disintegration. 5-Methylfurfural degrades native DNA through the formation of single-strand breaks .

HY-100549

(S)-Crizotinib	DNA/RNA Synthesis Apoptosis	Cancer
(S)-Crizotinib is a potent and selective MTH1 (mutT homologue) inhibitor with an IC₅₀ of 330 nM. (S)-Crizotinib disrupts nucleotide pool homeostasis via MTH1 inhibition, induces an increase in DNA single strand breaks, activates DNA repair in human colon carcinoma cells, and effectively suppresses tumour growth in animal models .

HY-135218

AV-153	DNA/RNA Synthesis	Cancer
AV-153, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 has anti-cancer activity .

HY-135218A

AV-153 free base 1 Publications Verification	DNA/RNA Synthesis	Cancer
AV-153 free base, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 free base interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 free base has anti-cancer activity .

HY-119182R

Mitonafide (Standard)	DNA/RNA Synthesis	Cancer
Mitonafide (Standard) is the analytical standard of Mitonafide. This product is intended for research and analytical applications. Mitonafide (NSC 300288) is a cytostatic agent. Mitonafide binds to double-stranded DNA through intercalation, and inhibits DNA and RNA synthesis. Mitonafide is an antitumor agent that can be used in the research of cancers, such as non-small cell lung cancer (NSCLC), leukemia .

HY-119182

Mitonafide NSC 300288	DNA/RNA Synthesis	Cancer
Mitonafide (NSC 300288) is a cytostatic agent. Mitonafide binds to double-stranded DNA through intercalation, and inhibits DNA and RNA synthesis. Mitonafide is an antitumor agent that can be used in the research of cancers, such as non-small cell lung cancer (NSCLC), leukemia .

Cat. No.	Product Name	Type

HY-D2353

Biotin-PEG3-benzophenone	Dyes
Biotin-PEG3-benzophenone is biotin-labeled Benzophenone (HY-Y0546). Benzophenone is an endogenous metabolite and a photosensitizer that has been implicated in photosensitive damage to DNA. Benzophenone causes nucleobase oxidation, formation of cyclobutane-pyrimidine dimers, single-strand breaks, DNA-protein cross-links or abasic sites, different pathologies that may occur in nucleosides, oligonucleotides or DNA .

Biotin-PEG3-benzophenone

Dyes

Biotin-PEG3-benzophenone is biotin-labeled Benzophenone (HY-Y0546). Benzophenone is an endogenous metabolite and a photosensitizer that has been implicated in photosensitive damage to DNA. Benzophenone causes nucleobase oxidation, formation of cyclobutane-pyrimidine dimers, single-strand breaks, DNA-protein cross-links or abasic sites, different pathologies that may occur in nucleosides, oligonucleotides or DNA .

Cat. No.	Product Name	Type

HY-W076740

8-Bromoadenine 8-Bromo-9H-purin-6-amine	Gene Sequencing and Synthesis
8-Bromoadenine (8-Bromo-9H-purin-6-amine) is a DNA radiosensitizer that inhibits DNA single-strand break repair in cells. 8-Bromoadenine is a brominated derivative of adenine, and radioactive adenine can be prepared by replacing bromine with deuterium .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13744

Rubitecan RFS 2000; 9-Nitrocamptothecin	Alkaloids Structural Classification Classification of Application Fields Source classification Quinoline Alkaloids Camptotheca acuminata Decne. Nyssaceae Plants Disease Research Fields Cancer	Topoisomerase
Rubitecan (RFS 2000), a Camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells .

HY-126490

Phleomycin 1 Publications Verification	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Anticancer Disease Research Fields Other Antibiotics	Bacterial Antibiotic DNA/RNA Synthesis
Phleomycin is a copper-dependent DNA damaging agent and antibiotic with antitumor activity. Phleomycin binds to DNA and produces ROS in the presence of reducing agents (such as dithiothreitol and glutathione), inducing single-strand and double-strand breaks in DNA. Phleomycin can induce cell apoptosis or mutation and is widely used in cancer inhibition, microbial genetic transformation (as a screening marker to improve fungal transformation efficiency) and DNA repair mechanism research .

HY-Y0543

5-Methylfurfural 1 Publications Verification	Structural Classification Cornaceae Classification of Application Fields Cornus officinalis Sieb. et Zucc. Ketones, Aldehydes, Acids Source classification Other Diseases Plants Disease Research Fields	Biochemical Assay Reagents COX
5-Methylfurfural is a chemical that can be utilized as food additive, intermediate in the production of agrochemicals, and precursor of certain anti-cancer natural products. 5-Methylfurfural is formed during the photoexposition of ranitidine hydrochloride. 5-Methylfurfural is an organic compound. 5-Methylfurfural has a strong tendency to be further hydrogenated to 2,5-dimethylfuran (DMF). 5-Methylfurfural can predominantly evoke skin inflammation and barrier disintegration. 5-Methylfurfural degrades native DNA through the formation of single-strand breaks .

HY-W012817

Methylhydroquinone	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields	COX
Methylhydroquinone is an orally active COX inhibitor with IC₅₀s of 480.7 μM and 52.2 μM for ovine COX-1 and human recombinant COX-2, respectively. Methylhydroquinone has potential DNA damaging effects: 1) inhibiting COX-1 to reduce prostaglandin synthesis and exert anti-inflammatory activity; 2) inducing DNA single-strand breaks. Methylhydroquinone exerts its effects by competitively binding to the active sites of COX-1 (such as Tyr385, Met522) and non-covalent interactions .

HY-117818

Sapurimycin Antibiotic DC 116	Structural Classification Microorganisms Antibiotics Source classification Disease Research Anticancer	Antibiotic
Sapurimycin is an antitumor antibiotic isolated from Streptomyces DO-116 and belongs to the capramycin family. Sapurimycin exhibits potent activity against Gram-positive bacteria and exhibits significant antitumor effects against leukemia P388 and sarcoma 180 in mouse models. In vitro studies have shown that Sapurimycin can induce single-strand breaks in supercoiled plasmid DNA .

HY-W012817R

Methylhydroquinone (Standard)	Structural Classification Natural Products Microorganisms Source classification	COX
Methylhydroquinone (Standard) is the analytical standard of Methylhydroquinone. This product is intended for research and analytical applications. Methylhydroquinone is an orally active COX inhibitor with IC50s of 480.7 μM and 52.2 μM for ovine COX-1 and human recombinant COX-2, respectively. Methylhydroquinone has potential DNA damaging effects: 1) inhibiting COX-1 to reduce prostaglandin synthesis and exert anti-inflammatory activity; 2) inducing DNA single-strand breaks. Methylhydroquinone exerts its effects by competitively binding to the active sites of COX-1 (such as Tyr385, Met522) and non-covalent interactions[1][2].

HY-Y0543R

5-Methylfurfural (Standard)	Structural Classification Microorganisms Cornaceae Cornus officinalis Sieb. et Zucc. Ketones, Aldehydes, Acids Source classification Plants	Biochemical Assay Reagents Reference Standards COX
5-Methylfurfural (Standard) is the analytical standard of 5-Methylfurfural. This product is intended for research and analytical applications. 5-Methylfurfural is a chemical that can be utilized as food additive, intermediate in the production of agrochemicals, and precursor of certain anti-cancer natural products. 5-Methylfurfural is formed during the photoexposition of ranitidine hydrochloride. 5-Methylfurfural is an organic compound. 5-Methylfurfural has a strong tendency to be further hydrogenated to 2,5-dimethylfuran (DMF). 5-Methylfurfural can predominantly evoke skin inflammation and barrier disintegration. 5-Methylfurfural degrades native DNA through the formation of single-strand breaks .

Cat. No.	Product Name	Chemical Structure

HY-132267S

N-Nitrosodibenzylamine-d4
N-Nitrosodibenzylamine-d₄ is deuterium labeled N-Nitrosodibenzylamine. N-Nitrosodibenzylamine is a potent and orally activity DNA damage inducer. N-Nitrosodibenzylamine induces DNA single-strand breaks (SSBs) .

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single-strand breaks

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

NaturalProducts

Isotope-Labeled Compounds

Natural
Products