Search Result
Results for "
similar compound
" in MedChemExpress (MCE) Product Catalog:
2
Biochemical Assay Reagents
2
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-121263
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Insecticide
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Cancer
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Dicyclanil is an insect growth regulator compound with a similar chemical structure to cyromazine .
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- HY-148087
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RXFP Receptor
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Cardiovascular Disease
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AZD5462 is a RXFP1 modulator, can be used for heart failure research. RXFP1 is the cognate receptor for human relaxin, belongs to GPCR family 1c number with anti-fibrotic and anti-inflammatory properties .
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- HY-131515
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- HY-135212
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Endogenous Metabolite
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Metabolic Disease
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Hydroxy ipronidazole (Ipronidazole-OH) is a metabolite of nitroimidazole antibiotics, such as ipronidazole (IPZ). Hydroxy ipronidazole may has similar mutagenic potential as the parent compound .
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- HY-126129
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Bacterial
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Infection
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Desacetylcefotaxime, the in vivo metabolite of Cefotaxime (CTX), possesses significant in vitro antimicrobial activity similar to the parent compound against a variety of aerobic and anaerobic bacteria .
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- HY-128454
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Endogenous Metabolite
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Others
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Dimethyl trisulfide is an organic chemical compound and the simplest organic trisulfide found in garlic, onion, broccoli, and similar plants. Dimethyl trisulfide is a cyanide antidote .
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- HY-119530
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BW 57-323
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Nucleoside Antimetabolite/Analog
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Others
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Thiamiprine (BW 57-323) is a compound related to azathioprine. Its nucleoside forms are similar to the parent compound in terms of cytotoxicity in vitro (except for the arabinoside). In the rat adjuvant arthritis model in vivo, its riboside and 2'-deoxyriboside are less active than the parent compound. The arabinoside is inactive and nontoxic. It has similar potency to the other parent compounds tested, but has a different safety profile.
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- HY-119821R
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Glycosidase
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Infection
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Thiamiprine (Standard) is the analytical standard of Thiamiprine. This product is intended for research and analytical applications. Thiamiprine (BW 57-323) is a compound related to azathioprine. Its nucleoside forms are similar to the parent compound in terms of cytotoxicity in vitro (except for the arabinoside). In the rat adjuvant arthritis model in vivo, its riboside and 2'-deoxyriboside are less active than the parent compound. The arabinoside is inactive and nontoxic. It has similar potency to the other parent compounds tested, but has a different safety profile.
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- HY-119530R
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Nucleoside Antimetabolite/Analog
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Others
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Thiamiprine (Standard) is the analytical standard of Thiamiprine. This product is intended for research and analytical applications. Thiamiprine (BW 57-323) is a compound related to azathioprine. Its nucleoside forms are similar to the parent compound in terms of cytotoxicity in vitro (except for the arabinoside). In the rat adjuvant arthritis model in vivo, its riboside and 2'-deoxyriboside are less active than the parent compound. The arabinoside is inactive and nontoxic. It has similar potency to the other parent compounds tested, but has a different safety profile.
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- HY-121263R
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Insecticide
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Cancer
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Dicyclanil (Standard) is the analytical standard of Dicyclanil. This product is intended for research and analytical applications. Dicyclanil is an insect growth regulator compound with a similar chemical structure to cyromazine .
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- HY-123175
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Bacterial
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Others
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Chinfloxacin is a compound with antibacterial activity. It is active against a variety of clinical isolates in vitro. Its antibacterial activity is similar to that of moxifloxacin, and it has a bactericidal effect in a concentration-dependent manner.
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- HY-169837
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- HY-168358
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Drug Derivative
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Others
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4'-Fluoro diazepam is a 1,4-benzodiazepine compound. 4'-Fluoro diazepam is structurally similar to Diazepam, but its has only minimal biological activity .
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- HY-119575
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1,3,7,9-Tetramethyluric acid; Theacrine
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Biochemical Assay Reagents
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Others
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Tetramethyluric acid (1,3,7,9-Tetramethyluric acid; Theacrine), also known as tetramethyluric acid or theophylline, is a purine alkaloid with a structure similar to caffeine. Tetramethyluric acid is a biomaterial or organic compound that can be used as a research-related biomaterial or organic compound in life sciences .
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- HY-W018677S
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Antibiotic
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Infection
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Quinoxaline-d4 is the deuterium labeled Quinoxaline . Quinoxaline is a chemical compound that acts as an intermediate for anti-tuberculosis agent Pyrazinamide. Quinoxaline presents a structure that is similar to quinolone antibiotics .
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- HY-167993
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Biochemical Assay Reagents
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Others
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(R)-GNA-T phosphoramiditec (compound 7a) is a monophosphate nucleoside similar to DNA or RNA but differing in the composition of its sugar-phosphodiester backbone, using propylene glycol in place of ribose or deoxyribose .
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- HY-161734
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Microtubule/Tubulin
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Cancer
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Microtubule inhibitor 11 (compound 33) is a microtubule inhibitor with a mechanism of action similar to colchicine (HY-N0282). Microtubule inhibitor 11 can be used in cancer-related research .
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- HY-12883A
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Sodium Channel
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Neurological Disease
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PF-05198007 is a potent, orally active and selective arylsulfonamide Nav1.7 inhibitor. PF-05198007 is a compound with a similar pharmacodynamic profile to PF-05089771 .
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- HY-120979
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Angiotensin Receptor
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Cardiovascular Disease
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NO-Losartan A (compound 2a) displays vasorelaxing effects, due to the release of NO, and antagonized the vasocontractile effects of Angiotensin II (HY-13948), with potency values similar to that of Losartan (HY-17512) .
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- HY-I0516
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GS-566500
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Endogenous Metabolite
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Infection
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PSI 352707 (GS-566500) is a sofosbuvir metabolite with activity similar to other antiviral compounds. PSI 352707 showed good safety and tolerability in inhibiting chronic hepatitis C virus infection .
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- HY-169223
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Endogenous Metabolite
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Endocrinology
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Roxatidine hydrochloride is an anti-ulcer compound with the activity of inhibiting gastric acid secretion. Roxatidine hydrochloride effectively inhibits duodenal and gastric ulcers and reduces ulcer pain. Roxatidine hydrochloride has a better safety profile than other similar compounds due to the lower dose required for effective inhibition .
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- HY-A0163A
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Dopamine Receptor
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Neurological Disease
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Clopenthixol is a thiaquinoline compound with inhibitory effects similar to those of phenothiazine antipsychotics. Clopenthixol is an antagonist of D1 and D2 dopamine receptors. Clopenthixol is mainly used to suppress schizophrenia and other mental disorders .
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- HY-16762
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OZ439
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Parasite
Ferroptosis
SARS-CoV
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Infection
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Artefenomel (OZ439) is an orally active, synthetic anti-malarial compound containing an artemisinin pharmacophore with a mechanism of action similar to that of artemisinin. Artefenomel has antiviral activity against SARS-CoV-2 .
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- HY-133122
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TNF Receptor
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Inflammation/Immunology
Cancer
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UCB-9260, an orally active compound, inhibits TNF signaling by stabilising an asymmetric form of the trimer. UCB-9260 is selective for TNF over other superfamily members, and binds TNF with a similar Kd of 13 nM .
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- HY-131515R
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Drug Derivative
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Cardiovascular Disease
Metabolic Disease
Inflammation/Immunology
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Tri-Salicylic acid (Standard) is the analytical standard of Tri-Salicylic acid. This product is intended for research and analytical applications. Tri-Salicylic acid is the compound with similar properties of salicylic acid. Tri-Salicylic acid has the potential for the research of inflammation, obesity and cardiovascular diseases (extracted from patent US20170368079A1, compound III) .
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- HY-129788
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Antibiotic
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Others
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Deltamycin A1 is a compound with antibacterial activity. Its structure belongs to the basic macrolide antibiotic family and is different from several other antibiotics of similar structure. Its structure was determined by spectroscopic properties and verified by chemical synthesis.
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- HY-135212S
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Isotope-Labeled Compounds
Endogenous Metabolite
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Metabolic Disease
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Hydroxy ipronidazole-d3 is the deuterium labeled Hydroxy ipronidazole. Hydroxy ipronidazole (Ipronidazole-OH) is a metabolite of nitroimidazole antibiotics, such as ipronidazole (IPZ). Hydroxy ipronidazole may has similar mutagenic potential as the parent compound .
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- HY-D2575
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Biochemical Assay Reagents
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Inflammation/Immunology
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WYneN (compound 10) is a functionalized Wittig-alkyne probe. WYneN exhibits strong reactivity with sulfinic acid dipeptide models, similar to the parent Wittig reagent. WYneN can be used to reveal the function of oxidative modifications on a proteome-wide scale .
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- HY-113206
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Endogenous Metabolite
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Metabolic Disease
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D-Sedoheptulose 7-phosphate is a common precursor for the heptoses of septacidin (group III) and hygromycin B (group IV). D-Sedoheptulose 7-phosphate can be converted to NDP-heptoses through similar biosynthetic pathways in those compounds .
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- HY-126129R
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Drug Metabolite
Bacterial
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Infection
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Desacetylcefotaxime (Standard) is the analytical standard of Desacetylcefotaxime. This product is intended for research and analytical applications. Desacetylcefotaxime, the in vivo metabolite of Cefotaxime (CTX), possesses significant in vitro antimicrobial activity similar to the parent compound against a variety of aerobic and anaerobic bacteria .
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- HY-118914
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GCGR
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Glucagon receptor antagonist inactive control (Compound 2) is a compound structurally similar to the glucagon receptor (GCGR) antagonist Glucagon receptor antagonist (Compound 1) but lacks antagonistic activity against glucagon receptor (GCGR). Glucagon receptor antagonist inactive control can be used as a negative control to study mechanisms related to glucagon receptor-mediated signaling pathways .
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- HY-135212R
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Endogenous Metabolite
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Metabolic Disease
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Hydroxy ipronidazole (Standard) is the analytical standard of Hydroxy ipronidazole. This product is intended for research and analytical applications. Hydroxy ipronidazole (Ipronidazole-OH) is a metabolite of nitroimidazole antibiotics, such as ipronidazole (IPZ). Hydroxy ipronidazole may has similar mutagenic potential as the parent compound .
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- HY-128454R
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Endogenous Metabolite
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Others
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Dimethyl trisulfide (Standard) is the analytical standard of Dimethyl trisulfide. This product is intended for research and analytical applications. Dimethyl trisulfide is an organic chemical compound and the simplest organic trisulfide found in garlic, onion, broccoli, and similar plants. Dimethyl trisulfide is a cyanide antidote .
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- HY-147821
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Cannabinoid Receptor
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Metabolic Disease
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CB1-IN-2 (Compound 4g) is a selective CB1 inhibitor with an IC50 of 0.644 μM. CB1-IN-2 can penetrates BBB and might cause CNS side effect similar with Rimonabant .
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- HY-N11975
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Others
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Others
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Glycyrrhizin-6′,6′′-dimethylester (compound 23) is a licorice saponin isolated from licorice root. Glycyrrhizin-6′,6′′-dimethylester can participate as an aglycone in the generation of methyl glucuronate, producing similar threshold sweetness, licorice, and bitterness .
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- HY-113206A
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Endogenous Metabolite
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Metabolic Disease
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D-Sedoheptulose-7-phosphate barium is a common precursor for the heptoses of septacidin (group III) and hygromycin B (group IV). D-Sedoheptulose-7-phosphate barium can be converted to NDP-heptoses through similar biosynthetic pathways in those compounds .
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- HY-161517
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PARP
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Cancer
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PARP1-IN-20 (compound 19A10) is a potent inhibitor of PARP1, with the IC50 of 4.62 nM and has similar low PARP-Trapping effect compared with Veliparib (HY-10129), IC50 (MDA-MB-436) >100 μM .
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- HY-W127809
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Biochemical Assay Reagents
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Others
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Chlorin e4 is an organic compound belonging to the family of chlorins, which are macrocyclic compounds with a similar structure to porphyrins. It is commonly used to improve photodynamic therapy for cancer and other diseases. Chlorin e4 has multiple applications in medical research, including as a photosensitizer for localized tumor destruction. In addition, its antimicrobial properties and potential use in disinfection applications were investigated.
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- HY-152899
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Endogenous Metabolite
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Cardiovascular Disease
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Selachyl alcohol is an orally active antihypertensive agent. Selachyl alcohol has similar activities with antihypertensive neutral renomedullary lipid (ANRL). Selachyl alcohol is an alkylglycerol compound in shark liver oil mixture with properties that reduce lung metastasis. Selachyl alcohol can be used for cardiovascular disease research .
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- HY-153435
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RIP kinase
Necroptosis
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Cancer
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RIP1 kinase inhibitor 5 (example 1) is a potent inhibitor of RIP1, which is used as a checkpoint kinase to control tumor immunity . RIP1 kinase inhibitor 5 is similar with SIR1-365 (compound 13), which inhibits necrosis and iron death activity .
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- HY-121111
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HIV Protease
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Cancer
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Agaritine is a compound isolated from the commonly cultivated commercial mushroom Agaricus bisporus. Agaritine is hydrolyzed by an enzyme system present in the mushroom into 4-(hydroxymethyl)benzenediazonium ion, which is a carcinogen in mice. Agaritine is structurally similar to some known carcinogens and can be used for research in cancer and food safety .
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- HY-117953
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Prostaglandin Receptor
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Endocrinology
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RU 59063 is an N-substituted arylthiohydantoin compound with antiandrogenic activity and high relative binding affinity for the rat androgen receptor. RU 59063 is a nonsteroidal androgen receptor that functions as a radioactive AR radioprobe (Ki: 0.71 nM, rAR) when its trifluoromethyl group is replaced by a similar hydrophobic iodine atom .
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- HY-103329
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MM22; Biotinylated N-arachidonoylethanolamine
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Cannabinoid Receptor
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Others
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b-AEA (MM22) is a biotinylated endocannabinoid analog with probe activity. b-AEA is able to accumulate intracellularly in a similar manner to the parent compound AEA. b-AEA does not interact with other components of the endocannabinoid system and therefore does not interfere with their function. b-AEA can be used to visualize the accumulation and intracellular distribution of endocannabinoids .
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- HY-130418
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Adrenergic Receptor
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Cancer
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(-)-Domesticine is an anti-α-1D-adrenoceptor compound with cytotoxic activity. (-)-Domesticine showed activity in MTS cytotoxicity assays against human colon cancer cell lines HCT-116 and Caco-2. (-)-Domesticine tolerates alkoxy substituents and benzoate functional groups at the C1 position in modifications of its chemical structure. The most potent compounds of (-)-Domesticine have IC50 values in the range of 23-38 μM, similar to the known cytotoxic compound etoposide .
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- HY-161842
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Cholinesterase (ChE)
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Neurological Disease
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AChE-IN-67 (compound 8n) is a potent AChE inhibitor, with an IC50 of 0.033 μM. AChE-IN-67 exhibits activity similar to Donepezil (HY-14566). AChE-IN-67 exhibits high blood-brain barrier (BBB) permeability. AChE-IN-67 can be used for Alzheimer's disease research .
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- HY-118242
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Estrogen Receptor/ERR
Calmodulin
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Others
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RU 45144 is an anti-estrogen compound that has the activity of antagonizing the binding of estrogen receptors to calmodulin. RU 45144 can inhibit the binding of estrogen receptors to calmodulin, and its effect is similar to that of tamoxifen. Its anti-estrogen effect may be related to specific side chains in the molecular structure, and the steroid skeleton may be involved in its anti-proliferative activity.
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- HY-126182
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Endogenous Metabolite
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Cardiovascular Disease
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Deacetyldiltiazem is a metabolite with coronary vasodilator activity. Deacetyldiltiazem is present in the plasma of individuals taking Diltiazem. The deacetylase activity of deacetyldiltiazem is mainly catalyzed by the rat Ces2a enzyme. In vitro experiments of deacetyldiltiazem showed that its Km value was similar to that of rat liver microsomes, showing efficient deacetylase activity. The study of deacetyldiltiazem helps to understand the differences in the metabolic kinetics of compounds between different species .
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- HY-119762
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AG-629
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Prostaglandin Receptor
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Cardiovascular Disease
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Spizofurone is an anti-ulcer compound with increased gastric mucosal blood flow activity and oral activity. Spizofurone has a similar mechanism of action to PGE2 (HY-101952), Spizofurone is capable of acting through local and systemic pathways and may promote ulcer healing by improving blood supply to the gastric mucosa. Spizofurone can be used to study the development strategy of gastric ulcer .
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- HY-106365A
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Endogenous Metabolite
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Inflammation/Immunology
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Rofleponide epimer is a compound with anti-inflammatory activity. Rofleponide epimer has shown high selectivity in the lungs in experiments. Rofleponide epimer exhibits excellent pharmacological properties by efficiently binding to the rat thymic glucocorticoid receptor. The biotransformation rate of Rofleponide epimer is 10 times higher than that of other known similar drugs, indicating that it has potential application value in inhibiting inflammatory diseases involving mucosa .
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- HY-142735
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Potassium Channel
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Neurological Disease
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KCa2 channel modulator 2 (compound 2q) is a potent subtype-selective positive modulator of KCa2 channel. KCa2 channel modulator 2 exhibits similar potency on the rat KCa2.2a and human KCa2.3 channel subtypes, with EC50s of 0.64 μM and 0.60 μM, respectively
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- HY-Y1644
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(E)-2-Butenoic acid; trans-2-Butenoic acid; trans-Crotonic acid
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Endogenous Metabolite
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Metabolic Disease
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NSC 8751 (trans-2-Butenoic acid; trans-Crotonic acid) is an unsaturated carboxylic acid compound containing α,β-unsaturated carboxylic acid groups. NSC 8751 is one of the important analogs for evaluating the safety of fragrance ingredients and is used to evaluate the toxicological properties of compounds with similar structures. When NSC 8751 is applied to local lymph nodes, a 50% concentration does not cause skin sensitization. Structural analogs of NSC 8751 have been shown to be non-genotoxic. trans-Crotonic acid can be used in the preparation of cosmetics and food additives .
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- HY-139693
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Phosphatase
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Inflammation/Immunology
Cancer
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PTPN22-IN-1 is a potent PTPN22 inhibitor (IC50=1.4 µM; Ki=0.50 µM). PTPN22-IN-1 exhibits >7-10 fold selectivity for PTPN22 over similar phosphatases. PTPN22-IN-1 augments antitumor immune responses . From WO2021007491A1 compound L-1.
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- HY-111817
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Parasite
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Infection
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ACT-451840 is an orally active, potent and low-toxicity compound, showing activity against sensitive and resistant plasmodium falciparum strains. ACT-451840 targets all asexual blood stages of the parasite, has a rapid onset of action. ACT-451840 behaves in a way similar to artemisinin derivatives, with very rapid onset of action and elimination of parasite. ACT-451840 can be used for the research of malarial .
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- HY-146351
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HDAC
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Neurological Disease
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HDAC-IN-38 (compound 13) is a potent HDAC inhibitor. HDAC-IN-38 shows similar micro-molar inhibitory activity toward HDAC1, 2, 3, 5, 6, and 8. HDAC-IN-38 increases cerebral blood flow (CBF), attenuates cognitive impairment, and improves hippocampal atrophy. HDAC-IN-38 also increases the level of histone acetylation (H3K14 or H4K5) .
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- HY-120625
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HSP
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Cancer
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PU3 is a small molecule inhibitor of Hsp90 that competes with geldanamycin for Hsp90. PU3 induces degradation of proteins, including Her2, similar to geldanamycin. PU3 inhibits the growth of breast cancer cells, causing retinoblastoma protein hypophosphorylation, G1 arrest, and differentiation. PU3 represents a novel class of synthetic compounds that bind to Hsp90 and inhibit the proliferation of cancer cells. PU3 could provide a new strategy for the treatment of cancers .
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- HY-W107077
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Bacterial
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Infection
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INF55 is a NoA multidrug resistance pump inhibitor with the activity of inhibiting the NoA pump. The heterocomplex formed by INF55 combined with berberine shows the potential to combat the resistance of bacterial compounds. INF55 can enhance the antibacterial activity of berberine by reducing its efflux. The structural variants of INF55 can show different NoA inhibitory activities, thereby affecting the antibacterial effect of its corresponding heterocomplexes. Different derivatives of INF55 show similar activity in terms of antibacterial dose and effectiveness .
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- HY-122300B
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Levoprotiline
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Adrenergic Receptor
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Neurological Disease
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R-(-)-Oxaprotiline (Levoprotiline) is an antidepressant with anticholinergic and sympathostimulatory activities. R-(-)-Oxaprotiline exhibits different abilities to block norepinephrine uptake and anticholinergic activity compared to its enantiomer C 49802 B-Ba. R-(-)-Oxaprotiline in human studies shows physiological effects consistent with those in animals. Administration of R-(-)-Oxaprotiline results in a modest increase in heart rate and arterial blood pressure. Salivation is inhibited with R-(-)-Oxaprotiline, consistent with its anticholinergic properties. R-(-)-Oxaprotiline has similar effects to the established antidepressant compound Levoprotiline and has a shorter onset of action .
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- HY-127004
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RGH-5002
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Sodium Channel
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Others
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Silperisone hydrochloride is an organosilicone compound similar to tolperisone that has centrally acting muscle relaxant properties. Silperisone (hydrochloride) is a sodium channel protein type 2 alpha channel blocker that blocks sodium and calcium channels in cells, reduces muscle cell excitability and contraction, reduces peripheral tone, and acts as a muscle relaxant and peripheral vascular dilator. Silperisone (hydrochloride) is used to study recurrent painful myoclonus due to spinal cord injury, abnormal hypertonia due to cerebrovascular disease, myotonia symptoms, pyramidal tonia syndrome, multiple sclerosis myospasm, and myelitis .
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- HY-136634
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mAChR
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Others
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BTM-1042 is a newly synthesized compound with antispasmodic effects. It can inhibit the twitch reaction of the guinea pig ileum under electrical stimulation and is not affected by naloxone. It has similar effects to atropine and can block muscarinic receptors, but has less effect on other types of receptors. BTM-1042 also has an inhibitory effect on the ileal reaction caused by nicotine and 5-hydroxytryptamine. BTM-1042 showed a dose-dependent inhibitory effect on the spontaneous movement of the rabbit stomach. In general, BTM-1042 is a agent with a strong antispasmodic effect.
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- HY-136805
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Potassium Channel
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Neurological Disease
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Kv1.5-IN-1 is a Kv1.5 channel inhibitor. Its target selectivity and pharmacodynamic effects were evaluated in an in vitro rat model. After the introduction of a methoxy group at the R5 position, Kv1.5-IN-1 showed inhibitory potency similar to that of the unsubstituted compound. Its IC50 value for hKv1.5 channels was 0.51 μM. Kv1.5-IN-1 exhibited a high degree of selectivity, nearly 2,600 times higher than compound Ik and 300 times higher than compound IId, indicating that it may be a safe inhibitor. Due to its good pharmacological behavior, Kv1.5-IN-1 deserves further pharmacodynamic and pharmacokinetic evaluation. These properties make Kv1.5-IN-1 a potential Kv1.5 channel inhibitor that may have application prospects in the treatment of related diseases.
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- HY-172813
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Bacterial
Antibiotic
Autophagy
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Infection
Cancer
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Vancomycin prodrug (compound 13c) is a Vancomycin (HY-B0671) prodrug. Vancomycin prodrug shows antibacterial effect with MICs of 0.78 μM, 0.78 μM, 1.56 μM for S. aureus 330041, MRSA USA 300 and MRSA 3390, respectively. Vancomycin prodrug has the ability to quickly bind to Cys-34 residue of plasma. Vancomycin prodrug exhibits a good therapeutic effect on MRSA USA300 infected mice similar to Vancomycin. Vancomycin prodrug, an albumin-binding acid-sensitive prodrug, effectively reduces Vancomycin’s nephrotoxicity while maintaining its efficacy for Gram-positive bacterial infections .
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- HY-W015229R
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Endogenous Metabolite
Reactive Oxygen Species
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Neurological Disease
Metabolic Disease
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3-Indolepropionic acid (Standard) is the analytical standard of 3-Indolepropionic acid. This product is intended for research and analytical applications. 3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease.
In Vitro: 3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease . 3-Indolepropionic acid is a more potent scavenger of hydroxyl radicals than melatonin. Similar to melatonin but unlike other antioxidants, 3-Indolepropionic acid scavenges radicals without subsequently generating reactive and pro-oxidant intermediate compounds . It is also suggested that indolepropionic acid, a gut microbiota-produced metabolite, is a potential biomarker for the development of type 2 diabetes (T2D) that may mediate its protective effect by preservation of β-cell function .
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- HY-118156
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Others
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Others
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L-699333 is a 5-lipoxygenase (5-LO) inhibitor belonging to the thieno[2,3,4-cd]indole class. This compound has a 2-ethoxybutyric acid side chain and is a potent inhibitor of the biosynthesis of 5-HPETE and LTB4 produced from human 5-LO, with ICm values of 22 nM, 7 nM, and 3.8 pM for human neutrophils and whole blood, respectively. L-699333 has shown anti-inflammatory and antiasthmatic effects in a variety of animal models, including rat pleurisy models, antigen-induced wheezing models, and awake macaque and sheep asthma models. Its inhibition of 5-LO is highly selective, with higher ICm values or stronger competitive inhibition in FLAP binding assays compared to inhibition of human 15-LO, porcine 12-LO, and ram epididymal cyclooxygenase. The racemic enantiomer 14g of L-699333 is the most potent enantiomer to date, with inhibitory effects similar to those of the known MK-0591, which has been shown in clinical trials to inhibit the biochemical effects of LTB4 biosynthesis in vitro and LTE4 excretion in urine.
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HY-L0107V
-
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13,236 compounds
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Natural products are small molecules produced naturally by any organism including primary and secondary metabolites. Nowadays, new drugs based on Natural products are successfully applied to treat tumors, viral and bacterial diseases, and nervous disorders.
In response to the current drug discovery demand, we created this natural product-like compound library with 13,236 in-stock synthetic compounds similar to natural ones. The library was designed by 2D fingerprint similarity filtering, chemical descriptor-based and natural-likeness scoring selection. These compounds are useful tools for high throughput screening (HTS) and high content screening (HCS) programs.
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Cat. No. |
Product Name |
Type |
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- HY-D2575
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Fluorescent Dyes/Probes
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WYneN (compound 10) is a functionalized Wittig-alkyne probe. WYneN exhibits strong reactivity with sulfinic acid dipeptide models, similar to the parent Wittig reagent. WYneN can be used to reveal the function of oxidative modifications on a proteome-wide scale .
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Cat. No. |
Product Name |
Type |
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- HY-119575
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1,3,7,9-Tetramethyluric acid; Theacrine
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Biochemical Assay Reagents
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Tetramethyluric acid (1,3,7,9-Tetramethyluric acid; Theacrine), also known as tetramethyluric acid or theophylline, is a purine alkaloid with a structure similar to caffeine. Tetramethyluric acid is a biomaterial or organic compound that can be used as a research-related biomaterial or organic compound in life sciences .
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- HY-W127809
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Biochemical Assay Reagents
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Chlorin e4 is an organic compound belonging to the family of chlorins, which are macrocyclic compounds with a similar structure to porphyrins. It is commonly used to improve photodynamic therapy for cancer and other diseases. Chlorin e4 has multiple applications in medical research, including as a photosensitizer for localized tumor destruction. In addition, its antimicrobial properties and potential use in disinfection applications were investigated.
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Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
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- HY-W018677S
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Quinoxaline-d4 is the deuterium labeled Quinoxaline . Quinoxaline is a chemical compound that acts as an intermediate for anti-tuberculosis agent Pyrazinamide. Quinoxaline presents a structure that is similar to quinolone antibiotics .
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- HY-135212S
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Hydroxy ipronidazole-d3 is the deuterium labeled Hydroxy ipronidazole. Hydroxy ipronidazole (Ipronidazole-OH) is a metabolite of nitroimidazole antibiotics, such as ipronidazole (IPZ). Hydroxy ipronidazole may has similar mutagenic potential as the parent compound .
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Cat. No. |
Product Name |
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Classification |
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- HY-161734
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Alkynes
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Microtubule inhibitor 11 (compound 33) is a microtubule inhibitor with a mechanism of action similar to colchicine (HY-N0282). Microtubule inhibitor 11 can be used in cancer-related research .
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