Search Result
        
        
            
                Results for "
racemic mixture
" in MedChemExpress (MCE) Product Catalog:
            
         
        
        
            
                
            
            
            
            
            
                
            
            
            
            
                
            
            
            
                
                    6
Isotope-Labeled Compounds
 
            
            
            
            
         
        
            
            
                
                    
                    
                        
                            | Cat. No. | Product Name | Target | Research Areas | Chemical Structure | 
                    
                    
                        
                            
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                                    - HY-100869B
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                                                |  | WDR5 | Cancer |  
                                                | MM-589 (racemic mixture) TFA, is a racemic mixture of MM-589 TFA (HY-100869A). MM-589 TFA is a potent inhibitor of WD repeat domain 5 (WDR5)  and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM . |  
 
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                                    - HY-145263A
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                                    - HY-110406A
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                                                | 13-Hydroperoxylinoleic acid;  Linoleic acid 13-hydroperoxide | Endogenous Metabolite | Others |  
                                                | (±)13-HpODE (13-hydroperoxylinoleic acid) is a racemic mixture of hydroperoxides, which is produced by the oxidation of linoleic acid by lipoxygenase . |  
 
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                                    - HY-10011B
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                                                |  | CXCR | Inflammation/Immunology
                                                    
                                                        Endocrinology |  
                                                | (Rac)-SCH 563705 is a racemic mixture of SCH 563705 (HY-10011). SCH 563705 (compound 16) is a potent and orally active CXCR2 and CXCR1 antagonist with IC50 values of 1.3 nM and 7.3 nM and Ki values of 1 nM and 3 nM, respectively  . |  
 
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                                    - HY-116663
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                                                | (±)20-HDoHE | Endogenous Metabolite | Neurological Disease |  
                                                | (±)20-HDHA ((±)20-HDoHE) is a racemic mixture and is an autoxidation product of Docosahexaenoic acid (DHA). (±)20-HDHA is also formed by peroxidation process in human platelets and rat brain homogenate   . |  
 
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                                    - HY-B2236
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                                                | (±)-2,6-Diaminocaproic acid | Endogenous Metabolite | Metabolic Disease |  
                                                | DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins . |  
 
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                                    - HY-134818
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                                                | 
                                                        
                                                            ML-SI1
                                                            
                                                        
                                                        
                                                            
                                                                
                                                                    Maximum Cited Publications 6 Publications Verification | TRP Channel | Neurological Disease |  
                                                | ML-SI1, a racemic mixture of diastereomers, is a TRPML inhibitor with an IC50 value of 15 μM for TRPML1 . |  
 
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                                    - HY-120109
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                                                |  | Endogenous Metabolite | Cancer |  
                                                | 13-HODE methyl ester, a racemic mixture of 13(R)-HODE methyl ester and 13(S)-HODE methyl ester, is a 15-lipoxygenase metabolite of Linoleic acid . |  
 
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                                    - HY-130319A
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                                                |  | PPAR | Cardiovascular Disease
                                                    
                                                        Metabolic Disease |  
                                                | 9-HEPE, a oxidation product of Eicosapentaenoic acid, is a racemic mixture of 9(R)-HEPE and 9(S)-HEPE. 9-HEPE induces fatty acid oxidation, adipogenesis, and glucose uptake via activation of PPARs in vivo . |  
 
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                                    - HY-172008
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                                    - HY-B2236A
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                                                | (±)-2,6-Diaminocaproic acid monohydrate | Biochemical Assay Reagents | Metabolic Disease |  
                                                | DL-Lysine monohydrate is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins . |  
 
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                                    - HY-B0399A
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                                                | (±)-Carnitin | Mitochondrial Metabolism | Metabolic Disease |  
                                                | DL-Carnitine is a racemic mixture of L-Carnitine and D-Carnitine, regulates fatty acid transport in mitochondria, elevates serum carnitine fractions. |  
 
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                                    - HY-12993A
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                                                | A-60444 racemate | RSV | Others |  
                                                | RSV604 (A-60444) racemate is a racemic mixture, shows less potency against strains of respiratory syncytial virus (RSV) than the S-isomer. |  
 
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                                    - HY-172009
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                                                |  | Drug Isomer | Others |  
                                                | 8-Amino-7-oxononanoic acid hydrochloride is a racemic mixture of 8(R)-KAPA and the vitamer of biotin 8(S)-KAPA. |  
 
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                                    - HY-W178699
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                                                |  | Others | Others |  
                                                | (±)-Neoisomenthol is a monoterpene. (±)-Neoisomenthol is a volatile constituent of Mentha arvensis with a peppermint odor and taste. (±)-Neoisomenthol is a chiral compound, existing as a racemic mixture of two enantiomers, (+)-Neoisomenthol and (-)-Neoisomenthol . |  
 
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                                    - HY-Y1315
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                                                |  | Biochemical Assay Reagents | Endocrinology |  
                                                | DL-Tartaric acid is an orally active and non-racemic mixture of L- and D-tartaric acid with antioxidant activity.  14C-labeled DL-Tartaric acid is nephrotoxic   . |  
 
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                                    - HY-I0635
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                                                | (Rac)-CC-10004 | Phosphodiesterase (PDE) | Inflammation/Immunology |  
                                                | (Rac)-Apremilast ((Rac)-CC-10004) is the racemic mixture of Apremilast. (Rac)-Apremilast has anti-inflammatory properties and can be used for research on inflammatory diseases, such as psoriasis  . |  
 
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                                    - HY-W010143
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                                                | (Rac)-Norcotinine | Drug Metabolite | Cardiovascular Disease |  
                                                | (R,S)-Norcotinine ((Rac)-Norcotinine) is the racemic mixture of Norcotinine. (R,S)-Norcotinine is a biomarker of secondhand smoke exposure and is associated with the toxic mechanisms of secondhand smoke on cardiovascular development . |  
 
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                                    - HY-15997C
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                                                | (±)-Trans-(1R,2R)-U-50488 hydrate hydrochloride | Opioid Receptor | Neurological Disease |  
                                                | (±)-U-50488 ((±)-Trans-(1R,2R)-U-50488) hydrate hydrochloride is a selective κ opioid receptor (KOR) agonist . |  
 
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                                    - HY-15997B
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                                                | (±)-Trans-(1R,2R)-U-50488 hydrochloride | Opioid Receptor | Neurological Disease |  
                                                | (±)-U-50488 ((±)-Trans-(1R,2R)-U-50488) hydrochloride is a selective κ opioid receptor (KOR) agonist . |  
 
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                                    - HY-130310B
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                                                | 11-hydroxy-12,14-Eicosadienoic acid | COX | Metabolic Disease |  
                                                | (±)11-HEDE is a racemic mixture of the monohydroxy fatty acids 11(S)-HEDE and 11(R)-HEDE. 11-HEDE is formed from eicosadienoic acid by cyclooxygenase (COX) and in macrophages. |  
 
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                                    - HY-112438A
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                                                |  | Deubiquitinase | Cancer |  
                                                | rac-MF-094 is the racemic mixture of MF-094 (HY-112438). MF-094 is a potent and selective USP30 inhibitor with an IC50 of 120 nM. MF-094 increases protein ubiquitination and accelerates mitophagy . |  
 
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                                    - HY-Y1315R
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                                                |  | Biochemical Assay Reagents
                                                    
                                                        Reference Standards | Others |  
                                                | DL-Tartaric acid (Standard) is the analytical standard of DL-Tartaric acid. This product is intended for research and analytical applications. DL-Tartaric acid is a non-racemic mixture of L- and D-tartaric acid with antioxidant activity.  14C-labeled DL-Tartaric acid is nephrotoxic   . |  
 
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                                    - HY-B2236S
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                                                | (±)-2,6-Diaminocaproic acid-d4 dihydrochloride | Isotope-Labeled Compounds | Metabolic Disease |  
                                                | DL-Lysine-4,4,5,5-d4 (dihydrochloride) is the deuterium labeled DL-Lysine. DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins . |  
 
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                                    - HY-100841
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                                                | 3HPG | mGluR | Neurological Disease |  
                                                | (Rac)-3-Hydroxyphenylglycine (3HPG) is a racemic mixture of (S)-3-hydroxyphenylglycine and (R)-3-hydroxyphenylglycine. (S)-3-Hydroxyphenylglycine is a potent and selective mGluR1 agonist  . |  
 
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                                    - HY-121987A
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                                                |  | Lipoxygenase | Inflammation/Immunology |  
                                                | (±)15-HEDE is a racemic mixture of the monohydroxy fatty acids 15(R)-HEDE and 15(S)-HEDE. 15-HEDE is formed from eicosadienoic acid in macrophages. It inhibits 5-lipoxygenase (5-LO; IC50=35 μM). |  
 
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                                    - HY-B0105BS
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                                                | (-)-Ketoconazol-d3; (-)-R 41400-d3 | Fungal | Infection
                                                    
                                                        Inflammation/Immunology |  
                                                | (-)-Ketoconazole-d3 is deuterium labeled (-)-Ketoconazole. (-)-Ketoconazole ((-)-R 41400) is one of the enantiomer of Ketoconazole. Ketoconazole is a racemic mixture of two enantiomers, levoketoconazole ((2S,4R)-(−)-ketoconazole) and dextroketoconazole ((2R,4S)-(+)-ketoconazole). |  
 
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                                    - HY-B2236S3
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                                                | (±)-2,6-Diaminocaproic acid-15N2 hydrochloride | Isotope-Labeled Compounds | Metabolic Disease |  
                                                | DL-Lysine- 15N2 hydrochloride ((±)-2,6-Diaminocaproic acid- 15N2 hydrochloride) is  15N labeled DL-Lysine (HY-B2236). DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins. |  
 
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                                    - HY-B2236S1
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                                                | (±)-2,6-Diaminocaproic acid-13C6 hydrochloride | Isotope-Labeled Compounds | Metabolic Disease |  
                                                | DL-Lysine- 13C6 hydrochloride ((±)-2,6-Diaminocaproic acid- 13C6 hydrochloride) is  13C-labeled DL-Lysine (HY-B2236). DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins. |  
 
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                                    - HY-176106
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                                                |  | Opioid Receptor | Others |  
                                                | 1-Naphthyl U-47700 is an α-isomer. 1-Naphthyl U-47700 is a racemic mixtures of the trans-isomers [R,R and S,S]. 1-Naphthyl U-47700 activates MOR in a concentration-dependent manner (EC50 > 23 μM) . |  
 
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                                    - HY-126108
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                                                |  | Others | Metabolic Disease |  
                                                | (±)8-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of (±)8-HEPE and 8(R)-HEPE. The ability of (±)8-HEPE to induce hatching of E. modestus and B. balanoides eggs is probably due to the presence of the 8(R) isomer within the racemic mixture. |  
 
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                                    - HY-B0105B
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                                                | (-)-Ketoconazol; (-)-R 41400 | Fungal
                                                    
                                                        Cytochrome P450 | Infection
                                                    
                                                        Inflammation/Immunology |  
                                                | (-)-Ketoconazole ((-)-R 41400) is one of the enantiomers of ketoconazole (HY-B0105). Ketoconazole is a racemic mixture of two enantiomers, levoketoconazole ((2S,4R)-(−)-ketoconazole) and dextroketoconazole ((2R,4S)-(+)-ketoconazole). Ketoconazole is an antifungal agent and a cytochrome P450 inhibitor. |  
 
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                                    - HY-12364C
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                                                | (+)-C75 | Mitochondrial Metabolism | Others |  
                                                | (+)-trans-C75 ((+)-C75) is an enantiomer of C75 (HY-12364) (a fatty acid synthase inhibitor). (+)-trans-C75 is less potent than the racemic mixture or the (-) enantiomer in enhancing the cancer-killing ability of ionizing radiation. (+)-trans-C75 inhibits CPT1 and is an anorectic agent  . |  
 
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                                    - HY-P2834
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                                                | PGA | Biochemical Assay Reagents | Infection
                                                    
                                                        Cancer |  
                                                | Penicillin amidase (EC 3.5.1.11) (Penicillin acylase) is an enzyme that cleaves the acyl side chains of penicillins. Penicillin amidase can be used for the production of 6-aminopenicillanic acid. Penicillin amidase can also be used in the resolution of racemic mixtures, peptide synthesis, and synthesis of semi-synthetic β-lactam antibiotics   . |  
 
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                                    - HY-118091
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                                                |  | 5 alpha Reductase | Endocrinology |  
                                                | LY191704, as a benzoquinolinone, is a potent, nonsteroidal, noncompetitive and selective human type I 5α-reductase inhibitor. LY191704 is a racemic mixture of the compounds LY300502 and LY300503. LY191704 may be useful in the research of human endocrine disorders associated with overproduction of dihydrotestosterone (DHT) by 5α-reductase type 1  . |  
 
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                                    - HY-137258
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                                                |  | Cytochrome P450 | Metabolic Disease |  
                                                | (±)-N-3-Benzylnirvanol is a racemic mixture of (+)-N-3-Benzylnirvanol and (-)-N-3-Benzylnirvanol. (+)-N-3-Benzylnirvanol and (–)-N-3-Benzylnirvanol are potent and selective cytochrome P450 inhibitors with Ki values of 0.25 and 5.3 μM for CYP2C19, respectively . |  
 
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                                    - HY-B2236S2
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                                                | (±)-2,6-Diaminocaproic acid-13C6,15N2 hydrochloride | Isotope-Labeled Compounds | Metabolic Disease |  
                                                | DL-Lysine- 13C6, 15N2 hydrochloride ((±)-2,6-Diaminocaproic acid- 13C6, 15N2 hydrochloride) is  13C and  15N-labeled DL-Lysine (HY-B2236). DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins. |  
 
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                                    - HY-B0827A
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                                                | (R)-MTI-446 | nAChR
                                                    
                                                        Parasite | Infection |  
                                                | (R)-Dinotefuran ((R)-MTI-446), a neonicotinoid pesticide, exhibits comparative insecticidal activities (1.7-2.4 times) to typical sucking pests Aphis gossypii and Apolygus lucorum compared to racemic mixtures by inhibiting nicotinic acetylcholine receptors. (R)-Dinotefuran has a good efficacy in controlling target pests while minimizing hazard to honeybees . |  
 
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                                    - HY-131904
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                                                            POMHEX
                                                            
                                                        
                                                        
                                                            
                                                                
                                                                
                                                                
                                                                    3 Publications Verification | Enolase
                                                    
                                                        Apoptosis | Metabolic Disease
                                                    
                                                        Cancer |  
                                                | POMHEX, a racemic mixture and a cell-permeable pivaloyloxymethyl (POM) proagent of HEX, is a potent, ENO2-specific inhibitor of enolase. POMHEX exhibits low-nanomolar potency against ENO1-deleted cells in vitro and is capable of eradicating ENO1-deleted xenografted tumours in vivo. POMHEX is a potent glycolysis inhibitor . |  
 
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                                    - HY-W1005647
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                                                |  | Biochemical Assay Reagents | Others |  
                                                | (rac)-Isoleucine is the racemic form of Isoleucine. Isoleucine is a mixture of the diastereomers L-isoleucine, L-alloisoleucine, D-isoleucine, and D-alloisoleucine. L-isoleucine is a branched-chain amino acid that acts as a nitrogen donor, and has roles in glucose consumption, fatty acid metabolism, as well as immune function. L-Alloisoleucine is generated by transamination of L-isoleucine. D-Isoleucine and D-alloisoleucine are enantiomers of L-isoleucine and L-alloisoleucine, respectively   . |  
 
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                                    - HY-19202
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                                                | rac-EMA401;  rac-PD-126055;  EMA400 | Angiotensin Receptor | Neurological Disease |  
                                                | rac-Olodanrigan (rac-EMA401; EMA400) is a racemic mixture of the S-enantiomer (EMA401; HY-13106) and R-enantiomer (EMA402). rac-Olodanrigan is a potent and selective AT2 receptor antagonist with IC50s of 75.2 nM and 2918 nM for AT2R and AT1R, respectively. rac-Olodanrigan evokes dose-dependent relief of mechanical allodynia in the ipsilateral hind paws of rats with a chronic constriction injury (CCI) of the sciatic nerve . |  
 
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                                    - HY-116790B
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                                                | (Rac)-Penbutolol;  (±)-Isopenbutolol | Adrenergic Receptor | Cardiovascular Disease |  
                                                | (±)-Penbutolol ((Rac)-Penbutolol) is the racemic mixture of Penbutolol. (±)-Penbutolol is an orally active β-adrenergic receptor antagonist. (±)-Penbutolol antagonizes exercise-induced tachycardia, reduces the increase in peak expiratory flow rate (PEFR) caused by exercise, and decreases resting plasma renin activity (PRA). (±)-Penbutolol reaches peak plasma concentration 1 hour after oral administration, with a half-life of 4.5 hours, and is converted into an active metabolite in the body. (±)-Penbutolol can be used in cardiovascular-related disease research . |  
 
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                                    - HY-W012908
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                                                |  | Biochemical Assay Reagents | Infection
                                                    
                                                        Cancer |  
                                                | DL-Proline is a racemic mixture of D-Proline and L-Prolin. DL-Proline is a cyclic imino acid with a five-membered ring structure. DL-Proline is a key structural unit in peptide synthesis. DL-Proline can stabilize the β-turn conformation and affect the secondary structure of the peptide. DL-Proline has biological activities such as regulating peptide conformation and enhancing the stability of cyclic peptides. DL-Proline can be used to study diseases related to peptide structure and function, such as cancer and bacterial infection  . |  
 
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                                    - HY-14545
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                                                | (Rac)-Aramisulpride; (Rac)-Esamisulpride;  DAN 2163 | Dopamine Receptor
                                                    
                                                        5-HT Receptor | Neurological Disease |  
                                                | Amisulpride ((Rac)-Aramisulpride) is a racemic (50:50) mixture of the R-Amisulpride (HY-109167) and S-Amisulpride (HY-126068). Amisulpride is a dopamine D2/D3 receptor antagonist with Ki values of 2.8 and 3.2 nM for human dopamine b>D2 and b>D3, respectively. Amisulpride is a 5-HT7 receptor antagonist with a Ki of 44 nM. Amisulpride can be used in psychiatric research   . |  
 
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                                    - HY-113764
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                                                | (Rac)-C4-HSL | Bacterial | Infection
                                                    
                                                        Inflammation/Immunology |  
                                                | N-Butanoyl-DL-homoserine lactone ((Rac)-C4-HSL) is a racemic mixture of N-Butanoyl-D-homoserine lactone and N-Butanoyl-L-homoserine lactone. N-Butanoyl-L-homoserine lactone is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm. N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa  . |  
 
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                                    - HY-118590A
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                                                |  | Topoisomerase
                                                    
                                                        DNA/RNA Synthesis
                                                    
                                                        Apoptosis
                                                    
                                                        Fungal | Infection
                                                    
                                                        Cardiovascular Disease
                                                    
                                                        Inflammation/Immunology
                                                    
                                                        Cancer |  
                                                | ICRF-196 is an racemic mixture of the (S,S)- and (R,R)-isomers of ICRF-193 (HY-118590). ICRF-193 is a DNA Topoisomerase II inhibitor.  ICRF-193 can inhibit DNA syntheses and induces apoptosis. ICRF-193 exhibits anti-cancer and anti-inflammation effects. ICRF-193 shows cardioprotective effect against anthracycline toxicity to cardiomyocytes. ICRF-193 can be used for the researches of cancer, infection, inflammation and cardiovascular disease, such as acute promyelocytic leukemia      . |  
 
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                                    - HY-103019A
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                                                | (±)-BAY-1251152; (±)-VIP152 | CDK
                                                    
                                                        Apoptosis
                                                    
                                                        DNA/RNA Synthesis | Cancer |  
                                                | (±)-Enitociclib ((±)-BAY-1251152) is the racemic mixture of Enitociclib (HY-103019E). Enitociclib is a selective CDK9 inhibitor and apoptosis inducer. Enitociclib inhibits CDK9 activity and reduces the phosphorylation of Ser2 in the carboxyl-terminal domain (CTD) of RNA polymerase Pol II, thereby downregulating the transcription of key oncogenes such as MYC and MCL1. Enitociclib has anti-proliferative activity targeting MYC + lymphoma and multiple myeloma (MM) cells, and has synergistic effects with Bortezomib (HY-10227) and Lenalidomide (HY-A0003), and can be used in the research of hematological malignancies  . |  
 
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                                    - HY-118590
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                                                |  | Topoisomerase
                                                    
                                                        DNA/RNA Synthesis
                                                    
                                                        Apoptosis
                                                    
                                                        Fungal | Infection
                                                    
                                                        Cardiovascular Disease
                                                    
                                                        Inflammation/Immunology
                                                    
                                                        Cancer |  
                                                | ICRF-193 is a DNA Topoisomerase II inhibitor. (S,S)- and (R,R)-isomers ICRF-193 make up an racemic mixture, ICRF-196 (HY-118590A). ICRF-193 can inhibit DNA syntheses and induces apoptosis. ICRF-193 exhibits anti-cancer and anti-inflammation effects. ICRF-193 shows cardioprotective effect against anthracycline toxicity to cardiomyocytes. ICRF-193 can be used for the researches of cancer, infection, inflammation and cardiovascular disease, such as acute promyelocytic leukemia      . |  
 
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                                    - HY-137390A
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                                                |  | HMG-CoA Reductase (HMGCR) | Cardiovascular Disease
                                                    
                                                        Metabolic Disease |  
                                                | (3S,5R)-Fluvastatin (potassium) is a synthetic hypolipidemic drug that inhibits HMG-CoA reductase activity. (3S,5R)-Fluvastatin (potassium) has similar antioxidative effects on copper ion-induced LDL oxidation compared to its 3R,5S enantiomer. (3S,5R)-Fluvastatin (potassium) and its metabolites demonstrate a potential to exhibit anti-atherosclerotic effects through their antioxidative activities. (3S,5R)-Fluvastatin (potassium) is clinically utilized as part of a racemic mixture for reducing plasma cholesterol levels. |  
 
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                                    - HY-113764R
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                                                |  | Bacterial | Infection
                                                    
                                                        Inflammation/Immunology |  
                                                | N-Butanoyl-DL-homoserine lactone (Standard) is the analytical standard of N-Butanoyl-DL-homoserine lactone. This product is intended for research and analytical applications. N-Butanoyl-DL-homoserine lactone ((Rac)-C4-HSL) is a racemic mixture of N-Butanoyl-D-homoserine lactone and N-Butanoyl-L-homoserine lactone. N-Butanoyl-L-homoserine lactone is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm. N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa  . |  
 
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                                    - HY-15997
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                                                | (-)-Trans-(1S,2S)-U-50488 hydrochloride | Opioid Receptor | Infection
                                                    
                                                        Cancer |  
                                                | (-)-U-50488 hydrochloride ((-)-Trans-(1S,2S)-U-50488 hydrochloride) is a selective kappa-opioid receptor (KOR) agonist (b>Kd=2.2 nM) over μ-opioid receptor (MOR) (b>Kd=430 nM). (-)-U-50488 hydrochloride is a more active enantiomer than (+)?trans-(1R,2R) U-50488 (HY-15997A)?or the (±)?trans-racemic mixture U-50488 (HY-15997B). (-)-U-50488 hydrochloride has a potent and sustained anti-HIV effect in fected blood monocyte-derived macrophages (MDM) . |  
 
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                                    - HY-132184S
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                                                | 5,6-EET-d11;  (±)5,6-EpETrE-d11 | Isotope-Labeled Compounds
                                                    
                                                        Adrenergic Receptor | Endocrinology |  
                                                | 5,6-Epoxyeicosatrienoic acid-d11 (5,6-EET-d11) is deuterium labeled 5,6-Epoxyeicosatrienoic acid. 5,6-Epoxyeicosatrienoic acid (5,6-EET; (±)5,6-EpETrE) is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5,6-Epoxyeicosatrienoic acid degrades into 5,6-DiHET and 5,6-δ-lactone, which can be converted to 5,6-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5,6-Epoxyeicosatrienoic acid has been implicated in the mobilization of calcium and hormone secretion. 5,6-Epoxyeicosatrienoic acid is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhibits isoforms Cav3.1, Cav3.2 (IC50=0.54 μM), and Cav3. and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 μM. In addition, it is a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 μM. (±)5,6-Epoxyeicosatrienoic acid is provided as a mixture of the free acid and lactone . |  
 
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                            | Cat. No. | Product Name | Target | Research Area | 
                    
                    
                        
                            
                            - 
                                
                                    - HY-W012908
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                                                |  | Biochemical Assay Reagents | Infection
                                                    
                                                        Cancer |  
                                                | DL-Proline is a racemic mixture of D-Proline and L-Prolin. DL-Proline is a cyclic imino acid with a five-membered ring structure. DL-Proline is a key structural unit in peptide synthesis. DL-Proline can stabilize the β-turn conformation and affect the secondary structure of the peptide. DL-Proline has biological activities such as regulating peptide conformation and enhancing the stability of cyclic peptides. DL-Proline can be used to study diseases related to peptide structure and function, such as cancer and bacterial infection  . |  
 
 
 
            
            
            
            
            
            
            
                
                    
                        
                            | Cat. No. | Product Name | Category | Target | Chemical Structure | 
                    
                    
                 
            
            
            
            
            
                
                    
                        
                            | Cat. No. | Product Name | Chemical Structure | 
                    
                    
                        
                            
                            - 
                                
                                    - HY-B2236S
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                                                |  |  
                                                | DL-Lysine-4,4,5,5-d4 (dihydrochloride) is the deuterium labeled DL-Lysine. DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins . |  
 
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                                    - HY-B0105BS
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                                                |  |  
                                                | (-)-Ketoconazole-d3 is deuterium labeled (-)-Ketoconazole. (-)-Ketoconazole ((-)-R 41400) is one of the enantiomer of Ketoconazole. Ketoconazole is a racemic mixture of two enantiomers, levoketoconazole ((2S,4R)-(−)-ketoconazole) and dextroketoconazole ((2R,4S)-(+)-ketoconazole). |  
 
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                                    - HY-B2236S3
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                                                |  |  
                                                | DL-Lysine- 15N2 hydrochloride ((±)-2,6-Diaminocaproic acid- 15N2 hydrochloride) is  15N labeled DL-Lysine (HY-B2236). DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins. |  
 
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                                    - HY-B2236S1
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                                                |  |  
                                                | DL-Lysine- 13C6 hydrochloride ((±)-2,6-Diaminocaproic acid- 13C6 hydrochloride) is  13C-labeled DL-Lysine (HY-B2236). DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins. |  
 
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                                    - HY-B2236S2
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                                                |  |  
                                                | DL-Lysine- 13C6, 15N2 hydrochloride ((±)-2,6-Diaminocaproic acid- 13C6, 15N2 hydrochloride) is  13C and  15N-labeled DL-Lysine (HY-B2236). DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins. |  
 
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                                    - HY-132184S
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                                                |  |  
                                                | 5,6-Epoxyeicosatrienoic acid-d11 (5,6-EET-d11) is deuterium labeled 5,6-Epoxyeicosatrienoic acid. 5,6-Epoxyeicosatrienoic acid (5,6-EET; (±)5,6-EpETrE) is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5,6-Epoxyeicosatrienoic acid degrades into 5,6-DiHET and 5,6-δ-lactone, which can be converted to 5,6-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5,6-Epoxyeicosatrienoic acid has been implicated in the mobilization of calcium and hormone secretion. 5,6-Epoxyeicosatrienoic acid is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhibits isoforms Cav3.1, Cav3.2 (IC50=0.54 μM), and Cav3. and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 μM. In addition, it is a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 μM. (±)5,6-Epoxyeicosatrienoic acid is provided as a mixture of the free acid and lactone . |  
 
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