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quinone oxidoreductase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Quinone Reductase (9) Aminotransferases (Transaminases) (1) AMPK (2) Apoptosis (2) Caspase (1) DNA Alkylator/Crosslinker (2) Isotope-Labeled Compounds (1) Keap1-Nrf2 (2) Microtubule/Tubulin (2) Mitochondrial Metabolism (6) Parasite (3) PDHK (2) Pyroptosis (1) Reactive Oxygen Species (ROS) (2) Reference Standards (1)
By Research Areas:	Cancer (12) Cardiovascular Disease (2) Infection (3) Metabolic Disease (3) Neurological Disease (2)

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Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Quinone Reductase Endoplasmic Reticulum Oxidoreductase 1 (ERO1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-125027

Isobutyl-deoxynyboquinone IB-DNQ	Quinone Reductase	Cancer
Isobutyl-deoxynyboquinone (IB-DNQ) is a selective substrate for NAD(P)H:quinone oxidoreductase (NQO1). Isobutyl-deoxynyboquinone can be used for the research of anticancer .

HY-118588

Diminutol	Quinone Reductase Microtubule/Tubulin	Others
Diminutol is an inhibitor for NADP-dependent quinone oxidoreductase (NQO1), that is involved in microtubule morphogenesis and cell devision .

HY-157744

Coumarin–quinone conjugate	Mitochondrial Metabolism	Cancer
Coumarin–quinone conjugate is a fluorescent substrate for NADH:ubiquinone oxidoreductases which consists of a coumarin fluorophore and a ubiquinone analog. Coumarin–quinone conjugate can be used to measure the kinetic parameters of AIFM2/FSP1 for researches such as ferroptosis .

HY-N0645

Dicoumarol Maximum Cited Publications 9 Publications Verification Dicumarol	Quinone Reductase PDHK	Cancer
Dicoumarol is an inhibitor of both *NAD(P)H:quinone* oxidoreductase 1 (NQO1) and PDK1 with IC₅₀**s of 0.37 and 19.42 μM, respectively.

HY-103667

2-HBA 3 Publications Verification	Quinone Reductase Caspase	Cancer
2-HBA is a potent inducer of *NAD(P)H:quinone* acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10**.

HY-144439

HTS07545	Mitochondrial Metabolism	Cardiovascular Disease Cancer
HTS07545 is a potent *sulfide:quinone* oxidoreductase (SQOR) inhibitor with an IC₅₀** of 30 nM. HTS07545 reduces the decomposition rate of hydrogen sulfide (H₂S). HTS07545 can be used in the research of heart failure and pancreatic ductal adenocarcinoma.

HY-N5018

Nepodin Musizin	Parasite AMPK	Infection
Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus .Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK .Nepodin (Musizin) has antidiabetic and antimalarial activities.

HY-141552

FC9402 2 Publications Verification	Mitochondrial Metabolism	Cardiovascular Disease
FC9402 is a potent and selective sulfide quinone oxidoreductase (SQOR) inhibitor extracted from patent WO 2020/146636 A1. FC9402 attenuates TAC-induced cardiomyocyte hypertrophy and left ventricle (LV) fibrosis. FC9402 can be used for cardiovascular regulation .

HY-169842

NSC 645827	Quinone Reductase	Cancer
NSC 645827 is an inhibitor for *NAD(P)H: quinone* oxidoreductase 1 (NQO1) with an IC₅₀** of 0.7 μM .

HY-N0645S

Dicoumarol-d8 Dicumarol-d8	Isotope-Labeled Compounds PDHK	Cancer
Dicoumarol-d₈ (Dicumarol-d₈) is the deuterium labeled Dicoumarol. Dicoumarol is an inhibitor of both NAD(P)H:quinone oxidoreductase 1 (NQO1) and PDK1 with IC₅₀s of 0.37 and 19.42 μM, respectively.

HY-168926

NQO2-IN-1	Reactive Oxygen Species (ROS) Apoptosis	Cancer
NQO2-IN-1 (Compound 20b) is the inhibitor for **quinone oxidoreductase (NQO) that inhibits NQO2 with an IC₅₀ of 95 nM. NQO2-IN-1 overcomes the resistance of NSCLC cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by induction of ROS and apoptosis** .

HY-N5018R

Nepodin (Standard) Musizin (Standard)	Reference Standards Parasite AMPK	Infection
Nepodin (Standard) is the analytical standard of Nepodin. This product is intended for research and analytical applications. Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus .Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK .Nepodin (Musizin) has antidiabetic and antimalarial activities.

HY-145820

Tubulin inhibitor 14	Apoptosis Microtubule/Tubulin	Cancer
Tubulin inhibitor 14 is a potent *NQO2 (quinone* oxidoreductase 2) inhibitor with an IC₅₀** of 1.0 μM. Tubulin inhibitor 14 also inhibits tubulin polymerization and the formation of endothelial cell capillary-like tubes. Tubulin inhibitor 14 is a microtubule-destabilizing agent with potential tumor-selectivity and antiangiogenic and vascular disrupting features .

HY-120338

RYL-552	Mitochondrial Metabolism Parasite	Infection
RYL-552, a mitochondrial electron transport chain (ETC) inhibitor, is a *P. falciparum NADH dehydrogenase 2 (PfNDH2)* inhibtor .

HY-W975966

CPDT	Keap1-Nrf2	Neurological Disease
CPDT is an orally active and highly potent inducer of phase 2 enzymes and an activator of Nrf2. The activities of key phase 2 enzymes, including glutathione S-transferase, NAD(P)H:quinone:oxidoreductase 1 and glutamate cysteine synthetase, and levels of glutathione were elevated by CPDT in rat bladder in vivo and in cultured bladder cells in vitro [2].

HY-125999

EPI-589	Reactive Oxygen Species (ROS)	Neurological Disease
EPI-589, a quinone derivative, is a safe and well tolerated oxidoreductase enzyme inhibitor and a free radical scavenger, with blood-brain barrier permeable and orally available. EPI-589 is a redox-active neuroprotectant that effectively delays the symptoms of motor neuron disease in wobbler mice. EPI-589 can be used in amyotrophic lateral sclerosis (ALS) research .

HY-150971

ICy-Q	Pyroptosis	Cancer
ICy-Q is a quinone oxidoreductase 1 (NQO-1)-activated near-infrared (NIR) reagent which can react with NQO-1 to release the reduction product ICy-OH. ICy-OH selectively induces pancreatic cancer cell death through the pyroptosis pathway. ICy-Q can be used as an effective tool for rapid and accurate diagnosis of intraoperative pathological sections .

HY-13543

Tretazicar CB 1954	Quinone Reductase DNA Alkylator/Crosslinker	Cancer
Tretazicar (CB 1954), an antitumor proagent, is highly selective against the Walker 256 rat tumour line. Tretazicar is enzymatically activated to generate a bifunctional agent, which can form DNA-DNA interstrand cross-links. Tretazicar in rat cells involves the reduction of its 4-nitro group to a 4-hydroxylamine by the enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1) .

HY-128895

KL1333 1 Publications Verification	Quinone Reductase Mitochondrial Metabolism	Metabolic Disease
KL1333, a derivative of β-lapachone, is an orally available NAD+ modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures .

HY-13543R

Tretazicar (Standard)	DNA Alkylator/Crosslinker	Cancer
Tretazicar (Standard) is the analytical standard of Tretazicar. This product is intended for research and analytical applications. Tretazicar (CB 1954), an antitumor proagent, is highly selective against the Walker 256 rat tumour line. Tretazicar is enzymatically activated to generate a bifunctional agent, which can form DNA-DNA interstrand cross-links. Tretazicar in rat cells involves the reduction of its 4-nitro group to a 4-hydroxylamine by the enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1) .

HY-171035

PRL-295	Quinone Reductase Keap1-Nrf2 Aminotransferases (Transaminases)	Metabolic Disease
PRL-295 is an orally active inhibitor targeting Keap1-Nrf2 interaction. PRL-295 increases the thermal stability of Keap1 and disrupts its interaction with Nrf2, thereby activating the Nrf2-dependent transcriptional target *NAD(P)H:quinone* oxidoreductase 1 (NQO1)**. PRL-295 protects against Acetaminophen (HY-66005)-induced liver injury in mice .

HY-128895A

KL1333 hydrochloride	Mitochondrial Metabolism Quinone Reductase	Metabolic Disease
KL1333 hydrochloride is an orally active NAD ⁺ modulator that reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, leading to increased intracellular NAD ⁺ levels through NADH oxidation. Elevated NAD ⁺ levels trigger activation of SIRT1 and AMPK, and subsequently activate PGC-1α. KL1333 hydrochloride improves energy metabolism and mitochondrial dysfunction in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) fibroblasts. KL1333 hydrochloride protects against cisplatin-induced ototoxicity in mouse cochlear cultures .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0645

Dicoumarol 5+ Cited Publications Dicumarol	Structural Classification Melilotus officinalis (L.) Pall. Classification of Application Fields Leguminosae Source classification Coumarins Phenylpropanoids Plants Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	Quinone Reductase PDHK
Dicoumarol is an inhibitor of both *NAD(P)H:quinone* oxidoreductase 1 (NQO1) and PDK1 with IC₅₀**s of 0.37 and 19.42 μM, respectively.

HY-N5018

Nepodin Musizin	Rumex crispus Linn. Infection Structural Classification Classification of Application Fields Polygonaceae Source classification Phenols Polyphenols Rumex japonicus Houtt. Plants Disease Research Fields	Parasite AMPK
Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus .Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK .Nepodin (Musizin) has antidiabetic and antimalarial activities.

HY-N5018R

Nepodin (Standard) Musizin (Standard)	Rumex crispus Linn. Structural Classification Polygonaceae Source classification Phenols Polyphenols Rumex japonicus Houtt. Plants	Reference Standards Parasite AMPK
Nepodin (Standard) is the analytical standard of Nepodin. This product is intended for research and analytical applications. Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus .Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK .Nepodin (Musizin) has antidiabetic and antimalarial activities.

Cat. No.	Compare	Product Name	Species	Source

HY-P74632

	PIG3 Protein, Human (His) quinone oxidoreductase PIG3; TP53I3; PIG3	Human	E. coli
	PIG3 is a key player in cellular processes, functioning as an enzyme that catalyzes NADPH-dependent quinone reduction. It exhibits moderate enzymatic activity towards β-naphthoquinone, with the para -quinone isomer (1,2-β-naphthoquinone) compared to the para -isomer (1,4-β-naphthoquinone). Obvious preference. PIG3 Protein, Human (His) is the recombinant human-derived PIG3 protein, expressed by E. coli , with N-6*His labeled tag.

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HY-N0645S

Dicoumarol-d8
Dicoumarol-d₈ (Dicumarol-d₈) is the deuterium labeled Dicoumarol. Dicoumarol is an inhibitor of both NAD(P)H:quinone oxidoreductase 1 (NQO1) and PDK1 with IC₅₀s of 0.37 and 19.42 μM, respectively.

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HY-P86526

	NQO1 Antibody (YA6218) NQO1; DIA4; NMOR1; NAD; P; H dehydrogenase [quinone] 1; Azoreductase; DT-diaphorase; DTD; Menadione reductase; NAD; P; H:quinone oxidoreductase 1; Phylloquinone reductase; quinone reductase 1; QR1	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	NQO1 Antibody (YA6218) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NQO1. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

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quinone oxidoreductase

Inhibitors & Agonists

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

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