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Results for "

quassinoid

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (5) Bcl-2 Family (3) c-Myc (2) Caspase (1) CDK (1) Influenza Virus (1) Keap1-Nrf2 (1) Mitochondrial Metabolism (1) Necroptosis (1) NF-κB (2) p38 MAPK (1) Parasite (6) Phosphatase (1) Ser/Thr Kinase (1) STAT (1) Survivin (1) TMV (2)
By Research Areas:	Cancer (11) Infection (11) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N3015

Bruceine E	Others	Metabolic Disease
Bruceine E is a quassinoid from seeds of Brucea javanica (L.) Merr, exhibiting hypoglycemia effect . Bruceine E exhibits blood glucose lowering effect in both nondiabetic mice and Streptozotocin (STZ (HY-13753))-induced diabetic rats at lower dose .

HY-133096

Yadanzioside K	Others	Others
Yadanzioside K is a natural quassinoid glucoside found in Brucea amarissima .

HY-N12151

Chaparrinone	Parasite	Infection
Chaparrinone is a quassinoid that can be isolated from the root of Eurycoma harmandiana. Chaparrinone has antimalarial and cytotoxic activities against Plasmodium falciparum and P-388 cells (IC₅₀: 0.037 and 0.34 μg/mL respectively) .

HY-N7194

Yadanzioside L	TMV	Infection
Yadanzioside L is a quassinoid and shows anti-tobacco mosaic virus (TMV) activity (IC₅₀=4.86 μM) .

HY-125067

Yadanzioside P	Others	Cancer
Yadanzioside P is an antileukemic quassinoid glycoside. Yadanzioside P can be isolated from the seeds of Brucea javanica (L.). Yadanzioside P can be used for the research of cancer .

HY-N10899

Bruceine J	Parasite	Infection
Bruceine J, a quassinoid, is a nature product that could be isolated from fruits of Br. jaVanica. Bruceine J has anti-Babesial activity .

HY-N10900

Bruceine C	Parasite	Infection
Bruceine C, a quassinoid, is a nature product that could be isolated from fruits of Br. jaVanica. Bruceine C has anti-Babesial activity .

HY-N10368

Shinjulactone M	Parasite	Infection Neurological Disease Inflammation/Immunology
Shinjulactone M is a quassinoid isolated from various parts of Ailanthus species. Ailanthus, an important genus of the Simaroubaceae family, can be used as an febrifuge (antimalarial) and anthelmintic, and is given for the research of chronic bronchitis, epilepsy and asthma .

HY-N9325

Pasakbumin D 13β,21-Dihydroxyeurycomanone	Others	Cancer
Pasakbumin D is a quassinoid and can be used for the research of cancer .

HY-N7189

Yadanzioside C	Others	Cancer
Yadanzioside C is a quassinoid glucoside found in seeds of Brucea amarissima .

HY-123083

Javanicin C	Others	Others
Javanicin C is a quassinoid that can be isolated from the bark of Picrasma javanica .

HY-N4257

Yadanzioside A	Others	Cancer
Yadanziolide A, a quassinoid glycoside from Brucea javanica, has antitumor activity .

HY-N8995

Bruceoside A	Others	Cancer
Bruceoside A, an abundant quassinoid glycoside in Fructus Bruceae, possesses anti-cancer activity .

HY-N8399

Yadanziolide B	Influenza Virus	Infection Inflammation/Immunology
Yadanziolide B, a natural quassinoid, is a potential H5N1 neuraminidase inhibitor .

HY-126613

Laurycolactone A	Others	Others
Laurycolactone A is a quassinoid with a C18 basic skeleton. Laurycolactone A can be isolated from Eurycoma longifolia .

HY-N7338

Yadanziolide C	Others	Cancer
Yadanziolide C is a quassinoid with antiproliferative and differentiation-inducing properties in promyelocytic HL-60 cells .

HY-N7532

Yadanzioside I	TMV	Infection
Yadanzioside I is a potent anti-tobacco mosaic virus (TMV) quassinoid with an IC₅₀ of 4.22 μM .

HY-113757

Picrasidine M	Others	Others
Picrasidine M (compound II) is an alkaloid that can be isolated from the root bark of Picrasma quassinoids BENNET .

HY-N4326

14,15 β-Dihydroxyklaineanone	Others	Cancer
14,15 D-dihydroxyklaineanone, a quassinoid isolated from the root of Eurycoma longifolia, possesses anti-cancer activity .

HY-N0840

Bruceantin 1 Publications Verification (-)-Bruceantin; NCI165563; NSC165563	c-Myc Caspase Mitochondrial Metabolism Apoptosis Parasite	Infection Cancer
Bruceantin ((-)-Bruceantin) is a quassinoid found in B. javanica. Bruceantin activates caspase signaling pathway, causes the mitochondrial dysfunction, inhibits cell proliferation, induces cell differentiation and apoptosis. Bruceantin exhibits anti-leukemia and antiprotozoal activities .

HY-N10313

Dehydrobruceine B	Bcl-2 Family Keap1-Nrf2 Apoptosis	Cancer
Dehydrobruceine B, a quassinoid, can be isolated from Brucea javanica. Dehydrobruceine B shows a synergistic effect with Cisplatin (HY-17394) to induce apoptosis via mitochondrial method. Dehydrobruceine B increases apoptosis-inducing factor (AIF) and Bax expression and suppresses Keap1-Nrf2 .

HY-N0841

Bruceine A 3 Publications Verification Dihydrobrusatol; NSC310616	Parasite NF-κB p38 MAPK Phosphatase Apoptosis	Infection Cancer
Bruceine A (Dihydrobrusatol) is a natural quassinoid. Bruceine A is an inhibitor of parasites, NF-κB, and PFKFB4 (K_d: 44 nM). Bruceine A is an activator of P38α MAPK. Bruceine A has antiparasitic activity. Bruceine A has antitumor activity and inhibits cancer cell migration. Bruceine A blocks the cell cycle and induces apoptosis. Bruceine A can be used in parasites, pancreatic cancer, and breast cancer research .

HY-N4327

Eurycomalactone	NF-κB Apoptosis Akt Bcl-2 Family	Infection Inflammation/Immunology
Eurycomalactone is an active quassinoid could be isolated from Eurycoma longifolia Jack. Eurycomalactone is a potent NF-κB inhibitor with an IC₅₀ value of 0.5 μM. Eurycomalactone inhibits protein synthesis and depletes cyclin D1. Eurycomalactone enhances radiosensitivity through arrest cell cycle at G2/M phase and delayed DNA double-strand break repair. Eurycomalactone inhibits the activation of AKT/NF-κB signaling, induces apoptosis and enhances chemosensitivity to Cisplatin (HY-17394) .

HY-N8146

Bruceantinol	STAT Bcl-2 Family Ser/Thr Kinase Survivin c-Myc Apoptosis Necroptosis CDK	Infection Cancer
Bruceantinol is a quassinoid that can be isolated from Brucea javanica, inhibits pepper mottle virus (PepMoV) in pepper. Bruceantinol is a STAT3 inhibitor demonstrating potent antitumor activity in in vitro and in vivo human colorectal cancer (CRC) models. Bruceantinol has potent anti-leukemic activity. Bruceantinol strongly inhibits STAT3 DNA-binding ability (IC₅₀ = 2.4 pM), blocks the constitutive and IL-6-induced STAT3 activation, and suppresses transcription of MCL-1, PTTG1, survivin and c-Myc. Bruceantinol binds with CDK2/4/6 to facilitate protein degradation through proteasome pathway. Bruceantinol can dose- and time-dependently reduces the cell growth, impede cell proliferation, disrupts the cell cycle, and induces necrosis in MCF-7 cells and apoptosis in MDA-MB-231 cells .

Bruceine E	Structural Classification Simaroubaceae Classification of Application Fields Terpenoids Source classification Metabolic Disease Diterpenoids Plants Disease Research Fields Brucea javanica (L.) Merr.	Others
Bruceine E is a quassinoid from seeds of Brucea javanica (L.) Merr, exhibiting hypoglycemia effect . Bruceine E exhibits blood glucose lowering effect in both nondiabetic mice and Streptozotocin (STZ (HY-13753))-induced diabetic rats at lower dose .

Yadanzioside K	Triterpenes Simaroubaceae Classification of Application Fields Terpenoids Source classification Other Diseases Plants Disease Research Fields Brucea javanica (L.) Merr.	Others
Yadanzioside K is a natural quassinoid glucoside found in Brucea amarissima .

Chaparrinone	Structural Classification Natural Products Simaroubaceae Source classification Eurycoma harmandiana Pierre Plants	Parasite
Chaparrinone is a quassinoid that can be isolated from the root of Eurycoma harmandiana. Chaparrinone has antimalarial and cytotoxic activities against Plasmodium falciparum and P-388 cells (IC₅₀: 0.037 and 0.34 μg/mL respectively) .

Yadanzioside L	Infection Structural Classification Simaroubaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Brucea javanica (L.) Merr.	TMV
Yadanzioside L is a quassinoid and shows anti-tobacco mosaic virus (TMV) activity (IC₅₀=4.86 μM) .

Yadanzioside P	Structural Classification Simaroubaceae Source classification Plants Saccharides Monosaccharides Brucea javanica (L.) Merr.	Others
Yadanzioside P is an antileukemic quassinoid glycoside. Yadanzioside P can be isolated from the seeds of Brucea javanica (L.). Yadanzioside P can be used for the research of cancer .

Bruceine J	Structural Classification Simaroubaceae Terpenoids Source classification Diterpenoids Plants Brucea javanica (L.) Merr.	Parasite
Bruceine J, a quassinoid, is a nature product that could be isolated from fruits of Br. jaVanica. Bruceine J has anti-Babesial activity .

Bruceine C	Structural Classification Simaroubaceae Terpenoids Source classification Diterpenoids Plants Brucea javanica (L.) Merr.	Parasite
Bruceine C, a quassinoid, is a nature product that could be isolated from fruits of Br. jaVanica. Bruceine C has anti-Babesial activity .

Shinjulactone M	Infection Simaroubaceae Ailanthus altissima (Mill.) Swingle Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Inflammation/Immunology Disease Research Fields	Parasite
Shinjulactone M is a quassinoid isolated from various parts of Ailanthus species. Ailanthus, an important genus of the Simaroubaceae family, can be used as an febrifuge (antimalarial) and anthelmintic, and is given for the research of chronic bronchitis, epilepsy and asthma .

Pasakbumin D 13β,21-Dihydroxyeurycomanone	other families Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Disease Research Fields Cancer	Others
Pasakbumin D is a quassinoid and can be used for the research of cancer .

Yadanzioside C	Simaroubaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Cancer Brucea javanica (L.) Merr.	Others
Yadanzioside C is a quassinoid glucoside found in seeds of Brucea amarissima .

Javanicin C	Structural Classification Natural Products Simaroubaceae Source classification Plants Picrasma chinensis P. Y. Chen	Others
Javanicin C is a quassinoid that can be isolated from the bark of Picrasma javanica .

Yadanzioside A	Simaroubaceae Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Disease Research Fields Cancer Brucea javanica (L.) Merr.	Others
Yadanziolide A, a quassinoid glycoside from Brucea javanica, has antitumor activity .

Bruceoside A	Natural Products Simaroubaceae Classification of Application Fields Source classification Plants Disease Research Fields Cancer Brucea javanica (L.) Merr.	Others
Bruceoside A, an abundant quassinoid glycoside in Fructus Bruceae, possesses anti-cancer activity .

Yadanziolide B	Simaroubaceae Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Disease Research Fields Inflammation/Immunology Brucea javanica (L.) Merr.	Influenza Virus
Yadanziolide B, a natural quassinoid, is a potential H5N1 neuraminidase inhibitor .

Laurycolactone A	Natural Products Simaroubaceae Plants	Others
Laurycolactone A is a quassinoid with a C18 basic skeleton. Laurycolactone A can be isolated from Eurycoma longifolia .

Yadanziolide C	Simaroubaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Cancer Brucea javanica (L.) Merr.	Others
Yadanziolide C is a quassinoid with antiproliferative and differentiation-inducing properties in promyelocytic HL-60 cells .

Yadanzioside I	Infection Structural Classification Simaroubaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Brucea javanica (L.) Merr.	TMV
Yadanzioside I is a potent anti-tobacco mosaic virus (TMV) quassinoid with an IC₅₀ of 4.22 μM .

Picrasidine M	Structural Classification Natural Products Simaroubaceae Source classification Plants Picrasma quassioides(D．Don)Benn．	Others
Picrasidine M (compound II) is an alkaloid that can be isolated from the root bark of Picrasma quassinoids BENNET .

14,15 β-Dihydroxyklaineanone	other families Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Disease Research Fields Cancer	Others
14,15 D-dihydroxyklaineanone, a quassinoid isolated from the root of Eurycoma longifolia, possesses anti-cancer activity .

Bruceantin 1 Publications Verification (-)-Bruceantin; NCI165563; NSC165563	Structural Classification Simaroubaceae Classification of Application Fields Brucea antidysenterica J.F.Mill. Terpenoids Source classification Diterpenoids Plants Disease Research Fields Brucea javanica (L.) Merr. Cancer	c-Myc Caspase Mitochondrial Metabolism Apoptosis Parasite
Bruceantin ((-)-Bruceantin) is a quassinoid found in B. javanica. Bruceantin activates caspase signaling pathway, causes the mitochondrial dysfunction, inhibits cell proliferation, induces cell differentiation and apoptosis. Bruceantin exhibits anti-leukemia and antiprotozoal activities .

Dehydrobruceine B	Structural Classification Natural Products Microorganisms Source classification	Bcl-2 Family Keap1-Nrf2 Apoptosis
Dehydrobruceine B, a quassinoid, can be isolated from Brucea javanica. Dehydrobruceine B shows a synergistic effect with Cisplatin (HY-17394) to induce apoptosis via mitochondrial method. Dehydrobruceine B increases apoptosis-inducing factor (AIF) and Bax expression and suppresses Keap1-Nrf2 .

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quassinoid

Inhibitors & Agonists

NaturalProducts

Natural
Products