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Results for "

platinum

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Antibody (1) Antibiotic (1) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (9) Autophagy (1) Bacterial (1) Bcl-2 Family (3) Biochemical Assay Reagents (10) Calmodulin (1) Caspase (2) COX (1) DNA Alkylator/Crosslinker (4) DNA/RNA Synthesis (5) Ferroptosis (2) JAK (2) Lipoxygenase (1) MDM-2/p53 (2) PARP (1) Peptide-Drug Conjugates (PDCs) (1) Pyroptosis (1) Reactive Oxygen Species (1) STAT (2) TAM Receptor (1)
By Research Areas:	Cancer (26) Infection (2)

By Targets:

ADC Antibody (1)

Antibiotic (1)

Antibody-Drug Conjugates (ADCs) (1)

Apoptosis (9)

Autophagy (1)

Bacterial (1)

Bcl-2 Family (3)

Biochemical Assay Reagents (10)

Calmodulin (1)

Caspase (2)

COX (1)

DNA Alkylator/Crosslinker (4)

DNA/RNA Synthesis (5)

Ferroptosis (2)

JAK (2)

Lipoxygenase (1)

MDM-2/p53 (2)

PARP (1)

Peptide-Drug Conjugates (PDCs) (1)

Pyroptosis (1)

Reactive Oxygen Species (1)

STAT (2)

TAM Receptor (1)

By Research Areas:

Cancer (26)

Infection (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W034985

Tetrakis(triphenylphosphine)platinum Tetrakis(triphenylphosphine)platinum(0)	Biochemical Assay Reagents	Others
Tetrakis(triphenylphosphine)platinum is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W075885

*trans-Platinum(II)diammine dichloride* trans-platinumdiamminedichloride	Biochemical Assay Reagents	Others
trans-Platinum(II)diammine dichloride (trans-platinumdiamminedichloride) is a biochemical assay reagent.

HY-109146

Imifoplatin PT-112	Apoptosis DNA Alkylator/Crosslinker	Cancer
Imifoplatin (PT-112) is a platinum-based active molecule and a member of the phosphaplatins family. Imifoplatin can induce Apoptosis and exhibits antitumor activity .

HY-W096169D

*Platinum*	Biochemical Assay Reagents	Cancer
Platinum is a metallic compound that can be used in cancer research .

HY-W075885R

*trans-Platinum(II)diammine dichloride (Standard)*	Biochemical Assay Reagents	Others
trans-Platinum(II)diammine dichloride (Standard) is the analytical standard of trans-Platinum(II)diammine dichloride. This product is intended for research and analytical applications. trans-Platinum(II)diammine dichloride (trans-platinumdiamminedichloride) is a biochemical assay reagent.

HY-105530

Zeniplatin CL 286558	Biochemical Assay Reagents	Cancer
Zeniplatin is a third-generation, water-soluble platinum compound that has shown broad antitumor activity. Zeniplatin can be used for cancer research .

HY-161623

ERCC1/XPA interaction inhibitor 1	DNA/RNA Synthesis	Cancer
ERCC1/XPA interaction inhibitor 1 (compound 27o) is a potent ERCC1/XPA67-80 interaction inhibitor with an EC₅₀ value of 4.7 µM. ERCC1/XPA interaction inhibitor 1 has the potential for the research of DNA damaging agents and overcoming resistance to platinum-based chemotherapy .

HY-16129

CBP-501	Calmodulin	Cancer
CBP-501 is a cell-permeable and calmodulin-binding peptide that enhances the influx of platinum agents into tumor cells and tumor immunogenicity. CBP-501 can be utilized in cancer research .

HY-155012

Mcl-1 inhibitor 16	Bcl-2 Family	Cancer
Mcl-1 inhibitor 16 (Compound 9) is a mitochondrial targeting Platinum-based inhibitor of Mcl-1. Mcl-1 inhibitor 1 induces Bax/Bak-dependent apoptosis in cancer cells. Mcl-1 inhibitor 16 can be used alone or together with ABT-199 (HY-15531) and shows anti-tumor activity .

HY-106588

Heptaplatin SKI 2053R	DNA Alkylator/Crosslinker	Cancer
Heptaplatin (SKI 2053R) is a platinum derivative with anticancer activity against various cancer cell lines, including cisplatin-resistant tumor cell lines. SKI-2053R is active in the research of gastric adenocarcinoma and has favorable toxicity profiles .

HY-W009311

Thiomichler's ketone 4,4'-Bis(dimethylamino)thiobenzophenone	Biochemical Assay Reagents	Others
Thiomichler's ketone (4,4'-Bis(dimethylamino)thiobenzophenone) can be used as a photometric reagent for the determination of gold, palladium, platinum, mercury, silver, and copper. Thiomichler's ketone is a kind of biological materials or organic compounds that are widely used in life science research .

HY-131468

Picoplatin AMD473; ZD0473	DNA/RNA Synthesis	Cancer
Picoplatin (AMD473) is a platinum-based antineoplastic agent. Picoplatin is specifically to circumvent thiol-mediated drug resistance by sterically hindering its reaction with glutathione (GSH) while still retaining the ability to form cytotoxic lesions with DNA .

HY-17394

Cisplatin Maximum Cited Publications 545 Publications Verification cis-platinum; CDDP; cis-Diaminodichloroplatinum	DNA Alkylator/Crosslinker Ferroptosis Autophagy Pyroptosis Lipoxygenase	Cancer
Cisplatin (CDDP) is an antineoplastic chemotherapy agent by cross-linking with DNA and causing DNA damage in cancer cells. Cisplatin activates ferroptosis and induces autophagy .

HY-W112941

(meso-Tetraphenylporphinato)platinum Pt(II) Meso-Tetraphenylporphine	Biochemical Assay Reagents	Others
Meso- tetraphenylporphyrin - pt(ii) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P10782

Pt(IV)-M13	Peptide-Drug Conjugates (PDCs)	Cancer
Pt(IV)-M13 is a BBB-penatrable Platinum (IV) prodrug-perfluoroaryl macrocyclic peptide conjugate. Pt(IV)-M13 is cytotoxic to glioma stem cells and increases uptake of platinum in the brain. Pt(IV)-M13 can be used in the study of glioblastoma .

HY-139813

Phenanthriplatin	DNA Alkylator/Crosslinker	Cancer
Phenanthriplatin is a monovalent platinum(II)-based complex with a large cytotoxicity against cancer cells .

HY-129909

Anticancer agent 173	Apoptosis	Infection Cancer
Anticancer agent 173 (compound 19) is a potent thioxodihydroquinazolinone analogs when combined with platinum drugs in inducing apoptotic cancer cells death .

HY-112030

Dipotassium tetrachloroplatinate Potassium tetrachloroplatinate(Ⅱ)	Biochemical Assay Reagents	Cancer
Dipotassium tetrachloroplatinate(Potassium tetrachloroplatinate(Ⅱ)) is an important reagent for the preparation of other platinum coordination complexes. Dipotassium tetrachloroplatinate can be used as a radiosensitizer to enhance the killing effect of hyperthermia. Dipotassium tetrachloroplatinate has anti-tumor activity .

HY-163383

L-Ent-oxPt(IV) L-EOP	Bacterial	Infection
L-Ent-oxPt IV (L-EOP) is a Oxaliplatin (HY-17371)-based siderophore-platinum conjugate. L-Ent-oxPt IV exhibits selectivity towards Escherichia coli and antibacterial activity through DNA damage .

HY-157222

Antitumor agent-125	Apoptosis Ferroptosis	Cancer
Antitumor agent-125 (compound 17A) is a novel platinum(IV) prodrug. Antitumor agent-125 can activate the mitochondrion-dependent apoptosis pathway. Antitumor agent-125 induces ferroptosis in HCT-116/OXA .

HY-P99229

Upifitamab 1 Publications Verification	ADC Antibody	Cancer
Upifitamab is an ADC Antibody (a naked antibody of upifitamab rilsodotin), which can be used for antibody-coupled agent (ADC) synthesis. Upifitamab rilsodotin is an ADC targeting NaPi2b and is used in ovarian cancer research, particularly in platinum-resistant recurrent ovarian cancer .

HY-105930

Lobaplatin 4 Publications Verification D-19466	Apoptosis Caspase Bcl-2 Family	Cancer
Lobaplatin (D-19466) is a diastereometric mixture of platinum(II) complexe. Lobaplatin arrests cell cycle at G1 and G2/M phase. Lobaplatin induces apoptosis by increasing expressions of caspase and Bax, decreasing expression of Bcl-2. Lobaplatin can be used for research of cancer .

HY-W073183

Dibenzo-24-crown-8-ether	Biochemical Assay Reagents	Others
Dibenzo-24-crown-8-ether is a phase transfer catalyst that can reduce H ²PtCl ⁶·6H ²O and FeCl ²·4H ²O in a thermal system to synthesize 17 nm monodispersed iron-platinum (FePt) alloy nanoparticles .

HY-151883

APE1-IN-2	Apoptosis MDM-2/p53	Cancer
APE1-IN-2 (compound AP1) is a Pt(IV) proagent, targeting a critical BER protein, apurinic/apyrimidinic endonuclease 1 (APE1). APE1-IN-2 shows anticancer activity. APE1-IN-2 induces intracellular accumulation of platinum and activates DNA damage response and apoptosis signals .

HY-125010

Dicycloplatin	DNA/RNA Synthesis Apoptosis	Cancer
Dicycloplatin is a DNA damage inducer. Dicycloplatin induces DNA damage by activating biphosphorylated checkpoint kinase 2 (CHK2), breast cancer 1 (BRCA1) and triphosphorylated p53. Dicycloplatin can induce cell cycle arrest, inhibit proliferation and lead to apoptosis in prostate cancer PC3 cells and lung cancer NCI/H446 cells. Dicycloplatin can be used in cancer researchr .

HY-155807

DPP	STAT JAK Apoptosis	Cancer
DPP is a Platinum(IV) complex, bearing pterostilbene-derived axial ligand. DPP inhibit the JAK2-STAT3 pathway in breast cancer (BC) cells with antiproliferative activity, and activates caspase-3 and cleaved poly ADP-ribose polymerase to induces apoptosis. DPP promotes the maturation and antigen presentation of dendritic cells, and exhibits in vivo safety .

HY-114842

TDRL-551	DNA/RNA Synthesis	Cancer
TDRL-551 is a potent replication protein A (RPA) inhibitor (IC₅₀=18 µM). TDRL-551 inhibits RPA-DNA interaction and increases the efficacy of Platinum (Pt)-based chemotherapy in lung and ovarian cancer. RPA plays essential roles in both nucleotide excision repair (NER) and homologous recombination (HR), along with its role in DNA replication and DNA damage checkpoint activation .

HY-168877

FMP	MDM-2/p53 Reactive Oxygen Species Apoptosis Caspase PARP Bcl-2 Family	Cancer
FMP is a Platinum(IV) complexe. FMP significantly upregulates the expression of γ-H2AX and p53. FMP increases the production of ROS. FMP markedly upregulates the expressions of Apoptosis-related proteins (DR5, Fas, caspase-8, Cyt-c, caspase-3, cleaved-PARP1, Bax). FMP shows antiproliferative activity against breast cancer .

HY-120420

N4Py	Antibiotic	Cancer
N4Py is a pentadentate ligand, that forms a stable complex with metal ions, such as iron, platinum, and copper. N4py mimics the metal binding domains of iron-dependent antibiotics like Bleomycin(HY-17565), forms the DNA-cleaving FeII-N4Py complexes, generates reactive oxygen species (ROS), and causes oxidative damage in cells. N4py can be used in cancer research .

HY-P99705

Lifastuzumab vedotin RG-7599; DNIB-0600A; NaPi2b-ADC	Antibody-Drug Conjugates (ADCs)	Cancer
Lifastuzumab vedotin (RG-7599; DNIB0600A) is an antibody-drug conjugate (ADC) that comprises a humanized IgG1 anti-NaPi2b monoclonal antibody (MNIB2126A) and a potent antimitotic agent, monomethyl auristatin E (MMAE), which inhibits cell division by blocking the polymerization of tubulin. Lifastuzumab vedotin has the potential for non-small cell lung cancer (NSCLC) and platinum-resistant ovarian cancer (PROC) research .

HY-155808

STAT3-IN-18	STAT JAK Apoptosis COX	Cancer
STAT3-IN-18 (compound SPP) is a platinum (IV) complex with an axial ligand derived from sandalwood. STAT3-IN-18 inhibits the JAK2-STAT3 pathway in breast cancer (BC) cells, with anti-proliferative activity. STAT3-IN-18 activates caspase-3 and increases cleaved polyADP-ribose polymerase to induce apoptosis. STAT3-IN-18 promotes maturation and antigen presentation of dendritic cells and demonstrates safety in vivo.

HY-P99463

Batiraxcept AVB-500; AVB-S6-500	TAM Receptor	Cancer
Batiraxcept (AVB-S6-500) is a highly potent and specific AXL inhibitor, a recombinant fusion protein dimer containing the extracellular domain of human AXLM and human immunoglobulin G1 heavy chain (Fc). Batiraxcept binds to GAS6 and inhibits the interaction of GAS6 with AXL, thereby substantially reducing AXL signaled invasion and migration of highly metastatic cells in vitro and inhibiting metastatic disease in nonclinical models of aggressive human cancers. Batiraxcept is available for studies in advanced or metastatic clear cell renal cell carcinoma (ccRCC) and platinum sensitive recurrent ovarian cancer .

HY-U00279B

Nitracrine hydrochloride	DNA/RNA Synthesis	Cancer
Nitracrine hydrochloride is a platinum-based antineoplastic drug with selective toxicity to hypoxic cells. Nitracrine hydrochloride exhibits significant cytotoxicity against the Chinese hamster ovary cell line AA8 under hypoxic conditions and is approximately 100,000 times more potent than misonidazole. Nitracrine hydrochloride exerts its effect by binding to the insertion of DNA and forming covalent adducts. The cytotoxicity of Nitracrine hydrochloride under hypoxic conditions is related to its reductive metabolism to form alkylated substances. At the same time, it may enhance the reactivity to DNA through the insertion of DNA, thereby improving the efficacy. Nitracrine hydrochloride can also inhibit RNA synthesis, contributing to its anti-tumor effect .

HY-W009022

Diantipyrylmethane	Biochemical Assay Reagents	Others
Diantipyrylmethane is a chromogenic agent commonly used in spectrophotometry and extraction photometry for the determination of metals such as Au(III), Ti(IV), Ir, Fe(III), Mo, Nd, U(IV), Ir, Pt, and Re. Diantipyrylmethane is a kind of biological materials or organic compounds that are widely used in life science research .

Cat. No.	Product Name	Type