2. Apoptosis Cell Cycle/DNA Damage
  3. Apoptosis DNA Alkylator/Crosslinker
  4. Imifoplatin

Imifoplatin (PT-112) is a platinum-based active molecule and a member of the phosphaplatins family. Imifoplatin can induce Apoptosis and exhibits antitumor activity.

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Imifoplatin

Imifoplatin Chemical Structure

CAS No. : 1339960-28-9

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Based on 1 publication(s) in Google Scholar

Imifoplatin Related Antibodies

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Description

Imifoplatin (PT-112) is a platinum-based active molecule and a member of the phosphaplatins family. Imifoplatin can induce Apoptosis and exhibits antitumor activity[1][2][3].

In Vitro

Imifoplatin (5–20 µM, 72 hours) shows dose-dependent proliferation inhibition in HCT116 cells[2].
Imifoplatin (10 µM, 24 hours) significantly induces apoptosis in HCT116 cells[2].
Imifoplatin (0.287–222.14 µM, 72 hours) significantly inhibits proliferation in CT26 cells[2].
Imifoplatin (2–10 μM, 24–72 hours) has notable selectivity, showing strong inhibition of glycolytic tumor cells with mtDNA mutations[3].
Imifoplatin (10 μM, 48–72 hours) significantly increases mtROS, especially in glycolytic L929dt and Cybrid cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Imifoplatin Related Antibodies

Cell Viability Assay[3]

Cell Line: Mouse fibroblast L929, mtDNA mutant L929dt, and Cybrid cells
Concentration: 2, 6, 10 μM
Incubation Time: 24–72 hours
Result: Inhibited L929dt and Cybrid cells by about 80% after 48 hours, while inhibition in OXPHOS-competent L929 cells was lower.

Cell Proliferation Assay[2]

Cell Line: HCT116 (human colorectal cancer cells)
Concentration: 5, 10, 20 µM
Incubation Time: 72 hours
Result: Significantly inhibited cell proliferation at higher concentrations.

Apoptosis Analysis[2]

Cell Line: HCT116 (human colorectal cancer cells)
Concentration: 10 µM
Incubation Time: 24 hours
Result: Increased proportions of early and late apoptotic cells.
In Vivo

Imifoplatin (90 mg/kg, i.v., once weekly for 5 weeks) demonstrates potent antitumor immune effects in the CT26 xenograft model[2].
Imifoplatin (90 mg/kg, i.v., once weekly for 7 weeks) shows synergistic antitumor effects in the MC38 xenograft model, especially with PD-1 blockade (Avelumab (HY-108730))[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MC38 colorectal carcinoma xenograft model in C57BL/6J mice[2]
Dosage: 90 mg/kg
Administration: Intravenous injection (i.v.), once weekly for 7 weeks
Result: Inhibited tumor growth, extended survival; further enhanced survival when combined with PD-1 blockade (Avelumab (HY-108730)).
Animal Model: CT26 colorectal carcinoma xenograft model in BALB/c mice[2]
Dosage: 90 mg/kg
Administration: Intravenous injection (i.v.), once weekly for 5 weeks
Result: Significantly inhibited tumor growth, increased T-cell infiltration, reduced immunosuppressive TAMs.
Clinical Trial
Molecular Weight

485.23

Formula

C6H16N2O7P2Pt
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=[P]([O-][Pt+2]1([O-][P]2(O)=O)[NH2][C@@](CCCC3)([H])[C@]3([H])[NH2]1)(O2)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 1.25 mg/mL (2.58 mM; Need ultrasonic; DMSO can inactivate Imifoplatin's activity)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0609 mL 10.3044 mL 20.6088 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥95.0%

SDS (251 KB)

COA (258 KB) HNMR (140 KB) CNMR (131 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.0609 mL 10.3044 mL 20.6088 mL 51.5220 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Imifoplatin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Imifoplatin1339960-28-9PT-112PT112PT 112ApoptosisDNA Alkylator/CrosslinkerplatinumphosphaplatinantineoplasticcancerInhibitorinhibitorinhibit

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