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phospho-Erk

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By Targets:	ERK (2) Melatonin Receptor (2) PERK (2) Phosphatase (1) PROTACs (1) Ras (1) Reference Standards (1)
By Research Areas:	Cancer (4) Neurological Disease (2)

6

Inhibitors & Agonists

8

Antibodies

Targets Recommended: ERK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

4-P-PDOT 5+ Cited Publications	Melatonin Receptor	Neurological Disease
4-P-PDOT is a potent, selective and affinity Melatonin receptor (MT2) antagonist. 4-P-PDOT is >300-fold more selective for MT2 than MT1. 4-P-PDOT significantly counteracts Melatonin-mediated antioxidant effects (GSH/GSSG ratio, phospho-ERK, Nrf2 nuclear translocation, Nrf2 DNA-binding activity) .

ERK1/2 inhibitor 9	ERK	Cancer
ERK1/2 inhibitor 9 (Probe 1) is a covalent ERK1/2 inhibitor. ERK1/2 inhibitor 9 shows sub-micromolar activity in cells (A375 GI50=0.47 μM). ERK1/2 inhibitor 9 causes the downregulation of phospho-ERK1/2. ERK1/2 inhibitor 9 tagged trans-cyclo-octene (TCO) and Tz-Thalidomide (tetrazine tagged Thalidomide) can form the corresponding ERK-CLIPTAC to elicit degradation of ERK1/2 .

NSC 295642	PERK Phosphatase	Cancer
NSC 295642 is a phosphatase inhibitor. NSC 295642 can significantly increase *phospho-Erk* cytonuclear differences in intact cells. NSC 295642 can be used for the research of cancer .

KRAS G12C inhibitor 61	ERK Ras	Cancer
KRAS G12C inhibitor 61 (Example 3) inhibits phospho-ERK 1/2 in MIA PaCa-2 cells with an IC₅₀ value of 9 nM. KRAS G12C inhibitor 61 can be used for research of pancreatic, colorectal, and lung cancers .

YF135	PROTACs PERK	Cancer
YF135 is an efficient and reversible-covalent KRAS ^G12C PROTAC. YF135 is designed and synthesized by tethering KRAS G12C inhibitor 48 (compound 6d) as the ligand, and basing on the scaffold of MRTX849 linkage VHL ligand. YF135 significantly induces the degradation of KRAS ^G12C in a reversible manner and decreases phospho-ERK level through the E3 ligase VHL mediated proteasome pathway .

4-P-PDOT (Standard)	Reference Standards Melatonin Receptor	Neurological Disease
4-P-PDOT (Standard) is the analytical standard of 4-P-PDOT. This product is intended for research and analytical applications. 4-P-PDOT is a potent, selective and affinity Melatonin receptor (MT2) antagonist. 4-P-PDOT is >300-fold more selective for MT2 than MT1. 4-P-PDOT significantly counteracts Melatonin-mediated antioxidant effects (GSH/GSSG ratio, phospho-ERK, Nrf2 nuclear translocation, Nrf2 DNA-binding activity) .

Cat. No.	Compare	Product Name	Application	Reactivity

	Phospho-Erk 1/2(Thr202/Tyr204) Antibody (YA5917) MAPK3; Erk1; PRKM3; Mitogen-activated protein kinase 3; MAP kinase 3; MAPK 3; ERT2; Extracellular signal-regulated kinase 1; Erk-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Phospho-Erk 1/2(Thr202/Tyr204) Antibody (YA5917) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Erk 1/2(Thr202/Tyr204).

	Phospho-ERK1/2 (Tyr204/Tyr187) Antibody 1 Publications Verification MAPK1/MAPK3	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	Phospho-ERK1/2 (Tyr204/Tyr187) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-ERK1/2 (Tyr204/Tyr187).

	Phospho-ERK1/2 (Thr202/Tyr204)/(Thr185/Tyr187) Antibody (YA455)	WB, IHC-P, ICC/IF, IP, FC, IF-Tissue	Human, Mouse, Rat
	Phospho-ERK1/2 (Thr202/Tyr204)/(Thr185/Tyr187) Antibody (YA455) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-ERK1/2 (Thr202/Tyr204)/(Thr185/Tyr187).

	Phospho-ERK1/2 (Thr202/Thr185) Antibody (YA200) 1 Publications Verification MAPK1/MAPK3	WB, IP	Human, Hamster, Rat
	Phospho-ERK1/2 (Thr202/Thr185) Antibody (YA200) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-ERK1/2 (Thr202/Thr185).

	Phospho-ERK1/2 (Thr202/Tyr204)/(Thr185/Tyr187) Antibody MAPK1/MAPK3	WB	Human, Mouse, Rat
	Phospho-ERK1/2 (Thr202/Tyr204)/(Thr185/Tyr187) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-ERK1/2 (Thr202/Tyr204)/(Thr185/Tyr187).

	Phospho-ERK1/2(Erk1/2)(Thr202/Tyr204) Antibody (YA5321) Erk 1; Erk 2; Erk-2; Erk1; Erk1/2; Erk2; ERT1; ERT2; Extracellular signal regulated kinase 1; Extracellular signal regulated kinase 1	WB	Human, Mouse
	Phospho-ERK1/2(Erk1/2)(Thr202/Tyr204) Antibody (YA5321) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Phospho-ERK1/2(Erk1/2)(Thr202/Tyr204).

	phospho-ERK1 + 2 (Thr183/Tyr185) Antibody Erk1 + Erk2 (phospho Thr183/Tyr185); phospho-Erk1/MAPK-1/2(Thr183/Tyr185); Erk 1; Erk 2; Erk-2; Erk1; Erk2; ERT1; ERT2; Extracellular signal regulated kinase 1; Extracellular signal regulated kinase 1; Extracellular signal regulated kinase 2; Extracellular signal regulated kinase 2; Extracellular signal-regulated kinase 2; HS44KDAP; HUMKER1A; Insulin stimulated MAP2 kinase; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42;	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse
	phospho-ERK1 + 2 (Thr183/Tyr185) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to phospho-ERK1 + 2 (Thr183/Tyr185).

	Phospho-ERK 1/2(Y222/205) Antibody (YA5760) MAPK1/MAPK3	IHC-P, ICC/IF	Human, Rat, Mouse
	Phospho-ERK 1/2(Y222/205) Antibody (YA5760) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Phospho-ERK 1/2(Y222/205).

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