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Results for "

pRb

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Anaplastic lymphoma kinase (ALK) (1) Apoptosis (2) c-Myc (2) CDK (8) FLT3 (2) JAK (2) Mitochondrial Metabolism (1) Molecular Glues (2) PI3K (1) Progesterone Receptor (2) PROTACs (2) Ser/Thr Kinase (1) Small Interfering RNA (siRNA) (7)
By Research Areas:	Cancer (11) Endocrinology (2)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (5) siRNAs (7)

Inhibitors & Agonists

Screening Libraries

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-158106

AZD8421	CDK	Cancer
AZD8421 is a selective CDK2 inhibitor (IC₅₀ = 9 nM) as well as achieving CDK family selectivity in cells versus key off-targets (CDK1, CDK4/6, CDK9), AZD8421 had no significant kinase inhibition outside the CDK family. AZD8421 inhibits cancer cell proliferation by inhibiting pRB phosphorylation, inducing cell cycle arrest in G1/S phase and senescence. AZD8421 can be studied in research for breast cancer and ovarian cancer .

HY-112158

NSC139021 1 Publications Verification ERGi-USU	Ser/Thr Kinase	Cancer
NSC139021 (ERGi-USU) is a RIOK2 inhibitor with anticancer activity. RIOK2 can highly selectively inhibit the growth of ERG-positive cancer cells with IC₅₀s of 30-400 nM against cell lines. RIOK2 also causes cell cycle arrest and apoptosis in glioblastoma via induction of Skp2 and Skp2-p27/p21-Cyclin E/CDK2-pRb signaling .

HY-162318

MYC degrader 1	Molecular Glues c-Myc	Cancer
MYC degrader 1 (compound A80.2HCl) is an orally available MYC molecular glues degrader with anti-tumor activity. MYC degrader 1 restores pRB1 protein activity and re-establishes sensitivity of MYC overexpressing cancer cells to CDK4/6 inhibitors .

HY-162318A

MYC degrader 1 TFA	Molecular Glues c-Myc	Cancer
MYC degrader 1 TFA (compound A80.2HCl) is an orally available MYC molecular glues degrader with anti-tumor activity. MYC degrader 1 TFA restores pRB1 protein activity and re-establishes sensitivity of MYC overexpressing cancer cells to CDK4/6 inhibitors .

HY-RS11052

PRB2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PRB2 Human Pre-designed siRNA Set A contains three designed siRNAs for PRB2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRB2 Human Pre-designed siRNA Set A PRB2 Human Pre-designed siRNA Set A

HY-RS11051

PRB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PRB1 Human Pre-designed siRNA Set A contains three designed siRNAs for PRB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRB1 Human Pre-designed siRNA Set A PRB1 Human Pre-designed siRNA Set A

HY-RS11053

PRB3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PRB3 Human Pre-designed siRNA Set A contains three designed siRNAs for PRB3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRB3 Human Pre-designed siRNA Set A PRB3 Human Pre-designed siRNA Set A

HY-RS11054

PRB4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PRB4 Human Pre-designed siRNA Set A contains three designed siRNAs for PRB4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRB4 Human Pre-designed siRNA Set A PRB4 Human Pre-designed siRNA Set A

HY-201330

CDK-IN-18	CDK	Cancer
CDK-IN-18 (Compound EX.161) is an orally active, brain-penetrant and selective inhibitor of CDK2, CDK4, and CDK6. CDK-IN-18 inhibits the activity of cyclin-CDK complexes, blocks phosphorylation of the retinoblastoma protein (pRb), arresting the cell cycle transition from G1 to S phase. CDK-IN-18 is promising for research of cancers, such as breast cancer (especially hormone receptor-positive, HER2-negative type), lung cancer, and colorectal cancer .

HY-147220

Dexamethasone oxetanone Dex-Ox	Progesterone Receptor	Endocrinology
Dexamethasone oxetanone (Dex-Ox), a derivative of the glucocorticoid-selective steroid Dexamethasone (Dex), is an antiglucocorticoid. Dexamethasone oxetanone is an antiprogestin with significant agonist activity with progesterone receptor (PR) A and B isoforms .

HY-16290

Lonaprisan ZK 230211; BAY86 5044	Progesterone Receptor	Endocrinology
Lonaprisan (ZK 230211; BAY86 5044) is an antagonist for progesterone receptor, with IC₅₀ of 3.6 pM and 2.5 pM for PR-A and PR-B, respectively. Lonaprisan exhibits antiprogestagenic activity in rabbits, interrupts early pregnancy in rats, and exhibits antitumor efficacy against DMBA (HY-W011845)-induced mammary tumor. Lonaprisan reveals antiglucocorticoid and antiandrogenic effect .

HY-RS16852

Rb1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Rb1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rb1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Rb1 Mouse Pre-designed siRNA Set A Rb1 Mouse Pre-designed siRNA Set A

HY-RS10397

Pgr Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pgr Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pgr gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pgr Mouse Pre-designed siRNA Set A Pgr Mouse Pre-designed siRNA Set A

HY-129180

XY028-133	PROTACs CDK	Cancer
XY028-133 (example 14) is a PROTAC-based CDK4/6 degrader with anti-tumor activity, which consists of ligands for von Hippel-Lindau and CDK .

HY-168660

CPD-10	PROTACs Apoptosis CDK	Cancer
CPD-10 is a potent CCND1 and CDK4 PROTAC degrader. CPD-10 shows anti-proliferation. CPD-10 induces apoptosis. CPD-10 decreases the protein expression of cyclin D1, cyclin D3, CDK4, P-Rb(5807/811) in a dose-dependent manner. (Pink: ligand for target protein (HY-50767); black: linker (HY-22391); Blue: E3 ligase ligand (HY-168667)) .

HY-15166A

(E/Z)-Zotiraciclib hydrochloride Maximum Cited Publications 6 Publications Verification (E/Z)-TG02 hydrochloride; (E/Z)-SB1317 hydrochloride	CDK JAK FLT3	Cancer
(E/Z)-Zotiraciclib ((E/Z)-TG02) is an orally active inhibitor of CDK2, JAK2 and FLT3 with IC₅₀s of 13, 73 and 56 nM, respectively. (E/Z)-Zotiraciclib effectively inhibits the proliferation of cancer cells, it can be used for the research of cancer .

HY-15166

(E/Z)-Zotiraciclib Maximum Cited Publications 6 Publications Verification (E/Z)-TG02; (E/Z)-SB1317	CDK JAK FLT3	Cancer
(E/Z)-Zotiraciclib ((E/Z)-TG02) is a potent inhibitor of CDK2, JAK2 and FLT3 with IC₅₀s of 13, 73 and 56 nM, respectively. (E/Z)-Zotiraciclib effectively inhibits the proliferation of cancer cells, it can be used for the research of cancer .

HY-RS11713

RB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RB1 Human Pre-designed siRNA Set A contains three designed siRNAs for RB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RB1 Human Pre-designed siRNA Set A RB1 Human Pre-designed siRNA Set A

HY-136726

CGP-82996 CINK4	CDK	Cancer
GP-82996 (CINK4) is a pharmacological inhibitor of CDK4/6. GP-82996 has IC₅₀s of 1.5, 5.6 and 25 μM for CDK4/cyclin D1, CDK6/cyclin D1 and Cdk5/p35, respectively. GP-82996 induces the apoptosis of cancer cells U2OS. GP-82996 can be used in the research of cancer .

HY-173007

ALK/PI3K/AKT-IN-1	Akt PI3K Anaplastic lymphoma kinase (ALK) CDK Apoptosis Mitochondrial Metabolism	Cancer
ALK/PI3K/AKT-IN-1 (Compound 45) inhibits the proliferation of cancer cell A549, H1975 and PC9 with an IC₅₀ of 0.44, 0.83 and 1.51 μM. ALK/PI3K/AKT-IN-1 increases the expression of p21 and p27, inhibits the activity of CDK2 and p-Rb, arrests the cell cycle at G1 phase. ALK/PI3K/AKT-IN-1 inhibits the ALK/PI3K/AKT signaling pathway, promotes the depolarization of mitochondrial membrane potential, and inducing apoptosis in A549 cell. ALK/PI3K/AKT-IN-1 inhibits the formation and growth of A549 cell spheroids .

Cat. No.	Product Name

HY-L201

Cell Proliferation Compound Library	2,824 compounds
Cell proliferation, the increase in cell numbers resulting from cell division, is a complex and tightly regulated process. Cell proliferation is regulated by coordinated entry into the cell cycle, and changes in proliferation are closely linked to disease development. Evolutionary dynamics links tumor growth and progression with cell proliferation, cell death, and mutation rates. In addition, cell proliferation is central to degenerative diseases, the development of which is often accompanied by accelerated multiplication of cancer cells. Therefore, assays of cell proliferation levels are frequently used for laboratory research purposes and increasingly for clinical assessment of tumor aggressiveness and potentially to guide care. It has been shown that multiple key targets are collectively involved in regulating the process of cell proliferation, such as CDK, E2F, pRB, β-Catenin, and others. MCE collects 2,824 compounds that target and regulate key targets of cell proliferation, which can be used in studies of cell proliferation mechanisms and drug discovery.

Cell Proliferation Compound Library

2,824 compounds

Cell proliferation, the increase in cell numbers resulting from cell division, is a complex and tightly regulated process. Cell proliferation is regulated by coordinated entry into the cell cycle, and changes in proliferation are closely linked to disease development. Evolutionary dynamics links tumor growth and progression with cell proliferation, cell death, and mutation rates. In addition, cell proliferation is central to degenerative diseases, the development of which is often accompanied by accelerated multiplication of cancer cells. Therefore, assays of cell proliferation levels are frequently used for laboratory research purposes and increasingly for clinical assessment of tumor aggressiveness and potentially to guide care. It has been shown that multiple key targets are collectively involved in regulating the process of cell proliferation, such as CDK, E2F, pRB, β-Catenin, and others.

MCE collects 2,824 compounds that target and regulate key targets of cell proliferation, which can be used in studies of cell proliferation mechanisms and drug discovery.

Cat. No.	Compare	Product Name	Species	Source

HY-P703588

	RB1 Protein, Human (StrepⅡ) Retinoblastoma-associated protein; p105-Rb; p110-RB1; pRb; Rb; pp110; RB1; Homo sapiens; Human; Rb; Chromatin regulator; DNA-binding; Repressor	Human	E. coli
	RB1 Protein, Human (Strep) is the recombinant human-derived RB1, expressed by E. coli , with Strep labeled tag. ,

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P85348

	Rb Antibody (YA5040) RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110	IHC-P, ICC/IF, ELISA	Human
	Rb Antibody (YA5040) is a mouse-derived and non-conjugated monoclonal antibody, targeting to Rb. It can be applicated for IHC-P, ICC/IF, ELISA assays, in the background of human.

HY-P81301

	Phospho-Rb (Thr356) Antibody (YA1029) RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110	WB, IHC-P, IP	Human, Rat
	Phospho-Rb (Thr356) Antibody (YA1029) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1029), targeting Phospho-Rb (Thr356), with a predicted molecular weight of 106 kDa (observed band size: 110 kDa). Phospho-Rb (Thr356) Antibody (YA1029) can be used for WB, IHC-P, IP experiment in human, rat background.

HY-P81301A

	Phospho-Rb (Ser780) Antibody (YA1030) RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110	WB, IP	Human, Rat
	Phospho-Rb (Ser780) Antibody (YA1030) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1030), targeting Phospho-Rb (Ser780), with a predicted molecular weight of 106 kDa (observed band size: 110 kDa). Phospho-Rb (Ser780) Antibody (YA1030) can be used for WB, IP experiment in human, rat background.

HY-P81301B

	Phospho-Rb (Ser811) Antibody (YA1031) RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110	WB	Human, Hamster
	Phospho-Rb (Ser811) Antibody (YA1031) is a non-conjugated IgG antibody, targeting Phospho-Rb (Ser811), with a predicted molecular weight of 106 kDa (observed band size: 110 kDa). Phospho-Rb (Ser811) Antibody (YA1031) can be used for WB experiment in human, hamster background.

HY-P81301C

	Phospho-Rb (Ser608) Antibody (YA1032) RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110	WB, IHC-P	Human, Rat
	Phospho-Rb (Ser608) Antibody (YA1032) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1032), targeting Phospho-Rb (Ser608), with a predicted molecular weight of 106 kDa (observed band size: 110 kDa). Phospho-Rb (Ser608) Antibody (YA1032) can be used for WB, IHC-P experiment in human, rat background.

HY-P81301D

	Phospho-Rb (Thr252) Antibody (YA1033) RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110	WB, IHC-P	Human, Rat
	Phospho-Rb (Thr252) Antibody (YA1033) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1033), targeting Phospho-Rb (Thr252), with a predicted molecular weight of 106 kDa (observed band size: 110 kDa). Phospho-Rb (Thr252) Antibody (YA1033) can be used for WB, IHC-P experiment in human, rat background.

HY-P86428

	E2F-1 Antibody (YA6120) E2F1; RBBP3; Transcription factor E2F1; E2F-1; PBR3; Retinoblastoma-associated protein 1; RBAP-1; Retinoblastoma-binding protein 3; RBBP-3; pRb-binding protein E2F-1	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	E2F-1 Antibody (YA6120) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to E2F-1. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

HY-P85613

	E2F-1 Antibody (YA5305) Dmel\CG6376; Dmel_CG6376; drosE2F1; E; Sev-CycE; 3A; E; var; 3-93E; E2-promoter binding facto; E2F 1; E2F transcription factor 1; E2F-1; E2f-PA; E2f-PB; E2f-PC; E2F1; E2f1 E2F transcription factor 1; E2F1_HUMAN; Evar; 3; 164; KIAA4009; l; 3; 07172; l; 3; j3B1; l; 3; j3C2; l; 3; rM729; mKIAA4009; OTTHUMP00000030661; PBR3; pRb binding protein E2F 1; pRb-binding protein E2F-1; RBAP 1; RBAP-1; RBAP1; RBBP-3; RBBP3; RBP 3; RBP3; Retinoblastoma-associated protein 1; Retinoblastoma-binding protein 3; Transcription factor E2F1.	WB, ICC/IF, IP	Human, Rat
	E2F-1 Antibody (YA5305) is a mouse-derived and non-conjugated monoclonal antibody, targeting to E2F-1. It can be applicated for WB, ICC/IF, IP assays, in the background of human, rat.

HY-P85616

	EIF2S1 Antibody (YA5308) Dmel\CG6376; Dmel_CG6376; drosE2F1; E; Sev-CycE; 3A; E; var; 3-93E; E2-promoter binding facto; E2F 1; E2F transcription factor 1; E2F-1; E2f-PA; E2f-PB; E2f-PC; E2F1; E2f1 E2F transcription factor 1; E2F1_HUMAN; Evar; 3; 164; KIAA4009; l; 3; 07172; l; 3; j3B1; l; 3; j3C2; l; 3; rM729; mKIAA4009; OTTHUMP00000030661; PBR3; pRb binding protein E2F 1; pRb-binding protein E2F-1; RBAP 1; RBAP-1; RBAP1; RBBP-3; RBBP3; RBP 3; RBP3; Retinoblastoma-associated protein 1; Retinoblastoma-binding protein 3; Transcription factor E2F1.	WB, ICC/IF, IP	Human, Mouse, Rat
	EIF2S1 Antibody (YA5308) is a mouse-derived and non-conjugated monoclonal antibody, targeting to eIF2α. It can be applicated for WB, ICC/IF, IP assays, in the background of human, mouse, rat.

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PRB2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PRB2 Human Pre-designed siRNA Set A contains three designed siRNAs for PRB2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRB1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PRB1 Human Pre-designed siRNA Set A contains three designed siRNAs for PRB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRB3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PRB3 Human Pre-designed siRNA Set A contains three designed siRNAs for PRB3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRB4 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PRB4 Human Pre-designed siRNA Set A contains three designed siRNAs for PRB4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Rb1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Rb1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rb1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pgr Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Pgr Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pgr gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

RB1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
RB1 Human Pre-designed siRNA Set A contains three designed siRNAs for RB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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