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Results for "

neprilysin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Neprilysin (18) Amyloid-β (1) Angiotensin Receptor (4) Angiotensin-converting Enzyme (ACE) (2) Apoptosis (1) Endogenous Metabolite (1) Isotope-Labeled Compounds (3) Reference Standards (3) Somatostatin Receptor (2)
By Research Areas:	Cancer (1) Cardiovascular Disease (9) Endocrinology (2) Infection (5) Inflammation/Immunology (2) Metabolic Disease (2) Neurological Disease (11)

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Isotope-Labeled Compounds

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Targets Recommended: Neprilysin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108499

NNC 26-9100	Somatostatin Receptor Amyloid-β	Neurological Disease
NNC 26-9100 is a selective somatostatin sst4 receptor full agonist (K_i: 6 nM, EC₅₀: 2 nM). NNC 26-9100 decreases total soluble Aβ42, increases brain neprilysin activity and improves learning .

HY-17620

Sacubitrilat 5+ Cited Publications Desethyl Sacubitril; LBQ-657	Neprilysin	Neurological Disease
Sacubitrilat (Desethyl Sacubitril) is an active *neprilysin* (NEP) inhibitor.

HY-17620S

Sacubitrilat-d4 Desethyl Sacubitril-d₄; LBQ-657-d₄	Isotope-Labeled Compounds Neprilysin	Neurological Disease
Sacubitrilat-d₄ is the deuterium labeled Sacubitrilat. Sacubitrilat (Desethyl Sacubitril) is an active neprilysin (NEP) inhibitor .

HY-173430

AD015	Angiotensin-converting Enzyme (ACE) Neprilysin	Cardiovascular Disease Neurological Disease
AD015 is a angiotensin-converting enzyme (ACE) and neprilysin (NEP) dual inhibitor. AD015 inhibits NEP, nACE and cACE with IC₅₀s of 0.009, 0.019 and 0.0008 μM, respectively .

HY-18207

Fasidotril Alatriopril	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Fasidotril is a dual inhibitor of *neprilysin* and angiotensin-converting enzyme (ACE) for the potential research of hypertension and congestive heart failure (CHF).

HY-W013375S

Thiorphan-d7	Neprilysin	Neurological Disease
Thiorphan-d₇ is the deuterium labeled Thiorphan . Thiorphan is a selective NEP (neprilysin) inhibitor with an IC₅₀ of 6.9 nM .

HY-17620R

Sacubitrilat (Standard) Desethyl Sacubitril (Standard); LBQ-657 (Standard)	Reference Standards Neprilysin	Neurological Disease
Sacubitrilat (Standard) is the analytical standard of Sacubitrilat. This product is intended for research and analytical applications. Sacubitrilat (Desethyl Sacubitril) is an active neprilysin (NEP) inhibitor.

HY-W747097

Sacubitrilat-13C4 Desethyl Sacubitril-¹³C₄; LBQ-657-¹³C₄	Isotope-Labeled Compounds Neprilysin	Neurological Disease
Sacubitrilat- ¹³C₄ (Desethyl Sacubitril- ¹³C₄) is ¹³C labeled Sacubitrilat. Sacubitrilat (Desethyl Sacubitril) is an active *neprilysin* (NEP) inhibitor.

HY-114657

Benproperine	Neprilysin	Others
Benproperine is a new neprilysin B inhibitor composed of N-acyl-L-prolyl-L-valine, whose N-acyl moiety is α-isobutylsuccinic acid β-hydroxamic acid.

HY-114635

Dexecadotril Retorphan	Neprilysin	Metabolic Disease
Dexecadotril (Retorphan) is a powerful and selective neprilysin (NEP) inhibitor. Dexecadotril is a prodrug of the R-enantiomers of Thiorphan (HY-W013375). Dexecadotril shows intestinal antisecretatory action .

HY-114412A

TD-0212 TFA	Angiotensin Receptor Neprilysin	Cardiovascular Disease Inflammation/Immunology
TD-0212 TFA is an orally active dual pharmacology angiotensin II type 1 receptor (AT₁) antagonist and neprilysin (NEP) inhibitor, with a pK_i of 8.9 for AT₁ and a pIC₅₀ of 9.2 for NEP .

HY-114412

TD-0212	Angiotensin Receptor Neprilysin	Inflammation/Immunology Endocrinology
TD-0212 (compound 35) is an orally active dual pharmacology angiotensin II type 1 receptor (AT₁) antagonist and neprilysin (NEP) inhibitor, with a pK_i of 8.9 for AT₁ and a pIC₅₀ of 9.2 for NEP .

HY-15407

Sacubitril 2 Publications Verification AHU-377	Neprilysin	Infection Cardiovascular Disease
Sacubitril (AHU-377) is a potent and orally active NEP (neprilysin) inhibitor with an IC₅₀ of 5 nM. Sacubitril is a component of the heart failure medicine LCZ696. Sacubitril can be used for the research of heart failure, hypertension and COVID-19 .

HY-15407B

Sacubitril sodium 2 Publications Verification AHU-377 sodium	Neprilysin	Infection Cardiovascular Disease
Sacubitril sodium is a potent and orally active NEP (neprilysin) inhibitor, with an IC₅₀ of 5 nM. Sacubitril sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril sodium is a component of the heart failure medicine LCZ696. Sacubitril sodium can be used for the research of heart failure, hypertension and COVID-19 .

HY-18204A

Sacubitril/Valsartan Maximum Cited Publications 9 Publications Verification LCZ696	Angiotensin Receptor Neprilysin Apoptosis	Cardiovascular Disease Endocrinology Cancer
Sacubitril/Valsartan (LCZ696), comprised Valsartan and Sacubitril (AHU377) in 1:1 molar ratio, is a first-in-class, orally bioavailable, and dual-acting *angiotensin receptor-neprilysin* (ARN)** inhibitor for hypertension and heart failure . Sacubitril/Valsartan ameliorates diabetic cardiomyopathy by inhibiting inflammation, oxidative stress and apoptosis .

HY-15407R

Sacubitril (Standard)	Neprilysin	Infection Cardiovascular Disease
Sacubitril (Standard) is the analytical standard of Sacubitril. This product is intended for research and analytical applications. Sacubitril (AHU-377) is a potent and orally active NEP (neprilysin) inhibitor with an IC50 of 5 nM. Sacubitril is a component of the heart failure medicine LCZ696. Sacubitril can be used for the research of heart failure, hypertension and COVID-19 .

HY-172904

Antidiabetic agent 15	Angiotensin Receptor Neprilysin	Cardiovascular Disease Neurological Disease Metabolic Disease
Antidiabetic agent 15 (compound 1B15) is a AT1R and NEP dual inhibitor. Antidiabetic agent 15 reduces the oxidative stress and restores the mitochondrial membrane potential .

HY-15407S3

Sacubitril-13C4 AHU-377-¹³C₄	Isotope-Labeled Compounds Neprilysin	Infection
Sacubitril-13C4 (AHU-377-13C4) is a 13C-labeled version of Sacubitril (HY-15407). Sacubitril is an orally active inhibitor of neprilysin NEP (IC₅₀=5 nM). Sacubitril is used in research on heart failure, hypertension and COVID-19 .

HY-B1746R

Pyridoxamine 5′-phosphate (Standard)	Reference Standards Endogenous Metabolite	Neurological Disease
Sacubitril (sodium) (Standard) is the analytical standard of Sacubitril (sodium). This product is intended for research and analytical applications. Sacubitril sodium is a potent and orally active NEP (neprilysin) inhibitor, with an IC50 of 5 nM. Sacubitril sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril sodium is a component of the heart failure medicine LCZ696. Sacubitril sodium can be used for the research of heart failure, hypertension and COVID-19 .

HY-15407BR

Sacubitril sodium (Standard) AHU-377 sodium (Standard)	Reference Standards Neprilysin	Infection Cardiovascular Disease
Sacubitril (sodium) (Standard) is the analytical standard of Sacubitril (sodium). This product is intended for research and analytical applications. Sacubitril sodium is a potent and orally active NEP (neprilysin) inhibitor, with an IC50 of 5 nM. Sacubitril sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril sodium is a component of the heart failure medicine LCZ696. Sacubitril sodium can be used for the research of heart failure, hypertension and COVID-19 .

HY-P1206

CH 275 1 Publications Verification	Somatostatin Receptor	Neurological Disease
CH 275 is a peptide analog of somatostatin and binds preferably to somatostatin receptor 1 (sst₁) with a K_i of 52 nM . CH 275 acts as a potent and selective sst₁ agonist (IC₅₀=30.9 nM) and also displays IC₅₀ values of 345 nM, >1 μM, >10 μM, >10 μM for human sst₃, sst₄, sst₂ and sst₅, respectively . CH 275 can be used for the research of alzheimer’s disease .

HY-W013375

Thiorphan 3 Publications Verification	Neprilysin	Neurological Disease
Thiorphan is a selective neprilysin (NEP) inhibitor with an IC₅₀ of 6.9 nM. Thiorphan competitively binds to NEP and blocks its activity, preventing the degradation of neuropeptides such as substance P (SP) and neurokinin NKA. In the field of neonatal brain injury research, Thiorphan can increase the levels of SP and NKA, activate NK1 and NK2 receptors and downstream transduction pathways, and inhibit excessive activation of NMDA receptors. Thus, Thiorphan can protect neocortical neurons from excitotoxic cell death. Thiorphan may also inhibit NEP from enhancing bronchoconstriction and can be used in the study of respiratory diseases .

Cat. No.	Product Name	Target	Research Area

HY-P1206

CH 275 1 Publications Verification	Somatostatin Receptor	Neurological Disease
CH 275 is a peptide analog of somatostatin and binds preferably to somatostatin receptor 1 (sst₁) with a K_i of 52 nM . CH 275 acts as a potent and selective sst₁ agonist (IC₅₀=30.9 nM) and also displays IC₅₀ values of 345 nM, >1 μM, >10 μM, >10 μM for human sst₃, sst₄, sst₂ and sst₅, respectively . CH 275 can be used for the research of alzheimer’s disease .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1746R

Pyridoxamine 5′-phosphate (Standard)	Alkaloids Human Gut Microbiota Metabolites Source classification Pyridine Alkaloids Endogenous metabolite	Reference Standards Endogenous Metabolite
Sacubitril (sodium) (Standard) is the analytical standard of Sacubitril (sodium). This product is intended for research and analytical applications. Sacubitril sodium is a potent and orally active NEP (neprilysin) inhibitor, with an IC50 of 5 nM. Sacubitril sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril sodium is a component of the heart failure medicine LCZ696. Sacubitril sodium can be used for the research of heart failure, hypertension and COVID-19 .

Species:	Human (4) Rhesus Macaque (1) Rat (1) Mouse (1) Cynomolgus (1)
Tag:	His (5) Tag Free (2) Fc (1)
Source:	HEK293 (8)

Cat. No.	Compare	Product Name	Species	Source

HY-P73746

	*MME/Neprilysin* Protein, Rat (HEK293, His)** neprilysin; CALLA; NEP; SFE; CD10; MME	Rat	HEK293
	Neprilysin/CD10 protein has a specificity similar to thermolysin and mainly acts on polypeptides of up to 30 amino acids. It plays a crucial role in degrading opioid peptides, including Met-enkephalin and Leu-enkephalin, by cleaving the Gly-Phe bond. MME/Neprilysin Protein, Rat (HEK293, His) is the recombinant rat-derived Neprilysin/CD10 protein, expressed by HEK293 , with N-His labeled tag.

HY-P75607

	*MME/Neprilysin* Protein, Rhesus Macaque (HEK293, His)** neprilysin; Atriopeptidase; CALLA; NEP; SFE; CD10; MME	Rhesus Macaque	HEK293
	MME is a cell-surface peptidase member of the M13 family of zinc peptidases, which also includes endothelin converting enzymes (ECE-1 and ECE-2), KELL and PEX. MME cleaves peptide bonds on the amino side of hydrophobic amino acids and is the key enzyme in processing of a variety of physiologically active peptides, such as GRP, neurotensin (NT), and vasoactive intestinal peptide (VIP). MME is downregulated in nearly 50% of primary and metastatic prostate cancers. MME/Neprilysin Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived Neprilysin/CD10 protein, expressed by HEK293 , with N-His labeled tag.

HY-P72876

	MME Protein, Human (HEK293) neprilysin; Atriopeptidase; CALLA; NEP; SFE; CD10; MME; EPN	Human	HEK293
	MME proteins exhibit thermolysin-like specificity and primarily degrade polypeptides of up to 30 amino acids. Crucially, it plays a key role in cleaving the Gly-Phe bond to degrade opioid peptides, including Met-enkephalin and Leu-enkephalin. MME Protein, Human (HEK293) is the recombinant human-derived MME protein, expressed by HEK293 , with tag free.

HY-P72878

	MME Protein, Mouse (HEK293, His) neprilysin; Atriopeptidase; CALLA; NEP; SFE; CD10; MME; EPN	Mouse	HEK293
	MME Protein, with thermolysin-like specificity, crucially degrades opioid peptides like Met- and Leu-enkephalins, cleaving a Gly-Phe bond.It also catalyzes the cleavage of bradykinin, substance P, neurotensin peptides, angiotensin-1, angiotensin-2, and angiotensin 1-9.Involved in atrial natriuretic factor (ANF) degradation, MME exhibits UV-inducible elastase activity towards skin preelastic and elastic fibers.MME Protein, Mouse (HEK293, His) is the recombinant mouse-derived MME protein, expressed by HEK293 , with N-His labeled tag.

HY-P72876A

	MME Protein, Human (HEK293, Tag Free) neprilysin; Atriopeptidase; CALLA; NEP; SFE; CD10; MME; EPN	Human	HEK293
	MME proteins exhibit thermolysin-like specificity and primarily degrade polypeptides of up to 30 amino acids. Crucially, it plays a key role in cleaving the Gly-Phe bond to degrade opioid peptides, including Met-enkephalin and Leu-enkephalin. MME Protein, Human (HEK293) is the recombinant human-derived MME protein, expressed by HEK293 , with tag free.

HY-P72505A

	MME Protein, Human (HEK293, N-His) neprilysin; Atriopeptidase; CALLA; NEP; SFE; CD10	Human	HEK293
	MME proteins exhibit thermolysin-like specificity and primarily degrade polypeptides of up to 30 amino acids. Crucially, it plays a key role in cleaving the Gly-Phe bond to degrade opioid peptides, including Met-enkephalin and Leu-enkephalin. MME Protein, Human (HEK293, N-His) is the recombinant human-derived MME protein, expressed by HEK293 , with N-His labeled tag.

HY-P72877

	MME Protein, Human (HEK293, Fc) neprilysin; Atriopeptidase; CALLA; NEP; SFE; CD10; MME; EPN	Human	HEK293
	MME proteins exhibit thermolysin-like specificity and primarily degrade polypeptides of up to 30 amino acids. Crucially, it plays a key role in cleaving the Gly-Phe bond to degrade opioid peptides, including Met-enkephalin and Leu-enkephalin. MME Protein, Human (HEK293, Fc) is the recombinant human-derived MME protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P703804

	MME Protein, Cynomolgus (HEK293, His) neprilysin; Atriopeptidase; Enkephalinase; Neutral endopeptidase 24.11; Skin fibroblast elastase; MME;	Cynomolgus	HEK293
	MME Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived MME protein, expressed by HEK293, with N-His tag.

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Cat. No.	Product Name	Chemical Structure

HY-17620S

Sacubitrilat-d4
Sacubitrilat-d₄ is the deuterium labeled Sacubitrilat. Sacubitrilat (Desethyl Sacubitril) is an active neprilysin (NEP) inhibitor .

HY-W013375S

Thiorphan-d7
Thiorphan-d₇ is the deuterium labeled Thiorphan . Thiorphan is a selective NEP (neprilysin) inhibitor with an IC₅₀ of 6.9 nM .

HY-W747097

Sacubitrilat-13C4
Sacubitrilat- ¹³C₄ (Desethyl Sacubitril- ¹³C₄) is ¹³C labeled Sacubitrilat. Sacubitrilat (Desethyl Sacubitril) is an active *neprilysin* (NEP) inhibitor.

HY-15407S3

Sacubitril-13C4
Sacubitril-13C4 (AHU-377-13C4) is a 13C-labeled version of Sacubitril (HY-15407). Sacubitril is an orally active inhibitor of neprilysin NEP (IC₅₀=5 nM). Sacubitril is used in research on heart failure, hypertension and COVID-19 .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81568

	CD10 Antibody (YA1313) CALLA, NEP,neprilysin; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; NEP; Neutral endopeptidase; Skin fibroblast elastase; SFE; CD10	WB, IHC-P, IP	Human, Rat
	CD10 Antibody (YA1313) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD10.

HY-P87376

	Neprilysin-2/MMEL1 Antibody (YA7059) Mel transforming oncogene like 1 antibody; Membrane metallo endopeptidase like 1 antibody; Membrane metallo endopeptidase like 2 antibody; Membrane metallo-endopeptidase-like 1 antibody; Membrane metallo-endopeptidase-like 2 antibody; MMEL1 antibody; MMEL1_HUMAN antibody; NEP2 antibody; NEP2(m) antibody; NEP2(s) antibody	IHC-P, FC	Human
	Neprilysin-2/MMEL1 Antibody (YA7059) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Neprilysin-2/MMEL1.

HY-P85660

	CD10 Antibody (YA5352) MME; EPN; neprilysin; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; NEP; Neutral endopeptidase; Skin fibroblast elastase; SFE; CD10	ICC/IF, IHC-P	Human, Mouse, Rat
	CD10 Antibody (YA5352) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD10.

HY-P86377

	CD10 Antibody (YA6069) MME; EPN; neprilysin; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; NEP; Neutral endopeptidase; Skin fibroblast elastase; SFE; CD10	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	CD10 Antibody (YA6069) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD10.

HY-P85080

	CD10 Antibody (YA4772) MME; EPN; neprilysin; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; NEP; Neutral endopeptidase; Skin fibroblast elastase; SFE; CD antigen CD10	WB, IHC-P, ICC/IF, ELISA	Human
	CD10 Antibody (YA4772) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD10.

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neprilysin

Inhibitors & Agonists

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