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nACh

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Drug Metabolite (1) Endogenous Metabolite (2) GABA Receptor (2) iGluR (1) Isotope-Labeled Compounds (1) nAChR (12) Reference Standards (2)
By Research Areas:	Metabolic Disease (2) Neurological Disease (11)

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Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107684

3-Bromocytisine 3-Br-cytisine	nAChR	Neurological Disease
3-Bromocytisine (3-Br-cytisine) is a potent *nACh* receptors agonist, with IC₅₀s are 0.28, 0.30 and 31.6 nM for hα4β4, hα4β2, and hα7-nACh, respectively. 3-Bromocytisine (3-Br-cytisine) shows different effects on high (HS) and low (LS) ACh sensitivity α4β2 nAChRs with EC₅₀s are 8 and 50 nM, respectively .

HY-W018653

Cyclohexaneacetic acid	Endogenous Metabolite	Metabolic Disease
Cyclohexaneacetic acid is recognized as an intermediate of the metabolism of n-alkylcyclohexanes (nACH) in microorganisms. Cyclohexaneacetic acid can be transformed to monohydroxycyclohexaneacetic acids in two Chlorella pyrenoidosa strains .

HY-B0429

Pancuronium dibromide	nAChR	Neurological Disease
Pancuronium dibromide, a bis-quaternary steroid, is a neuromuscular relaxant. Pancuronium dibromide inhibits neuromuscular transmission by competing with acetylcholine for binding sites on nACh receptors. Pancuronium dibromide also inhibits cardiac muscarinic receptors and has a sympathomimetic action .

HY-100637

Hydroxybupropion	Drug Metabolite Adrenergic Receptor nAChR	Neurological Disease
Hydroxybupropion is the major active metabolite of Bupropion. Hydroxybupropion is metabolized by CYP2B6. Bupropion is an atypical antidepressant and smoking-cessation agent. Hydroxybupropion inhibits norepinephrine uptake with an IC₅₀ value of 1.7 μM. Hydroxybupropion is also a nACh receptor antagonist .

HY-155381

APS3	GABA Receptor nAChR	Others
APS3 is a GABA and *nACh* receptors inhibitor, with a LC₅₀ of 7.2423 μg/mL against Plutella xylostella .

HY-U00199A

(S)-Norzopiclone (S)-N-Desmethyl zopiclone; SEP-174559	GABA Receptor nAChR iGluR	Neurological Disease
(S)-Norzopiclone ((S)-N-Desmethyl zopiclone; SEP-174559) is a metabolite of Zopiclone with anxiolytic and anticonvulsant effects. (S)-Norzopiclone has benzodiazepine-like actions at γ2-bearing subtypes of the GABA_A receptor and inhibits *nACh* and NMDA receptors .

HY-W062702

BMS-933043	nAChR	Neurological Disease
BMS-933043 is a potent and selective α7 nACh receptor partial agonist. BMS-933043 attenuates the cognitive impairment in mice and can be utilized in research related to cognitive dysfunction in schizophrenia .

HY-169742

Epibatidine	nAChR	Neurological Disease
Epibatidine is a *α7nACh* agonist with a K_d of 100 nM. Epibatidine can be used in the study of Alzheimer's, Parkinson's and schizophrenia .

HY-N9949

Sparteine Lupinidine	nAChR	Neurological Disease
Sparteine (Lupinidine) is an alkaloid compound derived from leguminous plants and can act as a ganglionic blocker. Sparteine competitively inhibits the activity of the neuronal nicotinic acetylcholine receptor (nACh receptor) .

HY-W018653R

Cyclohexaneacetic acid (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
Cyclohexaneacetic acid (Standard) is the analytical standard of Naloxone. This product is intended for research and analytical applications. Cyclohexaneacetic acid is recognized as an intermediate of the metabolism of n-alkylcyclohexanes (nACH) in microorganisms. Cyclohexaneacetic acid can be transformed to monohydroxycyclohexaneacetic acids in two Chlorella pyrenoidosa strains .

HY-N1064

Xanthoplanine	nAChR	Neurological Disease
Xanthoplanine, isolated from theroot of Xylopia parviflora, fully inhibits the EC₅₀ ACh responses of both alpha7 and alpha4beta2 nACh receptors with estimated IC₅₀ values of 9 μM (alpha7) and 5 μM (alpha4beta2) .

HY-B0429R

Pancuronium dibromide (Standard)	Reference Standards nAChR	Neurological Disease
Pancuronium (dibromide) (Standard) is the analytical standard of Pancuronium (dibromide). This product is intended for research and analytical applications. Pancuronium dibromide, a bis-quaternary steroid, is a neuromuscular relaxant. Pancuronium dibromide inhibits neuromuscular transmission by competing with acetylcholine for binding sites on nACh receptors. Pancuronium dibromide also inhibits cardiac muscarinic receptors and has a sympathomimetic action .

HY-118504

Sulfoxaflor 1 Publications Verification	nAChR	Neurological Disease
Sulfoxaflor is an orally active full agonist of insect nicotinic acetylcholine receptors (nAChRs), targeting the α-bungarotoxin-insensitive nAChR1 and nAChR2 subtypes. Sulfoxaflor binding to nACh is not inhibited by d-Tubocurarine (HY-125901), but is partially inhibited by Mecamylamine (HY-B1395A). Sulfoxaflor induces inward currents by activating nAChRs, leading to insect neurotoxicity. Sulfoxaflor can be used in the research of agricultural pest control, pesticide toxicology, insect neural receptor pharmacology, etc .

HY-118504S

Sulfoxaflor-d3	Isotope-Labeled Compounds nAChR	Neurological Disease
Sulfoxaflor-d₃ is the deuterium labeled Sulfoxaflor (HY-118504). Sulfoxaflor is an orally active full agonist of insect nicotinic acetylcholine receptors (nAChRs), targeting the α-bungarotoxin-insensitive nAChR1 and nAChR2 subtypes. Sulfoxaflor binding to nACh is not inhibited by d-Tubocurarine (HY-125901), but is partially inhibited by Mecamylamine (HY-B1395A). Sulfoxaflor induces inward currents by activating nAChRs, leading to insect neurotoxicity. Sulfoxaflor can be used in the research of agricultural pest control, pesticide toxicology, insect neural receptor pharmacology, etc .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W018653

Cyclohexaneacetic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Cyclohexaneacetic acid is recognized as an intermediate of the metabolism of n-alkylcyclohexanes (nACH) in microorganisms. Cyclohexaneacetic acid can be transformed to monohydroxycyclohexaneacetic acids in two Chlorella pyrenoidosa strains .

HY-N9949

Sparteine Lupinidine	Structural Classification Alkaloids Piperidine Alkaloids Source classification Plants Fabaceae Lupinus sulphureus Douglas	nAChR
Sparteine (Lupinidine) is an alkaloid compound derived from leguminous plants and can act as a ganglionic blocker. Sparteine competitively inhibits the activity of the neuronal nicotinic acetylcholine receptor (nACh receptor) .

HY-W018653R

Cyclohexaneacetic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite
Cyclohexaneacetic acid (Standard) is the analytical standard of Naloxone. This product is intended for research and analytical applications. Cyclohexaneacetic acid is recognized as an intermediate of the metabolism of n-alkylcyclohexanes (nACH) in microorganisms. Cyclohexaneacetic acid can be transformed to monohydroxycyclohexaneacetic acids in two Chlorella pyrenoidosa strains .

HY-N1064

Xanthoplanine	Alkaloids Structural Classification Monophenols other families Source classification Phenols Plants Isoquinoline Alkaloids	nAChR
Xanthoplanine, isolated from theroot of Xylopia parviflora, fully inhibits the EC₅₀ ACh responses of both alpha7 and alpha4beta2 nACh receptors with estimated IC₅₀ values of 9 μM (alpha7) and 5 μM (alpha4beta2) .

Cat. No.	Product Name	Chemical Structure

HY-118504S

Sulfoxaflor-d3
Sulfoxaflor-d₃ is the deuterium labeled Sulfoxaflor (HY-118504). Sulfoxaflor is an orally active full agonist of insect nicotinic acetylcholine receptors (nAChRs), targeting the α-bungarotoxin-insensitive nAChR1 and nAChR2 subtypes. Sulfoxaflor binding to nACh is not inhibited by d-Tubocurarine (HY-125901), but is partially inhibited by Mecamylamine (HY-B1395A). Sulfoxaflor induces inward currents by activating nAChRs, leading to insect neurotoxicity. Sulfoxaflor can be used in the research of agricultural pest control, pesticide toxicology, insect neural receptor pharmacology, etc .

Sulfoxaflor-d3

Sulfoxaflor-d₃ is the deuterium labeled Sulfoxaflor (HY-118504). Sulfoxaflor is an orally active full agonist of insect nicotinic acetylcholine receptors (nAChRs), targeting the α-bungarotoxin-insensitive nAChR1 and nAChR2 subtypes. Sulfoxaflor binding to nACh is not inhibited by d-Tubocurarine (HY-125901), but is partially inhibited by Mecamylamine (HY-B1395A). Sulfoxaflor induces inward currents by activating nAChRs, leading to insect neurotoxicity. Sulfoxaflor can be used in the research of agricultural pest control, pesticide toxicology, insect neural receptor pharmacology, etc .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81204

	Alpha-ENaC Antibody Alpha ENaC 2; Alpha ENaC; Alpha nACh; Alpha-nACh; Amiloride sensitive epithelial sodium channel alpha subunit; Amiloride sensitive sodium channel subunit alpha; Amiloride-sensitive sodium channel subunit alpha; ENaCa; ENaCalpha; Epithelial Na(+) channel subunit alpha; Epithelial Na+ channel subunit alpha; FLJ21883; Nonvoltage gated sodium channel 1 subunit alpha; Nonvoltage-gated sodium channel 1 subunit alpha; SCNEA; SCNN 1; SCNN1; SCNN1A; SCNNA_HUMAN; Sodium channel nonvoltage gated 1 alpha.	WB, ELISA, IHC-P, IHC-F, FC, ICC/IF	Human, Mouse, Rat
	Alpha-ENaC Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Alpha-ENaC.

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