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Results for "

menin-MLL interaction

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Androgen Receptor (1) Apoptosis (6) Endogenous Metabolite (1) Epigenetic Reader Domain (28) Potassium Channel (1)
By Research Areas:	Cancer (29) Inflammation/Immunology (2) Metabolic Disease (2)

Inhibitors & Agonists

Peptides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-128798

Menin-MLL inhibitor 20	Epigenetic Reader Domain	Cancer
Menin-MLL inhibitor 20 is an irreversible **menin-MLL interaction** inhibitor with antitumor activities (WO2020142557A1, Intermediate 6) .

HY-139076

Menin-MLL inhibitor 19	Epigenetic Reader Domain	Metabolic Disease Cancer
Menin-MLL inhibitor 19, a potent exo-aza spiro inhibitor of **menin-mll interaction*, example A17, extracted from patent WO2019120209A1. Menin-MLL* inhibitor 19 can be used for the reseaech of various diseases, such as cancer, myelodysplastic syndrome (MDS) and diabetes .

HY-15222

Menin-MLL inhibitor MI-2 4 Publications Verification	Epigenetic Reader Domain Apoptosis	Cancer
Menin-MLL inhibitor MI-2 is a competitive and selective *Menin-MLL* interaction inhibitor with an IC₅₀ value of 446 nM and a K_i value of 158 nM. Menin-MLL inhibitor MI-2 downregulates the expression of target genes such as HOXA9 and MEIS1, inhibits proliferation of leukemia cells and induces apoptosis and differentiation. Menin-MLL inhibitor MI-2 is proming for rasearch of MLL-rearranged acute leukemias (e.g., AML, ALL) .

HY-16925

MI-503 5+ Cited Publications	Epigenetic Reader Domain	Cancer
MI-503 is a highly potent and orally bioavailable small molecule inhibitor of the *menin-mLL* interaction.

HY-148367A

(1s,4s)-Menin-MLL inhibitor-23	Epigenetic Reader Domain	Cancer
(1s,4s)-Menin-MLL inhibitor-23 is the enantiomer of Menin-MLL inhibitor-23 (HY-148367). Menin-MLL inhibitor-23 (Example 99A) is a *menin-MLL* interaction inhibitor .

HY-157814

Menin-MLL inhibitor-25	Apoptosis Epigenetic Reader Domain	Cancer
Menin-MLL inhibitor-25 (compound A6) is a potent *Menin-MLL* interaction inhibitor with an IC₅₀ value of 0.38 µM. Menin-MLL inhibitor-25 shows anti-proliferative activity. Menin-MLL inhibitor-25 induces apoptosis and cell cycle arrest at G0/G1 phase. Menin-MLL inhibitor-25 reverses the differentiation arrest .

HY-129167

Menin-MLL inhibitor 4	Epigenetic Reader Domain	Cancer
Menin-MLL inhibitor 4 is an inhibitor of **Menin- MLL (mixed-lineage leukemia protein) interaction** extracted from patent WO2017214367, compound example 1. Menin-MLL inhibitor 4 has antitumor activity .

HY-P10066

Menin-MLL inhibitor 31	Epigenetic Reader Domain	Cancer
Menin-MLL inhibitor 31 (compound 18) is a potent inhibitor of the menin MLL interaction with an IC₅₀ value of 4.6 nM .

HY-15222A

Menin-MLL inhibitor MI-2 dihydrochloride	Epigenetic Reader Domain Apoptosis	Cancer
Menin-MLL inhibitor MI-2 dihydrochloride is a competitive and selective *Menin-MLL* interaction inhibitor with an IC₅₀ value of 446 nM and a K_i value of 158 nM. Menin-MLL inhibitor MI-2 dihydrochloride downregulates the expression of target genes such as HOXA9 and MEIS1, inhibits proliferation of leukemia cells and induces apoptosis and differentiation. Menin-MLL inhibitor MI-2 dihydrochloride is proming for rasearch of MLL-rearranged acute leukemias (e.g., AML, ALL) .

HY-111937

MI-1	Epigenetic Reader Domain	Cancer
MI-1 inhibits *Menin-MLL* interaction with an IC₅₀ of 1.9 μM .

HY-19809

MI-463 1 Publications Verification	Epigenetic Reader Domain	Cancer
MI-463 is a highly potent and orally bioavailable small molecule inhibitor of the *menin-mLL* interaction.

HY-108350

MI-2-2	Epigenetic Reader Domain	Cancer
MI-2-2 is a potent menin-MLL inhibitor. MI-2-2 binds to menin with low nanomolar affinity (K_d=22nM) and very effectively disrupts the bivalent protein-protein interaction between menin and MLL. MI-2-2 has specific and very pronounced activity in MLL leukemia cells, including inhibition of cell proliferation, down-regulation of Hoxa9 expression, and differentiation .

HY-133738

M-808	Epigenetic Reader Domain	Cancer
M-808 is a highly potent and efficacious covalent *Menin-MLL* interaction inhibitor, with a binding IC₅₀ value of 2.6 nM .

HY-132234

M-1211	Epigenetic Reader Domain	Cancer
M‑1121 is a covalent and orally active inhibitor of the menin-MLL interaction capable of achieving complete and persistent tumor regression .

HY-132001

Ziftomenib 1 Publications Verification KO-539	Epigenetic Reader Domain	Cancer
Ziftomenib (KO-539) is an orally active **menin-MLL interaction** inhibitor with antitumor activities (WO2017161028A1, compound 151) .

HY-114162A

VTP50469 fumarate Maximum Cited Publications 7 Publications Verification	Epigenetic Reader Domain Apoptosis	Cancer
VTP50469 fumarate is a potent, highly selective and orally active **Menin-MLL interaction inhibitor with a K_i** of 104 pM. VTP50469 fumarate has potently anti-leukemia activity .

HY-114162

VTP50469 Maximum Cited Publications 7 Publications Verification	Epigenetic Reader Domain Apoptosis	Cancer
VTP50469 is a potent, highly selective and orally active **Menin-MLL interaction inhibitor with a K_i** of 104 pM. VTP50469 has potently anti-leukemia activity .

HY-134921

MI-nc dihydrochloride	Epigenetic Reader Domain	Cancer
MI-nc dihydrochloride is a weak inhibitor of the *Menin-MLL* fusion protein interaction with an IC₅₀ of 193 μM. MI-nc dihydrochloride can be used as a negative control compound of MI-2 .

HY-151595

Menin-MLL inhibitor-22	Epigenetic Reader Domain	Cancer
Menin-MLL inhibitor-22 (compound C20) is an orally active inhibitor of the interaction between *menin* and mixed lineage leukemia (MLL) (IC₅₀=7 nM). Menin-MLL inhibitor-22 binds *menin* protein and inhibits cancer cell growth (MV4 cells, IC₅₀=0.3 μM). *Menin* is a putative tumor suppressor associated with multiple endocrine neoplasia type 1 (MEN-1 syndrome) .

HY-19319

MI-136	Epigenetic Reader Domain Androgen Receptor Apoptosis	Cancer
MI-136 is an inhibitor of the menin-MLL protein-protein interaction (PPI), with an IC₅₀ of 31 nM and a K_d of 23.6 nM. MI-136 shows to block AR signaling and has the potential for the study in castration-resistant tumors .

HY-117365

MI-1481	Epigenetic Reader Domain	Cancer
MI-1481 is a highly potent inhibitor of the **Menin-MLL1 interaction with IC₅₀** of 3.6 nM. MI-1481 markedly reduces cell growth of murine bone marrow cells transformed and inhibits leukemia progression .

HY-114699

DC_YM21	Endogenous Metabolite	Cancer
DC_YM21 is an inhibitor of menin-MLL interaction with potent and selective proliferation blocking activity. DC_YM21 can induce cell cycle arrest and differentiation of leukemia cells carrying MLL translocation. DC_YM21 shows potential application value in inhibiting MLL leukemia .

HY-124069

M-525	Epigenetic Reader Domain	Cancer
M-525 is a first-in-class, highly potent, irreversible and covalent *menin-MLL* protein-protein interaction inhibitor. M-525 binds to menin with an IC₅₀ of 3 nM and achieves low nanomolar potencies in cell growth inhibition and in suppression of MLL regulated gene expression in MLL leukemia cells. Anti-leukemia activity .

HY-128347

M‑89	Epigenetic Reader Domain	Inflammation/Immunology Cancer
M-89 is a highly potent and specific *menin* inhibitor, with a K_d of 1.4 nM for binding to menin. M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia. M-89 inhibits the cell growth in leukemia cell lines carrying MLL fusion .

HY-172416

Balomenib	Epigenetic Reader Domain	Cancer
Balomenib is the inhibitor for *menin-MLL* interaction, that inhibits the interaction between men1-MLL4-43 with an IC₅₀ < 0.075 μM. Balomenib inhibits the growth of MV4-11 (CC₅₀ < 0.1 μM), MOLM-13 (CC₅₀ 0.1~0.5 μM) and HEK293 (CC₅₀ < 2 μM). Balomenib exhibits antineoplastic activity .

HY-153714

Zefamenib BN-104; BNM-1192; menin-MLL inhibitor 27	Epigenetic Reader Domain Potassium Channel	Cancer
Zefamenib (BN-104) is an effective selective brain membrane protein inhibitor with oral activity, and it's also a *Menin* inhibitor, it can block the Menin-MLL interaction and leads to the degradation of Menin protein. Zefamenib is a weak hERG inhibitor, with an IC₅₀ greater than 100 μM. Zefamenib has anti-tumor activity and can be used in cancer research, such as for acute myeloid leukemia .

HY-136360

MI-3454 2 Publications Verification	Epigenetic Reader Domain	Cancer
MI-3454 is an orally active, highly potent and selective **menin-MLL1 interaction inhibitor with an IC₅₀** of 0.51 nM. MI-3454 inhibits proliferation, induces differentiation and complete remission or regression of leukemia in mouse models of MLL1-rearranged or NPM1-mutated leukemia through downregulation of key genes involved in leukemogenesis .

HY-176732

MJ-26	Epigenetic Reader Domain	Cancer
MJ-26 is an inhibitor targeting *Menin. MJ-26 has high binding affinity (K_i: 0.56 μM) and significant antiproliferative activity. MJ-26 works by inhibiting Menin-MLL* interaction and inducing Menin protein degradation. MJ-26 has significant antitumor effects on acute myeloid leukemia (AML). MJ-26 can be used in AML research .

HY-150105

Icovamenib BMF-219; menin-MLL inhibitor 21	Epigenetic Reader Domain	Metabolic Disease Inflammation/Immunology Cancer
Icovamenib (BMF-219) is a selective, orally active, irreversible Menin inhibitor. Icovamenib forms a stable and irreversible covalent bond with Menin. Icovamenib promotes selective and controlled proliferation of beta cells and improvement of beta cell function in ex vivo human islet cultures. Icovamenib enhances glycemic control in animal diabetic models. Icovamenib induces a dose-dependent enhancement in insulin secretion potentiated by the GLP-1 RA. Icovamenib can be used for the study of multiple hematologic malignancies, solid tumors, and diabetes mellitus, such as diffuse large B-cell lymphoma (DLBCL), multiple myeloma (MM) and chronic lymphocytic leukemia and type 2 diabetes .

Menin-MLL inhibitor 31	Epigenetic Reader Domain	Cancer
Menin-MLL inhibitor 31 (compound 18) is a potent inhibitor of the menin MLL interaction with an IC₅₀ value of 4.6 nM .

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