lytic

By Targets:	Amino Acid Derivatives (1) Antibiotic (1) Apoptosis (1) Bacterial (2) Caspase (1) CD20 (1) EBV (5) Epoxide Hydrolase (2) Fungal (1) JNK (1) mRNA (1) NF-κB (1) Osteopontin (1) p38 MAPK (1) Penicillin-binding protein (PBP) (1) Potassium Channel (1) Reference Standards (1) Virus Protease (1)
By Research Areas:	Cancer (5) Infection (6) Inflammation/Immunology (4) Neurological Disease (2)
Oligonucleotides:	mRNA (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-149577

*EBV lytic* cycle inducer-1**	EBV	Cancer
Epstein-Barr virus (EBV) lytic cycle inducer-1 Dp44mT (compound C7) is an iron-chelatoe-like compound. Dp44mT cooperates with HDAC inhibitor Romidespin (HY-15149) and SAHA to induce EBV lytic cycle. Dp44mT reactivates EBV lytic cycle by activating the ERK1/2-autophagy axis in epithelial cancers .

HY-P5475

BMLF1 (280–288)	EBV	Others
BMLF1 (280–288) is a biological active peptide. (HLA A2.1-restricted epitope from Epstein-Barr Virus lytic protein BMLF1 (280-288).)

HY-B2117

Valpromide	Epoxide Hydrolase EBV	Infection Neurological Disease
Valpromide is an amide derivative of Valproic acid (HY-10585) and an orally active epoxide hydrolase inhibitor that can cross the blood-brain barrier. Valpromide has antiepileptic, anticonvulsant, and antipsychotic effects. Valpromide also exhibits antiviral activity and can inhibit the reactivation of the EBV lytic cycle .

HY-P1911

*CEF27, Epstein-Barr Virus BRLF-1 lytic* (148-156)**	EBV	Infection
CEF27, Epstein-Barr Virus BRLF-1 lytic 148-156 corresponding to amino acids 148-156 of the BRLF1 protein. BRLF1 is a transcriptional activator that binds directly to a GC-rich motif present in some Epstein-Barr virus (EBV) lytic gene promoters .

HY-W747311

Ritipenem	Antibiotic Bacterial Penicillin-binding protein (PBP)	Infection
Ritipenem is a penicillin antibiotic, that targets penicillin-binding protein with good affinity (IC₅₀ in levels of ng/mL), and exhibits antibacterial properties. Ritipenem exhibits antiviral activity against Haemophilus influenzae .

HY-P1751

Ceratotoxin B	Bacterial	Infection
Ceratotoxins B is antibacterial peptide produced by the sexually mature females of Ceratitis capitata. Lytic and antibacterial activity .

HY-W748023

Cryptosporiopsin A	Fungal	Inflammation/Immunology
Cryptosporiopsin A, a polyketide with antifungal activity, exhibits motility inhibitory and lytic activities against zoospores of the grapevine downy mildew pathogen Plasmopara viticola .

HY-174788

HHV-1 UL48 mRNA	mRNA	Others
HHV-1 UL48 mRNA encodes the UL48 protein of human herpesvirus 1 (HHV-1). UL48 is a tanscriptional activator of immediate-early (IE) gene products (alpha genes). It acts as a key activator of lytic infection by initiating the lytic program through the assembly of the transcriptional regulatory VP16-induced complex composed of VP16 and two cellular factors, HCFC1 and POU2F 1.

HY-P10841

CyPep-1	Amino Acid Derivatives	Cancer
CyPep-1 is a novel cationic lytic peptide with antitumor activity. CyPep-1 is highly cytotoxic by interacting with the negatively charged cell membrane of cancer cells. CyPep-1 has strong cytolytic activity on cancer cells both in vivo and in vitro, and can be used in the study of solid tumors .

HY-B2117R

Valpromide (Standard)	Reference Standards Epoxide Hydrolase EBV	Infection Neurological Disease
Valpromide (Standard) is the analytical standard of Valpromide (HY-B2117). This product is intended for research and analytical applications. Valpromide is an amide derivative of Valproic acid (HY-10585) and an orally active epoxide hydrolase inhibitor that can cross the blood-brain barrier. Valpromide has antiepileptic, anticonvulsant, and antipsychotic effects. Valpromide also exhibits antiviral activity and can inhibit the reactivation of the EBV lytic cycle .

HY-P990116

Anti-Mouse osteopontin/SPP1 Antibody (103D6)	Osteopontin	Inflammation/Immunology
Anti-Mouse osteopontin/SPP1 Antibody (103D6) is a mouse-derived anti-mouse osteopontin/SPP1 IgG2c κ type antibody inhibitor. Anti-Mouse osteopontin/SPP1 Antibody (103D6) increases cytotoxic T lymphocyte lytic activity and suppresses colon tumor growth. Anti-Mouse osteopontin/SPP1 Antibody (103D6) ameliorates liver injury in common bile duct ligation (CBDL)-induced primary sclerosing cholangitis mice models .

HY-P9961

Ofatumumab GSK1841157; OMB-157	CD20	Cancer
Ofatumumab is a fully human anti-CD20 monoclonal antibody that induces antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) in CD20-expressing B lymphocytes. Ofatumumab has strong lytic activity against CD20-positive B lymphocytes and eliminates CD20-positive tumor cells through ADCC and CDC. Ofatumumab is particularly effective against drug-resistant cells with low CD20 expression and can be applied to the research of chronic lymphocytic leukemia (CLL) .

HY-N0763

Angelicin 5+ Cited Publications Isopsoralen	Apoptosis Virus Protease NF-κB p38 MAPK JNK Caspase	Infection Inflammation/Immunology Cancer
Angelicin is a furanocoumarin compound that functions as an inhibitor of NF-κB and MAPK signaling pathways, exhibiting anti-inflammatory, antiviral, and antitumor activities. It suppresses the lytic replication of γ-herpesviruses, such as MHV-68, early during viral infection, potentially inhibiting RTA gene expression (IC₅₀=28.95 μM). Angelicin also mitigates inflammation by inhibiting the phosphorylation and nuclear translocation of NF-κB, and the phosphorylation of p38 and JNK. Furthermore, it induces apoptosis in neuroblastoma cells by downregulating anti-apoptotic proteins like Bcl-2, Bcl-xL, and Mcl-1, while activating caspase-9 and caspase-3.

HY-P4121

L17E	Potassium Channel	Inflammation/Immunology Cancer
L17E is an attenuated cationic amphiphilic lytic (ACAL) peptide that can be used to deliver a variety of macromolecules, including proteins, antibodies, and DNA nanostructures. L17E inserts and cleaves the membrane structure through electrostatic interaction, enabling intracellular escape. The efficiency of L17E-mediated delivery is strongly correlated with the expression level of KCNN4 (the gene encoding the calcium-activated potassium channel KCa3.1). L17E also promotes the cellular uptake of macromolecules by inducing micropinocytosis. L17E can be further optimized and improved through dimerization strategies and in combination with other delivery systems, such as nuclear localization signal peptides and cell membrane-coated nanoparticles .

Cat. No.	Product Name

HY-L162

Cell Death Library	3,229 compounds
Cell death plays a crucial role in the development of the body and the maintenance of internal balance to prevent the development of diseases. According to the regulation of the involved processes, cell death can be defined as programmed and non-programmed death. Programmed cell death (PCD) can be divided into lytic cell death and nonlytic cell death, mainly including apoptosis, necrotic apoptosis and Pyroptosis. Non-Programmed cell death (Non-PCD) generally refers to necrosis. In stark contrast to Accidental Cell Death (ACD), Regulatory Cell Death (RCD) relies on specialized molecular mechanisms. Cell death includes internal apoptosis, external apoptosis, necrotic apoptosis, ferroptosis, pyroptosis, lysosome-dependent cell death, etc. MCE designs a unique collection of 3,229 cell death compounds, covering multiple targets, such as Apoptosis, Ferroptosis, Pyroptosis, Necroptosis, etc. It is a useful tool for screening cell death drugs.

Cell Death Library

3,229 compounds

Cell death plays a crucial role in the development of the body and the maintenance of internal balance to prevent the development of diseases. According to the regulation of the involved processes, cell death can be defined as programmed and non-programmed death. Programmed cell death (PCD) can be divided into lytic cell death and nonlytic cell death, mainly including apoptosis, necrotic apoptosis and Pyroptosis. Non-Programmed cell death (Non-PCD) generally refers to necrosis. In stark contrast to Accidental Cell Death (ACD), Regulatory Cell Death (RCD) relies on specialized molecular mechanisms. Cell death includes internal apoptosis, external apoptosis, necrotic apoptosis, ferroptosis, pyroptosis, lysosome-dependent cell death, etc.

MCE designs a unique collection of 3,229 cell death compounds, covering multiple targets, such as Apoptosis, Ferroptosis, Pyroptosis, Necroptosis, etc. It is a useful tool for screening cell death drugs.

Cat. No.	Product Name	Target	Research Area

HY-P5475

BMLF1 (280–288)	EBV	Others
BMLF1 (280–288) is a biological active peptide. (HLA A2.1-restricted epitope from Epstein-Barr Virus lytic protein BMLF1 (280-288).)

HY-P4121

L17E	Potassium Channel	Inflammation/Immunology Cancer
L17E is an attenuated cationic amphiphilic lytic (ACAL) peptide that can be used to deliver a variety of macromolecules, including proteins, antibodies, and DNA nanostructures. L17E inserts and cleaves the membrane structure through electrostatic interaction, enabling intracellular escape. The efficiency of L17E-mediated delivery is strongly correlated with the expression level of KCNN4 (the gene encoding the calcium-activated potassium channel KCa3.1). L17E also promotes the cellular uptake of macromolecules by inducing micropinocytosis. L17E can be further optimized and improved through dimerization strategies and in combination with other delivery systems, such as nuclear localization signal peptides and cell membrane-coated nanoparticles .

HY-P1911

*CEF27, Epstein-Barr Virus BRLF-1 lytic* (148-156)**	EBV	Infection
CEF27, Epstein-Barr Virus BRLF-1 lytic 148-156 corresponding to amino acids 148-156 of the BRLF1 protein. BRLF1 is a transcriptional activator that binds directly to a GC-rich motif present in some Epstein-Barr virus (EBV) lytic gene promoters .

HY-P1751

Ceratotoxin B	Bacterial	Infection
Ceratotoxins B is antibacterial peptide produced by the sexually mature females of Ceratitis capitata. Lytic and antibacterial activity .

HY-169756

L17E-OH	Peptides	Others
L17E-OH is a derived peptide of L17E, an endosomolytic peptide, a cationic amphipathic peptide with specific membrane lytic activity against late endosomes (Les) .

HY-P10841

CyPep-1	Amino Acid Derivatives	Cancer
CyPep-1 is a novel cationic lytic peptide with antitumor activity. CyPep-1 is highly cytotoxic by interacting with the negatively charged cell membrane of cancer cells. CyPep-1 has strong cytolytic activity on cancer cells both in vivo and in vitro, and can be used in the study of solid tumors .

Cat. No.	Product Name	Target	Research Area

HY-P990116

Anti-Mouse osteopontin/SPP1 Antibody (103D6)	Osteopontin	Inflammation/Immunology
Anti-Mouse osteopontin/SPP1 Antibody (103D6) is a mouse-derived anti-mouse osteopontin/SPP1 IgG2c κ type antibody inhibitor. Anti-Mouse osteopontin/SPP1 Antibody (103D6) increases cytotoxic T lymphocyte lytic activity and suppresses colon tumor growth. Anti-Mouse osteopontin/SPP1 Antibody (103D6) ameliorates liver injury in common bile duct ligation (CBDL)-induced primary sclerosing cholangitis mice models .

HY-P9961

Ofatumumab GSK1841157; OMB-157	CD20	Cancer
Ofatumumab is a fully human anti-CD20 monoclonal antibody that induces antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) in CD20-expressing B lymphocytes. Ofatumumab has strong lytic activity against CD20-positive B lymphocytes and eliminates CD20-positive tumor cells through ADCC and CDC. Ofatumumab is particularly effective against drug-resistant cells with low CD20 expression and can be applied to the research of chronic lymphocytic leukemia (CLL) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0763

Angelicin 5+ Cited Publications Isopsoralen	Classification of Application Fields Leguminosae Source classification Coumarins Phenylpropanoids Psoralea corylifolia L. Plants Disease Research Fields Cancer	Apoptosis Virus Protease NF-κB p38 MAPK JNK Caspase
Angelicin is a furanocoumarin compound that functions as an inhibitor of NF-κB and MAPK signaling pathways, exhibiting anti-inflammatory, antiviral, and antitumor activities. It suppresses the lytic replication of γ-herpesviruses, such as MHV-68, early during viral infection, potentially inhibiting RTA gene expression (IC₅₀=28.95 μM). Angelicin also mitigates inflammation by inhibiting the phosphorylation and nuclear translocation of NF-κB, and the phosphorylation of p38 and JNK. Furthermore, it induces apoptosis in neuroblastoma cells by downregulating anti-apoptotic proteins like Bcl-2, Bcl-xL, and Mcl-1, while activating caspase-9 and caspase-3.

HY-P1751

Ceratotoxin B	Infection Natural Products Classification of Application Fields Animals Source classification Disease Research Fields	Bacterial
Ceratotoxins B is antibacterial peptide produced by the sexually mature females of Ceratitis capitata. Lytic and antibacterial activity .

HY-W748023

Cryptosporiopsin A	Monophenols Microorganisms Source classification Phenols	Fungal
Cryptosporiopsin A, a polyketide with antifungal activity, exhibits motility inhibitory and lytic activities against zoospores of the grapevine downy mildew pathogen Plasmopara viticola .

Cat. No.	Product Name		Classification

HY-174788

HHV-1 UL48 mRNA		mRNA
HHV-1 UL48 mRNA encodes the UL48 protein of human herpesvirus 1 (HHV-1). UL48 is a tanscriptional activator of immediate-early (IE) gene products (alpha genes). It acts as a key activator of lytic infection by initiating the lytic program through the assembly of the transcriptional regulatory VP16-induced complex composed of VP16 and two cellular factors, HCFC1 and POU2F 1.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
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