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Results for "

local anesthetic activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (2) Calcium Channel (3) Cholinesterase (ChE) (2) Endogenous Metabolite (1) mAChR (3) NF-κB (4) NOD-like Receptor (NLR) (4) Phosphodiesterase (PDE) (3) Reference Standards (4) Sodium Channel (7)
By Research Areas:	Cardiovascular Disease (5) Inflammation/Immunology (3) Neurological Disease (10)

Inhibitors & Agonists

Screening Libraries

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0549A

Flavoxate hydrochloride Rec-7-0040; DW61	Phosphodiesterase (PDE) Calcium Channel mAChR	Neurological Disease
Flavoxate hydrochloride is a potent and competitive phosphodiesterase (PDE) inhibitor. Flavoxate hydrochloride is an antispasmodic agent and muscarinic mAChR antagonist. Flavoxate hydrochloride shows moderate calcium antagonistic activity and local anesthetic effect. Flavoxate hydrochloride can be used for the research of overactive bladder (OAB) and lower urinary tract infections .

HY-122364

Bucumolol hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Bucumolol hydrochloride is a β-adrenergic receptor antagonist that can slow heart rate (negative chronotropic effect) and reduce cardiac contractility (negative inotropic effect). Bucumolol hydrochloride has antiarrhythmic and local anesthetic activity and can be used in the study of cardiovascular diseases .

HY-121891

Rhinocaine	Others	Others
Rhinocaine is a compound with local anesthetic activity.

HY-122050

Oe-9000	Sodium Channel	Neurological Disease
Oe-9000 is a compound with local anesthetic activity that inhibits voltage-gated Na ⁺ currents in neurons, including both TTX-resistant and TTX-sensitive currents, with effects superior to those of some other local anesthetics.

HY-16259

Indecainide hydrochloride Ricainide hydrochloride; LY 135837	Sodium Channel	Cardiovascular Disease
Indecainide hydrochloride is a potent and orally active class I local anesthetic antiarrhythmic agent. Indecainide hydrochloride has Na ⁺-channel-blocking activity .

HY-105651A

Butalamine hydrochloride	Cholinesterase (ChE)	Cardiovascular Disease
Butalamine (hydrochloride) is a peripheral vasodilator with local anesthetic effects. :Butalamine (hydrochloride) can produce in animals coronary vasodilation, local anaesthesia, analgesia and a papaverine like action in duodenal preparations. Butalamine (hydrochloride) causes a slowing in rate of spontaneous activity, a decrease in amplitude and a reduction in isolated human smooth muscle .

HY-123287

Soquinolol	Adrenergic Receptor	Cardiovascular Disease
Soquinolol is a β adrenergic receptor antagonist. Soquinolol plays an important role in cardiac failure research .

HY-105651AR

Butalamine hydrochloride (Standard)	Cholinesterase (ChE) Reference Standards	Cardiovascular Disease
Butalamine (hydrochloride) (Standard) is the analytical standard of Butalamine (hydrochloride). This product is intended for research and analytical applications. Butalamine (hydrochloride) is a peripheral vasodilator with local anesthetic effects. :Butalamine (hydrochloride) can produce in animals coronary vasodilation, local anaesthesia, analgesia and a papaverine like action in duodenal preparations. Butalamine (hydrochloride) causes a slowing in rate of spontaneous activity, a decrease in amplitude and a reduction in isolated human smooth muscle .

HY-B0549

Flavoxate Rec-7-0040 free base; DW61 free base	Phosphodiesterase (PDE) Calcium Channel mAChR	Neurological Disease
Flavoxate is a potent and competitive phosphodiesterase (PDE) inhibitor. Flavoxate is an antispasmodic agent and muscarinic mAChR antagonist. Flavoxate shows moderate calcium antagonistic activity and local anesthetic effect. Flavoxate can be used for the research of overactive bladder (OAB) and lower urinary tract infections .

HY-Z6848

(R)-(+)-Bupivacaine hydrochloride	Sodium Channel	Neurological Disease
(R)-(+)-Bupivacaine hydrochloride is a voltage-gated sodium channel inhibitor. (R)-(+)-Bupivacaine hydrochloride can selectively block the voltage-gated sodium channels on nerve cell membranes, inhibit the influx of sodium ions, and thus prevent the generation and conduction of nerve impulses, exerting local anesthetic activity. (R)-(+)-Bupivacaine hydrochloride can be used in research of acute pains .

HY-121886

Bucricaine	Endogenous Metabolite	Neurological Disease
Bucricaine is an anesthetic compound with analgesic activity. Bucricaine is used in clinical anesthesia to reduce pain during surgery. The mechanism of action of Bucricaine involves inhibition of nerve signaling. Bucricaine's applications include local anesthesia and dental anesthesia. Bucricaine is widely used during surgery and other medical procedures to improve patient comfort .

HY-B0549AR

Flavoxate hydrochloride (Standard) Rec-7-0040 (Standard); DW61 (Standard)	Reference Standards Phosphodiesterase (PDE) Calcium Channel mAChR	Neurological Disease
Flavoxate (hydrochloride) (Standard) is the analytical standard of Flavoxate (hydrochloride). This product is intended for research and analytical applications. Flavoxate hydrochloride is a potent and competitive phosphodiesterase (PDE) inhibitor. Flavoxate hydrochloride is an antispasmodic agent and muscarinic mAChR antagonist. Flavoxate hydrochloride shows moderate calcium antagonistic activity and local anesthetic effect. Flavoxate hydrochloride can be used for the research of overactive bladder (OAB) and lower urinary tract infections .

HY-B0516

Articaine hydrochloride Hoe-045	Sodium Channel NF-κB NOD-like Receptor (NLR)	Neurological Disease Inflammation/Immunology
Articaine (Hoe-045) hydrochloride is a selective inhibitor of voltage-gated sodium channels (such as rNav1.4, hNav1.7, and rNav1.8), with an IC₅₀ of 15.8 μM for open-state Na ⁺ channels, and IC₅₀ of 40.6 μM and 378 μM for inactivated and resting-state Na ⁺ channels, respectively. Articaine hydrochloride exerts local anesthetic activity by inhibiting Na ⁺ influx to block nerve impulse conduction, and can also inhibit NF-κB activation and NLRP3 inflammasome pathways, exhibiting anti-inflammatory function. Articaine hydrochloride can be used in the study of dental local anesthesia and inflammatory-related diseases (such as acute kidney injury) .

HY-B0516A

Articaine Hoe-045 free base	Sodium Channel NF-κB NOD-like Receptor (NLR)	Neurological Disease Inflammation/Immunology
Articaine (Hoe-045) is a selective inhibitor of voltage-gated sodium channels (such as rNav1.4, hNav1.7, and rNav1.8), with an IC₅₀ of 15.8 μM for open-state Na ⁺ channels, and IC₅₀ of 40.6 μM and 378 μM for inactivated and resting-state Na ⁺ channels, respectively. Articaine exerts local anesthetic activity by inhibiting Na ⁺ influx to block nerve impulse conduction, and can also inhibit NF-κB activation and NLRP3 inflammasome pathways, exhibiting anti-inflammatory function. Articaine can be used in the study of dental local anesthesia and inflammatory-related diseases (such as acute kidney injury) .

HY-B1032

Dropropizine (±)-Dropropizine; UCB-196	Others	Neurological Disease
Dropropizine ((±)-Dropropizine; UCB-196) is an orally effective, peripherally selective antitussive that inhibits the activity of peripheral receptors and afferent nerves in the respiratory tract. Dropropizine acts on the cough reflex pathway, does not pass the blood-brain barrier, and has no central nervous system side effects. Dropropizine mainly regulates the level of sensory neuropeptides and inhibits the afferent signal transmission of the cough reflex, thereby alleviating the symptoms of dry cough, and has both mild local anesthetic and antihistamine activity. Dropropizine is mainly used for symptomatic research on dry cough caused by respiratory diseases .

HY-B0516R

Articaine hydrochloride (Standard) Hoe-045 (Standard)	Reference Standards Sodium Channel NF-κB NOD-like Receptor (NLR)	Neurological Disease
Articaine (Hoe-045) hydrochloride (Standard) is the analytical standard of Articaine hydrochloride (HY-B0516). This product is intended for research and analytical applications. Articaine (Hoe-045) hydrochloride is a selective inhibitor of voltage-gated sodium channels (such as rNav1.4, hNav1.7, and rNav1.8), with an IC₅₀ of 15.8 μM for open-state Na ⁺ channels, and IC₅₀ of 40.6 μM and 378 μM for inactivated and resting-state Na ⁺ channels, respectively. Articaine hydrochloride exerts local anesthetic activity by inhibiting Na ⁺ influx to block nerve impulse conduction, and can also inhibit NF-κB activation and NLRP3 inflammasome pathways, exhibiting anti-inflammatory function. Articaine hydrochloride can be used in the study of dental local anesthesia and inflammatory-related diseases (such as acute kidney injury) .

HY-B0516AR

Articaine (Standard) Hoe-045 free base (Standard)	Reference Standards Sodium Channel NF-κB NOD-like Receptor (NLR)	Inflammation/Immunology
Articaine (Standard) is the analytical standard of Articaine (HY-B0516A). This product is intended for research and analytical applications. Articaine (Hoe-045) hydrochloride is a selective inhibitor of voltage-gated sodium channels (such as rNav1.4, hNav1.7, and rNav1.8), with an IC₅₀ of 15.8 μM for open-state Na ⁺ channels, and IC₅₀ of 40.6 μM and 378 μM for inactivated and resting-state Na ⁺ channels, respectively. Articaine hydrochloride exerts local anesthetic activity by inhibiting Na ⁺ influx to block nerve impulse conduction, and can also inhibit NF-κB activation and NLRP3 inflammasome pathways, exhibiting anti-inflammatory function. Articaine hydrochloride can be used in the study of dental local anesthesia and inflammatory-related diseases (such as acute kidney injury) .

Cat. No.	Product Name

HY-L071

Alkaloids Library	555 compounds
Alkaloids are a large and complex group of cyclic compounds that contain N. About 2,000 different alkaloids have been isolated. Important alkaloids include morphine, strychnine, atropine, colchicine, ephedrine, quinine, and nicotine. Alkaloids are useful as diet ingredients, supplements, and pharmaceuticals, in medicine and in other applications in human life. They showed anti-inflammatory, anticancer, analgesics, local anesthetic and pain relief, neuropharmacologic, antimicrobial, antifungal, and many other activities. Alkaloids are also important compounds in organic synthesis for searching new semisynthetic and synthetic compounds with possibly better biological activity than parent compounds. MCE designs a unique collection of 555 alkaloids that all come from natural products. MCE Alkaloids Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).

Alkaloids Library

555 compounds

Alkaloids are a large and complex group of cyclic compounds that contain N. About 2,000 different alkaloids have been isolated. Important alkaloids include morphine, strychnine, atropine, colchicine, ephedrine, quinine, and nicotine. Alkaloids are useful as diet ingredients, supplements, and pharmaceuticals, in medicine and in other applications in human life. They showed anti-inflammatory, anticancer, analgesics, local anesthetic and pain relief, neuropharmacologic, antimicrobial, antifungal, and many other activities. Alkaloids are also important compounds in organic synthesis for searching new semisynthetic and synthetic compounds with possibly better biological activity than parent compounds.

MCE designs a unique collection of 555 alkaloids that all come from natural products. MCE Alkaloids Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).

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