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Results for "

hyperexcitability

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Angiotensin Receptor (2) Apoptosis (2) Cholinesterase (ChE) (1) Endogenous Metabolite (1) iGluR (1) Isotope-Labeled Compounds (3) Parasite (2) Potassium Channel (4) Ras (2) Reference Standards (1) Sodium Channel (6)
By Research Areas:	Cancer (2) Cardiovascular Disease (2) Endocrinology (2) Inflammation/Immunology (2) Neurological Disease (11)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-110162

QO 58	Potassium Channel	Neurological Disease
QO 58 is a potent modulator of K(v)7 channels. QO-58 increases the current amplitudes, shifts the voltage-dependent activation curve in a more negative direction and slows the deactivation of K(v)7.2/K(v)7.3 currents. QO-58 has the potential for the research of diseases associated with neuronal hyperexcitability .

HY-12646

Rhosin hydrochloride Maximum Cited Publications 29 Publications Verification	Ras Apoptosis	Cancer
Rhosin hydrochloride is a potent, specific RhoA subfamily Rho GTPases inhibitor. Rhosin hydrochloride specifically binds to RhoA to inhibit RhoA-GEF interaction with a K_d of ~ 0.4 uM, and does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin hydrochloride induces cell apoptosis . Rhosin hydrochloride promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability .

HY-123264

RL648_81	Potassium Channel	Neurological Disease
RL648_81 is a specific KQT-like subfamily 2/3 (KCNQ2/3) activator with an EC₅₀ of 190 nM. RL648_81 robustly shifts the V1/2 of KCNQ2/3 channels towards hyperpolarized potentials.RL648_81 does not shift the V1/2 of either KCNQ4 or KCNQ5.RL648_81 has?the?potential?for?neurologic disorders associated with neuronal hyperexcitability research .

HY-A0042

Rufinamide CGP 33101; E 2080; RUF 331	Sodium Channel	Neurological Disease
Rufinamide (CGP 33101) is an orally active antiepileptic compound that inhibits Na ⁺ current activation, inhibits neuronal hyperexcitability, and has anticonvulsant effects. Rufinamide is used in the study of Lennox-Gastaut syndrome .

HY-A0042S

Rufinamide-d2 CGP 33101-d₂; E 2080-d2; RUF 331-d₂	Isotope-Labeled Compounds Sodium Channel	Neurological Disease
Rufinamide-d₂ (CGP 33101-d₂) is the deuterium labeled Rufinamide (HY-A0042). Rufinamide (CGP 33101) is an orally active antiepileptic compound that inhibits Na ⁺ current activation, inhibits neuronal hyperexcitability, and has anticonvulsant effects. Rufinamide is used in the study of Lennox-Gastaut syndrome .

HY-A0042S1

Rufinamide-15N,d2 CGP 33101-¹⁵N,d₂; E 2080-¹⁵N,d₂; RUF 331-¹⁵N,d₂	Isotope-Labeled Compounds Sodium Channel	Neurological Disease
Rufinamide- ¹⁵N,d₂ (CGP 33101- ¹⁵N,d₂) is the deuterium and ¹⁵N labeled Rufinamide (HY-A0042).Rufinamide (CGP 33101) is an orally active antiepileptic compound that inhibits Na ⁺ current activation, inhibits neuronal hyperexcitability, and has anticonvulsant effects. Rufinamide is used in the study of Lennox-Gastaut syndrome .

HY-12646A

Rhosin	Ras Apoptosis	Cancer
Rhosin is a potent, specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction with a K_d of ~ 0.4 uM, and does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin induces cell apoptosis . Rhosin promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability .

HY-A0042R

Rufinamide (Standard) CGP 33101 (Standard); E 2080 (Standard); RUF 331 (Standard)	Sodium Channel	Neurological Disease
Rufinamide (Standard) is the analytical standard of Rufinamide (HY-A0042). This product is intended for research and analytical applications. Rufinamide (CGP 33101) is an orally active antiepileptic compound that inhibits Na ⁺ current activation, inhibits neuronal hyperexcitability, and has anticonvulsant effects. Rufinamide is used in the study of Lennox-Gastaut syndrome .

HY-B0828

Triazophos	Parasite Cholinesterase (ChE)	Others
Triazophos, a non-systemic insecticide and acaricide that acts as an acetylcholinesterase (AChE) inhibitor, covalently and irreversibly binds to the acetylcholine binding site, thus blocking the hydrolysis of acetylcholine and leading to hyperexcitability; it is effective against a variety of soil insects and mites, including aphids, thrips, midges, beetles, Lepidoptera larvae, cutworms, and spider mites in crops such as ornamentals, cotton, rice, maize, soybeans, oil palms, olives, and coffee.

HY-A0042S2

Rufinamide-15N,d2-1 CGP 33101-¹⁵N,d₂-1; E 2080-¹⁵N,d₂-1; RUF 331-¹⁵N,d₂-1	Isotope-Labeled Compounds Sodium Channel	Neurological Disease
Rufinamide- ¹⁵N,d₂-1 (CGP 33101- ¹⁵N,d₂-1) is ¹⁵N- and deuterium-labeled Rufinamide (HY-A0042).Rufinamide (CGP 33101) is an orally active antiepileptic compound that inhibits Na ⁺ current activation, inhibits neuronal hyperexcitability, and has anticonvulsant effects. Rufinamide is used in the study of Lennox-Gastaut syndrome .

HY-100196AR

Pyrroloquinoline quinone disodium salt (Standard) PQQ disodium salt (Standard); Methoxatin disodium salt (Standard)	Reference Standards Endogenous Metabolite	Inflammation/Immunology
Triazophos (Standard) is the analytical standard of Triazophos. This product is intended for research and analytical applications. Triazophos, a non-systemic insecticide and acaricide that acts as an acetylcholinesterase (AChE) inhibitor, covalently and irreversibly binds to the acetylcholine binding site, thus blocking the hydrolysis of acetylcholine and leading to hyperexcitability; it is effective against a variety of soil insects and mites, including aphids, thrips, midges, beetles, Lepidoptera larvae, cutworms, and spider mites in crops such as ornamentals, cotton, rice, maize, soybeans, oil palms, olives, and coffee.

HY-B0828R

Triazophos (Standard)	Parasite	Others
Triazophos (Standard) is the analytical standard of Triazophos. This product is intended for research and analytical applications. Triazophos, a non-systemic insecticide and acaricide that acts as an acetylcholinesterase (AChE) inhibitor, covalently and irreversibly binds to the acetylcholine binding site, thus blocking the hydrolysis of acetylcholine and leading to hyperexcitability; it is effective against a variety of soil insects and mites, including aphids, thrips, midges, beetles, Lepidoptera larvae, cutworms, and spider mites in crops such as ornamentals, cotton, rice, maize, soybeans, oil palms, olives, and coffee.

HY-13106

Olodanrigan 2 Publications Verification EMA401; PD-126055; (S)-EMA400	Angiotensin Receptor	Cardiovascular Disease Neurological Disease Endocrinology
Olodanrigan (EMA401) is a highly selective, orally active, peripherally restricted angiotensin II type 2 receptor (AT2R) antagonist. It is under development as a neuropathic pain therapeutic agent. Olodanrigan (EMA401) analgesic action appears to involve inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons .

HY-13106A

Olodanrigan sodium EMA401 sodium; PD-126055 sodium	Angiotensin Receptor	Neurological Disease Endocrinology
Olodanrigan (EMA401) sodium is a highly selective, orally active, peripherally restricted angiotensin II type 2 receptor (AT2R) antagonist. Olodanrigan sodium is under development as a neuropathic pain therapeutic agent. Olodanrigan sodium analgesic action appears to involve inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons .

HY-W709349

Flupirtine hydrochloride D 9998 hydrochloride	Potassium Channel iGluR	Inflammation/Immunology
Flupirtine hydrochloride (D 9998 hydrochloride) is a selective neuropotassium channel opener with analgesic activity. Flupirtine hydrochloride is used to inhibit a variety of pain conditions, including chronic musculoskeletal pain, migraines, and neuralgia. Flupirtine hydrochloride has antidepressant and antioxidant properties and may increase the analgesic effect in combination therapy with morphine. Flupirtine hydrochloride relieves abnormally increased muscle tension and has a muscle relaxant effect. Flupirtine hydrochloride is clinically superior to other drugs, such as tramadol and pantoxan, plus its side effects are better tolerated. Flupirtine hydrochloride has a significant effect on inhibiting neural hyperexcitability and therefore exhibits inhibitory potential in various pain states .

HY-15416

NS309	Potassium Channel	Cardiovascular Disease Neurological Disease
NS309 is a potent and selective activator of the Ca ²⁺-activated SK/IK potassium channels, but displays no activity at BK channels .

HY-147423

Zandatrigine 1 Publications Verification NBI-921352; XEN901	Sodium Channel	Neurological Disease
Zandatrigine (NBI-921352; XEN901) is a selective, orally active, voltage-gated sodium channel Na_V1.6/SCN8A inhibitor that can penetrate the blood-brain barrier. Zandatrigine inhibits sodium influx by non-covalently binding to the VSD4 structure of Na_V1.6, blocking the persistent and resuscitative currents under pathological conditions. Zandatrigine can reduce neuronal hyperexcitability and reduce epileptic seizures. Zandatrigine is 134-756-fold selective for other isoforms such as Na_V1.1 and Na_V1.2, and has minimal effect on Na_V1.1 expressed by inhibitory interneurons. Zandatrigine can be used to study Na_V1.6-mediated neuroexcitability diseases such as SCN8A-related developmental epileptic encephalopathy (SCN8A-DEE) and adult focal epilepsy .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-100196AR

Pyrroloquinoline quinone disodium salt (Standard) PQQ disodium salt (Standard); Methoxatin disodium salt (Standard)	Quinones Structural Classification Microorganisms Source classification Benzene Quinones Endogenous metabolite	Reference Standards Endogenous Metabolite
Triazophos (Standard) is the analytical standard of Triazophos. This product is intended for research and analytical applications. Triazophos, a non-systemic insecticide and acaricide that acts as an acetylcholinesterase (AChE) inhibitor, covalently and irreversibly binds to the acetylcholine binding site, thus blocking the hydrolysis of acetylcholine and leading to hyperexcitability; it is effective against a variety of soil insects and mites, including aphids, thrips, midges, beetles, Lepidoptera larvae, cutworms, and spider mites in crops such as ornamentals, cotton, rice, maize, soybeans, oil palms, olives, and coffee.

Cat. No.	Product Name	Chemical Structure

HY-A0042S

Rufinamide-d2
Rufinamide-d₂ (CGP 33101-d₂) is the deuterium labeled Rufinamide (HY-A0042). Rufinamide (CGP 33101) is an orally active antiepileptic compound that inhibits Na ⁺ current activation, inhibits neuronal hyperexcitability, and has anticonvulsant effects. Rufinamide is used in the study of Lennox-Gastaut syndrome .

HY-A0042S1

Rufinamide-15N,d2
Rufinamide- ¹⁵N,d₂ (CGP 33101- ¹⁵N,d₂) is the deuterium and ¹⁵N labeled Rufinamide (HY-A0042).Rufinamide (CGP 33101) is an orally active antiepileptic compound that inhibits Na ⁺ current activation, inhibits neuronal hyperexcitability, and has anticonvulsant effects. Rufinamide is used in the study of Lennox-Gastaut syndrome .

HY-A0042S2

Rufinamide-15N,d2-1
Rufinamide- ¹⁵N,d₂-1 (CGP 33101- ¹⁵N,d₂-1) is ¹⁵N- and deuterium-labeled Rufinamide (HY-A0042).Rufinamide (CGP 33101) is an orally active antiepileptic compound that inhibits Na ⁺ current activation, inhibits neuronal hyperexcitability, and has anticonvulsant effects. Rufinamide is used in the study of Lennox-Gastaut syndrome .

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hyperexcitability

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products