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Results for "

hydrochloride

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (4) Adrenergic Receptor (1) Akt (1) Apoptosis (1) Autophagy (1) Calcium Channel (1) Calmodulin (1) CDK (1) Cholinesterase (ChE) (2) CRFR (1) Dopamine Receptor (1) Drug Intermediate (2) Drug Metabolite (2) EGFR (1) Endogenous Metabolite (1) FKBP (1) Glucosylceramide Synthase (GCS) (1) iGluR (2) Imidazoline Receptor (1) Ligands for Target Protein for PROTAC (1) mAChR (3) MAP4K (1) Potassium Channel (1) PROTACs (1) Reference Standards (3) Serotonin Transporter (1) Sodium Channel (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (10) Cardiovascular Disease (2) Endocrinology (1) Inflammation/Immunology (1) Neurological Disease (11)

By Targets:

5-HT Receptor (4)

Adrenergic Receptor (1)

Akt (1)

Apoptosis (1)

Autophagy (1)

Calcium Channel (1)

Calmodulin (1)

CDK (1)

Cholinesterase (ChE) (2)

CRFR (1)

Dopamine Receptor (1)

Drug Intermediate (2)

Drug Metabolite (2)

EGFR (1)

Endogenous Metabolite (1)

FKBP (1)

Glucosylceramide Synthase (GCS) (1)

iGluR (2)

Imidazoline Receptor (1)

Ligands for Target Protein for PROTAC (1)

mAChR (3)

MAP4K (1)

Potassium Channel (1)

PROTACs (1)

Reference Standards (3)

Serotonin Transporter (1)

Sodium Channel (1)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (10)

Cardiovascular Disease (2)

Endocrinology (1)

Inflammation/Immunology (1)

Neurological Disease (11)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145514C

dTAGV-1 hydrochloride 3 Publications Verification	FKBP PROTACs	Cancer
dTAGV-1 hydrochloride is a potent and selective degrader of FKBP12 ^F36V-tagged proteins PROTAC degrader. dTAGV-1 hydrochloride can induce degradation of FKBP12 ^F36V-Nluc in vivo. (Pink: Target Protein Ligand (HY-114420); Black: Linker (HY-W012001); Blue: VHL Ligand (HY-112078); VHL Ligan+Linker (HY-173628A)) .

HY-138813

N-Desethyl Sunitinib hydrochloride Maximum Cited Publications 6 Publications Verification SU-12662 hydrochloride	Drug Metabolite	Cancer
N-Desethyl Sunitinib (SU-12662) (hydrochloride) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor with K_i values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively .

HY-101100

Anpirtoline hydrochloride D-16949 hydrochloride	5-HT Receptor	Neurological Disease
Anpirtoline (D-16949) hydrochloride is a centrally acting 5-HT_1B receptor agonist, with K_is of 28 nM (5-HT_1B), 150 nM (5-HT_1A) and 1.49 μM (5-HT2). Anpirtoline hydrochloride has serotonergic, antinociceptive, antidepressant-like effects .

HY-116392B

DL-threo-PDMP hydrochloride	Glucosylceramide Synthase (GCS)	Cancer
DL-threo-PDMP hydrochloride is the hydrochloride form of DL-threo-PDMP that is a competitive glucosylceramide synthase (GCS) inhibitor. DL-threo-PDMP resensitizes refractory testicular germ cell tumors and epithelial ovarian cancer orthoxenografts to cisplatin in mice .

HY-W013776

meta-Fluoxetine hydrochloride	Serotonin Transporter Autophagy 5-HT Receptor	Neurological Disease Cancer
meta-Fluoxetine hydrochloride is the isomer of Fluoxetine hydrochloride (HY-B0102A). meta-Fluoxetine hydrochloride is a weak serotonin selective reuptake inhibitor (SSRI) .

HY-103425

JHW007 hydrochloride	Dopamine Receptor	Neurological Disease
JHW007 hydrochloride is the hydrochloride of JHW007. JHW007 is an antagonist of cocaine .

HY-103376

NBI-27914 hydrochloride	CRFR	Neurological Disease
NBI-27914 (hydrochloride) is a selective Corticotropin-Releasing Factor 1 (CRF1) receptor antagonist with a K_i value of 1.7 nM .

HY-N9910

Visamminol	Endogenous Metabolite	Others
Visamminol is a spasmolytic which can be extracted from Cimicifuga dahurica. Visamminol exhibits a spasmolytic action that is one-third as potent as that of papaverine hydrochloride .

HY-138813R

N-Desethyl Sunitinib hydrochloride (Standard) SU-12662 hydrochloride (Standard)	Reference Standards Drug Metabolite	Cancer
Glycochenodeoxycholic acid sodium salt (Standard) is the analytical standard of Glycochenodeoxycholic acid sodium salt. This product is intended for research and analytical applications. Glycochenodeoxycholic acid sodium salt (Sodium glycochenodeoxycholate) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid sodium salt inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid sodium salt induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid sodium salt is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC) .

HY-N1777R

3,4-Dimethoxybenzamide (Standard)	Reference Standards Drug Intermediate	Others
3,4-Dimethoxybenzamide (Standard) is the analytical standard of 3,4-Dimethoxybenzamide. This product is intended for research and analytical applications. 3,4-Dimethoxybenzamide, amide, is isolated from the solid culture of Streptoverticillium morookaense. 3,4-Dimethoxybenzamide can be used as the starting material to preparation Itopride hydrochloride[1][2].

HY-N1777

3,4-Dimethoxybenzamide	Drug Intermediate	Others
3,4-Dimethoxybenzamide, amide, is isolated from the solid culture of Streptoverticillium morookaense. 3,4-Dimethoxybenzamide can be used as the starting material to preparation Itopride hydrochloride .

HY-126534A

Abemaciclib metabolite M18 hydrochloride 1 Publications Verification LSN3106729 hydrochloride	Ligands for Target Protein for PROTAC CDK	Cancer
Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib (HY-16297A), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader .

HY-101820A

Simotinib hydrochloride	EGFR	Cancer
Simotinib hydrochloride is a selective, specific, and orally bioavailable EGFR tyrosine kinase inhibitor, with an IC₅₀ of 19.9 nM. Antineoplastic activities .

HY-19562A

PF-06260933 hydrochloride	MAP4K	Inflammation/Immunology
PF-06260933 hydrochloride is the hydrochloride form of PF-06260933 (HY-19562). PF-06260933 hydrochloride is an orally active and highly selective inhibitor of MAP4K4 with IC₅₀s of 3.7 and 160 nM for kinase and cell, respectively .

HY-116459

trans-Cevimeline hydrochloride AF102A hydrochloride	mAChR	Neurological Disease
Trans-Cevimeline (AF102A) (hydrochloride), as a trans-isomer of AF102B, is a M1 selective cholinergic agonist. Trans-Cevimeline (AF102A) (hydrochloride) can be used for the research of Alzheimer's disease .

HY-U00443

SB 258719	5-HT Receptor	Neurological Disease Cancer
SB 258719 is a selective 5-HT₇ receptor antagonist with high affinity (pK_i=7.5) for the receptor. SB 258719 can be used for the research of cancer and neurological disease .

HY-103123

SB 258719 hydrochloride	5-HT Receptor	Neurological Disease Cancer
SB 258719 hydrochloride is a selective 5-HT₇ receptor antagonist displayed high affnity (pK_i=7.5) for the receptor. SB-258719 hydrochloride can be used for the research of cancer and neurological diseases .

HY-107922

Ethopropazine hydrochloride 1 Publications Verification Isothazine	Cholinesterase (ChE) iGluR mAChR	Neurological Disease
Ethopropazine (Isothazine) hydrochloride is a potent and selective BChE inhibitor, a poor AChE inhibitor and a non-selective mAChR and NMDA antagonist. Ethopropazine hydrochloride has anticholinergic, antihistamine, antiadrenergic actions and properties. Ethopropazine hydrochloride alleviates thermal hyperalgesia in a dose dependent manner. Ethopropazine hydrochloride can be used for the research of Parkinson’s disease .

HY-107922R

Ethopropazine hydrochloride (Standard) Isothazine (Standard)	Reference Standards Cholinesterase (ChE) iGluR mAChR	Neurological Disease
Ethopropazine (hydrochloride) (Standard) is the analytical standard of Ethopropazine (hydrochloride) (HY-107922). This product is intended for research and analytical applications. Ethopropazine (Isothazine) hydrochloride is a potent and selective BChE inhibitor, a poor AChE inhibitor and a non-selective mAChR and NMDA antagonist. Ethopropazine hydrochloride has anticholinergic, antihistamine, antiadrenergic actions and properties. Ethopropazine hydrochloride alleviates thermal hyperalgesia in a dose dependent manner. Ethopropazine hydrochloride can be used for the research of Parkinson’s disease .

HY-B0194A

Tizanidine hydrochloride	Adrenergic Receptor Apoptosis Akt Wnt β-catenin	Neurological Disease Endocrinology Cancer
Tizanidine hydrochloride, a skeletal muscle relaxant, is an orally effective central α₂-adrenoceptor agonist (IC₅₀ = 6.9 nmol). Tizanidine hydrochloride primarily exerts muscle relaxation effects by inhibiting the release of excitatory amino acids (glutamate and aspartate) from the presynaptic terminals of spinal cord interneurons. Tizanidine hydrochloride has anti-injury activity and can inhibit gastrointestinal (GI) transport. Tizanidine hydrochloride can inhibit the proliferation, migration, and invasion of lung cancer cells and induce cell apoptosis by upregulating Nischarin and inhibiting the AKT and Wnt3a/β-catenin signaling pathways. Tizanidine hydrochloride can be used to treat spasticity caused by diseases such as multiple sclerosis (MS), stroke, and spinal cord injury (SCI) .

HY-101374A

AGN 192403 hydrochloride BRD4780 hydrochloride	Imidazoline Receptor	Cardiovascular Disease Neurological Disease
AGN 192403 (BRD4780) hydrochloride is an I1-Imidazoline receptor antagonist for cardiovascular and neurological research .

HY-A0236A

Aprindine hydrochloride	Sodium Channel Potassium Channel Calcium Channel Calmodulin	Cardiovascular Disease
Aprindine hydrochloride is an Ib-class anti-arrhythmic agent. Aprindine hydrochloride mainly exerts its effect by blocking sodium channels (I_Na), thereby reducing the excitability and conduction velocity of cardiac muscle cells. Aprindine hydrochloride significantly inhibits delayed potassium currents, which helps to prolong the atrial effective refractory period (AERP) and inhibit the occurrence of atrial fibrillation. Aprindine hydrochloride can also regulate intracellular calcium ion concentration by inhibiting Na ⁺/Ca ²⁺ exchange current (INCX), thereby further stabilizing cardiac electrical activity. Aprindine hydrochloride can be used for the study of atrial fibrillation (AF) and ventricular arrhythmias .

3,4-Dimethoxybenzamide	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields	Drug Intermediate
3,4-Dimethoxybenzamide, amide, is isolated from the solid culture of Streptoverticillium morookaense. 3,4-Dimethoxybenzamide can be used as the starting material to preparation Itopride hydrochloride .

Visamminol	Structural Classification Ketones, Aldehydes, Acids Artemisia cana Pursh Source classification Umbelliferae Plants	Endogenous Metabolite
Visamminol is a spasmolytic which can be extracted from Cimicifuga dahurica. Visamminol exhibits a spasmolytic action that is one-third as potent as that of papaverine hydrochloride .

3,4-Dimethoxybenzamide (Standard)	Structural Classification Natural Products Microorganisms Source classification	Reference Standards Drug Intermediate
3,4-Dimethoxybenzamide (Standard) is the analytical standard of 3,4-Dimethoxybenzamide. This product is intended for research and analytical applications. 3,4-Dimethoxybenzamide, amide, is isolated from the solid culture of Streptoverticillium morookaense. 3,4-Dimethoxybenzamide can be used as the starting material to preparation Itopride hydrochloride[1][2].

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hydrochloride

Inhibitors & Agonists

NaturalProducts

Natural
Products