highly reactive molecule

By Targets:	Biochemical Assay Reagents (8) Drug Derivative (1) Microtubule/Tubulin (1)
By Research Areas:	Cancer (1)
Oligonucleotides:	Phospholipids (1)

Targets Recommended: Reactive Oxygen Species (ROS) ALCAM/CD166

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W140439

1-Oleoyl-sn-glycero-3-phosphocholine	Biochemical Assay Reagents	Others
1-Oleoyl-sn-glycero-3-phosphocholine is an unsaturated 18:1 lysophosphatidylcholine formed in plasma by lecithin:cholesterol acyltransferase (LCAT).

HY-164165

Paclitaxel-2′-succinate NHS ester	Microtubule/Tubulin Drug Derivative	Cancer
Paclitaxel-2′-succinate NHS ester is a paclitaxel derivative with a succinic acid linker, in which the carboxyl group is activated by the NHS ester. The NHS ester group is highly reactive toward amino or hydroxyl groups and can be used to conjugate with other molecules such as peptides, proteins, antibodies, enzymes or polymers. Paclitaxel-2′-succinate NHS ester can be used in the development of nanomedicines and in the study of cancer therapy .

HY-174949B

FMOC-NH-PEG-SH (MW 3400) FMOC-NH-PEG-Thiol (MW 3400)	Biochemical Assay Reagents	Others
FMOC-NH-PEG-SH (MW 3400) (FMOC-NH-PEG-Thiol (MW 3400)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.

HY-174949

FMOC-NH-PEG-SH (MW 1000) FMOC-NH-PEG-Thiol (MW 1000)	Biochemical Assay Reagents	Others
FMOC-NH-PEG-SH (MW 1000) (FMOC-NH-PEG-Thiol (MW 1000)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.

HY-174949C

FMOC-NH-PEG-SH (MW 5000) FMOC-NH-PEG-Thiol (MW 5000)	Biochemical Assay Reagents	Others
FMOC-NH-PEG-SH (MW 5000) (FMOC-NH-PEG-Thiol (MW 5000)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.

HY-174949D

FMOC-NH-PEG-SH (MW 10000) FMOC-NH-PEG-Thiol (MW 10000)	Biochemical Assay Reagents	Others
FMOC-NH-PEG-SH (MW 10000) (FMOC-NH-PEG-Thiol (MW 10000)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.

HY-174949A

FMOC-NH-PEG-SH (MW 2000) FMOC-NH-PEG-Thiol (MW 2000)	Biochemical Assay Reagents	Others
FMOC-NH-PEG-SH (MW 2000) (FMOC-NH-PEG-Thiol (MW 2000)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.

HY-174944

Thiol-PEG4-NH2 SH-PEG4-NH2	Biochemical Assay Reagents	Others
Thiol-PEG4-NH2 (SH-PEG4-NH2) is a PEG derivative consisting of a thiol (-SH), 1 PEG unit, and NH2. Thiol is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds.

HY-W190877

Thiol-PEG1-acid SH-PEG1-COOH	Biochemical Assay Reagents	Others
Thiol-PEG1-acid (SH-PEG1-COOH) is a PEG derivative consisting of a thiol (-SH), 1 PEG unit, and a carboxyl (-COOH). The thiol is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. The carboxyl group can easily form stable amide bonds with amino groups, and can also form ester bonds with hydroxyl groups.

Cat. No.	Product Name

HY-L036

Covalent Screening Library	1,430 compounds
Small molecule covalent inhibitors, or irreversible inhibitors, are a type of inhibitors that exert their biological functions by irreversibly binding to target through covalent bonds. Compared with non-covalent inhibitors, covalent inhibitors have obvious advantages in bioactivity, such that covalent warheads can target rare residues of a particular target protein, thus leading to the development of highly selective inhibitors and achieving a more complete and continued target occupancy in living systems. In recent years, the distinct strengths of covalent inhibitors in overcoming drug resistance had been recognized. However, toxicity can be a real challenge related to this class of therapeutics due to their potential for off-target reactivity and has led to these drugs being disfavored as a drug class. The drug design and optimization of covalent inhibitors has become a hot spot in drug discovery. MCE covalent inhibitor library contains 1,430 small molecules including identified covalent inhibitors and other bioactive molecules having common covalent reactive groups as warheads, such as acrylamides, activated terminal acetylenes, Sulfonyl fluorides/esters, cloracetamides, alkyl halides, epoxides, aziridines, disulfides, etc.

Covalent Screening Library

1,430 compounds

Small molecule covalent inhibitors, or irreversible inhibitors, are a type of inhibitors that exert their biological functions by irreversibly binding to target through covalent bonds. Compared with non-covalent inhibitors, covalent inhibitors have obvious advantages in bioactivity, such that covalent warheads can target rare residues of a particular target protein, thus leading to the development of highly selective inhibitors and achieving a more complete and continued target occupancy in living systems. In recent years, the distinct strengths of covalent inhibitors in overcoming drug resistance had been recognized. However, toxicity can be a real challenge related to this class of therapeutics due to their potential for off-target reactivity and has led to these drugs being disfavored as a drug class. The drug design and optimization of covalent inhibitors has become a hot spot in drug discovery.

MCE covalent inhibitor library contains 1,430 small molecules including identified covalent inhibitors and other bioactive molecules having common covalent reactive groups as warheads, such as acrylamides, activated terminal acetylenes, Sulfonyl fluorides/esters, cloracetamides, alkyl halides, epoxides, aziridines, disulfides, etc.

HY-L036P

Covalent Screening Library Plus	5,794 compounds
Small molecule covalent inhibitors, or irreversible inhibitors, are a type of inhibitors that exert their biological functions by irreversibly binding to target through covalent bonds. Compared with non-covalent inhibitors, covalent inhibitors have obvious advantages in bioactivity, such that covalent warheads can target rare residues of a particular target protein, thus leading to the development of highly selective inhibitors and achieving a more complete and continued target occupancy in living systems. In recent years, the distinct strengths of covalent inhibitors in overcoming drug resistance had been recognized. However, toxicity can be a real challenge related to this class of therapeutics due to their potential for off-target reactivity and has led to these drugs being disfavored as a drug class. The drug design and optimization of covalent inhibitors has become a hot spot in drug discovery. MCE covalent inhibitor library contains 5,794 small molecules including identified covalent inhibitors and other molecules having common covalent reactive groups as warheads, such as acrylamides, activated terminal acetylenes, sulfonyl fluorides/esters, cloracetamides, alkyl halides, epoxides, aziridines, disulfides, etc. MCE Covalent inhibitor Library plus, with more powerful screening capability, further complement Covalent inhibitor Library (HY-L036) by adding some fragment compounds with covalent warheads.

Covalent Screening Library Plus

5,794 compounds

Small molecule covalent inhibitors, or irreversible inhibitors, are a type of inhibitors that exert their biological functions by irreversibly binding to target through covalent bonds. Compared with non-covalent inhibitors, covalent inhibitors have obvious advantages in bioactivity, such that covalent warheads can target rare residues of a particular target protein, thus leading to the development of highly selective inhibitors and achieving a more complete and continued target occupancy in living systems. In recent years, the distinct strengths of covalent inhibitors in overcoming drug resistance had been recognized. However, toxicity can be a real challenge related to this class of therapeutics due to their potential for off-target reactivity and has led to these drugs being disfavored as a drug class. The drug design and optimization of covalent inhibitors has become a hot spot in drug discovery.

MCE covalent inhibitor library contains 5,794 small molecules including identified covalent inhibitors and other molecules having common covalent reactive groups as warheads, such as acrylamides, activated terminal acetylenes, sulfonyl fluorides/esters, cloracetamides, alkyl halides, epoxides, aziridines, disulfides, etc.

MCE Covalent inhibitor Library plus, with more powerful screening capability, further complement Covalent inhibitor Library (HY-L036) by adding some fragment compounds with covalent warheads.

HY-L908

Lead-like Covalent Screening Library	1,271 compounds
Small molecule covalent inhibitors, or irreversible inhibitors, are a type of inhibitors that exert their biological functions by irreversibly binding to target through covalent bonds. Compared with non-covalent inhibitors, covalent inhibitors have obvious advantages in bioactivity, such that covalent warheads can target rare residues of a particular target protein, thus leading to the development of highly selective inhibitors and achieving a more complete and continued target occupancy in living systems. In recent years, the distinct strengths of covalent inhibitors in overcoming drug resistance had been recognized. However, toxicity can be a real challenge related to this class of therapeutics due to their potential for off-target reactivity and has led to these drugs being disfavored as a drug class. The drug design and optimization of covalent inhibitors has become a hot spot in drug discovery. MCE Lead-like Covalent Screening Library offers a valuable resource of 1,049 lead-like compounds with commonly used covalent warheads. These warheads, such as acrylamide, activated terminal alkyne, acyloxymethyl ketone, and boronic acid, are capable of reacting with specific amino acid residues, including cysteine, lysine, serine, and histidine. The inclusion of these reactive warheads in the library allows researchers to explore the potential of covalent inhibition, a powerful approach in drug discovery.

Lead-like Covalent Screening Library

1,271 compounds

Small molecule covalent inhibitors, or irreversible inhibitors, are a type of inhibitors that exert their biological functions by irreversibly binding to target through covalent bonds. Compared with non-covalent inhibitors, covalent inhibitors have obvious advantages in bioactivity, such that covalent warheads can target rare residues of a particular target protein, thus leading to the development of highly selective inhibitors and achieving a more complete and continued target occupancy in living systems. In recent years, the distinct strengths of covalent inhibitors in overcoming drug resistance had been recognized. However, toxicity can be a real challenge related to this class of therapeutics due to their potential for off-target reactivity and has led to these drugs being disfavored as a drug class. The drug design and optimization of covalent inhibitors has become a hot spot in drug discovery.

MCE Lead-like Covalent Screening Library offers a valuable resource of 1,049 lead-like compounds with commonly used covalent warheads. These warheads, such as acrylamide, activated terminal alkyne, acyloxymethyl ketone, and boronic acid, are capable of reacting with specific amino acid residues, including cysteine, lysine, serine, and histidine. The inclusion of these reactive warheads in the library allows researchers to explore the potential of covalent inhibition, a powerful approach in drug discovery.

Cat. No.	Product Name	Type

HY-174949B

FMOC-NH-PEG-SH (MW 3400) FMOC-NH-PEG-Thiol (MW 3400)	Drug Delivery
FMOC-NH-PEG-SH (MW 3400) (FMOC-NH-PEG-Thiol (MW 3400)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.

FMOC-NH-PEG-SH (MW 3400)

FMOC-NH-PEG-Thiol (MW 3400)

Drug Delivery

FMOC-NH-PEG-SH (MW 3400) (FMOC-NH-PEG-Thiol (MW 3400)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.

HY-174949

FMOC-NH-PEG-SH (MW 1000) FMOC-NH-PEG-Thiol (MW 1000)	Drug Delivery
FMOC-NH-PEG-SH (MW 1000) (FMOC-NH-PEG-Thiol (MW 1000)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.

FMOC-NH-PEG-SH (MW 1000)

FMOC-NH-PEG-Thiol (MW 1000)

Drug Delivery

FMOC-NH-PEG-SH (MW 1000) (FMOC-NH-PEG-Thiol (MW 1000)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.

HY-174949C

FMOC-NH-PEG-SH (MW 5000) FMOC-NH-PEG-Thiol (MW 5000)	Drug Delivery
FMOC-NH-PEG-SH (MW 5000) (FMOC-NH-PEG-Thiol (MW 5000)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.

FMOC-NH-PEG-SH (MW 5000)

FMOC-NH-PEG-Thiol (MW 5000)

Drug Delivery

FMOC-NH-PEG-SH (MW 5000) (FMOC-NH-PEG-Thiol (MW 5000)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.

HY-174949D

FMOC-NH-PEG-SH (MW 10000) FMOC-NH-PEG-Thiol (MW 10000)	Drug Delivery
FMOC-NH-PEG-SH (MW 10000) (FMOC-NH-PEG-Thiol (MW 10000)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.

FMOC-NH-PEG-SH (MW 10000)

FMOC-NH-PEG-Thiol (MW 10000)

Drug Delivery

FMOC-NH-PEG-SH (MW 10000) (FMOC-NH-PEG-Thiol (MW 10000)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.

HY-174949A

FMOC-NH-PEG-SH (MW 2000) FMOC-NH-PEG-Thiol (MW 2000)	Drug Delivery
FMOC-NH-PEG-SH (MW 2000) (FMOC-NH-PEG-Thiol (MW 2000)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.

FMOC-NH-PEG-SH (MW 2000)

FMOC-NH-PEG-Thiol (MW 2000)

Drug Delivery

FMOC-NH-PEG-SH (MW 2000) (FMOC-NH-PEG-Thiol (MW 2000)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.

HY-174944

Thiol-PEG4-NH2 SH-PEG4-NH2	Drug Delivery
Thiol-PEG4-NH2 (SH-PEG4-NH2) is a PEG derivative consisting of a thiol (-SH), 1 PEG unit, and NH2. Thiol is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds.

HY-W190877

Thiol-PEG1-acid SH-PEG1-COOH	Drug Delivery
Thiol-PEG1-acid (SH-PEG1-COOH) is a PEG derivative consisting of a thiol (-SH), 1 PEG unit, and a carboxyl (-COOH). The thiol is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. The carboxyl group can easily form stable amide bonds with amino groups, and can also form ester bonds with hydroxyl groups.

Cat. No.	Product Name		Classification

HY-W140439

1-Oleoyl-sn-glycero-3-phosphocholine		Phospholipids
1-Oleoyl-sn-glycero-3-phosphocholine is an unsaturated 18:1 lysophosphatidylcholine formed in plasma by lecithin:cholesterol acyltransferase (LCAT).

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Screening Libraries

Biochemical Assay Reagents

Oligonucleotides

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