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heat shock factor 1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HSP (10) Androgen Receptor (1) Apoptosis (2) Eukaryotic Initiation Factor (eIF) (1) Keap1-Nrf2 (1) Mitophagy (1) NF-κB (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (1) Inflammation/Immunology (1) Metabolic Disease (2)

10

Inhibitors & Agonists

1

Natural
Products

4

Antibodies

Targets Recommended: HSP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

KRIBB11 15+ Cited Publications	HSP Apoptosis	Cancer
KRIBB11 is an inhibitor of Heat shock factor 1 (HSF1), with IC₅₀ of 1.2 μM.

CCT245232	HSP	Cancer
CCT245232 is a potent inhibitor of heat shock factor 1 (HSF1). HSF1 is the master regulator of the heat shock response, in which multiple genes are induced in response to temperature increase and other stresses. CCT245232 has the potential for the research of proliferative diseases, such as cancer (extracted from patent WO2015049535A1) .

NXP800 1 Publications Verification CCT361814	HSP	Cancer
NXP800 (CCT361814) is a potent and orally active heat shock factor 1 (HSF1) pathway inhibitor. NXP800 has the potential for cancer research .

Cholesterol β-D-glucoside Cholesteryl glucoside	HSP	Metabolic Disease
Cholesterol β-D-glucoside (Cholesteryl glucoside) is a heat shock transcription factor 1 (HSF1) activator. Cholesterol β-D-glucoside induces HSP70 in fibroblast cells .

CCT251236 3 Publications Verification	HSP	Cancer
CCT251236 is an orally available pirin ligand from a heat shock transcription factor 1 (hsf1) phenotypic screen with an IC₅₀ of 19 nM for inhibition of HSF1-mediated HSP72 induction.

Chetomin	HSP Apoptosis	Cancer
Chetomin, an active component of Chaetomium globosum, is a heat shock protein 90/hypoxia-inducible factor 1 alpha (Hsp90/HIF1α) pathway inhibitor. Chetomin is a potent, nontoxic non-small cell lung cancer cancer stem cells (NSCLC CSC)-targeting molecule .

HSF1A 2 Publications Verification	HSP	Cardiovascular Disease Cancer
HSF1A is a cell-permeable activator of heat shock transcription factor 1 (HSF1) . HSF1A also acts as a specific inhibitor of TRiC/CCT. Chaperonin TCP-1 ring complex (TRiC)/chaperonin containing TCP-1 (CCT) plays a pivotal role in toxin translocation and/or refolding .

Rocaglamide Maximum Cited Publications 29 Publications Verification Roc-A	NF-κB HSP Eukaryotic Initiation Factor (eIF)	Inflammation/Immunology Cancer
Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC₅₀ of ~50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia .

DTHIB 4 Publications Verification	HSP	Cancer
DTHIB is a direct and selective heat shock factor 1 (HSF1) inhibitor with a K_d of 160 nM for DTHIB binding to the HSF1 DNA binding domain (DBD). DTHIB inhibits HSF1 cancer gene signature (HSF1 CaSig) and selectively stimulates degradation of nuclear HSF1. DTHIB has potently anticancer activities and can be used for prostate cancer research .

Rosolutamide ASC-JM17; ALZ-003	Keap1-Nrf2 Androgen Receptor HSP Mitophagy	Metabolic Disease
Rosolutamide (ASC-JM17), a curcumin analog, is an orally active, potent Nrf1 and Nrf2 activator. Rosolutamide activates Nrf1, Nrf2 and heat shock factor 1 (Hsf1), thereby activating the expression of proteasome subunits, antioxidant enzymes and molecular chaperones. Rosolutamide degrades the polyglutamine (polyQ) androgen receptor (AR) via the ubiquitin-proteasome pathway and improves motor function in mouse models of spinal and bulbar muscular atrophy (SBMA). Rosolutamide improves mitochondrial function and promotes autophagy, decreases mutant protein aggregates, and attenuates intracellular/mitochondrial reactive oxygen species (ROS) levels .

Cat. No.	Compare	Product Name	Application	Reactivity

	HSF1 Antibody (YA896) HSF1; HSTF1; heat shock factor protein 1; HSF 1; heat shock transcription factor 1; HSTF 1	WB, IHC-P, ICC/IF, IP, FC	Human
	HSF1 Antibody (YA896) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HSF1.

	Phospho-HSF1 (Ser326) Antibody(YA894) 1 Publications Verification HSF1; HSTF1; heat shock factor protein 1; HSF 1; heat shock transcription factor 1; HSTF 1	WB, ICC/IF, IHC-P, IP, FC	Human
	Phospho-HSF1 (Ser326) Antibody(YA894) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-HSF1 (Ser326).

	Phospho-HSF1 (Ser303/Ser307) Antibody (YA188) HSF1; HSTF1; heat shock factor protein 1; HSF 1; heat shock transcription factor 1; HSTF 1	WB, IHC-P	Human
	Phospho-HSF1 (Ser303/Ser307) Antibody (YA188) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-HSF1 (Ser303/Ser307).

	phospho-HSF1 (Ser326) Antibody (YA6363) HSF1(S326); HSF1(phospho S326); p-HSF1(phospho S326); heat shock factor 1; heat shock factor protein 1; heat shock transcription factor 1; HSF 1; hsf1; HSTF 1; HSTF1; HSF1_HUMAN.	WB, IHC-P, IHC-F, IF-Tissue, FC	Human, Mouse
	phospho-HSF1 (Ser326) Antibody (YA6363) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to phospho-HSF1 (Ser326).

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