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hCA I/II

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By Targets:	Adenosine Receptor (1) Apoptosis (1) Bacterial (1) Carbonic Anhydrase (59) CDK (2) Cholinesterase (ChE) (9) Dipeptidyl Peptidase (1) Endogenous Metabolite (2) Fungal (1) HSV (1) mTOR (1) NKCC (1) Reference Standards (1) VEGFR (3)
By Research Areas:	Cancer (32) Cardiovascular Disease (2) Endocrinology (2) Infection (7) Inflammation/Immunology (6) Metabolic Disease (5) Neurological Disease (15)
Click Chemistry:	Azide (1)

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Targets Recommended: Photosystem II GPR109A CD74

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148135

hCAI/II-IN-6	Carbonic Anhydrase	Neurological Disease
hCAI/II-IN-6 is an orally active human carbonic anhydrase (CA) inhibitor. hCAI/II-IN-6 selectively inhibits hCA II and hCA VII isoforms with K_i values of 220, 4.9, 6.5 and ＞50000 nM for hCA I, hCA II , hCA VII and hCA XII respectively. hCAI/II-IN-6 shows anticonvulsant activity and anti maximal electroshock (MES) activity in vivo. hCAI/II-IN-6 can be used for the research of epilepsy .

HY-172103

hCAI/II-IN-10	Carbonic Anhydrase	Others
hCAI/II-IN-10 (Compound 5d) is a human carbonic anhydrase I and II (hCA I and hCA II) inhibitor with IC₅₀ values are 4.32 and 3.89 nM respectively .

HY-146385

hCAI/II-IN-1	Carbonic Anhydrase	Cancer
hCAI/II-IN-1 (Compound 3h) is a human carbonic anhydrase I and II (hCA *I/II) inhibitor with IC₅₀* values of 0.047 µM and 0.024 µM against hCA I and hCA II, respectively .

HY-147922

hCAI/II-IN-2	Carbonic Anhydrase	Inflammation/Immunology
hCAI/II-IN-2 (compound 2b) is a potent dual **hCA I/II** inhibitor with K_i values of 40.97, 15.15 and 61.88 nM for hCA I, hCA II and hCA Ⅸ. hCAI/II-IN-2 possesses anti-hypoxic activity against acute mountain sickness (AMS) and low cellular activity .

HY-147923

hCAI/II-IN-3	Carbonic Anhydrase	Inflammation/Immunology
hCAI/II-IN-3 (compound 5b) is a potent dual **hCA I/II** inhibitor with K_i values of 51.25, 13.15 and 42.18 nM for hCA I, hCA II and hCA Ⅸ. hCAI/II-IN-3 possesses anti-hypoxic activity against acute mountain sickness (AMS) and low cellular activity .

HY-147925

hCAI/II-IN-4	Carbonic Anhydrase	Others
hCAI/II-IN-4 (compound 6d) is a potent dual **hCA I/II** inhibitor with K_i values of 16.95, 15.22 and 27.04 nM for hCA I, hCA II and hCA Ⅸ, respectively. hCAI/II-IN-4 has anti-hypoxia activities and low toxicity. hCAI/II-IN-4 can be used for acute mountain sickness (AMS) research .

HY-161507

hCAI/II-IN-8	Carbonic Anhydrase Cholinesterase (ChE)	Metabolic Disease
hCAI/II-IN-8 (Compound 8) is a hydrazide derivative based on 4-hydroxybenzaldehyde. hCAI/II-IN-8 primarily targets human carbonic anhydrase isomerase I (hCA I) and II (hCA II) for inhibition (IC₅₀ = 21.35 ± 0.39 nM (hCA I); 7.12 ± 0.12 nM (hCA II)). hCAI/II-IN-8 inhibits AChE and BChE as well(IC₅₀ = 46.27 ±0.75 nM (AChE); 43.38 ± 0.83 nM (BChE)). . .

HY-129986

hCAI/II-IN-9	Endogenous Metabolite	Others
hCAI/II-IN-9 is a carbonic anhydrase inhibitor with inhibitory activity against human carbonic anhydrase isoforms I, II, IX, and XII. The inhibition constants (Ki) of hCAI/II-IN-9 for hCA I are in the range of 7.9-894 nM, for hCA II are in the range of 7.5-1645 nM, for hCA IX are in the range of 5.0-240 nM, and for hCA XII are in the range of 0.47-2.83 nM. hCAI/II-IN-9 may have potential applications in inhibiting a variety of pathologies involving these carbonic anhydrase isoforms .

HY-157321

hCAI/II-IN-7	Carbonic Anhydrase	Neurological Disease
hCAI/II-IN-7 (compound 1F) is a potent carbonic anhydrase (CA) inhibitor with K_i values of 23 nM, 44 nM and 20.57 µM for hCA-I, hCA-II and bovine CA, respectively .

HY-176055

hCAI/II-IN-11	Carbonic Anhydrase	Infection
hCAI/II-IN-11 (compound 2c) is a Carbonic Anhydrase Inhibitor with IC₅₀ values of 12.56 μM and 13.02 μM for hCA I and hCA II, respectively. hCAI/II-IN-11 shows antioxidant and antimicrobial effects .

HY-147955

hCAI/II-IN-5	Carbonic Anhydrase Cholinesterase (ChE)	Neurological Disease Metabolic Disease
hCAI/II-IN-5 (compound MZ8) is a potent hCA I and hCA II (human carbonic anhydrase isoenzymes I and II) inhibitor, with IC₅₀ values of 37.88 and 45.23 nM, respectively. hCAI/II-IN-5 also shows inhibition profile against α-Glycosidase and AChE, with IC₅₀ values of 48.98 and 420.14 nM, respectively. hCAI/II-IN-5 can be used for the research of many diseases such as diabetes, Alzheimer’s disease, heart failure, ulcer, and epilepsy .

HY-174835

hCA-I/hCA-II-IN-1	Carbonic Anhydrase	Cardiovascular Disease
hCA-I/hCA-II-IN-1 (Compound P4) is a potent dual human carbonic anhydrase I (hCA-I) and human carbonic anhydrase II (hCA-II) inhibitor with K_i values of 0.22 μM and 0.33 μM, respectively. hCA-I/hCA-II-IN-1 can be used in research on diseases related to CA enzymes such as glaucoma, hypertension, and ulcers .

HY-149012

*AChE/hCA* I/II-IN-1**	Cholinesterase (ChE) Carbonic Anhydrase	Neurological Disease Endocrinology
AChE/hCA I/II-IN-1 (Compound 6) is a potent inhibitor of *AChE/Hca* with IC₅₀ values of 22.21, 60.79 and 66.64 nM for AChE, Hca Ⅰ and Hca Ⅱ. AChE/hCA I/II-IN-1 can be used for the rsearch for glaucoma, Alzheimer's disease, diabetes .

HY-144641

Carbonic anhydrase inhibitor 7	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 7 (compound 5b) is a potent inhibitor of human carbonic anhydrase (hCA), with K_is of 6.5 nM, 7.1 nM, 72.1 nM, and 255.8 nM for hCA IX, hCA II, hCA XII and hCA I, respectively .

HY-144640

Carbonic anhydrase inhibitor 6	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 6 (compound 9b) is a potent inhibitor of human carbonic anhydrase (hCA), with K_is of 9.7 nM, 35.2 nM, 88.5 nM, and 91.8 nM for hCA IX, hCA II, hCA XII and hCA I, respectively .

HY-162063

hCAIX/XII-IN-9	Carbonic Anhydrase	Inflammation/Immunology Cancer
hCAIX/XII-IN-9 (compound 8) is a potent carbonic anhydrase (CA) inhibitor with K_i values of 1658 nM, 184.8 nM, 8.9 nM, 64.8 nM for hCA I, hCA II, hCA IX, and hCA XII, respectively .

HY-163268

Carbonic anhydrase inhibitor 18	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 18 (Compound 9) is a human carbonic anhydrase (hCA) isoform inhibitor, with K_is of 604.8, 333.6, 1.9 and 6.7 nM for hCA I, hCA II, hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor 18 can be used for the research of cancer .

HY-156169

hCAIX/XII-IN-7	Carbonic Anhydrase	Cancer
hCAIX/XII-IN-7 (compound 3e) is a potent hCA IX and XII inhibitor with K_is of 3.2 nM, 9.2 nM, 503.7 nM and 59 nM for hCA I, hCA II, hCA IX and hCA XII, respectively. hCAIX/XII-IN-7 has the potential for hypoxic tumors research .

HY-161142

Carbonic anhydrase/AChE-IN-1	Carbonic Anhydrase Cholinesterase (ChE)	Neurological Disease
Carbonic anhydrase/AChE-IN-1 (compound 16) is a carbonic anhydrase and AChE inhibitor with K_is of 24.42 nM, 19.95 nM, and 5.07 nM for hCA I, hCA II, and AChE, respectively .

HY-W008343

1,3-Dimethyluracil	Endogenous Metabolite	Metabolic Disease
1,3-Dimethyluracil is a pyrimidone derives from a uracil. 1,3-Dimethyluracil found occasionally in human urine. 1,3-Dimethyluracil shows inhibition activity against hCA I and hCA II (human carbonic anhydrase) with K_i of 316.2 μM and 166.4 μM, respectively .

HY-146979

*hA2A/hCA* XII modulator 1**	Adenosine Receptor Carbonic Anhydrase	Cancer
hA2A/hCA XII modulator 1 (compound 14), a triazolopirazine, is a potent hA_2A adenosine receptor (hA_2AAR) antagonist with K_is of 6.4 nM, 4.819 μM, >30 μM for hA_2AAR, hA₁AR, hA₃AR, respectively. hA2A/hCA XII modulator 1 is a potent *human carbonic anhydrase XII (hCA* XII) inhibitor with K_i*s of 6.2 nM, 46 nM, 466 nM, 8.351 μM for hCA* XII, hCA II, hCA IX and hCA I, respectively. hA2A/hCA XII modulator 1 has the potential for cancer research .

HY-151472

hCAIX/XII-IN-6	Carbonic Anhydrase	Infection
hCAIX/XII-IN-6 is an orally active carbonic anhydrase (CA) inhibitor. hCAIX/XII-IN-6 inhibits human CA isoforms hCA I, II, IV, IX, and XII with K_i values of 6697 nM, 2950 nM, 4093 nM, 4.1 nM and 7.7 nM, respectively. hCAIX/XII-IN-6 can be used for the research of rheumatoid arthritis (RA) .

HY-147986

hCA I-IN-2	Carbonic Anhydrase	Cancer
hCA I-IN-2 (Compound 6d) is a selective *human carbonic anhydrase I (hCA* I) inhibitor with K_i** values of 18.8, 375.1, 1721 and 283.9 nM against hCA I, hCA II, hCAIX and hCAXII, respectively .

HY-147985

hCA I-IN-1	Carbonic Anhydrase	Cancer
hCA I-IN-1 (Compound 6q) is a *human carbonic anhydrase I (hCA* I) inhibitor with K_i** values of 38.3, 716.4, 940.1 and 192.8 nM against hCA I, hCA II, hCAIX and hCAXII, respectively .

HY-147799

hCA XII/II/IX-IN-1	Carbonic Anhydrase	Cancer
hCA XII/II/IX-IN-1 (Compound 3) is a potent human carbonic anhydrase (hCA) inhibitor with IC₅₀ values of 2.6, 0.004, 0.005 and 0.001 μM against hCA I, hCA II, hCA IX and hCA XII, respectively. hCA XII/II/IX-IN-1 shows anticancer activity .

HY-158372

hCA I-IN-3	Carbonic Anhydrase	Cancer
hCA I-IN-3 (compound 24), an aryl ether derivative, is a potent carbonic anhydrase inhibitor. hCA I-IN-3 can inhibit carbonic anhydrase hCA I and hCA II isoenzymes, with IC₅₀ values of 4.77 and 9.66 nM, respectively. hCA I-IN-3 can be used for cancer research .

HY-170560

*AChE/hCA* I-IN-1**	Cholinesterase (ChE) Carbonic Anhydrase	Neurological Disease
AChE/hCA I-IN-1 (Compound L3) is the inhibitor for acetylcholinesterase (AChE) and carbonic anhydrase (CA), that inhibits AChE, hCA I and hCA II with IC₅₀ of 302, 265 and 283 nM, respectively .

HY-147829

hCAXII-IN-2	Carbonic Anhydrase	Cancer
hCAXII-IN-2 (compound 5i) is a potent *human carbonic anhydrase XII (hCA* XII)** and hCA IX inhibitor with K_i values of 84.2 nM and 268.5 nM, respectively. hCAXII-IN-2 shows less active against hCA I and hCA II .

HY-169962

hCA I-IN-4	Carbonic Anhydrase Cholinesterase (ChE)	Neurological Disease Cancer
hCA I-IN-4 (Compound 14) is the inhibitor for carbonic anhydrase and cholinesterase, that inhibits hCA I, hCA II, AChE, and BChE with K_i of 29.94 nM, 17.72 nM, 21.21 nM, and 7.65 nMrespectively. hCA I-IN-4 exhibits cytotoxicity in BT-549 with IC₅₀ of 16.59 μM .

HY-146355

hCAII-IN-2	Carbonic Anhydrase	Cancer
hCAII-IN-2 (Compound 11f) is a cytosolic human carbonic anhydrase (hCA) inhibitor with K_i values of 261.4, 3.8, 19.6 and 45.2 nM against hCA I, hCA II, hCA IX and hCA XII, respectively .

HY-146206

HCAIX-IN-1	Carbonic Anhydrase	Cancer
HCAIX-IN-1 (compound 21e) is a potent and selective HCAIX inhibitor with K_Is of 694.9, 126.6, 3.3, 9.8 nM for hCA I, hCA II, hCA IX, hCA XII, respectively .

HY-132156

Carbonic anhydrase inhibitor 22	Carbonic Anhydrase	Neurological Disease
Carbonic anhydrase inhibitor 22 (Compd 2g), a sulfonamide carbonic anhydrase inhibitor, with K_i values of 762 nM (hCA I), 20.3 nM (hCA II), 8.3 nM (hCA VII), 17.9 nM (hCA IX) and 10.5 nM (hCA XII), repectively .

HY-W012168

4-Chloro-3-sulfamoylbenzoic acid	Carbonic Anhydrase	Cancer
4-Chloro-3-sulfamoylbenzoic acid is an inhibitor of human carbonic anhydrase, targeting the cytosolic isoforms hCA I and hCA II (glaucoma-associated), and the transmembrane isoforms hCA IV and hCA IX (tumor hypoxia-induced) .

HY-146007

hCAIX-IN-17	Carbonic Anhydrase	Cancer
hCA IX-IN-1 (Compound 6f) is a human carbonic anhydrase (hCA) inhibitor with K_i values of 331.4, 28.4, 9.4 and 17.8 nM against hCA I, hCA II, hCA IX and hCA XII, respectively. hCA IX-IN-1 shows anticancer activity .

HY-146008

hCAII-IN-3	Carbonic Anhydrase	Cancer
hCAII-IN-3 (Compound 16) is a human carbonic anhydrase (hCA) inhibitor with K_i values of 403.8, 5.1, 10.2 and 5.2 nM against hCA I, hCA II, hCA IX and hCA XII, respectively. hCA IX-IN-2 shows anticancer activity .

HY-172607

Carbonic anhydrase inhibitor 30	Carbonic Anhydrase	Infection
Carbonic anhydrase inhibitor 30 (compound 17) is an inhibitor of carbonic anhydrase with K_i values of 2.13 μM and 0.161 nM for hCA I and hCA II, respectively ^{[1] ^.}

HY-163753

Carbonic anhydrase inhibitor 25	Carbonic Anhydrase	Others
Carbonic anhydrase inhibitor 25 (compound 6a) is a potent carbonic anhydrase inhibitor. Carbonic anhydrase inhibitor 25 shows inhibition for hCA I and hCA II receptor .

HY-172816

Carbonic anhydrase inhibitor 32	Carbonic Anhydrase mTOR NKCC	Neurological Disease
Carbonic anhydrase inhibitor 32 (compound 5B) is an orally active and selective **hCA (Carbonic anhydrase ) II/VII inhibitor with the K_i** values of 6.3 nM, 10.1 nM and 681 nM for hCA II, hCA VII and hCA I,respectively. Carbonic anhydrase inhibitor 32 shows neuroprotective and anticonvulsant potential by reducing mTOR activation, and raising hippocampus KCC2 levels .

HY-163109

Carbonic anhydrase inhibitor 16	Carbonic Anhydrase	Infection
Carbonic anhydrase inhibitor 16 (compound 1) is a dengue protease inhibitor with inhibitory activity against carbonic anhydrase hCA I and hCA II (K_i: 28.5 nM, 2.2 nM) .

HY-W031519

Chloraminophenamide	Carbonic Anhydrase	Cardiovascular Disease
Chloraminophenamide (Compound 14) is a carbonic anhydrase inhibitor, with *K_is of 75, 160 and 8400 nM for hCA* II, bCA IV and hCA I, respectively. Chloraminophenamide has the potential for antiglaucoma research .**

HY-163660

Carbonic anhydrase inhibitor 23	Carbonic Anhydrase	Infection
Carbonic anhydrase inhibitor 23 (compound 40) is a potent inhibitor of carbonic anhydrase (CA), with the K_i of 617.2 nM and 434.1 nM for hCA I (α) and hCA II (α), respectively .

HY-161374

Carbonic anhydrase inhibitor 20	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 20 (compound 11) is an inhibitor of piperazinosulfonamide carbonic anhydrase (Carbonic Anhydrase). The Ki of Carbonic anhydrase inhibitor 20 for hCA I, hCA II, hCA IX, and hCA XII are 47.6 nM, 36.5 nM, 8.3 nM, and 2.7 nM respectively .

HY-159128

hCAIX-IN-21	Carbonic Anhydrase	Cancer
hCAIX-IN-21 (compound 16c) is a potent hCAIX inhibitor with K_I values of 5.2, 3.5, 12.6, 13600 nM for hCAIX, hCA II, hCA XII, hCA I, respectively. hCAIX-IN-21 inhibits cathepsin B enzyme activity .

HY-144268

hCAII-IN-7	Carbonic Anhydrase	Cancer
hCAII-IN-7 (Compound R-13) is a potent human carbonic anhydrase *(hCA)* inhibitor with K_is of 60.7, 320.7, 2298, and 35.2 nM for hCA I, II, IV and IX, respectively .

HY-161282

hCAII-IN-10	Carbonic Anhydrase	Neurological Disease Cancer
hCAII-IN-10 (compound 11d) is hCA II inhibitor with the IC₅₀s of 14 nM and 29.2 μM for hCA II and hCA I, respectively. hCAII-IN-10 inhibits cell growth against HT-29 cells with the IC₅₀ of 74 μM. hCAII-IN-10 shows strongly lowered intraocular pressure in the glaucomatous rabbit eye model .

HY-144264

hCAII-IN-6	Carbonic Anhydrase	Endocrinology
hCAII-IN-6 (Compound S-13) is a potent human carbonic anhydrase II (hCA II) inhibitor with a K_i of 4.4 nM. hCAII-IN-6 also inhibits other hCAs isoforms I, IV and IX, with K_i values of 9.2 nM, 480.2 nM and 14.7 nM, respectively. hCAII-IN-6 can be used for glaucoma research .

HY-169163

BChE-IN-36	Carbonic Anhydrase Cholinesterase (ChE)	Neurological Disease
hBChE-IN-4 (compound 40) is a potent *hCA* activator and BChE inhibitor with K_A values of 266, 76.9, 918, 893, 98.0 nM for hCA I, hCA II, hCA IV, hCA VB, hCA VII, IC₅₀ values of 72.1, 4.2 nM for eeAChE, eqBChE, respectively. hBChE-IN-4 shows no cytotoxicity. hBChE-IN-4 shows potent procognitive effects. hBChE-IN-4 has the potential for the research of neurodegenerative diseases and other neuropsychiatric disorders .

HY-155760

hCA/VEGFR-2-IN-3	VEGFR Carbonic Anhydrase	Cancer
hCA/VEGFR-2-IN-3 (compound 8j) is an indolinonylbenzenesulfonamide and a potential dual inhibitor of cancer-associated hCA IX/XII and VEGFR-2. hCA/VEGFR-2-IN-3 inhibits VEGFR-2 (IC₅₀=358 nM), has high binding activity to hCAs with Ki of 4.2 nM (hCA IX), 22.9 nM (hCA II), 25.1 nM (hCA I), 28.0 nM (hCA XII), respectively. hCA/VEGFR-2-IN-3 has antiproliferative activity against VEGFR-2 overexpressing breast cancer cells .

HY-150570

Carbonic anhydrase inhibitor 14	Carbonic Anhydrase CDK	Cancer
Carbonic anhydrase inhibitor 14 (Compound 8b) is a carbonic anhydrase (CA) inhibitor with K_i values of 1203, 99.7, 9.4 and 27.7 nM against hCA I, hCA II, hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor 14 can also inhibit CDK2 with an IC₅₀ of 20.3 μM. Carbonic anhydrase inhibitor 14 shows antitumor activity .

HY-155763

hCA/VEGFR-2-IN-4	VEGFR Carbonic Anhydrase	Cancer
hCA/VEGFR-2-IN-4 (compound 15b) is an indolinylbenzenesulfonamide and a potential dual inhibitor of cancer-associated hCA IX/XII and VEGFR-2. hCA/VEGFR-2-IN-4 inhibits VEGFR-2 (IC₅₀=0.811 μM) and has high binding activity to hCAs, with Ki of 3.8 nM (hCA XII), 6.2 nM (hCA IX), 19.8 nM (hCA II), and 35.5 nM (hCA I), respectively. hCA/VEGFR-2-IN-4 has antiproliferative activity on VEGFR-2-overexpressing breast cancer cells .

Cat. No.	Product Name		Classification

HY-159128

hCAIX-IN-21		Azide
hCAIX-IN-21 (compound 16c) is a potent hCAIX inhibitor with K_I values of 5.2, 3.5, 12.6, 13600 nM for hCAIX, hCA II, hCA XII, hCA I, respectively. hCAIX-IN-21 inhibits cathepsin B enzyme activity .

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hCA I/II

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