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fungus metabolite

" in MedChemExpress (MCE) Product Catalog:

52

Inhibitors & Agonists

1

Peptides

46

Natural
Products

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-119663
    Averantin

    		Fungal Infection
    Averantin is the minor metabolite of the fungus Cercospora arachidicola . Averantin is an aflatoxin B1 precursor that can be used in the biosynthetic pathway .
    Averantin
  • HY-N8552
    Banksialactone A

    		Endogenous Metabolite Infection
    Banksialactone A is the metabolite of an Australian fungus, Aspergillus banksianus .
    Banksialactone A
  • HY-N10299
    Guignardone J

    		Endogenous Metabolite Infection
    Guignardone J is the secondary metabolite isolated from endophytic fungus Phyllosticta capitalensis .
    Guignardone J
  • HY-113622
    Cladospirone bisepoxide

    Palmarumycin C13; Diepoxin ζ; Antibiotic Sch53514

    		 Fungal Antibiotic Infection
    Cladospirone bisepoxide is a metabolite that isolated from cultures of a fungus. Cladospirone bisepoxide displays selective antibiotic activity against several bacteria and fungi and inhibits germinations of Lepidium sativum at low concentrations .
    Cladospirone bisepoxide
  • HY-N8846
    dl-Aloesol

    		Fungal Infection
    dl-Aloesol is a natural product that can be isolated from fungus Aspergillus sp. Aspergillus sp metabolites has cytotoxic, antibacterial, free radical scavenging, anti-parasitic, antiviral and antiproliferative activities, etc .
    dl-Aloesol
  • HY-119328
    Pestalotin

    		Endogenous Metabolite Others
    Pestalotin, a fungal lactone, is a secondary metabolite of endophytic fungus Pestalotiopsis microspore .
    Pestalotin
  • HY-129515
    Trichodecenin II

    		Fungal Others
    Trichodecenin II is a fungal metabolite that can be found in conidia of the fungus, Trichoderma viride .
    Trichodecenin II
  • HY-125706
    1233B

    		Fungal Antibiotic Infection
    1233B is a secondary metabolite from filamentous fungus, Fusarium sp. RK97-94 .
    1233B
  • HY-N12194
    Cytochalasin O

    		Others Infection
    Cytochalasin O (compound 13) is a secondary metabolite of the phytopathogenic fungus P. sp. CIB-109 .
    Cytochalasin O
  • HY-N10301
    Guignardone L

    		Toll-like Receptor (TLR) Infection
    Guignardone L is a metabolite isolated from the endophytic fungus Guignardia mangiferae with toll-like receptor 3 regulating activity .
    Guignardone L
  • HY-121395
    Lepiochlorin

    		Antibiotic Fungal Infection
    Lepiochlorin is an antibiotic metabolite produced by a fungus (Lepiota species) that is cultivated by ants, which can prevent fungal contamination .
    Lepiochlorin
  • HY-N7023
    7-Prenyloxycoumarin

    7-O-Prenylumbelliferone

    		 Fungal Infection
    7-Prenyloxycoumarin (7-O-Prenylumbelliferone) is a secondary metabolite from the endophytic fungus of Annulohypoxylon ilanense .
    7-Prenyloxycoumarin
  • HY-170738
    Oudenone derivative-1 potassium

    		Tryptophan Hydroxylase Neurological Disease
    Oudenone derivative-1 potassium is a derivative of Oudenone. Oudenone, a metabolite of the fungus, is a catecholamine biosynthesis and tyrosine hydroxylases inhibitor .
    Oudenone derivative-1 potassium
  • HY-N10262
    Piliformic acid

    		Endogenous Metabolite Others
    Piliformic acid is a fungal metabolite found in the endophytic fungus Xylariasp sp.(No. 2508) from mangrove trees from the coast of the South China Sea .
    Piliformic acid
  • HY-B1086
    Afalanine

    N-Acetyl-DL-phenylalanine

    		 Endogenous Metabolite Neurological Disease
    Afalanine (N-Acetyl-DL-phenylalanine) is an endogenous metabolite of an endophytic fungus with antidepressant activity. Afalanine can be used in combination with antibiotics to prevent renal damage.
    Afalanine
  • HY-W017445
    Homogentisic acid lactone

    		Fungal Infection
    Homogentisic acid lactone (Compound 1) is a fungal metabolite with fungicidal activity, which is found in the fungus WF5. Homogentisic acid lactone is active against the plant pathogenic fungus F. graminearum. Homogentisic acid lactone can be used as a substrate in the determination of serum paraoxonase/arylesterase 1 (PON1) activity .
    Homogentisic acid lactone
  • HY-N10289
    Cytosporone C

    		Fungal Infection
    Cytosporone C is an antifungal metabolite from the Melia azedarach-Associated Fungus Diaporthe eucalyptorum. Cytosporone C exhibits antifungal activities against Alternaria solani .
    Cytosporone C
  • HY-N16432
    Nidulol

    		Fungal Infection
    Nidulol is a compound that can be isolated from the fungus Aspergillus nidulans metabolites. Nidulol shows no phytotoxic activity against Zea mays and Medicago polymorpha L. at a concentration of 5 mM .
    Nidulol
  • HY-119821
    Terphenyllin

    		Glycosidase Infection
    Terphenyllin is a naturally abundant p-terphenyl metabolite isolated from the coral derived fungus Aspergillus candidus, has significant α-glucosidase inhibitory activity .
    Terphenyllin
  • HY-N12893
    Sclerodione

    		Fungal Lipase Infection
    Sclerodione is a metabolite that can be produced by the Scleroderris canker fungus, Gremmeniellaabietina. Sclerodione has antifungal activity. Sclerodione is a lipase inhibitor (IC50: 1 μM) .
    Sclerodione
  • HY-122474
    Acetylaranotin

    		Drug Derivative Cancer
    Acetylaranotin is a metabolite produced by the fungus Arachniotus aureus, exhibiting antitumor activity. Acetylaranotin is utilized in research within the field of oncology for its potential in anti-cancer applications .
    Acetylaranotin
  • HY-N12179
    Brevianamide M

    		Bacterial Others
    Brevianamide M (compound 4) is a metabolite of Aspergillus versicolor. This is an endophytic fungus isolated from the marine brown alga Sargassum. Brevianamide M has antimicrobial activity against Escherichia coli and Staphylococcus aureus .
    Brevianamide M
  • HY-N13021
    2-(2-Hydroxy-5-methoxyphenoxy)-acrylic acid

    		Endogenous Metabolite Others
    2-(2-Hydroxy-5-methoxyphenoxy)-acrylic acid is a metabolite, which can be isolated from endophytic fungus Phoma macrostoma inhabiting the inner tissue of medicinal plant Glycyrrhiza glabra Linn .
    2-(2-Hydroxy-5-methoxyphenoxy)-acrylic acid
  • HY-N7569
    Demethoxyfumitremorgin C

    		Apoptosis Caspase PPAR Cancer
    Demethoxyfumitremorgin C is a secondary metabolite of the marine fungus, Aspergillus fumigatus. Demethoxyfumitremorgin C induces prostate cancer cell apoptosis. Demethoxyfumitremorgin C activates caspase-3, -8, and -9, leading to PARP/ cleavage .
    Demethoxyfumitremorgin C
  • HY-N10184
    Paecilaminol

    FKI-0550

    		 Others Infection
    Paecilaminol (FKI-0550) is potent NADH-fumarate reductase inhibitor. Paecilaminol exhibits an IC50 value of 5.1 μM against Ascaris suum NADH-fumarate reductase .
    Paecilaminol
  • HY-W971442
    Moniliphenone

    		Endogenous Metabolite NF-κB Inflammation/Immunology
    Moniliphenone (Compounds 5) is a secondary metabolite. Moniliphenone can be isolated from the endophytic fungus Penicillium chrysogenum. Moniliphenone has an anti-inflammatory activity and significantly inhibits TNF-α-stimulated NF-κB activation .
    Moniliphenone
  • HY-N8511
    Acremine I

    		Fungal Infection
    Acremine I is a fungi inhibitor and also a metabolite of the endophytic fungus Acremonium byssoides. Acremine I can effectively inhibit Plasmopara viticola. Acremine I can be used for research on plant diseases, such as grape downy mildew .
    Acremine I
  • HY-75564
    Cyclo(Ala-Gly)

    		Endogenous Metabolite Cancer
    Cyclo(Ala-Gly), a metabolite of a mangrove endophytic fungus, Penicillium thomi, exhibits cytotoxicity against A549, HepG2 and HT29 cells. The IC50 values range from 9.5 to 18.1 μM .
    Cyclo(Ala-Gly)
  • HY-B1086R
    Afalanine (Standard)

    		Endogenous Metabolite Neurological Disease
    Afalanine (Standard) is the analytical standard of Afalanine. This product is intended for research and analytical applications. Afalanine (N-Acetyl-DL-phenylalanine) is an endogenous metabolite of an endophytic fungus with antidepressant activity. Afalanine can be used in combination with antibiotics to prevent renal damage.
    Afalanine (Standard)
  • HY-N8406
    Monomethylsulochrin

    		Bacterial Antibiotic Infection
    Monomethylsulochrin is a potent antibacterial metabolite from endophytic fungus Aspergillus fumigatus, isolated from Albizia lucidior leaves (fabaceae). Monomethylsulochrin exhibits anti-Staphylococcus aureus activity with minimum inhibitory concentration (MIC) of 31.25 μg/mL .
    Monomethylsulochrin
  • HY-N13024
    Radulone A

    		Fungal Infection
    Radulone A is a secondary metabolite, which can be isolated from the wood decomposing fungus Granulobasidium vellereum. Radulone A inhibits spore germination of Phlebiopsis gigantea, Coniophora puteana and Heterobasidion occidentale, with concentrations of 10 µM, 500 µM and 100 µM, respectively .
    Radulone A
  • HY-N10288
    Eucalyptacid A

    		Fungal Endogenous Metabolite Infection
    Eucalyptacid A, an antifungal metabolite, exhibits antifungal activities against Alternaria solani, with MIC values from 6.25 to 50 μM .
    Eucalyptacid A
  • HY-N15359
    Germicidin C

    		Bacterial Infection
    Germicidin C is a microbial metabolite with antibacterial activity, which is found in the marine sponge-derived fungus Aspergillus niger. Germicidin C can inhibit the growth of various pathogenic bacteria such as Staphylococcus aureus, Escherichia coli, and Bacillus subtilis with MIC values ranging from 32 to 64 µg/mL .
    Germicidin C
  • HY-N12229
    Penipurdin A

    		Endogenous Metabolite Bacterial Infection
    Penipurdin A (Compound 1), an anthraquinone, is a microbial secondary metabolite. Penipurdin A can be isolated from the soil fungus Penicillium purpurogenum SC0070. Penipurdin A has no significant cytotoxicity against cancer cells, such as A549, HepG2 and Hela cells. Penipurdin A has antibacterial activity against Enterococcus faecalis and Staphylococcus aureus .
    Penipurdin A
  • HY-N10269
    Phomalactone

    		Fungal Endogenous Metabolite Infection
    Phomalactone, produced by the fungus Nigrospora sphaerica, specifically inhibits the mycelial growth of Phytophthora infestans, with an MIC value of 2.5 mg/L . Phomalactone is phytotoxic to Z. elegans and other plant species by inhibition of seedling growth and by causing electrolyte leakage from photosynthetic tissues of both Z. elegans leaves and cucumber cotyledons .
    Phomalactone
  • HY-N16442
    Pyrrocidine B

    		Endogenous Metabolite Prolyl Endopeptidase (PREP) Cancer
    Pyrrocidine B (Compound 6), an alkaloid, is a microbial secondary metabolite. Pyrrocidine B can be isolated from the endophytic fungus Neonectria ramulariae Wollenw KS-246. Pyrrocidine B has significant cytotoxicity against leukemia cells (IC50 of 4.6  μM for HL60 cells) with a weak Prolyl oligopeptidase (POP) inhibitory activity .
    Pyrrocidine B
  • HY-N16441
    Pulvic acid

    		Endogenous Metabolite Influenza Virus Infection
    Pulvic acid (Compound 3), a butenolide, is a microbial secondary metabolite. Pulvic acid can be isolated from the marine-derived fungus Aspergillus terreus Gwq-48. Pulvic acid has significant antiviral activity with an IC50 of 29.1 μg/mL for influenza A H1N1 virus. Pulvic acid can be used for influenza virus infections research .
    Pulvic acid
  • HY-142088
    Beauverolide Ka

    		Endogenous Metabolite Metabolic Disease
    Beauverolide Ka, a cyclotetradepsipeptide, is a metabolite of Beauveria bassiana fungus. Beauverolide Ka stimulates glucose uptake in cultured rat L6 myoblasts at 50 μM. Beauverolide Ka exhibits protecting effects on HEI-OC1 cells at 10 μM and shows dose-dependent activity in both L6 myoblasts and myotubes .
    Beauverolide Ka
  • HY-N16428
    Neoaspergillic acid

    NSC 356436

    		 Endogenous Metabolite Fungal Bacterial Infection Cancer
    Neoaspergillic acid (NSC 356436) (Compound 2) is a microbial secondary metabolite. Neoaspergillic acid can be isolated from the endophytic fungus Aspergillus sp. SPH2. Neoaspergillic acid has potent antifungal activity against Alternaria alternata, Botrytis cinerea and Fusarium oxysporum. Neoaspergillic acid appears during the exponential phase of fungal growth. Neoaspergillic acid also antitumor and antibacterial effects .
    Neoaspergillic acid
  • HY-N16394
    4-Hydroxyscytalone

    		Endogenous Metabolite Cancer
    4-Hydroxyscytalone (Compound 3) is a microbial secondary metabolite. 4-Hydroxyscytalone can be isolated from the oak fungus Diplodia corticola. 4-Hydroxyscytalone has toxicity against Artemia salina with a LC50 of 90.6 μ/mL, but no significant antifungal activity. 4-Hydroxyscytalone can be used for cancer therapy research .
    4-Hydroxyscytalone
  • HY-75564R
    Cyclo(Ala-Gly) (Standard)

    		Reference Standards Endogenous Metabolite Cancer
    Cyclo(Ala-Gly) (Standard) is the analytical standard of Cyclo(Ala-Gly). This product is intended for research and analytical applications. Cyclo(Ala-Gly), a metabolite of a mangrove endophytic fungus, Penicillium thomi, exhibits cytotoxicity against A549, HepG2 and HT29 cells. The IC50 values range from 9.5 to 18.1 μM[1].
    Cyclo(Ala-Gly) (Standard)
  • HY-W751002
    Orthosporin

    (+)-Orthosporin

    		 Endogenous Metabolite Bacterial HIV Reverse Transcriptase Infection
    Orthosporin ((+)-Orthosporin), a phytotoxic isocoumarin compound, is a microbial secondary metabolite. Orthosporin can be isolated from the endophytic fungus Lasiodiplodia tbeobromae. Orthosporin has potent antibacterial activity against B. subtilis, E. coli and P. aeruginosa. Orthosporin also has antioxidant activity against DPPH radical and antiviral activities with inhibition of HIV-1 reverse transcriptase activity .
    Orthosporin
  • HY-W714837
    5-Phenyllevulinic acid

    4-Oxo-5-phenylpentanoic acid; 5-Phenyl-4-oxopentanoic acid

    		 Bacterial Fungal Antibiotic Drug Intermediate Endogenous Metabolite Sigma Receptor Infection
    5-Phenyllevulinic acid (4-Oxo-5-phenylpentanoic acid) is an endogenous fungal metabolite with inhibitory activity against the bacterium B. megaterium, the plant pathogenic fungus S. tritici, and the alga C. fusca. 5-Phenyllevulinic acid is also an intermediate in the synthesis of σ receptor ligands. 5-Phenyllevulinic acid holds potential for research in the field of anti-infection studies .
    5-Phenyllevulinic acid
  • HY-N12390
    Alternaphenol B2

    		Isocitrate Dehydrogenase (IDH) Cancer
    Alternaphenol B2 is a selective IDH1 inhibitor from the coral-derived fungus Parengyodontium album SCSIO SX7W11. Alternaphenol B2 shows inhibitory activity against isocitrate dehydrogenase mutant R132H (IDH1m), with IC50 values of 41.9 μM .
    Alternaphenol B2
  • HY-N7307
    Pachybasin

    		Bacterial Infection
    Pachybasin is a major metabolite from culture broth of endophytic coelomyceteous AFKR-18 fungus. Pachybasin showes antimicrobial activities against E. coli, B. subtilis, M. luteus, S. cerevisiae, C. albicans, A. niger, and A. flavus, with MIC values of 64.0 μg/mL, and against S. aureus and F. oxysporum with MIC values of 32.0 and 16.0 μg/mL respectively .
    Pachybasin
  • HY-N16457
    5,6-Dihydro-6-hydroxypenicillic acid

    		Endogenous Metabolite Influenza Virus Infection
    5,6-Dihydro-6-hydroxypenicillic acid (Compound 6) is a microbial secondary metabolite. 5,6-Dihydro-6-hydroxypenicillic acid can be isolated from the endophytic fungus Talaromyces sp. CPCC 400783 of Reynoutria japonica Houtt. 5,6-Dihydro-6-hydroxypenicillic acid has antiviral activity against influenza A virus with an IC50 of 65.45 μM .
    5,6-Dihydro-6-hydroxypenicillic acid
  • HY-N10113
    Verrucarin J

    Muconomycin B

    		 Apoptosis Arenavirus Fungal Antibiotic Reactive Oxygen Species (ROS) Infection Cancer
    Verrucarin J (Muconomycin B) is a metabolite of the Myrothecium fungus family. Verrucarin J generates reactive oxygen species (ROS) and induces apoptosis of cancer cell lines, such as A549, HCT 116 and SW-620 cells. Verrucarin J shows activities against Candida albicans and Mucor miehei. Verrucarin J inhibits arenavirus Junin (JUNV) yield with an IC50 of 1.2 ng/mL .
    Verrucarin J
  • HY-N12198
    Mollicellin H

    		Others Cancer
    Mollicellin H is a secondary metabolite of the fungus C. brasiliense and has a wide range of biological activities, including immunomodulation, cytotoxicity and anti-tumor effects. The growth inhibitory effects (GI50s) of Mollicellin H on human breast cancer (Bre04), human lung (Lu04) and human neuroma (N04) cell lines are 5.1 μg/mL, 6.5 μg/mL and 2.5 μg/mL respectively .
    Mollicellin H
  • HY-126167
    Deacetylsclerotiorin

    		Fungal Phosphodiesterase (PDE) Infection
    Deacetylsclerotiorin is a secondary metabolite of chloramphenicol isolated from the fungus Bartalinia robillardoides strain LF550. Deacetylsclerotiorin has significant inhibitory effects on Candida albicans (IC50=24 μM), Trichophyton rubrum (IC50=2.83 μM) and Septoria tritici (IC50=7..45 μM). In addition, Deacetylsclerotiorin also exhibits inhibitory effects on the enzyme phosphodiesterase 4 (PDE4) (IC50=2.8 μM) .
    Deacetylsclerotiorin
  • HY-N16448
    Xanthoascin

    		Bacterial Infection
    Xanthoascin (Compound 1) is a natural phenolic metabolite with strong anti plant pathogen activity. Xanthoascin can be extracted from the solid fermentation product of endophytic fungus Aspergillus sp. IFB-YXS isolated from Ginkgo biloba leaves. Xanthoascin has a MIC of 0.3125 µg/mL against Clavibacter michiganense subsp. Sepedonicus and moderate inhibitory activity against other pathogens (MIC = 5-20 µg/mL). Xanthoascin can disrupt the permeability of bacterial cell membranes, leading to nucleic acid leakage .
    Xanthoascin

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