Search Result
Results for "
fluorogenic substrate
" in MedChemExpress (MCE) Product Catalog:
7
Biochemical Assay Reagents
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-155002
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Cytochrome P450
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Metabolic Disease
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hCYP3A4 Fluorogenic substrate 1 is a potrnt hCYP3A4 fluorogenic substrate with an Km value of 0.36 μM. hCYP3A4 Fluorogenic substrate 1 can be used for cell and in vivo imaging .
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-
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- HY-134961
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fluorogenic Proteasome substrate; Z-ARR-AMC
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Proteasome
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Others
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Z-Ala-Arg-Arg-AMC (Fluorogenic Proteasome Substrate) is a fluorogenic substrate for assaying trypsin-like activity of proteasome .
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-
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- HY-P10189
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-
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- HY-P2179
-
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Fluorescent Dye
MMP
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Others
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MMP-1/MMP-9 Substrate, Fluorogenic is a fluorogenic substrate for MMP-1 and MMP-9 .Ex/Em = 340/440 nm
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-
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- HY-P10163
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Fluorescent Dye
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Others
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α-Secretase Substrate II, Fluorogenic is an internally quenched fluorogenic peptide substrate for α-Secretase that contains the α-secretase cleavage site of β-Amyloid precursor protein (APP) .Ex/Em = 340/490 nm
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-
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- HY-D2284
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Sphingosine-1-phosphate lyase fluorogenic substrate
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Fluorescent Dye
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Cancer
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SGPL1 fluorogenic substrate is the fluorogenic substrate of sphingosine-1-phosphate lyase (SGPL1) that can be used to measure the activity of SGPL1 .
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-
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- HY-P2682
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MMP
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Metabolic Disease
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MMP-8/MMP-26 Fluorogenic substrate (DNP-Pro-Leu-Ala-Tyr-Trp-Ala-Arg) is a matrix metalloproteinase-8 (MMP-8) fluorogenic substrate. MMP-8/MMP-26 Fluorogenic substrate can be used for the research of atherosclerosis, pulmonary fibrosis, and sepsis .
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-
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- HY-P10073
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Fluorescent Dye
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Others
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Calpain-1 substrate, fluorogenic serves as a sensitive and specific substrate for calpain-1 that cleaves Tyr-Gly bond and results in enhanced fluorescence .(Ex/Em = 490 nm/518 nm)
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-
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- HY-W719799
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-
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- HY-P4366
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-
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- HY-116583
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-
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- HY-P2498A
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Cathepsin
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Cancer
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Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D .
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- HY-P2498
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Cathepsin
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Others
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Cathepsin D and E FRET Substrate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D .
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-
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- HY-W286423
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-
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- HY-P5993
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Fluorescent Dye
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Others
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MeOSuc-Ala-Ala-Pro-Val-4-MNA is a elastase fluorogenic substrate that can be detected at 425 nm (with excitation at 340 nm) .
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-
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- HY-W357142
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-
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- HY-D0063
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Fluorescent Dye
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Others
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6,7-Diethoxy-4-methylcoumarin is a fluorogenic substrate and is also a metabolite of Cordyceps militaris .
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- HY-137928
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Fluorescent Dye
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Others
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H-Ala-4MβNA hydrochloride is a specific fluorogenic substrate for aminopeptidase M .
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-
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- HY-P4334
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Bz-Arg-Gly-Phe-Phe-Leu-4MβNA
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Fluorescent Dye
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Others
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Bz-RGFFL-4MβNA (Bz-Arg-Gly-Phe-Phe-Leu-4MβNA) is a peptide and can be used fluorogenic substrate .
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- HY-P3484
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MMP
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Cancer
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Dnp-PLGLWA-DArg-NH2 TFA is a fluorogenic substrate for MMP-1 and MMP-9. Dnp-PLGLWA-DArg-NH2 TFA can be used to quantify the activity of MMPs (Ex=280 nm, Em=360 nm) .
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- HY-123052
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-
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- HY-P3699
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Fluorescent Dye
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Others
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TNO003 is a selective fluorogenic substrate. TNO003 can be used for the research of various biochemical .
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- HY-134432A
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Ser/Thr Protease
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Others
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Boc-Gln-Ala-Arg-AMC hydrochloride is a fluorogenic substrate for trypsin. Boc-Gln-Ala-Arg-AMC hydrochloride can also be used for measuring the proteolytic activity of TMPRSS2 .
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- HY-134432B
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Ser/Thr Protease
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Others
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Boc-Gln-Ala-Arg-AMC acetate is a fluorogenic substrate for trypsin. Boc-Gln-Ala-Arg-AMC acetate can also be used for measuring the proteolytic activity of TMPRSS2 .
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- HY-155667A
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Cathepsin
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Others
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Z-Nle-Lys-Arg-AMC acetate is a fluorogenic peptide substrate that specifically monitors cathepsin B activity over a broad pH range .
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- HY-P3475
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Fluorescent Dye
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Others
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Mca-VDQMDGWK-(Dnp)-NH2 is a fluorogenic substrate for caspase-3 and can be used to quantify caspase-3 activity .
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- HY-D1705
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Proteasome
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Inflammation/Immunology
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Ac-ANW-AMC is a fluorogenic substrate for immunoproteasome. Ac-ANW-AMC can be used to measure β5i activity (Ex=345 nm, Em=445 nm) .
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- HY-P4427
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Fluorescent Dye
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Others
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Z-VAN-AMC is a fluorogenic substrate. Z-VAN-AMC can be hydrolysed by a phytophagous mite of legumain-like activity .
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- HY-134435
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Fluorescent Dye
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Others
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Z-Arg-AMC hydrochloride is a fluorogenic substrate for trypsin and papain. Z-Arg-AMC hydrochloride can be used to research activity of trypsin (Ex/Em=355/460 nm) .
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- HY-D0994
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4-MUP; MUP
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Phosphatase
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Others
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4-Methylumbelliferyl phosphate (4-MUP), an anionic organophosphate, is a acid and alkaline phosphatase fluorogenic substrate. 4-Methylumbelliferyl phosphate is also a nerve agent simulant .
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- HY-123051
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- HY-155667
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Cathepsin
Fluorescent Dye
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Others
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Z-Nle-Lys-Arg-AMC is a fluorogenic peptide substrate that specifically monitors cathepsin B activity over a broad pH range .
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-
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- HY-P3477
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Fluorescent Dye
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Others
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Mca-PLA-Nva-Dap(Dnp)-AR-NH2 is a fluorogenic substrate for matrix metalloproteinase-2 (MMP-2) .
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- HY-136865
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Fluorescent Dye
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Others
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MeOSuc-AAPV-AMC is a fluorogenic substrate for human leukocyte and porcine pancreatic elastase (Km: 362 μM, Ex=380 nm, Em=460 nm) .
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- HY-P5996
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Fluorescent Dye
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Others
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MCA-Gly-Asp-Ala-Glu-pTyr-Ala-Ala-Lys(DNP)-Arg-NH2 is a protein tyrosine phosphatase fluorogenic substrate that can be detected at 393 nm (with excitation at 325 nm) .
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- HY-P1169
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Caspase
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Others
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Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B .
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- HY-P3362
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Fluorescent Dye
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Others
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Ac-IETD-AMC is a fluorogenic caspase-8/granzyme B substrate containing the acetyl (Ac) moiety. Ac-IETD-AMC is frequently used to measure caspase-8 activity .
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- HY-113862
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Fluorescent Dye
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Others
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PHOME is a fluorogenic substrate for sEH. sEH can hydrolyze the epoxy ring in the PHOME substrate. PHOME can be used for fluorescent epoxide hydrolase assay .
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- HY-120166
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DiFMUP
1 Publications Verification
6,8-Difluoro-4-methylumbelliferyl phosphate
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Phosphatase
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Others
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DiFMUP is a fluorogenic substrate, and has been widely used for the continuous detection of phosphatase activities. DiFMUP is hydrolysis by a phosphatase results in the release of Xuorescent DIFMU, which can be easily followed in continuous mode by a Xuorescence reader .
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- HY-W354821
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4-MUD
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Fluorescent Dye
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Metabolic Disease
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4-Methyl-2-oxo-2H-1-benzopyran-7-yl decanoate is a fluorogenic substrate used to follow the hydrolytic activity of carboxylesterases .
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- HY-W275616
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Others
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Others
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4-Methylumbelliferyl nonanoate is a fluorogenic substrate of esterases. 4-Methylumbelliferyl nonanoate can be hydrolyzed to 4-methylumbelliferone with bright blue fluorescence .
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- HY-P2617
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Caspase
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Inflammation/Immunology
Cancer
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Ac-WEHD-AFC is a fluorogenic caspase-1 substrate. Ac-WEHD-AFC can measure caspase-1 fluorogenic activity and can be used for the research of tumor and inflammation .
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- HY-D1080
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EDANS
1 Publications Verification
1,5-EDANS
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Fluorescent Dye
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Others
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EDANS (1,5-EDANS) is a novel and quenched fluorogenic substrate for assaying retroviral protease by resonance energy transfer (RET) .
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- HY-P4466
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HIV Protease
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Infection
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Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 is a fluorogenic substrate of HIV-1 protease. Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 can be used to test HIV-1 protease activity .
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- HY-P3476
-
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Fluorescent Dye
Caspase
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Cancer
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Mca-VDQVDGW-Lys(Dnp)-NH2 is a fluorogenic substrate of caspase-7. Mca-VDQVDGW-K(Dnp)-NH2 can be used to quantify caspase-7 activity.
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- HY-P2617A
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Caspase
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Inflammation/Immunology
Cancer
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Ac-WEHD-AFC TFA is a fluorogenic caspase-1 substrate. Ac-WEHD-AFC TFA can measure caspase-1 fluorogenic activity and can be used for the research of tumor and inflammation .
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- HY-P4465
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Fluorescent Dye
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Others
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Gly-Arg-pNA is a fluorogenic substrate for the measurement of protease activity. Gly-Arg-pNA undergoes hydrolysis and releases the fluorescent product p-nitroaniline. p-nitroaniline is in a fluorescent state under ultraviolet light irradiation and can emit a fluorescent signal .
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- HY-P4331
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Fluorescent Dye
Ser/Thr Protease
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Cardiovascular Disease
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Boc-Gln-Gly-Arg-AMC is a fluorogenic substrate for factor XIIa and trypsin. The cleavage of the amide bond between arginine and the methylcoumarin amide group releases fluorescent 7-Amino-4-methylcoumarin (HY-D0027) .
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- HY-P2536
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- HY-D1670
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- HY-P4417
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Fluorescent Dye
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Others
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Ac-IEPD-AMC is a fluorogenic substrate for the determination of protease activity. Ac-IEPD-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
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- HY-118135
-
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4MU-α-Gal
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Fluorescent Dye
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Others
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4-Methylumbelliferyl-α-D-galactopyranoside (4MU-α-Gal), a substrate for α-galactosidase A (GLA), is a blue pro-fluorogenic substrate. 4-Methylumbelliferyl-α-D-galactopyranoside forms two products, galactose and fluorescent 4MU, upon cleavage by GLA .
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- HY-P4419
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Fluorescent Dye
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Others
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Boc-Asp(OBzl)-Pro-Arg-AMC is a fluorogenic substrate for the determination of protease activity. Boc-Asp(OBzl)-Pro-Arg-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). The excitation and emission wavelengths are 351 nm and 430 nm, respectively .
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- HY-P2620
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Fluorescent Dye
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Metabolic Disease
Cancer
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Ac-LETD-AFC is a caspase-8 fluorogenic substrate. Ac-LETD-AFC can measure caspase-8 fluorogenic activity and can be used for the research of cancer cell apoptosis and oxidative stress metabolism .
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- HY-P4408
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Fluorescent Dye
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Others
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Ac-Arg-Gly-Lys-AMC is a fluorogenic substrate for the determination of protease activity. Ac-Arg-Gly-Lys-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
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- HY-P4323
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Fluorescent Dye
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Others
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Boc-Gln-Arg-Arg-AMC is a fluorogenic substrate for the determination of protease activity. Boc-Gln-Arg-Arg-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
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- HY-P4323A
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Fluorescent Dye
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Others
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Boc-Gln-Arg-Arg-AMC acetate is a fluorogenic substrate for the determination of protease activity. Boc-Gln-Arg-Arg-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
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- HY-P4333
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Fluorescent Dye
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Cardiovascular Disease
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Boc-Glu(OBzl)-Gly-Arg-AMC is a fluorogenic substrate for factors IXa and XIIa. The cleavage of the amide bond between arginine and the methylcoumarin amide group releases fluorescent 7-Amino-4-methylcoumarin (HY-D0027) .
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- HY-P4419A
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Fluorescent Dye
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Others
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Boc-Asp(OBzl)-Pro-Arg-AMC acetate is a fluorogenic substrate for the determination of protease activity. Boc-Asp(OBzl)-Pro-Arg-AMC acetate undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
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- HY-P4400
-
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Fluorescent Dye
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Others
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Z-VDVAD-AFC is a fluorogenic substrate. Z-VDVAD-AFC is used to measure the activity of cysteine protease 3 (Caspase-3). Z-VDVAD-AFC undergoes hydrolysis to release 7-amino-4-trifluoromethylcoumarin (AFC). AFC is fluorescent under ultraviolet light and can emit fluorescent signals .
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- HY-P4416
-
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Fluorescent Dye
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Others
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Ac-Gly-Ala-Lys(Ac)-AMC is a fluorogenic substrate for the determination of protease activity. Ac-Gly-Ala-Lys(Ac)-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
|
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- HY-P4332
-
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Fluorescent Dye
Ser/Thr Protease
|
Cardiovascular Disease
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Boc-Glu(OBzl)-Ala-Arg-AMC is a fluorogenic substrate for coagulation factor XIa and trypsin. The cleavage of the amide bond between arginine and the methylcoumarin amide group releases fluorescent 7-Amino-4-methylcoumarin (HY-D0027) .
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- HY-P4406
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Fluorescent Dye
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Others
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Abz-AGLA-Nba is a fluorogenic substrate for the determination of protease activity. Abz-AGLA-Nba is hydrolyzed to release aminoacyl benzimide (Abz-AGLA) and 2-naphthylaminoacyl (Nba). The product Abz-AGLA produced by this hydrolysis reaction is fluorescent under ultraviolet light and can emit a fluorescent signal .
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- HY-145519
-
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Fluorescent Dye
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Neurological Disease
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Mu-6S-Palm-β-Glc is a fluorogenic substrate for palmitoyl-protein thioesterase (PPT). Mu-6S-Palm-β-Glc can be used for the research of neuronal ceroid lipofuscin disease in infants .
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- HY-D1080R
-
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1,5-EDANS (Standard)
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Fluorescent Dye
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Others
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EDANS (1,5-EDANS) (Standard) is an analytical standard for EDANS. This product is intended for research and analytical applications. EDANS (1,5-EDANS) is a novel quenched fluorogenic substrate for the analysis of retroviral proteases by resonance energy transfer .
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- HY-P2295
-
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SARS-CoV
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Others
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Dabcyl-KTSAVLQSGFRKME-Edans TFA is a fluorogenic peptide. Dabcyl-KTSAVLQSGFRKME-Edans TFA is used as the substrate to measure the enzymatic activities of protease forms. Dabcyl-KTSAVLQSGFRKME-Edans TFA has the potential for study 2019-nCoV (COVID-19) infection .
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- HY-P3749
-
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Fluorescent Dye
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Others
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Mca-(ala7,lys(dnp)9)-bradykinin is a sensitive fluorogenic substrate for ECE-1 (endothelin-converting enzyme-1). The incorporation of a (7-methoxycoumarin-4-yl)acetyl (Mca) fluorescent group and a 2,4-dinitrophenyl (Dnp) quenching group has resulted in a large fluorescence increase upon substrate cleavage .
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- HY-135036
-
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Fluorescent Dye
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Others
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4-Methylumbelliferyl butyrate (4-MUB) is a coumarin-based fluorogenic substrate used for the identification of M. catarrhalis C4- esterase. 4-Methylumbelliferyl butyrate can converse to the blue-emissive 4-methylumbelliferone (4-MU; HY-N0187) .
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-
- HY-123633
-
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Glycosidase
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Others
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4-Methylumbelliferyl β-D-Glucopyranoside, a β-D-glucoside, is a fluorogenic substrate for β-glucosidase, utilizes to assay β-glucosidase activity . 4-Methylumbelliferyl β-D-Glucopyranoside releases the highly fluorescent 4-methylumbelliferyl (4-MU), which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively .
|
-
- HY-137844
-
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Leu-AMC hydrochloride
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Fluorescent Dye
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Others
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L-Leucine-7-amido-4-methylcoumarin (Leu-AMC) hydrochloride is a bright blue fluorogenic peptidyl substrate for LAP3 (leucine aminopeptidase). L-Leucine-7-amido-4-methylcoumarin hydrochloride can be used for leucine aminopeptidase inhibition assays in vitro .
|
-
- HY-116862
-
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DBF
|
Cytochrome P450
Fluorescent Dye
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Others
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Dibenzylfluorescein (DBF) is a fluorogenic probe (Fluoresecent dye) that acts as a substrate for specific cytochrome P450 (CYP) isoforms, including CYP3A4, CYP2C8, CYP2C9, CYP2C19, and aromatase (CYP19). Dibenzylfluorescein is typically used near its Km value of 0.87-1.9 μM (Ex=485 nm，Em=535 nm). Dibenzylfluorescein is used to detect changes in CYP catalytic activity caused by drugs or disease .
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- HY-P2296
-
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Fluorescent Dye
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Others
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Abz-FRLKGGAPIKGV-EDDNP TFA is a fluorogenic substrate used to measure the enzymatic activities of protease forms, such as papain-like protease 2 (PLP2) from severe acute respiratory syndrome coronavirus (SARS-CoV). Abz-FRLKGGAPIKGV-EDDNP TFA has the potential for study 2019-nCoV (COVID-19) infection .
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- HY-D1632
-
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Fluorescent Dye
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Others
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4-MU-α-GlcNS sodium is a fluorogenic substrate of heparin sulphamidase, is desulfurized into 4-MU-α-GlcNH2. 4-MU-α-GlcNH2 can liberate 4-methylumbelliferone (4-MU, fluorescent product) via α-glucosaminidase catalysis, with the emission wavelength maxima of 445-454 nm. 4-MU-α-GlcNS sodium can be used to heparin sulphamidase deficiencies associated with Mucopolisaccaridosis IIIA and other lysosomal disorders researches .
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- HY-P4737
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- HY-P1448
-
-
- HY-D0719
-
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3,6-Diacetoxyfluoran; Di-O-acetylfluorescein
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Biochemical Assay Reagents
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Others
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Fluorescein diacetate is a cell permeable esterase-substrate. Fluorescein diacetate can be used as a fluorogenic substrate for hGSTP1-1.
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- HY-P10240
-
-
- HY-P10050
-
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Proteasome
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Others
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Calpain substrate is the membrane non-permeable fluorogenic calpain substrate and can be used in Calpain enzymatic activity assay .
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- HY-D1740
-
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DHTM Ros
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Fluorescent Dye
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Others
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Dihydrotetramethylrosamine (DHTM Ros) is a fluorogenic substrate for peroxidase that oxidizes to fluorescent tetramethylrosamine chloride.
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-
- HY-101880
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ADHP
1 Publications Verification
10-Acetyl-3,7-dihydroxyphenoxazine
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Fluorescent Dye
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Others
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ADHP is a fluorogenic peroxidase substrate (λex=530 nm, λem=590 nm).
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-
- HY-153104
-
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Sirtuin
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Cancer
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CrBKA is a fluorogenic small-molecule substrate of SIRT6 with weak activity .
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- HY-P3364
-
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Sirtuin
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Others
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Ac-QPKK(Ac)-AMC is a fluorogenic substrate for sirtuin through sirtuin deacetylation .
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- HY-P1005
-
-
- HY-P2614
-
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Caspase
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Others
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Mca-DEVDAP-K(Dnp)-OH is a fluorogenic substrate for caspase-3 .
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- HY-P4312
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- HY-P4426
-
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Fluorescent Dye
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Others
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Lys-Pro-AMC is a fluorogenic substrate for the detection and measurement of the activity of specific enzymes .
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- HY-P4426A
-
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Fluorescent Dye
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Others
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Lys-Pro-AMC diTFA is a fluorogenic substrate for the detection and measurement of the activity of specific enzymes .
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- HY-P4319
-
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Fluorescent Dye
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Others
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Boc-Glu-Lys-Lys-AMC is a sensitive fluorogenic substrate for urokinase-activated plasmin .
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-
- HY-W283359
-
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Fluorescent Dye
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Others
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4-Methylumbelliferyl β-D-ribofuranoside is a fluorogenic substrate of β-ribosidase .
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-
- HY-P4777
-
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Dabcyl-CMV-Edans
|
Fluorescent Dye
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Infection
|
|
Dabcyl-RGVVNASSRLA-Edans (Dabcyl-CMV-Edans) is a fluorogenic substrate for human cytomegalovirus (HCMV) protease .
|
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- HY-P1853
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-
- HY-D1634
-
|
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Cathepsin
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Others
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Bz-FVR-AMC is a fluorogenic substrate for procathepsin with a kcat/Km value of 1070 mM -1s -1. The high concentration of BZ-FVR-AMC inhibits the substrate .
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-
- HY-P4339
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Fluorescent Dye
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Others
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Ala-Phe-Lys-AMC is a fluorogenic substrate, which can be used for residual plasmin activity assay .
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-
- HY-P4448
-
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Fluorescent Dye
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Others
|
|
Ac-Gly-Pro-AFC is a fluorogenic substrate for the determination of fibroblast activation protein (FAP) endopeptidase activity .
|
-
- HY-P4367
-
|
|
Fluorescent Dye
|
Others
|
|
TRH-AMC is a fluorogenic substrate used in a coupled assay for thyrotropin-releasing hormone(TRH)-degrading ectoenzyme .
|
-
- HY-D1634A
-
|
|
Cathepsin
|
Others
|
|
Bz-FVR-AMC TFA is a fluorogenic substrate for procathepsin with a kcat/Km value of 1070 mM -1s -1. The high concentration of BZ-FVR-AMC inhibits the substrate .
|
-
- HY-P5983
-
|
|
Caspase
|
Cancer
|
|
Ac-VEID-AFC is a caspase-6 fluorogenic substrate, and can be used in the caspase 6 activity assay .
|
-
- HY-P4326
-
|
|
Fluorescent Dye
|
Others
|
|
Boc-Val-Pro-Arg-MCA is a sensitive fluorogenic substrate for measuring trypsin-like serine proteases activity .
|
-
- HY-P4449
-
|
|
Caspase
|
Cancer
|
|
Ac-VRPR-AMC is a fluorogenic metacaspase substrate. Ac-VRPR-AMC can be used to tests metacaspase activity .
|
-
- HY-137784
-
|
|
Fluorescent Dye
|
Others
|
|
Boc-Val-Pro-Arg-AMC hydrochloride is a sensitive fluorogenic substrate for measuring trypsin-like serine proteases activity .
|
-
- HY-D0719R
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Fluorescein Diacetate (Standard) is the analytical standard of Fluorescein Diacetate. This product is intended for research and analytical applications. Fluorescein diacetate is a cell permeable esterase-substrate. Fluorescein diacetate can be used as a fluorogenic substrate for hGSTP1-1.
|
-
- HY-129867
-
|
Z-LLL-AMC
|
Proteasome
|
Others
|
|
Z-Leu-Leu-Leu-AMC is a fluorogenic substrate for measuring the chymotrypsin-like protease activity of the 20S proteasome .
|
-
- HY-127008
-
|
|
Fluorescent Dye
|
Others
|
|
N-Butylfluorescein is an alkyl-substituted fluorescein, can be used for synthesis of fluorogenic substrates for assaying phosphatidylinositol-specific phospholipase C .
|
-
- HY-101895
-
|
FDG
|
Fluorescent Dye
|
Others
|
|
Fluorescein di(β-D-galactopyranoside) is a fluorogenic substrate for β-galactosidase (λex=485 nm, λem=535 nm).
|
-
- HY-137164
-
|
|
Endogenous Metabolite
|
Others
|
|
Ala-Ala-Phe-AMC serves as a fluorogenic substrate that exhibits positively charged properties, making it suitable for assessing proteolytic activity.
|
-
- HY-P4548
-
|
Boc-RVRR-AMC
|
Furin
|
Others
|
|
Boc-Arg-Val-Arg-Arg-AMC hydrochloride (Boc-RVRR-AMC) is a synthetic fluorogenic substrate that is efficiently cleaved by furin .
|
-
- HY-129887
-
|
|
Fluorescent Dye
|
Others
|
|
Fluorescein diphosphate tetraammonium is a fluorescent dye, it can be used as a fluorogenic substrate and generats fluorescein as a fluorescent product .
|
-
- HY-P4547
-
|
AC-WEHD-AMC
|
Caspase
|
Others
|
|
Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) is a potent fluorogenic substrate of caspase-1 .
|
-
- HY-D1530
-
|
|
Fluorescent Dye
|
Others
|
|
4-Methylumbelliferyl-N-acetyl-α-D-glucosaminide is a fluorogenic substrate for detecting α-N-acetylglucosaminidase .
|
-
- HY-P3115
-
-
- HY-P4449A
-
|
|
Caspase
|
Cancer
|
|
Ac-VRPR-AMC TFA is a fluorogenic metacaspase substrate. Ac-VRPR-AMC TFA can be used to assay metacaspase activity .
|
-
- HY-P1729
-
-
- HY-P1002
-
-
- HY-P2616
-
-
- HY-P2616A
-
-
- HY-P5280
-
|
|
Ser/Thr Protease
|
Others
|
|
Ac-KQL-AMC is a fluorogenic substrate that can be used to quantify Trypsin-like activity, resulting in detectable fluorescence when cleaved by the proteasome .
|
-
- HY-D1079
-
|
|
DNA Stain
|
Others
|
|
EDANS sodium is a potent fluorogenic substrates. EDANS sodium is a donor for FRET-based nucleic acid probes and protease substrates. EDANS sodium is often paired with DABCYL or DABSYL. The optimal absorbance and emission wavelengths of EDANS sodium are λabs = 336 nm and λem = 490 nm respectively .
|
-
- HY-P5354
-
|
|
Fluorescent Dye
|
Others
|
|
FRETS-VWF73, a 73-amino-acid peptide, is a fluorogenic substrate for ADAMTS13 assay (Ex=340 nm; Em=450 nm). .
|
-
- HY-P2237
-
-
- HY-P4725
-
|
|
Fluorescent Dye
|
Others
|
|
Abz-Thr-Ile-Nle-p-nitro-Phe-Gln-Arg-NH2 is a fluorogenic substrate, that can be used for the fluorescence screening assay .
|
-
- HY-P4209A
-
|
|
Virus Protease
|
Others
|
|
Boc-GRR-AMC (TFA) is a tri-peptide Substrate. Boc-GRR-AMC can be used for a fluorogenic West Nile virus (WNV) substrate, profiling the substrate specificity for the NS2B-NS3 proteases or determining the pH optimum of LdMC activity .
|
-
- HY-120659
-
|
|
Fluorescent Dye
|
Others
|
|
Gly-Gly-AMC is a fluorogenic peptide substrate. Gly-Gly-AMC can be used to assess bacterial protease activity of P. aeruginosa and S. aureus .
|
-
- HY-P2008
-
|
IEGR-AMC
|
Factor Xa
|
Cardiovascular Disease
|
|
Boc-Ile-Glu-Gly-Arg-AMC (IEGR-AMC) is an activated factor X (FXa) specific fluorogenic peptide substrate used for Factor VIII determination .
|
-
- HY-D1026
-
|
3-Carboxyumbelliferyl-β-D-galactopyranoside
|
Fluorescent Dye
|
Others
|
|
CUG (3-Carboxyumbelliferyl-β-D-galactopyranoside) is a fluorogenic substrate (λex=386, λem=445 nm, ε=32K).
|
-
- HY-137853
-
|
|
Fluorescent Dye
|
Others
|
|
4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside is a fluorogenic substrate for N-acetyl-β-D-glucosaminidase .
|
-
- HY-P4360
-
|
|
Fluorescent Dye
|
Others
|
|
Suc-Ala-Phe-Lys-AMC is a highly sensitive fluorogenic substrate for plasmin. Suc-Ala-Phe-Lys-AMC is also used for assaying gingipain K .
|
-
- HY-P3120
-
|
|
MMP
|
Others
|
|
Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 is a fluorogenic substrate for matrix metalloproteinase-14 (MMP-14).
|
-
- HY-P0019
-
-
- HY-D1532
-
|
|
Parasite
|
Others
|
|
DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS is a fluorescent dye, and can be applied in a fluorogenic substrate for an aspartyl proteinase from human malaria parasite .
|
-
- HY-P0019A
-
|
|
Fluorescent Dye
Thrombin
|
Others
|
|
Z-Gly-Gly-Arg-AMC acetate is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP) (Ex/Em = 390/480 nm) .
|
-
- HY-116141
-
|
7-HCA; Umbelliferyl Arachidonate; 7-HC-arachidonate
|
Phospholipase
MAGL
|
Others
|
|
7-Hydroxycoumarinyl arachidonate (7-HCA) is a fluorogenic substrate of cytosolic phospholipase A2 (PLA2). 7-Hydroxycoumarinyl arachidonate is also a fluorogenic substrate for monoacylglycerol lipase (MAGL). MAGL protein catalyzes the hydrolysis of 7-Hydroxycoumarinyl arachidonat to generate Arachidonic acid (AA) and the highly fluorescent 7-hydroxyl coumarin (7-HC; HY-N0573). Release of 7-HC can be measured using a fluorometer .
|
-
- HY-D0994A
-
|
4-MUP disodium; MUP disodium
|
Phosphatase
|
Others
|
|
4-Methylumbelliferyl phosphate (4-MUP) disodium, an anionic organophosphate, is a acid and alkaline phosphatase fluorogenic substrate. 4-Methylumbelliferyl phosphate disodium is also a nerve agent simulant .
|
-
- HY-117095
-
|
|
Fluorescent Dye
|
Metabolic Disease
|
|
4-Methylumbelliferyl oleate is a fluorogenic substrate for acid and alkaline lipases. 4-Methylumbelliferyl oleate is cleaved by lipases, liberating 4-Methylumbelliferyl (Ex/Em=320/450 nm) .
|
-
- HY-115391
-
|
Boc-Leu-Arg-Arg-AMC
|
Biochemical Assay Reagents
|
Others
|
|
Boc-LRR-AMC (Boc-Leu-Arg-Arg-AMC) is a fluorogenic substrate, which can be utilized for detecting the trypsin-like activity of the 26S proteasome or the 20S proteasome core .
|
-
- HY-P4310
-
|
|
Ser/Thr Protease
|
Others
|
|
Boc-Val-Leu-Lys-AMC is a sensitive, fluorogenic, and specific substrate of plasmin, as well as acrosin from the ascidian Halocynthia roretzi, porcine calpain isozymes I and II, and papain .
|
-
- HY-D1647
-
|
|
Phospholipase
|
Others
|
|
7-Hydroxycoumarinyl-γ-linolenate is a cytosolic phospholipase A2 (cPLA2) fluorogenic substrate. 7-Hydroxycoumarinyl-γ-linolenate can be used to monitor the enzymatic activity of cPLA2 .
|
-
- HY-137164A
-
|
|
Fluorescent Dye
|
Others
|
|
Ala-Ala-Phe-AMC TFA is the TFA salt form for Ala-Ala-Phe-AMC. Ala-Ala-Phe-AMC TFA is a fluorogenic substrate, which is used to for tripeptidyl peptidase II (TPPII) activity determination .
|
-
- HY-137337
-
|
|
Fluorescent Dye
|
Others
|
|
Suc-Ala-Ala-Phe-AMC is a fluorogenic chymotrypsin substrate, can be hydrolyzed by endopeptidase. Suc-Ala-Ala-Phe-AMC has been used in both in vivo assays of the acrosome reaction and in vitro enzyme assays .
|
-
- HY-P4417A
-
|
|
Fluorescent Dye
|
Others
|
|
Ac-IEPD-AMC TFA is a fluorescent substrate used to measure protease activity. Ac-IEPD-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC fluoresces under UV light irradiation and can emit fluorescent signals .
|
-
- HY-P5123
-
|
|
Angiotensin Receptor
|
Others
|
|
Arg-Glu(edans)-Ile-His-Pro-Phe-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(dabcyl)-Ar is a fluorogenic renin substrate based on the N-terminal tetradecapeptide sequence of human angiotensinogen (hTDP) .
|
-
- HY-P5123A
-
|
|
Angiotensin Receptor
|
Others
|
|
Arg-Glu(edans)-Ile-His-Pro-Phe-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(dabcyl)-Ar TFA is a fluorogenic renin substrate based on the N-terminal tetradecapeptide sequence of human angiotensinogen (hTDP) .
|
-
- HY-P5202
-
|
|
Amino Acid Derivatives
|
Others
|
|
H-Gly-Gly-Arg-AMC is a fluorogenic peptidyl-AMC substrate containing C-terminal 7-amino-4-methylcoumarin (AMC). H-Gly-Gly-Arg-AMC is a suitable for monitoring continuous thrombin generation (TGT) .
|
-
- HY-131127
-
|
AMQI
|
Cholinesterase (ChE)
|
Others
|
|
7-Acetoxy-1-methylquinolinium iodide (AMQI) is a fluorogenic substrate for cholinesterase (Ex = 320 nm, Em = 410 nm). Hydrolysis of 7-acetoxy-1-methylquinolinium iodide is used at the fluorometric flow system for the detection and identification of inhibitors. .
|
-
- HY-135070
-
|
Ac-Arg-Leu-Arg-AMC
|
Proteasome
|
Others
|
|
Ac-RLR-AMC (Ac-Arg-Leu-Arg-AMC) is a fluorogenic substrate for the 26S proteasome (Ex/Em: 380/440-460 nm). AMC is released upon cleavage, and its fluorescence can be used to quantify the trypsin-like activity of 26S proteasomes .
|
-
- HY-P5415
-
|
|
HIV
|
Others
|
|
DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS is a biological active peptide. (DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS is also called HIV protease substrate I in some literature. It is widely used for the continuous assay for HIV protease activity. The 11-kD protease (PR) encoded by the human immunodeficiency virus 1 (HIV-1) is essential for the correct processing of viral polyproteins and the maturation of infectious virus, and is therefore a target for the design of selective acquired immunodeficiency syndrome (AIDS) therapeutics. The FRET-based fluorogenic substrate is derived from a natural processing site for HIV-1 PR. Incubation of recombinant HIV-1 PR with the fluorogenic substrate resulted in specific cleavage at the Tyr-Pro bond and a time-dependent increase in fluorescence intensity that is linearly related to the extent of substrate hydrolysis. The fluorescence quantum yields of the HIV-1 PR substrate in the FRET assay increased by 40.0- and 34.4-fold, respectively, per mole of substrate cleaved. Because of its simplicity and precision in the determination of reaction rates required for kinetic analysis, this substrate offers many advantages over the commonly used HPLC or electrophoresis-based assays for peptide substrate hydrolysis by retroviral PRs. Abs/Em = 340nm/490nm.)
|
-
- HY-P3110
-
|
|
Fluorescent Dye
|
Others
|
|
Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity .
|
-
- HY-135070B
-
|
Ac-Arg-Leu-Arg-AMC TFA
|
Proteasome
|
Others
|
|
Ac-RLR-AMC (Ac-Arg-Leu-Arg-AMC) TFA is a fluorogenic substrate for the 26S proteasome (Ex/Em: 380/440-460 nm). AMC is released upon cleavage, and its fluorescence can be used to quantify the trypsin-like activity of 26S proteasomes .
|
-
- HY-D1652
-
|
|
Caspase
|
Others
|
|
Ac-LEHD-AMC is a fluorogenic substrate for caspase-9 (Excitation: 341 nm; Emission: 441 nm). Caspase-9 can induce hydrolysis of Ac-LEHD-AMC, resulting in the release of AMC fluorophore and its fluorescence can be used to quantify caspase-9 activity .
|
-
- HY-D1341
-
|
|
Fluorescent Dye
|
Cancer
|
|
Coumberone is a metabolic fluorogenic probe, and isoform-selective substrate for all AKR1C isoforms. Coumberone can be reduced by all four members of the AKR1C family to its fluorescent alcohol coumberol. Coumberone can be used for the research of AKR1C .
|
-
- HY-P4931A
-
|
|
Fluorescent Dye
|
Others
|
|
Mca-KPLGL-Dap(Dnp)-AR-NH2 TFA is a fluorogenic substrate for matrix metalloproteinases (MMPs). 7-methoxycoumarin-4 acetyl (Mac) is released and its fluorescence can be used to quantify MMP activity. Mac displays Ex/Em of 328/420 nm .
|
-
- HY-D0055
-
|
|
Cytochrome P450
|
Others
|
|
3-Cyano-7-ethoxycoumarin is a fluorogenic cytochrome P-450 substrate that generates blue fluorescent product upon enzyme cleavage
Target: Cytochrome P450
3-Cyano-7-ethoxycoumarin is a fluorescent probe useful in microsomal dealkylase studies.
|
-
- HY-W753820A
-
|
Boc-Leu-Arg-Arg-AMC TFA
|
Biochemical Assay Reagents
|
Others
|
|
Boc-LRR-AMC TFA (Boc-Leu-Arg-Arg-AMC TFA) is the TFA salt form of Boc-LRR-AMC (HY-115391). Boc-LRR-AMC TFA is a fluorogenic substrate, which can be utilized for detecting the trypsin-like activity of the 26S proteasome or the 20S proteasome core .
|
-
- HY-P2628
-
|
|
Fluorescent Dye
|
Others
|
|
Dabcyl-YVADAPV-EDANS is a fluorogenic interleukin-1β converting enzyme (ICE) substrate for measuring ICE-like protease activity. Dabcyl-YVADAPV-EDANS detects fluorescence at 360 nm excitation and 480 nm emission wavelengths. ICE-like protease is a critical mediator of K + deprivation-induced apoptosis of cerebellar granule neurons .
|
-
- HY-D0146
-
|
BzRes; 7-Benzyloxyresorufin; 7-Benzyloxyphenoxazone
|
Fluorescent Dye
|
Others
|
|
Resorufin benzyl ether (BzRes), a fluorogenic enzyme substrate, can be used to detect CYP3A4 enzyme activity. Resorufin benzyl ether modified with a recognizing moiety boronate, can be used for ONOO - detection via a self-immolation mechanism. Ex/Em=530-570 nm/590 nm .
|
-
- HY-P0019B
-
|
|
Fluorescent Dye
Thrombin
|
Others
|
|
Z-Gly-Gly-Arg-AMC TFA is the TFA salt form of Z-Gly-Gly-Arg-AMC (HY-P0019). Z-Gly-Gly-Arg-AMC TFA is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP) (Ex/Em = 390/480 nm) .
|
-
- HY-P1986
-
|
|
Caspase
|
Cancer
|
|
Z-DEVD-AFC is a cell-permeant substrate for caspase-3, which causes a shift in fluorescence uponcleavage of the AFC fluorophore. Z-DEVD-AFC can be used to detect caspase-3-like enzymes activity .
|
-
- HY-P4403
-
|
(Z-Asp-Glu-Val-Asp)₂-Rhodamine 110
|
Fluorescent Dye
Apoptosis
Caspase
|
Others
|
|
Z-DEVD-R110 ((Z-Asp-Glu-Val-Asp)2-Rhodamine 110) is a fluorogenic caspase-3/7 substrate. Z-DEVD-R110 can be used to detect apoptosis. Z-DEVD-R110 is a rhodamine derivative with two four–amino acid (DEVD) peptides linked to the fuorophore .
|
-
- HY-P5272
-
|
|
Bacterial
|
Inflammation/Immunology
|
|
Histatin-3 TFA, a 32 amino acid peptide, possesses powerful antimicrobial properties. Histatin-3 TFA behaves as a substrate for proprotein convertase 1 (PC1), being cleaved by this endoprotease primarily at a site carboxy terminal to the single Arg25 residue (HRGYR decrease SN). Histatin-3 TFA is a moderately potent, reversible and competitive inhibitor of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate, with an estimated inhibition constant Ki of 1.98 μM .
|
-
- HY-P3106
-
|
(Z-Ala-Ala-Ala-Ala)2Rhodamine110; bis-CBZ-L-alanyl-L-arginine amide Rhodamine 110
|
Fluorescent Dye
|
Others
|
|
(Z-Ala-Ala-Ala-Ala)2Rh110 is a sensitive fluorogenic elastase substrate. The colorless and nonfluorescent (Z-Ala-Ala-Ala-Ala)2Rh110 is selectively cleaved by elastase to yield the highly fluorescent compound rhodamine 110, which can be analyzed with an excitation wavelength of 485 nm and emission wavelength of 525 nm.
|
-
- HY-P2176A
-
|
Z-Leu-Arg-Gly-Gly-AMC TFA
|
Fluorescent Dye
|
Others
|
|
Z-LRGG-AMC TFA is the trifluoroacetate salt of Z-LRGG-AMC (HY-P2176). Z-LRGG-AMC TFA is a fluorogenic substrate for isopeptidase T. Upon cleavage of Z-LRGG-AMC TFA by isopeptidase T, 7-amino-4-methylcoumarin (AMC) is released, and its fluorescence can be used to quantify isopeptidase T activity (Ex/Em : 360/460 nm) .
|
-
- HY-W776853
-
|
|
Biochemical Assay Reagents
|
|
|
4-Methylumbelliferyl β-DN,N',N'',N'''-tetraacetylchitotetraoside is a fluorogenic substrate with activity for lysozyme assays. 4-Methylumbelliferyl β-DN,N',N'',N'''-tetraacetylchitotetraoside can be used to study enzyme activity and its applications in biomedicine. 4-Methylumbelliferyl β-DN,N',N'',N'''-tetraacetylchitotetraoside exhibits high sensitivity in analyzing enzyme reactions in biological samples.
|
-
- HY-169491
-
|
|
Fluorescent Dye
|
Metabolic Disease
|
|
Pantothenate-AMC is a fluorogenic substrate used for detecting the enzymatic activity of vanin-1, an enzyme involved in the recycling of L-pantothenic acid. Upon enzymatic cleavage by vanin-1, 7-amino-7-methylcoumarin (AMC) is released, and its fluorescence can be used to quantify vanin-1 activity. The excitation/emission maxima of AMC are 340-360 nm and 440-460 nm, respectively .
|
-
- HY-P3098
-
|
|
MMP
|
Others
|
|
Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1), MMP-3, and MMP-26. Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 can be used to quantify MMP-1, MMP-3 and MMP-26 activity .
|
-
- HY-P5380
-
|
Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2
|
MMP
|
Others
|
|
TNO211 is a biological active peptide. (Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.This peptide is a highly soluble fluorogenic MMP substrate for MMP-2, 8, 12, 13 and 14, containing the MMP cleavable Gly-Leu bond and EDANS/DABCYL. Fluorogenic assays using TNO211 are sensitive and can detect MMP activity in culture medium from endothelial cells and untreated synovial fluid from patients. Abs/Em = 340/490 nm.)
|
-
- HY-123000
-
|
|
Biochemical Assay Reagents
|
|
|
4-Methylumbelliferyl 2-acetamido-2-deoxy-α-D-galactopyranoside is a fluorogenic substrate for studying the enzymatic activity of α-galactosidase. 4-Methylumbelliferyl 2-acetamido-2-deoxy-α-D-galactopyranoside is used to analyze enzyme activity in various biological samples, helping scientists gain insight into the function of the enzyme in vivo. 4-Methylumbelliferyl 2-acetamido-2-deoxy-α-D-galactopyranoside can also be used to screen potential compounds to inhibit or activate this enzyme.
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-116583
-
|
|
Fluorescent Dyes/Probes
|
|
Resorufin butyrate is a fluorogenic substrate for triglyceride lipases and cholinesterase (Ex=570 nm, Em=580 nm) .
|
-
- HY-134432B
-
|
|
Dyes
|
|
Boc-Gln-Ala-Arg-AMC acetate is a fluorogenic substrate for trypsin. Boc-Gln-Ala-Arg-AMC acetate can also be used for measuring the proteolytic activity of TMPRSS2 .
|
-
- HY-D1705
-
|
|
Fluorescent Dyes/Probes
|
|
Ac-ANW-AMC is a fluorogenic substrate for immunoproteasome. Ac-ANW-AMC can be used to measure β5i activity (Ex=345 nm, Em=445 nm) .
|
-
- HY-134435
-
|
|
Fluorescent Dyes/Probes
|
|
Z-Arg-AMC hydrochloride is a fluorogenic substrate for trypsin and papain. Z-Arg-AMC hydrochloride can be used to research activity of trypsin (Ex/Em=355/460 nm) .
|
-
- HY-D0994
-
|
4-MUP; MUP
|
Chromogenic Substrates
|
|
4-Methylumbelliferyl phosphate (4-MUP), an anionic organophosphate, is a acid and alkaline phosphatase fluorogenic substrate. 4-Methylumbelliferyl phosphate is also a nerve agent simulant .
|
-
- HY-D2284
-
|
Sphingosine-1-phosphate lyase fluorogenic substrate
|
Fluorescent Dyes/Probes
|
|
SGPL1 fluorogenic substrate is the fluorogenic substrate of sphingosine-1-phosphate lyase (SGPL1) that can be used to measure the activity of SGPL1 .
|
-
- HY-W357142
-
-
- HY-137928
-
-
- HY-P3484
-
|
|
Fluorescent Dyes/Probes
|
|
Dnp-PLGLWA-DArg-NH2 TFA is a fluorogenic substrate for MMP-1 and MMP-9. Dnp-PLGLWA-DArg-NH2 TFA can be used to quantify the activity of MMPs (Ex=280 nm, Em=360 nm) .
|
-
- HY-P3475
-
|
|
Fluorescent Dyes/Probes
|
|
Mca-VDQMDGWK-(Dnp)-NH2 is a fluorogenic substrate for caspase-3 and can be used to quantify caspase-3 activity .
|
-
- HY-123051
-
-
- HY-136865
-
|
|
Fluorescent Dyes/Probes
|
|
MeOSuc-AAPV-AMC is a fluorogenic substrate for human leukocyte and porcine pancreatic elastase (Km: 362 μM, Ex=380 nm, Em=460 nm) .
|
-
- HY-P1169
-
|
|
Fluorescent Dyes/Probes
|
|
Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B .
|
-
- HY-P3362
-
|
|
Fluorescent Dyes/Probes
|
|
Ac-IETD-AMC is a fluorogenic caspase-8/granzyme B substrate containing the acetyl (Ac) moiety. Ac-IETD-AMC is frequently used to measure caspase-8 activity .
|
-
- HY-113862
-
|
|
Dyes
|
|
PHOME is a fluorogenic substrate for sEH. sEH can hydrolyze the epoxy ring in the PHOME substrate. PHOME can be used for fluorescent epoxide hydrolase assay .
|
-
- HY-W354821
-
-
- HY-D1080
-
EDANS
1 Publications Verification
1,5-EDANS
|
Fluorescent Dyes/Probes
|
|
EDANS (1,5-EDANS) is a novel and quenched fluorogenic substrate for assaying retroviral protease by resonance energy transfer (RET) .
|
-
- HY-P2536
-
|
|
Fluorescent Dyes/Probes
|
|
Mca-Ala-Pro-Lys(Dnp)-OH, a specific ACE2 quenched fluorogenic substrate, can be used to detect ACE2 activity, such as urinary, heart and lung .
|
-
- HY-D1670
-
-
- HY-P3749
-
|
|
Fluorescent Dyes/Probes
|
|
Mca-(ala7,lys(dnp)9)-bradykinin is a sensitive fluorogenic substrate for ECE-1 (endothelin-converting enzyme-1). The incorporation of a (7-methoxycoumarin-4-yl)acetyl (Mca) fluorescent group and a 2,4-dinitrophenyl (Dnp) quenching group has resulted in a large fluorescence increase upon substrate cleavage .
|
-
- HY-137844
-
|
Leu-AMC hydrochloride
|
Fluorescent Dyes/Probes
|
|
L-Leucine-7-amido-4-methylcoumarin (Leu-AMC) hydrochloride is a bright blue fluorogenic peptidyl substrate for LAP3 (leucine aminopeptidase). L-Leucine-7-amido-4-methylcoumarin hydrochloride can be used for leucine aminopeptidase inhibition assays in vitro .
|
-
- HY-116862
-
|
DBF
|
Fluorescent Dyes/Probes
|
|
Dibenzylfluorescein (DBF) is a fluorogenic probe (Fluoresecent dye) that acts as a substrate for specific cytochrome P450 (CYP) isoforms, including CYP3A4, CYP2C8, CYP2C9, CYP2C19, and aromatase (CYP19). Dibenzylfluorescein is typically used near its Km value of 0.87-1.9 μM (Ex=485 nm，Em=535 nm). Dibenzylfluorescein is used to detect changes in CYP catalytic activity caused by drugs or disease .
|
-
- HY-D1632
-
|
|
Fluorescent Dyes/Probes
|
|
4-MU-α-GlcNS sodium is a fluorogenic substrate of heparin sulphamidase, is desulfurized into 4-MU-α-GlcNH2. 4-MU-α-GlcNH2 can liberate 4-methylumbelliferone (4-MU, fluorescent product) via α-glucosaminidase catalysis, with the emission wavelength maxima of 445-454 nm. 4-MU-α-GlcNS sodium can be used to heparin sulphamidase deficiencies associated with Mucopolisaccaridosis IIIA and other lysosomal disorders researches .
|
-
- HY-P1448
-
-
- HY-D0719
-
|
3,6-Diacetoxyfluoran; Di-O-acetylfluorescein
|
Dyes
Enzyme Substrates
|
|
Fluorescein diacetate is a cell permeable esterase-substrate. Fluorescein diacetate can be used as a fluorogenic substrate for hGSTP1-1.
|
-
- HY-D1740
-
|
DHTM Ros
|
Fluorescent Dyes/Probes
|
|
Dihydrotetramethylrosamine (DHTM Ros) is a fluorogenic substrate for peroxidase that oxidizes to fluorescent tetramethylrosamine chloride.
|
-
- HY-101880
-
ADHP
1 Publications Verification
10-Acetyl-3,7-dihydroxyphenoxazine
|
Fluorescent Dyes/Probes
|
|
ADHP is a fluorogenic peroxidase substrate (λex=530 nm, λem=590 nm).
|
-
- HY-P1005
-
-
- HY-P2614
-
-
- HY-D1634
-
|
|
Chromogenic Substrates
|
|
Bz-FVR-AMC is a fluorogenic substrate for procathepsin with a kcat/Km value of 1070 mM -1s -1. The high concentration of BZ-FVR-AMC inhibits the substrate .
|
-
- HY-D0719R
-
|
|
Dyes
Enzyme Substrates
|
|
Fluorescein Diacetate (Standard) is the analytical standard of Fluorescein Diacetate. This product is intended for research and analytical applications. Fluorescein diacetate is a cell permeable esterase-substrate. Fluorescein diacetate can be used as a fluorogenic substrate for hGSTP1-1.
|
-
- HY-101895
-
|
FDG
|
Chromogenic Substrates
|
|
Fluorescein di(β-D-galactopyranoside) is a fluorogenic substrate for β-galactosidase (λex=485 nm, λem=535 nm).
|
-
- HY-129887
-
|
|
Fluorescent Dyes/Probes
|
|
Fluorescein diphosphate tetraammonium is a fluorescent dye, it can be used as a fluorogenic substrate and generats fluorescein as a fluorescent product .
|
-
- HY-D1530
-
|
|
Fluorescent Dyes/Probes
|
|
4-Methylumbelliferyl-N-acetyl-α-D-glucosaminide is a fluorogenic substrate for detecting α-N-acetylglucosaminidase .
|
-
- HY-P1002
-
|
|
Fluorescent Dyes/Probes
|
|
Suc-Leu-Leu-Val-Tyr-AMC is a membrane-permeable calpain-specific fluorogenic substrate (Ex/Em = 390/480 nm) .
|
-
- HY-P2616
-
|
|
Chromogenic Substrates
|
|
Mca-YVADAP-Lys(Dnp)-OH is a fluorogenic substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2) .
|
-
- HY-D1026
-
|
3-Carboxyumbelliferyl-β-D-galactopyranoside
|
Chromogenic Substrates
|
|
CUG (3-Carboxyumbelliferyl-β-D-galactopyranoside) is a fluorogenic substrate (λex=386, λem=445 nm, ε=32K).
|
-
- HY-P3120
-
|
|
Chromogenic Substrates
|
|
Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 is a fluorogenic substrate for matrix metalloproteinase-14 (MMP-14).
|
-
- HY-P0019
-
|
|
Chromogenic Substrates
|
|
Z-Gly-Gly-Arg-AMC is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP) (Ex/Em = 390/480 nm) .
|
-
- HY-D1532
-
|
|
Fluorescent Dyes/Probes
|
|
DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS is a fluorescent dye, and can be applied in a fluorogenic substrate for an aspartyl proteinase from human malaria parasite .
|
-
- HY-P0019A
-
|
|
Chromogenic Substrates
|
|
Z-Gly-Gly-Arg-AMC acetate is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP) (Ex/Em = 390/480 nm) .
|
-
- HY-D0994A
-
|
4-MUP disodium; MUP disodium
|
Chromogenic Substrates
|
|
4-Methylumbelliferyl phosphate (4-MUP) disodium, an anionic organophosphate, is a acid and alkaline phosphatase fluorogenic substrate. 4-Methylumbelliferyl phosphate disodium is also a nerve agent simulant .
|
-
- HY-D1647
-
|
|
Chromogenic Substrates
|
|
7-Hydroxycoumarinyl-γ-linolenate is a cytosolic phospholipase A2 (cPLA2) fluorogenic substrate. 7-Hydroxycoumarinyl-γ-linolenate can be used to monitor the enzymatic activity of cPLA2 .
|
-
- HY-P3110
-
|
|
Dyes
|
|
Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity .
|
-
- HY-D0055
-
|
|
Chromogenic Substrates
|
|
3-Cyano-7-ethoxycoumarin is a fluorogenic cytochrome P-450 substrate that generates blue fluorescent product upon enzyme cleavage
Target: Cytochrome P450
3-Cyano-7-ethoxycoumarin is a fluorescent probe useful in microsomal dealkylase studies.
|
-
- HY-P2628
-
|
|
Fluorescent Dyes/Probes
|
|
Dabcyl-YVADAPV-EDANS is a fluorogenic interleukin-1β converting enzyme (ICE) substrate for measuring ICE-like protease activity. Dabcyl-YVADAPV-EDANS detects fluorescence at 360 nm excitation and 480 nm emission wavelengths. ICE-like protease is a critical mediator of K + deprivation-induced apoptosis of cerebellar granule neurons .
|
-
- HY-D0146
-
|
BzRes; 7-Benzyloxyresorufin; 7-Benzyloxyphenoxazone
|
Dyes
|
|
Resorufin benzyl ether (BzRes), a fluorogenic enzyme substrate, can be used to detect CYP3A4 enzyme activity. Resorufin benzyl ether modified with a recognizing moiety boronate, can be used for ONOO - detection via a self-immolation mechanism. Ex/Em=530-570 nm/590 nm .
|
-
- HY-P1986
-
|
|
Fluorescent Dyes/Probes
|
|
Z-DEVD-AFC is a cell-permeant substrate for caspase-3, which causes a shift in fluorescence uponcleavage of the AFC fluorophore. Z-DEVD-AFC can be used to detect caspase-3-like enzymes activity .
|
-
- HY-P3098
-
|
|
Chromogenic Substrates
|
|
Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1), MMP-3, and MMP-26. Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 can be used to quantify MMP-1, MMP-3 and MMP-26 activity .
|
| Cat. No. |
Product Name |
Type |
-
- HY-D0719
-
|
3,6-Diacetoxyfluoran; Di-O-acetylfluorescein
|
Dyes
Enzyme Substrates
|
|
Fluorescein diacetate is a cell permeable esterase-substrate. Fluorescein diacetate can be used as a fluorogenic substrate for hGSTP1-1.
|
-
- HY-D0719R
-
|
|
Dyes
Enzyme Substrates
|
|
Fluorescein Diacetate (Standard) is the analytical standard of Fluorescein Diacetate. This product is intended for research and analytical applications. Fluorescein diacetate is a cell permeable esterase-substrate. Fluorescein diacetate can be used as a fluorogenic substrate for hGSTP1-1.
|
-
- HY-123000
-
|
|
Enzyme Substrates
|
|
4-Methylumbelliferyl 2-acetamido-2-deoxy-α-D-galactopyranoside is a fluorogenic substrate for studying the enzymatic activity of α-galactosidase. 4-Methylumbelliferyl 2-acetamido-2-deoxy-α-D-galactopyranoside is used to analyze enzyme activity in various biological samples, helping scientists gain insight into the function of the enzyme in vivo. 4-Methylumbelliferyl 2-acetamido-2-deoxy-α-D-galactopyranoside can also be used to screen potential compounds to inhibit or activate this enzyme.
|
-
- HY-W286423
-
|
|
Enzyme Substrates
|
|
L-Pyroglutamic acid 7-amido-4-methylcoumarin is a fluorogenic substrate for pyroglutamate aminopeptidase 1 (PGP-1) .
|
-
- HY-W283359
-
|
|
Carbohydrates
|
|
4-Methylumbelliferyl β-D-ribofuranoside is a fluorogenic substrate of β-ribosidase .
|
-
- HY-137164
-
|
|
Biochemical Assay Reagents
|
|
Ala-Ala-Phe-AMC serves as a fluorogenic substrate that exhibits positively charged properties, making it suitable for assessing proteolytic activity.
|
-
- HY-W776853
-
|
|
Enzyme Substrates
|
|
4-Methylumbelliferyl β-DN,N',N'',N'''-tetraacetylchitotetraoside is a fluorogenic substrate with activity for lysozyme assays. 4-Methylumbelliferyl β-DN,N',N'',N'''-tetraacetylchitotetraoside can be used to study enzyme activity and its applications in biomedicine. 4-Methylumbelliferyl β-DN,N',N'',N'''-tetraacetylchitotetraoside exhibits high sensitivity in analyzing enzyme reactions in biological samples.
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-134961
-
|
fluorogenic Proteasome substrate; Z-ARR-AMC
|
Proteasome
|
Others
|
|
Z-Ala-Arg-Arg-AMC (Fluorogenic Proteasome Substrate) is a fluorogenic substrate for assaying trypsin-like activity of proteasome .
|
-
- HY-P10189
-
-
- HY-P10191
-
|
|
Peptides
|
Others
|
|
β-Secretase Substrate-1, Fluorogenic is a fluorogenic substrate of β-Secretase that can be used to test β-Secretase activity .
|
-
- HY-P2179
-
|
|
Fluorescent Dye
MMP
|
Others
|
|
MMP-1/MMP-9 Substrate, Fluorogenic is a fluorogenic substrate for MMP-1 and MMP-9 .Ex/Em = 340/440 nm
|
-
- HY-P10163
-
|
|
Fluorescent Dye
|
Others
|
|
α-Secretase Substrate II, Fluorogenic is an internally quenched fluorogenic peptide substrate for α-Secretase that contains the α-secretase cleavage site of β-Amyloid precursor protein (APP) .Ex/Em = 340/490 nm
|
-
- HY-P2682
-
|
|
MMP
|
Metabolic Disease
|
|
MMP-8/MMP-26 Fluorogenic substrate (DNP-Pro-Leu-Ala-Tyr-Trp-Ala-Arg) is a matrix metalloproteinase-8 (MMP-8) fluorogenic substrate. MMP-8/MMP-26 Fluorogenic substrate can be used for the research of atherosclerosis, pulmonary fibrosis, and sepsis .
|
-
- HY-P10073
-
|
|
Fluorescent Dye
|
Others
|
|
Calpain-1 substrate, fluorogenic serves as a sensitive and specific substrate for calpain-1 that cleaves Tyr-Gly bond and results in enhanced fluorescence .(Ex/Em = 490 nm/518 nm)
|
-
- HY-W719799
-
-
- HY-P4366
-
-
- HY-P2689
-
|
|
Peptides
|
Others
|
|
DNP-PLGMWSR is a? fluorogenic substrate for MMP-2 and MMP-9 .
|
-
- HY-P2498A
-
|
|
Cathepsin
|
Cancer
|
|
Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D .
|
-
- HY-P2498
-
|
|
Cathepsin
|
Others
|
|
Cathepsin D and E FRET Substrate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D .
|
-
- HY-P5993
-
|
|
Fluorescent Dye
|
Others
|
|
MeOSuc-Ala-Ala-Pro-Val-4-MNA is a elastase fluorogenic substrate that can be detected at 425 nm (with excitation at 340 nm) .
|
-
- HY-P4334
-
|
Bz-Arg-Gly-Phe-Phe-Leu-4MβNA
|
Fluorescent Dye
|
Others
|
|
Bz-RGFFL-4MβNA (Bz-Arg-Gly-Phe-Phe-Leu-4MβNA) is a peptide and can be used fluorogenic substrate .
|
-
- HY-P3484
-
|
|
MMP
|
Cancer
|
|
Dnp-PLGLWA-DArg-NH2 TFA is a fluorogenic substrate for MMP-1 and MMP-9. Dnp-PLGLWA-DArg-NH2 TFA can be used to quantify the activity of MMPs (Ex=280 nm, Em=360 nm) .
|
-
- HY-P3699
-
|
|
Fluorescent Dye
|
Others
|
|
TNO003 is a selective fluorogenic substrate. TNO003 can be used for the research of various biochemical .
|
-
- HY-134432B
-
|
|
Ser/Thr Protease
|
Others
|
|
Boc-Gln-Ala-Arg-AMC acetate is a fluorogenic substrate for trypsin. Boc-Gln-Ala-Arg-AMC acetate can also be used for measuring the proteolytic activity of TMPRSS2 .
|
-
- HY-P3475
-
|
|
Fluorescent Dye
|
Others
|
|
Mca-VDQMDGWK-(Dnp)-NH2 is a fluorogenic substrate for caspase-3 and can be used to quantify caspase-3 activity .
|
-
- HY-P4427
-
|
|
Fluorescent Dye
|
Others
|
|
Z-VAN-AMC is a fluorogenic substrate. Z-VAN-AMC can be hydrolysed by a phytophagous mite of legumain-like activity .
|
-
- HY-123051
-
-
- HY-P3477
-
|
|
Fluorescent Dye
|
Others
|
|
Mca-PLA-Nva-Dap(Dnp)-AR-NH2 is a fluorogenic substrate for matrix metalloproteinase-2 (MMP-2) .
|
-
- HY-136865
-
|
|
Fluorescent Dye
|
Others
|
|
MeOSuc-AAPV-AMC is a fluorogenic substrate for human leukocyte and porcine pancreatic elastase (Km: 362 μM, Ex=380 nm, Em=460 nm) .
|
-
- HY-P5996
-
|
|
Fluorescent Dye
|
Others
|
|
MCA-Gly-Asp-Ala-Glu-pTyr-Ala-Ala-Lys(DNP)-Arg-NH2 is a protein tyrosine phosphatase fluorogenic substrate that can be detected at 393 nm (with excitation at 325 nm) .
|
-
- HY-P1169
-
|
|
Caspase
|
Others
|
|
Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B .
|
-
- HY-P3362
-
|
|
Fluorescent Dye
|
Others
|
|
Ac-IETD-AMC is a fluorogenic caspase-8/granzyme B substrate containing the acetyl (Ac) moiety. Ac-IETD-AMC is frequently used to measure caspase-8 activity .
|
-
- HY-P2617
-
|
|
Caspase
|
Inflammation/Immunology
Cancer
|
|
Ac-WEHD-AFC is a fluorogenic caspase-1 substrate. Ac-WEHD-AFC can measure caspase-1 fluorogenic activity and can be used for the research of tumor and inflammation .
|
-
- HY-P4466
-
|
|
HIV Protease
|
Infection
|
|
Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 is a fluorogenic substrate of HIV-1 protease. Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 can be used to test HIV-1 protease activity .
|
-
- HY-P3476
-
|
|
Fluorescent Dye
Caspase
|
Cancer
|
|
Mca-VDQVDGW-Lys(Dnp)-NH2 is a fluorogenic substrate of caspase-7. Mca-VDQVDGW-K(Dnp)-NH2 can be used to quantify caspase-7 activity.
|
-
- HY-P2617A
-
|
|
Caspase
|
Inflammation/Immunology
Cancer
|
|
Ac-WEHD-AFC TFA is a fluorogenic caspase-1 substrate. Ac-WEHD-AFC TFA can measure caspase-1 fluorogenic activity and can be used for the research of tumor and inflammation .
|
-
- HY-P4465
-
|
|
Fluorescent Dye
|
Others
|
|
Gly-Arg-pNA is a fluorogenic substrate for the measurement of protease activity. Gly-Arg-pNA undergoes hydrolysis and releases the fluorescent product p-nitroaniline. p-nitroaniline is in a fluorescent state under ultraviolet light irradiation and can emit a fluorescent signal .
|
-
- HY-P4331
-
|
|
Fluorescent Dye
Ser/Thr Protease
|
Cardiovascular Disease
|
|
Boc-Gln-Gly-Arg-AMC is a fluorogenic substrate for factor XIIa and trypsin. The cleavage of the amide bond between arginine and the methylcoumarin amide group releases fluorescent 7-Amino-4-methylcoumarin (HY-D0027) .
|
-
- HY-P2536
-
-
- HY-P4417
-
|
|
Fluorescent Dye
|
Others
|
|
Ac-IEPD-AMC is a fluorogenic substrate for the determination of protease activity. Ac-IEPD-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
|
-
- HY-P4419
-
|
|
Fluorescent Dye
|
Others
|
|
Boc-Asp(OBzl)-Pro-Arg-AMC is a fluorogenic substrate for the determination of protease activity. Boc-Asp(OBzl)-Pro-Arg-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). The excitation and emission wavelengths are 351 nm and 430 nm, respectively .
|
-
- HY-P2620
-
|
|
Fluorescent Dye
|
Metabolic Disease
Cancer
|
|
Ac-LETD-AFC is a caspase-8 fluorogenic substrate. Ac-LETD-AFC can measure caspase-8 fluorogenic activity and can be used for the research of cancer cell apoptosis and oxidative stress metabolism .
|
-
- HY-P4408
-
|
|
Fluorescent Dye
|
Others
|
|
Ac-Arg-Gly-Lys-AMC is a fluorogenic substrate for the determination of protease activity. Ac-Arg-Gly-Lys-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
|
-
- HY-P4323
-
|
|
Fluorescent Dye
|
Others
|
|
Boc-Gln-Arg-Arg-AMC is a fluorogenic substrate for the determination of protease activity. Boc-Gln-Arg-Arg-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
|
-
- HY-P4323A
-
|
|
Fluorescent Dye
|
Others
|
|
Boc-Gln-Arg-Arg-AMC acetate is a fluorogenic substrate for the determination of protease activity. Boc-Gln-Arg-Arg-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
|
-
- HY-P4333
-
|
|
Fluorescent Dye
|
Cardiovascular Disease
|
|
Boc-Glu(OBzl)-Gly-Arg-AMC is a fluorogenic substrate for factors IXa and XIIa. The cleavage of the amide bond between arginine and the methylcoumarin amide group releases fluorescent 7-Amino-4-methylcoumarin (HY-D0027) .
|
-
- HY-P4419A
-
|
|
Fluorescent Dye
|
Others
|
|
Boc-Asp(OBzl)-Pro-Arg-AMC acetate is a fluorogenic substrate for the determination of protease activity. Boc-Asp(OBzl)-Pro-Arg-AMC acetate undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
|
-
- HY-P4400
-
|
|
Fluorescent Dye
|
Others
|
|
Z-VDVAD-AFC is a fluorogenic substrate. Z-VDVAD-AFC is used to measure the activity of cysteine protease 3 (Caspase-3). Z-VDVAD-AFC undergoes hydrolysis to release 7-amino-4-trifluoromethylcoumarin (AFC). AFC is fluorescent under ultraviolet light and can emit fluorescent signals .
|
-
- HY-P4416
-
|
|
Fluorescent Dye
|
Others
|
|
Ac-Gly-Ala-Lys(Ac)-AMC is a fluorogenic substrate for the determination of protease activity. Ac-Gly-Ala-Lys(Ac)-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
|
-
- HY-P4332
-
|
|
Fluorescent Dye
Ser/Thr Protease
|
Cardiovascular Disease
|
|
Boc-Glu(OBzl)-Ala-Arg-AMC is a fluorogenic substrate for coagulation factor XIa and trypsin. The cleavage of the amide bond between arginine and the methylcoumarin amide group releases fluorescent 7-Amino-4-methylcoumarin (HY-D0027) .
|
-
- HY-P4406
-
|
|
Fluorescent Dye
|
Others
|
|
Abz-AGLA-Nba is a fluorogenic substrate for the determination of protease activity. Abz-AGLA-Nba is hydrolyzed to release aminoacyl benzimide (Abz-AGLA) and 2-naphthylaminoacyl (Nba). The product Abz-AGLA produced by this hydrolysis reaction is fluorescent under ultraviolet light and can emit a fluorescent signal .
|
-
- HY-P2295
-
|
|
SARS-CoV
|
Others
|
|
Dabcyl-KTSAVLQSGFRKME-Edans TFA is a fluorogenic peptide. Dabcyl-KTSAVLQSGFRKME-Edans TFA is used as the substrate to measure the enzymatic activities of protease forms. Dabcyl-KTSAVLQSGFRKME-Edans TFA has the potential for study 2019-nCoV (COVID-19) infection .
|
-
- HY-P3749
-
|
|
Fluorescent Dye
|
Others
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Mca-(ala7,lys(dnp)9)-bradykinin is a sensitive fluorogenic substrate for ECE-1 (endothelin-converting enzyme-1). The incorporation of a (7-methoxycoumarin-4-yl)acetyl (Mca) fluorescent group and a 2,4-dinitrophenyl (Dnp) quenching group has resulted in a large fluorescence increase upon substrate cleavage .
|
-
- HY-P2296
-
|
|
Fluorescent Dye
|
Others
|
|
Abz-FRLKGGAPIKGV-EDDNP TFA is a fluorogenic substrate used to measure the enzymatic activities of protease forms, such as papain-like protease 2 (PLP2) from severe acute respiratory syndrome coronavirus (SARS-CoV). Abz-FRLKGGAPIKGV-EDDNP TFA has the potential for study 2019-nCoV (COVID-19) infection .
|
-
- HY-P4737
-
-
- HY-P1448
-
-
- HY-P10240
-
- HY-P10050
-
|
|
Proteasome
|
Others
|
|
Calpain substrate is the membrane non-permeable fluorogenic calpain substrate and can be used in Calpain enzymatic activity assay .
|
- HY-P3364
-
|
|
Sirtuin
|
Others
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|
Ac-QPKK(Ac)-AMC is a fluorogenic substrate for sirtuin through sirtuin deacetylation .
|
- HY-P1005
-
- HY-P2614
-
|
|
Caspase
|
Others
|
|
Mca-DEVDAP-K(Dnp)-OH is a fluorogenic substrate for caspase-3 .
|
- HY-P4312
-
- HY-P4426
-
|
|
Fluorescent Dye
|
Others
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|
Lys-Pro-AMC is a fluorogenic substrate for the detection and measurement of the activity of specific enzymes .
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- HY-P4426A
-
|
|
Fluorescent Dye
|
Others
|
|
Lys-Pro-AMC diTFA is a fluorogenic substrate for the detection and measurement of the activity of specific enzymes .
|
- HY-P4319
-
|
|
Fluorescent Dye
|
Others
|
|
Boc-Glu-Lys-Lys-AMC is a sensitive fluorogenic substrate for urokinase-activated plasmin .
|
- HY-P2715
-
|
|
Peptides
|
Others
|
|
Boc-Leu-Ser-Thr-Arg-AMC is a fluorogenic AMC-linked protease substrate .
|
- HY-137811
-
|
Suc-Ala-Ala-Pro-Phe-AMC
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Peptides
|
Others
|
|
Suc-AAPF-AMC is an α-chymotrypsin fluorogenic substrate for the quantitative determination of chymotrypsin activity .
|
- HY-P4777
-
|
Dabcyl-CMV-Edans
|
Fluorescent Dye
|
Infection
|
|
Dabcyl-RGVVNASSRLA-Edans (Dabcyl-CMV-Edans) is a fluorogenic substrate for human cytomegalovirus (HCMV) protease .
|
- HY-P1853
-
- HY-P4339
-
|
|
Fluorescent Dye
|
Others
|
|
Ala-Phe-Lys-AMC is a fluorogenic substrate, which can be used for residual plasmin activity assay .
|
- HY-P4448
-
|
|
Fluorescent Dye
|
Others
|
|
Ac-Gly-Pro-AFC is a fluorogenic substrate for the determination of fibroblast activation protein (FAP) endopeptidase activity .
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- HY-P4367
-
|
|
Fluorescent Dye
|
Others
|
|
TRH-AMC is a fluorogenic substrate used in a coupled assay for thyrotropin-releasing hormone(TRH)-degrading ectoenzyme .
|
- HY-D1634A
-
|
|
Cathepsin
|
Others
|
|
Bz-FVR-AMC TFA is a fluorogenic substrate for procathepsin with a kcat/Km value of 1070 mM -1s -1. The high concentration of BZ-FVR-AMC inhibits the substrate .
|
- HY-P5983
-
|
|
Caspase
|
Cancer
|
|
Ac-VEID-AFC is a caspase-6 fluorogenic substrate, and can be used in the caspase 6 activity assay .
|
- HY-P4326
-
|
|
Fluorescent Dye
|
Others
|
|
Boc-Val-Pro-Arg-MCA is a sensitive fluorogenic substrate for measuring trypsin-like serine proteases activity .
|
- HY-P4449
-
|
|
Caspase
|
Cancer
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|
Ac-VRPR-AMC is a fluorogenic metacaspase substrate. Ac-VRPR-AMC can be used to tests metacaspase activity .
|
- HY-137784
-
|
|
Fluorescent Dye
|
Others
|
|
Boc-Val-Pro-Arg-AMC hydrochloride is a sensitive fluorogenic substrate for measuring trypsin-like serine proteases activity .
|
- HY-129867
-
|
Z-LLL-AMC
|
Proteasome
|
Others
|
|
Z-Leu-Leu-Leu-AMC is a fluorogenic substrate for measuring the chymotrypsin-like protease activity of the 20S proteasome .
|
- HY-P4548
-
|
Boc-RVRR-AMC
|
Furin
|
Others
|
|
Boc-Arg-Val-Arg-Arg-AMC hydrochloride (Boc-RVRR-AMC) is a synthetic fluorogenic substrate that is efficiently cleaved by furin .
|
- HY-P4547
-
|
AC-WEHD-AMC
|
Caspase
|
Others
|
|
Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) is a potent fluorogenic substrate of caspase-1 .
|
- HY-P3115
-
- HY-P4449A
-
|
|
Caspase
|
Cancer
|
|
Ac-VRPR-AMC TFA is a fluorogenic metacaspase substrate. Ac-VRPR-AMC TFA can be used to assay metacaspase activity .
|
- HY-P1729
-
- HY-P1002
-
- HY-P2616
-
- HY-P2616A
-
- HY-P5280
-
|
|
Ser/Thr Protease
|
Others
|
|
Ac-KQL-AMC is a fluorogenic substrate that can be used to quantify Trypsin-like activity, resulting in detectable fluorescence when cleaved by the proteasome .
|
- HY-P4209
-
|
|
Peptides
|
Others
|
|
Boc-GRR-AMC is a tri-peptide Substrate. Boc-GRR-AMC can be used for a fluorogenic West Nile virus (WNV) substrate, profiling the substrate specificity for the NS2B-NS3 proteases or determining the pH optimum of LdMC activity .
|
- HY-P5354
-
|
|
Fluorescent Dye
|
Others
|
|
FRETS-VWF73, a 73-amino-acid peptide, is a fluorogenic substrate for ADAMTS13 assay (Ex=340 nm; Em=450 nm). .
|
- HY-P2237
-
- HY-P4725
-
|
|
Fluorescent Dye
|
Others
|
|
Abz-Thr-Ile-Nle-p-nitro-Phe-Gln-Arg-NH2 is a fluorogenic substrate, that can be used for the fluorescence screening assay .
|
- HY-P4209A
-
|
|
Virus Protease
|
Others
|
|
Boc-GRR-AMC (TFA) is a tri-peptide Substrate. Boc-GRR-AMC can be used for a fluorogenic West Nile virus (WNV) substrate, profiling the substrate specificity for the NS2B-NS3 proteases or determining the pH optimum of LdMC activity .
|
- HY-P2008
-
|
IEGR-AMC
|
Factor Xa
|
Cardiovascular Disease
|
|
Boc-Ile-Glu-Gly-Arg-AMC (IEGR-AMC) is an activated factor X (FXa) specific fluorogenic peptide substrate used for Factor VIII determination .
|
- HY-P4360
-
|
|
Fluorescent Dye
|
Others
|
|
Suc-Ala-Phe-Lys-AMC is a highly sensitive fluorogenic substrate for plasmin. Suc-Ala-Phe-Lys-AMC is also used for assaying gingipain K .
|
- HY-P3120
-
|
|
MMP
|
Others
|
|
Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 is a fluorogenic substrate for matrix metalloproteinase-14 (MMP-14).
|
- HY-P0019
-
- HY-D1532
-
|
|
Parasite
|
Others
|
|
DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS is a fluorescent dye, and can be applied in a fluorogenic substrate for an aspartyl proteinase from human malaria parasite .
|
- HY-P0019A
-
|
|
Fluorescent Dye
Thrombin
|
Others
|
|
Z-Gly-Gly-Arg-AMC acetate is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP) (Ex/Em = 390/480 nm) .
|
- HY-115391
-
|
Boc-Leu-Arg-Arg-AMC
|
Biochemical Assay Reagents
|
Others
|
|
Boc-LRR-AMC (Boc-Leu-Arg-Arg-AMC) is a fluorogenic substrate, which can be utilized for detecting the trypsin-like activity of the 26S proteasome or the 20S proteasome core .
|
- HY-P4310
-
|
|
Ser/Thr Protease
|
Others
|
|
Boc-Val-Leu-Lys-AMC is a sensitive, fluorogenic, and specific substrate of plasmin, as well as acrosin from the ascidian Halocynthia roretzi, porcine calpain isozymes I and II, and papain .
|
- HY-137164A
-
|
|
Fluorescent Dye
|
Others
|
|
Ala-Ala-Phe-AMC TFA is the TFA salt form for Ala-Ala-Phe-AMC. Ala-Ala-Phe-AMC TFA is a fluorogenic substrate, which is used to for tripeptidyl peptidase II (TPPII) activity determination .
|
- HY-137337
-
|
|
Fluorescent Dye
|
Others
|
|
Suc-Ala-Ala-Phe-AMC is a fluorogenic chymotrypsin substrate, can be hydrolyzed by endopeptidase. Suc-Ala-Ala-Phe-AMC has been used in both in vivo assays of the acrosome reaction and in vitro enzyme assays .
|
- HY-P4417A
-
|
|
Fluorescent Dye
|
Others
|
|
Ac-IEPD-AMC TFA is a fluorescent substrate used to measure protease activity. Ac-IEPD-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC fluoresces under UV light irradiation and can emit fluorescent signals .
|
- HY-P5123
-
|
|
Angiotensin Receptor
|
Others
|
|
Arg-Glu(edans)-Ile-His-Pro-Phe-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(dabcyl)-Ar is a fluorogenic renin substrate based on the N-terminal tetradecapeptide sequence of human angiotensinogen (hTDP) .
|
- HY-P5123A
-
|
|
Angiotensin Receptor
|
Others
|
|
Arg-Glu(edans)-Ile-His-Pro-Phe-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(dabcyl)-Ar TFA is a fluorogenic renin substrate based on the N-terminal tetradecapeptide sequence of human angiotensinogen (hTDP) .
|
- HY-P5202
-
|
|
Amino Acid Derivatives
|
Others
|
|
H-Gly-Gly-Arg-AMC is a fluorogenic peptidyl-AMC substrate containing C-terminal 7-amino-4-methylcoumarin (AMC). H-Gly-Gly-Arg-AMC is a suitable for monitoring continuous thrombin generation (TGT) .
|
- HY-135070
-
|
Ac-Arg-Leu-Arg-AMC
|
Proteasome
|
Others
|
|
Ac-RLR-AMC (Ac-Arg-Leu-Arg-AMC) is a fluorogenic substrate for the 26S proteasome (Ex/Em: 380/440-460 nm). AMC is released upon cleavage, and its fluorescence can be used to quantify the trypsin-like activity of 26S proteasomes .
|
- HY-P5415
-
|
|
HIV
|
Others
|
|
DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS is a biological active peptide. (DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS is also called HIV protease substrate I in some literature. It is widely used for the continuous assay for HIV protease activity. The 11-kD protease (PR) encoded by the human immunodeficiency virus 1 (HIV-1) is essential for the correct processing of viral polyproteins and the maturation of infectious virus, and is therefore a target for the design of selective acquired immunodeficiency syndrome (AIDS) therapeutics. The FRET-based fluorogenic substrate is derived from a natural processing site for HIV-1 PR. Incubation of recombinant HIV-1 PR with the fluorogenic substrate resulted in specific cleavage at the Tyr-Pro bond and a time-dependent increase in fluorescence intensity that is linearly related to the extent of substrate hydrolysis. The fluorescence quantum yields of the HIV-1 PR substrate in the FRET assay increased by 40.0- and 34.4-fold, respectively, per mole of substrate cleaved. Because of its simplicity and precision in the determination of reaction rates required for kinetic analysis, this substrate offers many advantages over the commonly used HPLC or electrophoresis-based assays for peptide substrate hydrolysis by retroviral PRs. Abs/Em = 340nm/490nm.)
|
- HY-P3110
-
|
|
Fluorescent Dye
|
Others
|
|
Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity .
|
- HY-135070B
-
|
Ac-Arg-Leu-Arg-AMC TFA
|
Proteasome
|
Others
|
|
Ac-RLR-AMC (Ac-Arg-Leu-Arg-AMC) TFA is a fluorogenic substrate for the 26S proteasome (Ex/Em: 380/440-460 nm). AMC is released upon cleavage, and its fluorescence can be used to quantify the trypsin-like activity of 26S proteasomes .
|
- HY-P4931A
-
|
|
Fluorescent Dye
|
Others
|
|
Mca-KPLGL-Dap(Dnp)-AR-NH2 TFA is a fluorogenic substrate for matrix metalloproteinases (MMPs). 7-methoxycoumarin-4 acetyl (Mac) is released and its fluorescence can be used to quantify MMP activity. Mac displays Ex/Em of 328/420 nm .
|
- HY-W753820A
-
|
Boc-Leu-Arg-Arg-AMC TFA
|
Biochemical Assay Reagents
|
Others
|
|
Boc-LRR-AMC TFA (Boc-Leu-Arg-Arg-AMC TFA) is the TFA salt form of Boc-LRR-AMC (HY-115391). Boc-LRR-AMC TFA is a fluorogenic substrate, which can be utilized for detecting the trypsin-like activity of the 26S proteasome or the 20S proteasome core .
|
- HY-P2628
-
|
|
Fluorescent Dye
|
Others
|
|
Dabcyl-YVADAPV-EDANS is a fluorogenic interleukin-1β converting enzyme (ICE) substrate for measuring ICE-like protease activity. Dabcyl-YVADAPV-EDANS detects fluorescence at 360 nm excitation and 480 nm emission wavelengths. ICE-like protease is a critical mediator of K + deprivation-induced apoptosis of cerebellar granule neurons .
|
- HY-P0019B
-
|
|
Fluorescent Dye
Thrombin
|
Others
|
|
Z-Gly-Gly-Arg-AMC TFA is the TFA salt form of Z-Gly-Gly-Arg-AMC (HY-P0019). Z-Gly-Gly-Arg-AMC TFA is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP) (Ex/Em = 390/480 nm) .
|
- HY-P1986
-
|
|
Caspase
|
Cancer
|
|
Z-DEVD-AFC is a cell-permeant substrate for caspase-3, which causes a shift in fluorescence uponcleavage of the AFC fluorophore. Z-DEVD-AFC can be used to detect caspase-3-like enzymes activity .
|
- HY-P4403
-
|
(Z-Asp-Glu-Val-Asp)₂-Rhodamine 110
|
Fluorescent Dye
Apoptosis
Caspase
|
Others
|
|
Z-DEVD-R110 ((Z-Asp-Glu-Val-Asp)2-Rhodamine 110) is a fluorogenic caspase-3/7 substrate. Z-DEVD-R110 can be used to detect apoptosis. Z-DEVD-R110 is a rhodamine derivative with two four–amino acid (DEVD) peptides linked to the fuorophore .
|
- HY-P5272
-
|
|
Bacterial
|
Inflammation/Immunology
|
|
Histatin-3 TFA, a 32 amino acid peptide, possesses powerful antimicrobial properties. Histatin-3 TFA behaves as a substrate for proprotein convertase 1 (PC1), being cleaved by this endoprotease primarily at a site carboxy terminal to the single Arg25 residue (HRGYR decrease SN). Histatin-3 TFA is a moderately potent, reversible and competitive inhibitor of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate, with an estimated inhibition constant Ki of 1.98 μM .
|
- HY-P3106
-
|
(Z-Ala-Ala-Ala-Ala)2Rhodamine110; bis-CBZ-L-alanyl-L-arginine amide Rhodamine 110
|
Fluorescent Dye
|
Others
|
|
(Z-Ala-Ala-Ala-Ala)2Rh110 is a sensitive fluorogenic elastase substrate. The colorless and nonfluorescent (Z-Ala-Ala-Ala-Ala)2Rh110 is selectively cleaved by elastase to yield the highly fluorescent compound rhodamine 110, which can be analyzed with an excitation wavelength of 485 nm and emission wavelength of 525 nm.
|
- HY-P2176A
-
|
Z-Leu-Arg-Gly-Gly-AMC TFA
|
Fluorescent Dye
|
Others
|
|
Z-LRGG-AMC TFA is the trifluoroacetate salt of Z-LRGG-AMC (HY-P2176). Z-LRGG-AMC TFA is a fluorogenic substrate for isopeptidase T. Upon cleavage of Z-LRGG-AMC TFA by isopeptidase T, 7-amino-4-methylcoumarin (AMC) is released, and its fluorescence can be used to quantify isopeptidase T activity (Ex/Em : 360/460 nm) .
|
- HY-P3098
-
|
|
MMP
|
Others
|
|
Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1), MMP-3, and MMP-26. Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 can be used to quantify MMP-1, MMP-3 and MMP-26 activity .
|
- HY-P5380
-
|
Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2
|
MMP
|
Others
|
|
TNO211 is a biological active peptide. (Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.This peptide is a highly soluble fluorogenic MMP substrate for MMP-2, 8, 12, 13 and 14, containing the MMP cleavable Gly-Leu bond and EDANS/DABCYL. Fluorogenic assays using TNO211 are sensitive and can detect MMP activity in culture medium from endothelial cells and untreated synovial fluid from patients. Abs/Em = 340/490 nm.)
|
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