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falciparum malaria

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66

Inhibitors & Agonists

1

Fluorescent Dye

1

Peptides

14

Natural
Products

4

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-12651A
    Primaquine
    5 Publications Verification

    		 Parasite Infection Cancer
    Primaquine is a potent antimalaria agent and a potent gametocytocide in falciparum malaria. Primaquine prevents relapse in vivax and ovale malaria .
    Primaquine
  • HY-W078844
    PfDHODH-IN-2

    		Dihydroorotate Dehydrogenase Parasite Infection
    PfDHODH-IN-2, a dihydrothiophenone derivative (Compound 11), is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor with an IC50 of 1.11 µM. PfDHODH-IN-2 acts as an antimalarial agent and can be used for the research of malaria .
    PfDHODH-IN-2
  • HY-103397
    Nanaomycin A
    3 Publications Verification

    		 Antibiotic DNA Methyltransferase Parasite Infection Cancer
    Nanaomycin A is the first selective DNMT3B inhibitor with an IC50 of 500 nM. Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells . Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC80 value of 33.1 nM .
    Nanaomycin A
  • HY-103353A
    SID 26681509 quarterhydrate
    5 Publications Verification

    		 Cathepsin Parasite Infection Cancer
    SID 26681509 quarterhydrate is a potent, reversible, competitive, and selective inhibitor of human cathepsin L with an IC50 of 56 nM. SID 26681509 quarterhydrate inhibits in vitro propagation of malaria parasite Plasmodium falciparum and inhibits Leishmania major with IC50s of 15.4 μM and 12.5 μM, respectively. SID 26681509 quarterhydrate shows no inhibitory activity against cathepsin G .
    SID 26681509 quarterhydrate
  • HY-10852A
    Arterolane maleate

    OZ 277 maleate; RBx 11160 maleate

    		 Parasite Infection
    Arterolane (OZ 277) (maleate) is an orally active antimalarial. Arterolane exhibits potent activity against erythrocytic stages of P. falciparum and Plasmodium vivax. Arterolane (maleate) is promising for research of falciparum malaria .
    Arterolane maleate
  • HY-12651AR
    Primaquine (Standard)

    		Parasite Infection Cancer
    Primaquine (Standard) is the analytical standard of Primaquine. This product is intended for research and analytical applications. Primaquine is a potent antimalaria agent and a potent gametocytocide in falciparum malaria. Primaquine prevents relapse in vivax and ovale malaria .
    Primaquine (Standard)
  • HY-145704
    Antimalarial agent 8

    		Parasite Infection
    Antimalarial agent 8 (Compound 7e) is a novel orally active class of antimalarials. Antimalarial agent 8 is potent in vitro against P. falciparum and is orally efficacious (40 mg/kg) in an in vivo mouse model of malaria .
    Antimalarial agent 8
  • HY-149289
    DNMT-IN-3

    		Parasite DNA Methyltransferase Others
    DNMT-IN-3 is an DNA Methyltransferase (DNMT) inhibitor, and plays an antimalarial role with IC50 of 60 nM against Plasmodium falciparum (Plasmodium). DNMT-IN-3 can be used for malaria related research .
    DNMT-IN-3
  • HY-151575
    PfGSK3/PfPK6-IN-2

    		GSK-3 Infection
    PfGSK3/PfPK6-IN-2 is a potent dual PfGSK3/PfPK6 (Plasmodium falciparum GSK3/PK6) inhibitor (IC50: 172 nM and 11 nM respectively). PfGSK3/PfPK6-IN-2 can be used in the research of Malaria .
    PfGSK3/PfPK6-IN-2
  • HY-134914
    Fosmidomycin

    		Antibiotic Parasite Infection
    Fosmidomycin is an orally active antibiotic, which exhibits antimalarial activity through inhibition of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DOXP reductoisomerase). Fosmidomycin inhibits P. falciparum strains 3D7, HB3, Dd2 and A2, with IC50s of 150, 71, 170 and 150 ng/mL, respectively. Fosmidomycin exhibits synergistic effect with Clindamycin (HY-B1455), and ameliorates malaria in mouse model .
    Fosmidomycin
  • HY-103397R
    Nanaomycin A (Standard)

    		Antibiotic Reference Standards DNA Methyltransferase Parasite Infection Cancer
    Nanaomycin A (Standard) is the analytical standard of Nanaomycin A. This product is intended for research and analytical applications. Nanaomycin A is the first selective DNMT3B inhibitor with an IC50 of 500 nM. Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells[1]. Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC80 value of 33.1 nM[2].
    Nanaomycin A (Standard)
  • HY-117015
    Purfalcamine

    		Parasite Infection
    Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC50 of 17 nM and an EC50 of 230 nM. Purfalcamine has antimalarial activity and causes malaria parasites developmental arrest at the schizont stage .
    Purfalcamine
  • HY-12651
    Primaquine diphosphate
    5 Publications Verification

    Primaquine phosphate; Primaquine bisphosphate

    		 Parasite Infection Cancer
    Primaquine diphosphate is a potent antimalaria agent and a potent gametocytocide in falciparum malaria. Primaquine diphosphate prevents relapse in vivax and ovale malaria .
    Primaquine diphosphate
  • HY-N0402
    Artemether
    2 Publications Verification

    Dihydroqinghaosu methyl ether; Dihydroartemisinin methyl ether; SM224

    		 Parasite Infection Inflammation/Immunology Cancer
    Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria .
    Artemether
  • HY-N0402S
    Artemether-d3

    Dihydroqinghaosu methyl ether-d3; Dihydroartemisinin methyl ether-d3; SM224-d3

    		 Isotope-Labeled Compounds Parasite Infection Cancer
    Artemether-d3 is the deuterium labeled Artemether. Artemether is an antimalarial for the treatment of resistant strains of falciparum malaria.
    Artemether-d3
  • HY-169816
    MMV03

    		Parasite Infection
    MMV03 is an anti-malaria agent, and is active against P. falciparum (EC50: 0.6 μM) .
    MMV03
  • HY-12651R
    Primaquine diphosphate (Standard)

    Primaquine phosphate (Standard); Primaquine bisphosphate (Standard)

    		 Reference Standards Parasite Infection Cancer
    Primaquine (diphosphate) (Standard) is the analytical standard of Primaquine (diphosphate). This product is intended for research and analytical applications. Primaquine diphosphate is a potent antimalaria agent and a potent gametocytocide in falciparum malaria. Primaquine diphosphate prevents relapse in vivax and ovale malaria .
    Primaquine diphosphate (Standard)
  • HY-N10928
    Lettowienolide

    		Parasite Infection
    Lettowienolide, a geranylbenzoquinonoid, exhibits mild in vitro activity against the Plasmodium falciparum malaria parasite (IC50~20 μg/mL) .
    Lettowienolide
  • HY-A0148B
    (-)-Halofantrine

    (-)-SKF-102886 free base; (-)-WR-171669

    		 Parasite Infection
    (-)-Halofantrine ((-)-SKF-102886 free base; (-)-WR-171669) is an inhibitor of the malignant malaria parasite (P. falciparum) and targets multidrug-resistant P. falciparum. The pharmacokinetic parameters of (-)-Halofantrine in rats vary depending on the route of administration, distinguishing it from other isomers .
    (-)-Halofantrine
  • HY-160675
    TCMDC-137332

    		Parasite Infection
    TCMDC-137332 is a compound that exhibits antimalarial activity against Plasmodium falciparum with an IC50 value of 7 nM. TCMDC-137332 can be utilized for the research of malaria .
    TCMDC-137332
  • HY-N8513
    Brevicompanine B

    		Parasite Infection
    Brevicompanine B, a diketopiperazine alkaloid, is an antiplasmodial agent. Brevicompanine B is active against the malaria parasite Plasmodium falciparum 3D7 IC50 of 35 mg/mL .
    Brevicompanine B
  • HY-N0402R
    Artemether (Standard)

    Dihydroqinghaosu methyl ether (Standard); Dihydroartemisinin methyl ether (Standard); SM224 (Standard)

    		 Reference Standards Parasite Infection Inflammation/Immunology Cancer
    Artemether (Standard) is the analytical standard of Artemether. This product is intended for research and analytical applications. Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria .
    Artemether (Standard)
  • HY-148433
    SpdSyn binder-1

    		Parasite Infection Inflammation/Immunology
    SpdSyn binder-1 is a weak binder, which binds in the active site of plasmodium falciparum spermidine synthase. SpdSyn binder-1 can be used for the research of malaria .
    SpdSyn binder-1
  • HY-173567
    WJM664

    		Parasite Infection
    WJM664 is a potent Plasmodium falciparum PfATP4 inhibitor. WJM664 shows strong activity against malaria parasites. WJM664 blocks gamete development and transmission to mosquitoes by inhibiting PfATP4-mediated Na +-dependent ATPase activity, and acts on multiple stages of the malaria parasite life cycle .
    WJM664
  • HY-153007
    DHFR-IN-5

    		Dihydrofolate reductase (DHFR) Infection
    DHFR-IN-5 is a potent and orally active dihydrofolate reductase (DHFR) inhibitor with a Ki value of 0.54 nM for quadruple mutant Plasmodium falciparum DHFR. DHFR-IN-5 shows anti-malaria activity .
    DHFR-IN-5
  • HY-153007A
    DHFR-IN-5 hydrochloride

    		Dihydrofolate reductase (DHFR) Infection
    DHFR-IN-5 hydrochloride is a potent and orally active dihydrofolate reductase (DHFR) inhibitor with a Ki value of 0.54 nM for quadruple mutant Plasmodium falciparum DHFR. DHFR-IN-5 hydrochloride shows anti-malaria activity .
    DHFR-IN-5 hydrochloride
  • HY-145327
    Antimalarial agent 7

    		Na+/K+ ATPase Parasite Infection
    Antimalarial agent 7 is a potent inhibitor of PfATP4. PfATP4 is an essential ion pump on the parasite surface. Antimalarial agent 7 has the potential for the research of human malaria parasite, Plasmodium falciparum .
    Antimalarial agent 7
  • HY-146143
    Falcipain-2/3-IN-2

    		Parasite Infection
    Falcipain-2/3-IN-2 (Compound 12) is a dual falcipain-2 and falcipain-3 inhibitor .
    Falcipain-2/3-IN-2
  • HY-175362
    WEHI-326

    		Parasite Infection
    WEHI-326 is a potent antimalarial agent targeting Plasmodium falciparum ROM8 and CSC1 proteins (IC50=0.006 μM). WEHI-326 is promising for research of malaria .
    WEHI-326
  • HY-N10096
    Epoxyazadiradione

    		Parasite Infection
    Epoxyazadiradione is a limonoid purified from neem (Azadirachta indica) fruits. Epoxyazadiradione inhibits the tautomerase activity of MIF of both human (huMIF) and malaria parasites (Plasmodium falciparum (PfMIF) and Plasmodium yoelii (PyMIF)) non-competitively in a reversible fashion (Ki, 2.11-5.23 μM). Epoxyazadiradione has the potential against proinflammatory reactions induced by MIF of both malaria parasites and human .
    Epoxyazadiradione
  • HY-B0770
    Artemotil
    1 Publications Verification

    β-Arteether; (+)-Arteether; Arteether

    		 CXCR Parasite Infection Cancer
    Artemotil (β-Arteether) has antimalarial activity for the treatment of chloroquine-resistant Plasmodium falciparum malaria with an IC50 of 1.61 nM. Artemotil also has central nervous system (CNS) neurotoxicity and anorectic toxicity in rats, dogs and monkeys .
    Artemotil
  • HY-169233
    MED6-189

    		Parasite Infection
    MED6-189, a kalihinol analog, disrupts apicoplast function and vesicular trafficking in P. falciparum malaria (IC50 < 50 nM). MED6-189 targets the apicoplast, a nonphotosynthetic plastid found in most Apicomplexa parasites that is crucial for the synthesis of isoprenoids .
    MED6-189
  • HY-N10624
    Koshidacin B

    		Parasite Infection
    Koshidacin B is an antiplasmodial cyclic tetrapeptide with antiplasmodial activity against P. falciparum FCR3 and K1 strain with IC50 values of 0.89 and 0.83 μM, respectively. Koshidacin B suppresses malaria parasites in vivo, it can be used for the research of parasites infection .
    Koshidacin B
  • HY-174342
    ELQ-453

    		Cytochrome P450 Parasite Infection
    ELQ-453 is an inhibitor targeting the Qo site of the Plasmodium falciparum cytochrome bc1 complex (CytB) with an IC50 value of 0.57 nM. ELQ-453 blocks the mitochondrial function of the parasite, and suppresses Plasmodium infection in mosquitoes. ELQ-453 is promising for research of malaria .
    ELQ-453
  • HY-137126
    Photosensitizer Pc 4

    NSC-676418

    		 Parasite Infection
    Photosensitizer Pc 4 (NSC-676418) is a photosensitizer, which inhibits Plasmodium falciparum in dark or under red light by disturbing the protein/DNA synthesis, with an IC50 of 24 nM .
    Photosensitizer Pc 4
  • HY-W768856
    Artemether-13C,d3

    Dihydroqinghaosu methyl ether-13C,d3; Dihydroartemisinin methyl ether-13C,d3; SM224-13C,d3

    		 Isotope-Labeled Compounds Parasite Infection Inflammation/Immunology Cancer
    Artemether- 13C,d3 (Dihydroqinghaosu methyl ether- 13C,d3) is the deuterium and 13C-labeled Artemether (HY-N0402). Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria .
    Artemether-13C,d3
  • HY-161905
    ML471

    		Parasite Infection
    ML471 is an oral active parasite tyrosyl-tRNA synthetase (PfTyrRS) inhibitor and can be used for study of malaria .
    ML471
  • HY-120104
    Nitidanin

    (±)-Nitidanin

    		 Parasite HCV Infection
    Nitidanin ((±)-Nitidanin) is an antimalarial and antiviral compound that can be isolated from the wood of Xanthoxylum nitidun D. C. Nitidanin is shows IC50 values of 21.2 and 18.4 μM for D6 and W2 clones of Plasmodium falciparum, respectively. Nitidanin can be used for the research of malaria and virus infection .
    Nitidanin
  • HY-126392
    Isonardoperoxide

    		Parasite Infection
    Isonardoperoxide is a potent antimalaria agent with an EC50 of 0.6 μM for Plasnwdium fulciparum malaria .
    Isonardoperoxide
  • HY-N15403
    Acetylcaranine

    		Parasite Infection Cancer
    Acetylcaranine is a alkaloids that can isolated from bulbs of Amaryllis belladonna Steud. Acetylcaranine shows exhibited strong antiplasmodial activity and anticancer activity .
    Acetylcaranine
  • HY-163765
    Antimalarial agent 41

    		PI4K Potassium Channel Infection
    Antimalarial agent 41 (Compound 17) exhibits antimalarial activity, which inhibits Plasmodium falciparum with an IC50 of 40 nM (NF54 strain) and 76 nM (K1 strain). Antimalarial agent 41 is an inhibitor for P. falciparum phosphatidylinositol-4-kinase β (Pf PI4K) and hERG channel, with an IC50 of 53 nM and 3 μM. Antimalarial agent 41 exhibits cytotoxicity to CHO cells with an IC50 of 34 μM. Antimalarial agent 41 ameliorates the malaria infection and exhibits good pharmacokinetic characters in mouse models .
    Antimalarial agent 41
  • HY-103353
    SID 26681509
    5 Publications Verification

    		 Cathepsin Parasite Infection Cancer
    SID 26681509 is a potent, reversible, competitive, and selective inhibitor of human cathepsin L with an IC50 of 56 nM. SID 26681509 inhibits in vitro propagation of malaria parasite Plasmodium falciparum and inhibits Leishmania major with IC50s of 15.4 μM and 12.5 μM, respectively. SID 26681509 shows no inhibitory activity against cathepsin G .
    SID 26681509
  • HY-N15748
    Pelorol

    (-)-Pelorol

    		 Parasite Infection
    Pelorol ((-)-Pelorol) is a sesquiterpene found in the tropical marine sponge Dactylospongia elegans. Pelorol has weak antitrypanosomal activity with an IC50 of 17.4 μg/mL and antiplasmodial activity against Plasmodium falciparum clones K1 and NF54 with IC50 values of 786 ng/mL and 1911 ng/mL, respectively. Pelorol is promising for research of parasitic diseases, such as trypanosomiasis and malaria .
    Pelorol
  • HY-129476
    L-Canaline

    		Parasite Endogenous Metabolite Infection Cancer
    L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite Plasmodium falciparum with an IC50 of 297 nM. L-Canaline has anticancer and antiproliferative effects .
    L-Canaline
  • HY-13832
    Atovaquone
    4 Publications Verification

    Atavaquone

    		 Parasite Cytochrome P450 Antibiotic Bacterial Infection Cancer
    Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and  P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia .
    Atovaquone
  • HY-175215
    PfPK6-IN-1

    		Parasite Infection
    PfPK6-IN-1 is a potent and selective PfPK6 inhibitor with an IC50 of 0.3 μM. PfPK6-IN-1 inhibits hemozoin formation, a Plasmodium-specific pathway with IC50 of 13 μM against β-hematin (βH). PfPK6-IN-1 exhibits rapid and broad-spectrum anti-malarial properties, being effective against both chloroquine-sensitive and resistant strains.PfPK6-IN-1 can be used for the study of antimalarial .
    PfPK6-IN-1
  • HY-119707
    TDR 32750

    		Parasite Infection
    TDR 32750 is an antimalarial agent. TDR 32750 inhibits P. falciparum activity with an ED50 value of 0.014 μM .
    TDR 32750
  • HY-P5344
    Dabcyl-LNKRLLHETQ-Edans

    Fluorigenic PEXEL peptide

    		 Parasite Others
    Dabcyl-LNKRLLHETQ-Edans (Fluorigenic PEXEL peptide) is a biological active peptide. (This FRET substrate peptide for Plasmepsin V (PMV) is derived from the conserved Plasmodium Export Element (PEXEL) motif of Histidine-Rich Protein II (HRPII). PMV is an ER aspartic protease that recognizes and cleaves the RXL sequence within the PEXEL motif of proteins exported by human malaria parasite Plasmodium falciparum, allowing them to translocate into host erythrocytes.)
    Dabcyl-LNKRLLHETQ-Edans
  • HY-13832S2
    Atovaquone-d5

    Atavaquone-d5

    		 Isotope-Labeled Compounds Parasite Cytochrome P450 Antibiotic Infection
    Atovaquone-d5 is the deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome?bc1?complex. Atovaquone is against human and ?P. falciparum?cytochrome?bc1?activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia .
    Atovaquone-d5
  • HY-13832S3
    cis-Atovaquone-d4

    cis-Atavaquone-d4

    		 Isotope-Labeled Compounds Parasite Cytochrome P450 Antibiotic Infection
    cis-Atovaquone-d4 is deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and  P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].
    cis-Atovaquone-d4

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