C3361 

C3361 is a moderate specific Plasmodium falciparum hexose transporter 1 (PfHT1) and Plasmodium berghei hexose transporter 1 (PbHT1) inhibitor with K_i values of 8.6 and 9.4 μM. C3361 inhibits TgGT1 with a K_i of 82 μM. C3361 attenuates hepatic (IC₅₀ = 15 μM) and ookinete development of P. berghei. C3361 can suppress the growth of blood-stage parasites. C3361 can be used for the research of infection, such as malaria^[1][2].

C3361 reduces 75% ookinete formation^[1].
C3361 (1-100 μM, 68 h) prevent the maturation of the liver-stage schizonts in sporozoite-infected hepatoma cells^[1].
C3361 shows growth inhibition of P. berghei with an IC₅₀ of 15 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

C3361 (2 mg/kg, i.v., daily) reduces parasite burden in GFP-expressing parasite-infected blood cells infected mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

332.43

C₁₇H₃₂O₆

91042-00-1

C=CCCCCCCCCCO[C@H]1[C@@H]([C@H](OC([C@@H]1O)O)CO)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Huang J, et al. Orthosteric-allosteric dual inhibitors of PfHT1 as selective antimalarial agents. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2017749118.  [Content Brief]

  [2]. Blume M, et al. A constitutive pan-hexose permease for the Plasmodium life cycle and transgenic models for screening of antimalarial sugar analogs. FASEB J. 2011 Apr;25(4):1218-29.  [Content Brief]