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disubstituted

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (1) Apoptosis (3) Bacterial (2) Biochemical Assay Reagents (11) Drug Intermediate (1) EGFR (2) GABA Receptor (1) Glutathione S-transferase (2) HIV (1) Integrin (1) Keap1-Nrf2 (1) P-glycoprotein (1) Parasite (1) Reactive Oxygen Species (ROS) (1) SARS-CoV (1) Sirtuin (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (1) Infection (5) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (1)
Click Chemistry:	ADC Synthesis (1) Azide (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13306

Pyrintegrin 4 Publications Verification	Integrin	Metabolic Disease
Pyrintegrin is an β1-integrin agonist and a 2,4-disubstituted pyrimidine that promotes embryonic stem cells survival. Pyrintegrin enhances cell-extracellular matrix (ECM) adhesion-mediated integrin signaling. Pyrintegrin can be used as a podocyte-protective agent and has robustly adipogenic .

HY-136240

Tioxazafen	Parasite	Infection
Tioxazafen is a disubstituted oxadiazole and a broad-spectrum seed treatment nematicide. Tioxazafen is designed to provide consistent broad-spectrum control of nematodes in corn, soy, and cotton .

HY-W811579

Bensuldazic acid	Bacterial	Infection
Bensuldazic acid (compound 4f) is a lipophilic 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione (THTT) derivative that can be used as a prodrug model. Bensuldazic acid has antifungal activity .

HY-W811579A

Bensuldazic acid sodium	Bacterial	Infection
Bensuldazic acid sodium (compound 4f) is a lipophilic 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione (THTT) derivative that can be used as a prodrug model. Bensuldazic acid has antifungal activity .

HY-W1120356B

Bis-PEG24-NHS ester	Biochemical Assay Reagents	Others
Bis-PEG24-NHS Ester is a homofunctional disubstituted PEG derivative for drug delivery.

HY-W1120356A

Bis-PEG37-NHS ester	Biochemical Assay Reagents	Others
Bis-PEG37-NHS Ester is a homofunctional disubstituted PEG derivative for drug delivery.

HY-W1120356C

Bis-PEG8-NHS ester	Biochemical Assay Reagents	Others
Bis-PEG8-NHS Ester is a homofunctional disubstituted PEG derivative for drug delivery.

HY-W1120356

Bis-PEG12-NHS Ester	Biochemical Assay Reagents	Others
Bis-PEG12-NHS Ester is a homofunctional disubstituted PEG derivative for drug delivery.

HY-W788246

Bis-PEG1-sulfonic acid	Biochemical Assay Reagents	Others
Bis-PEG1-sulfonic acid is a homofunctional disubstituted PEG derivative useful for drug delivery .

HY-W190751C

Bis-PEG33-t-butyl ester	Biochemical Assay Reagents	Others
Bis-PEG33-t-butyl ester is a disubstituted PEG derivative with the same functional group and can be used for drug delivery.

HY-W190751A

Bis-PEG11-t-butyl ester	Biochemical Assay Reagents	Others
Bis-PEG11-t-butyl ester is a disubstituted PEG derivative with the same functional group and can be used for drug delivery.

HY-W190751

Bis-PEG9-t-butyl ester	Biochemical Assay Reagents	Others
Bis-PEG9-t-butyl ester is a disubstituted PEG derivative with the same functional group and can be used for drug delivery.

HY-W190754

Bis-PEG13-t-butyl ester	Biochemical Assay Reagents	Others
Bis-PEG13-t-butyl ester is a disubstituted PEG derivative with the same functional group and can be used for drug delivery.

HY-W190751B

Bis-PEG12-t-butyl ester	Biochemical Assay Reagents	Others
Bis-PEG12-t-butyl ester is a disubstituted PEG derivative with the same functional group and can be used for drug delivery.

HY-116918

N,N-Diphenylacetamide N-Acetyldiphenylamine	Drug Intermediate	Others
N,N-Diphenylacetamide (N-Acetyldiphenylamine) has N,N-disubstituted amide group and can be used as a mono- as well as a bidentate ligand generating four-membered chelate rings .

HY-17499

EGFR-IN-12	EGFR Apoptosis	Cancer
EGFR-IN-12 is a 4,6-disubstituted pyrimidine and is a potent, ATP-competitive, irreversible and highly selective EGFR inhibitor with an IC₅₀of 21 nM. EGFR-IN-12 also inhibits mutant EGFR ^L858R and EGFR ^L861Q with IC₅₀s of 63 nM and 4 nM, respectively. EGFR-IN-12 displays strong selectivity for EGFR over HER4 (IC₅₀ = 7640 nM) and a panel of 55 other kinases. EGFR-IN-12 induces cells apoptosis and has antitumor activity .

HY-116152

Cipepofol Ciprofol; HSK3486	GABA Receptor Sirtuin Keap1-Nrf2 Apoptosis	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Cipepofol (Ciprofol), a novel 2,6-disubstituted phenol derivative, is a positive allosteric modulator and direct agonist of the GABA_A receptor. Cipepofol can cause the central nerve inhibition and promote sleep based on the structural modification of Propofol (HY-B0649). Cipepofol can activate the sirtuin1 (Sirt1)/Nrf2 pathway. Cipepofol protects the heart against Isoproterenol (ISO; HY-B0468)-induced myocardial infarction by reducing cardiac oxidative stress, inflammatory response and cardiomyocyte apoptosis .

HY-149360

P-gb-IN-1	P-glycoprotein	Cancer
P-gb-IN-1 (compound Ⅲ-8), a 2,5-disubstituted furan derivative, is a highly effective, broadspectrum P-glycoprotein (P-gp) inhibitor. P-gb-IN-1 displayed the reversal activity by inhibiting P-gp efflux. P-gb-IN-1 has a potent affinity to P-gp by forming H-bond interactions with residues Asn 721 and Met 986. P-gb-IN-1 possesses broad-spectrum reversal activity and low toxicity in MCF-7/ADR cells .

HY-17499R

EGFR-IN-12 (Standard)	EGFR Apoptosis	Cancer
EGFR-IN-12 (Standard) is the analytical standard of EGFR-IN-12. This product is intended for research and analytical applications. EGFR-IN-12 is a 4,6-disubstituted pyrimidine and is a potent, ATP-competitive, irreversible and highly selective EGFR inhibitor with an IC50of 21 nM. EGFR-IN-12 also inhibits mutant EGFRL858R and EGFRL861Q with IC50s of 63 nM and 4 nM, respectively. EGFR-IN-12 displays strong selectivity for EGFR over HER4 (IC50 = 7640 nM) and a panel of 55 other kinases. EGFR-IN-12 induces cells apoptosis and has antitumor activity .

HY-174906

Bis-PEG-COOH (MW 1000)	Biochemical Assay Reagents	Others
Bis-PEG-COOH (MW 1000) is a disubstituted PEG derivative with the same functional group. The carboxylic acid group in Bis-PEG-COOH (MW 1000) can react with other compounds containing amino, hydroxyl and other functional groups to form stable chemical bonds, which can be used for drug delivery .

HY-162604

SARS-CoV-2-IN-90	SARS-CoV	Infection
SARS-CoV-2-IN-90 (compound 3i) is a SARS-CoV-2 inhibitor. SARS-CoV-2-IN-90 can be used in coronavirus infection related research .

HY-106429

OT-551 free base	Reactive Oxygen Species (ROS)	Others
OT-551 (free base) is a lipophilic, disubstituted hydroxylamine with antioxidant properties. OT-551 can be used as an eye drop and can be converted by intraocular esterases to its active metabolite, Tempol-H (TP-H). OT-551 can be utilized in geographic atrophy and macular degeneration research .

HY-N0548

α-Angelica lactone 2 Publications Verification	Glutathione S-transferase	Cancer
α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes .

HY-N0548R

α-Angelica lactone (Standard)	Glutathione S-transferase	Cancer
α-Angelica lactone (Standard) is the analytical standard of α-Angelica lactone. This product is intended for research and analytical applications. α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes .

HY-119202

(S)-BMS-378806 (S)-BMS-806	HIV	Infection
(S)-BMS-378806 ((S)-BMS-806) is an orally bioavailable HIV-1 inhibitor with activity against gp120-CD4 interactions. (S)-BMS-378806 exhibits micromolar inhibition of HIV-1 gp120-CD4 binding. The design and synthesis of (S)-BMS-378806 was based on a comprehensive study of protein-ligand interactions, which guided the identification and design of novel symmetrical N,N'-disubstituted aminoureas and thioureas. (S)-BMS-378806, synthesized in aqueous media using microwave irradiation, was validated for its inhibitory activity in HIV-1 gp120-CD4 capture ELISA .

HY-145149

Duostatin 5	ADC Payload	Cancer
Duostatin 5 is a ADC Cytotoxin designed based on MMAF (HY-15579) and can be used to synthesize ADCs. The preparation of Duostatin 5 has the advantages of fewer synthetic steps, simple operation, less difficulty in quality control, and more stable chemical synthesis process. Duostatin 5 can be linked to the antibody targeting 5T4 (ZV05) by cross-linking with interchain cysteines through a disubstituted C-Lock linker. Duostatin 5 is a click chemistry reagent. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups[1][2].

Bis-PEG9-t-butyl ester	Drug Delivery
Bis-PEG9-t-butyl ester is a disubstituted PEG derivative with the same functional group and can be used for drug delivery.

Bis-PEG13-t-butyl ester	Drug Delivery
Bis-PEG13-t-butyl ester is a disubstituted PEG derivative with the same functional group and can be used for drug delivery.

Bis-PEG24-NHS ester	Drug Delivery
Bis-PEG24-NHS Ester is a homofunctional disubstituted PEG derivative for drug delivery.

Bis-PEG37-NHS ester	Drug Delivery
Bis-PEG37-NHS Ester is a homofunctional disubstituted PEG derivative for drug delivery.

Bis-PEG8-NHS ester	Drug Delivery
Bis-PEG8-NHS Ester is a homofunctional disubstituted PEG derivative for drug delivery.

Bis-PEG12-NHS Ester	Drug Delivery
Bis-PEG12-NHS Ester is a homofunctional disubstituted PEG derivative for drug delivery.

Bis-PEG1-sulfonic acid	Drug Delivery
Bis-PEG1-sulfonic acid is a homofunctional disubstituted PEG derivative useful for drug delivery .

Bis-PEG33-t-butyl ester	Drug Delivery
Bis-PEG33-t-butyl ester is a disubstituted PEG derivative with the same functional group and can be used for drug delivery.

Bis-PEG11-t-butyl ester	Drug Delivery
Bis-PEG11-t-butyl ester is a disubstituted PEG derivative with the same functional group and can be used for drug delivery.

Bis-PEG12-t-butyl ester	Drug Delivery
Bis-PEG12-t-butyl ester is a disubstituted PEG derivative with the same functional group and can be used for drug delivery.

Bis-PEG-COOH (MW 1000)	Drug Delivery
Bis-PEG-COOH (MW 1000) is a disubstituted PEG derivative with the same functional group. The carboxylic acid group in Bis-PEG-COOH (MW 1000) can react with other compounds containing amino, hydroxyl and other functional groups to form stable chemical bonds, which can be used for drug delivery .

α-Angelica lactone 2 Publications Verification	Structural Classification Natural Products Classification of Application Fields Source classification Dicerothamnus rhinocerotis Umbelliferae Plants Disease Research Fields Cancer	Glutathione S-transferase
α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes .

α-Angelica lactone (Standard)	Structural Classification Natural Products Source classification Dicerothamnus rhinocerotis Umbelliferae Plants	Glutathione S-transferase
α-Angelica lactone (Standard) is the analytical standard of α-Angelica lactone. This product is intended for research and analytical applications. α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes .

Cat. No.	Product Name		Classification

HY-145149

Duostatin 5		ADC Synthesis Azide
Duostatin 5 is a ADC Cytotoxin designed based on MMAF (HY-15579) and can be used to synthesize ADCs. The preparation of Duostatin 5 has the advantages of fewer synthetic steps, simple operation, less difficulty in quality control, and more stable chemical synthesis process. Duostatin 5 can be linked to the antibody targeting 5T4 (ZV05) by cross-linking with interchain cysteines through a disubstituted C-Lock linker. Duostatin 5 is a click chemistry reagent. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups[1][2].

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disubstituted

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Click Chemistry

Natural
Products