diabetic wound healing

By Targets:	Akt (1) AMPK (1) Apoptosis (1) Bacterial (2) Caspase (1) ERK (1) FGFR (1) Fluorescent Dye (1) Leukotriene Receptor (1) MDM-2/p53 (1) MMP (1) NF-κB (1) NOD-like Receptor (NLR) (1) PARP (1) PI3K (1) Pyroptosis (1) Reactive Oxygen Species (2) Ser/Thr Protease (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (5) Metabolic Disease (6) Neurological Disease (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-124373

ND-336	MMP	Metabolic Disease
ND-336 is a selective inhibitor of matrix metalloproteinase (MMP)-2, MMP-9, and MMP-14, with K_is of 85, 150, and 120 nM, respectively. ND-336 accelerates diabetic wound healing in mice by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound .

HY-N6580

Ginsenoside Rg4	Bacterial	Infection Metabolic Disease Inflammation/Immunology
Ginsenoside Rg4 is a major protopanaxatriol type ginsenoside isolated from the leaves of Panax ginseng C. A. Meyer. The protopanaxatriol type ginsenosides (such as Ginsenoside Rg4) exhibits various biological activities including anti-septic, anti-diabetic, wound healing, immune-stimulatory, and anti-antioxidant activity .

HY-N0726

Dracorhodin perchlorate Dracohodin perochlorate	Apoptosis Akt PI3K NF-κB MDM-2/p53 Caspase Reactive Oxygen Species Toll-like Receptor (TLR) PARP	Metabolic Disease Cancer
Dracorhodin perchlorate (Dracohodin perochlorate) is a natural product. Dracorhodin perchlorate can be obtained from the natural active molecule Dragon's blood. Dracorhodin perchlorate inhibits PI3K/Akt and NF-κB activation, upregulates p53 expression, activates caspase, produces ROS, and promotes Apoptosis. Dracorhodin perchlorate regulates the TLR4. Dracorhodin perchlorate promotes wound healing, improves diabetes. Dracorhodin perchlorate has anti-tumor activity against prostate cancer, breast cancer, cervical cancer and other cancers .

HY-142521

BLT2 probe 1	Leukotriene Receptor	Metabolic Disease
BLT2 probe 1 (compound 13) is a fluorescent probe based on the synthetic BLT2 agonist CAY10583. BLT2 is a promising target for diabetic wound healing and gastrointestinal lesions. BLT2 probe 1 is suitable to investigate the pharmacology of BLT2 receptor ligands in a variety of assay systems .

HY-P2821

Plasminogen, Human plasma	Ser/Thr Protease	Inflammation/Immunology
Plasminogen, Human plasma is a secreted protein that upon cleavage by urokinase plasminogen activator (uPA) or tissue plasminogen activator (tPA) is converted to plasmin, a broad range protease capable of cleaving fibrin and other ECM components. Plasminogen also is a proinflammatory regulator that accelerates the healing of acute and diabetic wounds. Plasminogen can be used in studies of wound healing, inflammation and hypoplasminogenemia .

HY-NP192

Sericin	Reactive Oxygen Species Bacterial	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Sericin is a type of spherical protein that can be isolated from silk cocoons. Sericin is a cognitive enhancer and pain reliever. Sericin is a fetal bovine serum- or DMSO-replacing cryoprotectant agent. Sericin reduces oxidative stress and reactive oxygen species (ROS). Sericin can repair wounds by producing collagen. Sericin has antioxidant, anti-diabetic, anti-hyperlipidemic, anti-inflammatory, skin moisturizer, wound healing, antibacterial, antimicrobial, and anti-tumor protector .

HY-164853

Kanglexin	Pyroptosis NOD-like Receptor (NLR) ERK FGFR AMPK	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Kanglexin is an orally active and novel anthraquinone compound. Kanglexin inhibits NLRP3 inflammatory body activation and cell pyroptosis, and has a cardioprotective effect. Kanglexin promotes angiogenesis through FGFR1/ERK signaling pathway and accelerates diabetic wound healing. In addition, Kanglexin has the effect of lipid-lowering and inhibiting the dedifferentiation of vascular smooth muscle cells, and can be used in the study of hyperlipidemia, fatty liver and atherosclerosis .

HY-149837

PRO-F	Fluorescent Dye	Inflammation/Immunology
PRO-F is a photoactivable H₂S donor with ROS scavenging ability. PRO-F can be activated by light to produce fluorescent signal, for real-time tracking of released H₂S. PRO-F activation doesn’t consume endogenous substances. deliver H₂S in an intracellular environment to protect cells from excessive reactive oxygen species (ROS) induced damage. PRO-F shows enhancement on chronic wound healing, researched in diabetic models as well .

Cat. No.	Product Name	Type

HY-NP192

Sericin	Native Proteins
Sericin is a type of spherical protein that can be isolated from silk cocoons. Sericin is a cognitive enhancer and pain reliever. Sericin is a fetal bovine serum- or DMSO-replacing cryoprotectant agent. Sericin reduces oxidative stress and reactive oxygen species (ROS). Sericin can repair wounds by producing collagen. Sericin has antioxidant, anti-diabetic, anti-hyperlipidemic, anti-inflammatory, skin moisturizer, wound healing, antibacterial, antimicrobial, and anti-tumor protector .

Sericin

Native Proteins

Sericin is a type of spherical protein that can be isolated from silk cocoons. Sericin is a cognitive enhancer and pain reliever. Sericin is a fetal bovine serum- or DMSO-replacing cryoprotectant agent. Sericin reduces oxidative stress and reactive oxygen species (ROS). Sericin can repair wounds by producing collagen. Sericin has antioxidant, anti-diabetic, anti-hyperlipidemic, anti-inflammatory, skin moisturizer, wound healing, antibacterial, antimicrobial, and anti-tumor protector .

Cat. No.	Product Name	Target	Research Area

HY-P4866

Q-Peptide	Peptides	Metabolic Disease
Q-Peptide is the angiopoietin-1 derived peptide (QHREDGS).Q-Peptide increases keratinocyte migration to improve wound healing, in diabetic mouse model. Q-Peptide accelerates wound closure .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6580

Ginsenoside Rg4	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Source classification Metabolic Disease Plants Disease Research Fields Inflammation/Immunology Araliaceae	Bacterial
Ginsenoside Rg4 is a major protopanaxatriol type ginsenoside isolated from the leaves of Panax ginseng C. A. Meyer. The protopanaxatriol type ginsenosides (such as Ginsenoside Rg4) exhibits various biological activities including anti-septic, anti-diabetic, wound healing, immune-stimulatory, and anti-antioxidant activity .

HY-N0726

Dracorhodin perchlorate Dracohodin perochlorate	Structural Classification Natural Products Monophenols other families Classification of Application Fields Source classification Phenols Draconis sanguis Palmae Plants Disease Research Fields Cancer	Apoptosis Akt PI3K NF-κB MDM-2/p53 Caspase Reactive Oxygen Species Toll-like Receptor (TLR) PARP
Dracorhodin perchlorate (Dracohodin perochlorate) is a natural product. Dracorhodin perchlorate can be obtained from the natural active molecule Dragon's blood. Dracorhodin perchlorate inhibits PI3K/Akt and NF-κB activation, upregulates p53 expression, activates caspase, produces ROS, and promotes Apoptosis. Dracorhodin perchlorate regulates the TLR4. Dracorhodin perchlorate promotes wound healing, improves diabetes. Dracorhodin perchlorate has anti-tumor activity against prostate cancer, breast cancer, cervical cancer and other cancers .

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