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Results for "

cockroaches

" in MedChemExpress (MCE) Product Catalog:

18

Inhibitors & Agonists

7

Peptides

2

Natural
Products

2

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-121248
    Hydramethylnon

    AC217300

    		 Mitochondrial Metabolism Infection
    Hydramethylnon (AC217300) is an amidinohydrazone insecticide. Hydramethylnon's mechanism of action is through inhibition of mitochondrial respiration by inhibiting the electron transport chain at the cytochrome b-c1 complex. Hydramethylnon can be used to eliminate red imported fire ants, cockroaches, and other insects .
    Hydramethylnon
  • HY-W561401
    Blattellaquinone

    		Others Endocrinology
    Blattellaquinone is a sex pheromone isolated from German cockroaches .
    Blattellaquinone
  • HY-B0822
    Fipronil

    		GABA Receptor Cytochrome P450 Apoptosis Neurological Disease
    Fipronil is a broad-spectrum insecticide effective against Lepidoptera species as well as thrips, locusts, ants, cockroaches, fleas and ticks. Fipronil selectively inhibits GABA receptor with IC50s of 30 nM and 1600 nM for cockroach and rat GABA receptors, respectively. Glutamate-gated chloride channels (GluCls), which are present in cockroaches but not in mammals, are sensitive to the blocking effect of Fipronil. Fipronil also induces apoptosis in HepG2 cells and promotes the expression of CYP1A1 and CYP3A4 mRNA in human hepatocytes .
    Fipronil
  • HY-145297
    Flupyrimin

    		nAChR Insecticide Neurological Disease
    Flupyrimin is the antagonist for insect nicotinic acetylcholine receptor (nAChR) that exhibits insecticidal effect by targeting insect nervous system .
    Flupyrimin
  • HY-P4989
    Type A Allatostatin III

    		Biochemical Assay Reagents Infection
    Type A Allatostatin III (allatostatin 3) is a blood-brain barrier permeable and reversible neuropeptide that inhibits hormone synthesis in juvenile female cockroaches. Type A Allatostatin III can be used in pesticide research .
    Type A Allatostatin III
  • HY-B0822R
    Fipronil (Standard)

    		Reference Standards GABA Receptor Cytochrome P450 Apoptosis Neurological Disease
    Fipronil (Standard) is the analytical standard of Fipronil. This product is intended for research and analytical applications. Fipronil is a broad-spectrum insecticide effective against Lepidoptera species as well as thrips, locusts, ants, cockroaches, fleas and ticks. Fipronil selectively inhibits GABA receptor with IC50s of 30 nM and 1600 nM for cockroach and rat GABA receptors, respectively. Glutamate-gated chloride channels (GluCls), which are present in cockroaches but not in mammals, are sensitive to the blocking effect of Fipronil. Fipronil also induces apoptosis in HepG2 cells and promotes the expression of CYP1A1 and CYP3A4 mRNA in human hepatocytes .
    Fipronil (Standard)
  • HY-124232
    BTG 502

    		Parasite Sodium Channel Neurological Disease
    BTG 502 is an alkylamide insecticide. BTG 502 can reduce sodium current and antagonize the effect of bat toxin (BTX) on cockroach sodium channels .
    BTG 502
  • HY-B0841S
    Acephate-d3

    		Isotope-Labeled Compounds Cholinesterase (ChE) Neurological Disease
    Acephate-d3 is the deuterium labeled Acephate. Acephate is an anticholinesterase insecticide that produces cholinotoxicity. Acephate displays weak inhibition of rat AChE but potently inhibits cockroach AChE.
    Acephate-d3
  • HY-P5162
    Dc1a

    		Sodium Channel Inflammation/Immunology
    Dc1a potently promotes opening of the German cockroach Nav channel (BgNav1). Dc1a is a toxin can be isolated from the desert bush spider Diguetia canities .
    Dc1a
  • HY-145297R
    Flupyrimin (Standard)

    		Reference Standards nAChR Insecticide Neurological Disease
    Flupyrimin (Standard) is the analytical standard of Flupyrimin. This product is intended for research and analytical applications. Flupyrimin is the antagonist for insect nicotinic acetylcholine receptor (nAChR) that exhibits insecticidal effect by targeting insect nervous system .
    Flupyrimin (Standard)
  • HY-N7491
    Verticilide

    		Calcium Channel Inflammation/Immunology
    Verticilide is a ryanodine-binding inhibitor and inhibits ryanodine binding to ryanodine receptors in the cockroach at an IC50 value of 4.2 μM (whereas inhibition against mouse ryanodine receptors was weak (IC50=53.9 μM)) .
    Verticilide
  • HY-B0822S1
    Fipronil-13C6

    		GABA Receptor Cytochrome P450 Inflammation/Immunology
    Fipronil- 13C6 is the 13C-labeled Fipronil. Fipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC50s = 30 nM and 1,600 nM for cockroach and rat receptors, respectively). Fipronil also inhibits desensitizing and non-desensitizing glutamate-induced chloride currents in cockroach neurons (IC50s = 800 nM and 10 nM, respectively). Fipronil induces activity of the cytochrome P450 (CYP) isoforms CYP1A1/2, CYP2B1/2, and CYP3A1/2 in isolated rat liver microsomes.
    Fipronil-13C6
  • HY-W587768
    Metoxadiazone

    S-21074

    		 Insecticide Others
    Metoxadiazone is a type of insecticide that effectively controls a wide range of insects, including cockroaches and ants. Metoxadiazone exerts its insecticidal effect by impacting the nervous system of insects. Metoxadiazone can be used for research into its potential toxicity to humans and other non-target organisms .
    Metoxadiazone
  • HY-P5179
    Huwentoxin I

    HWTX-I

    		 Calcium Channel Sodium Channel Neurological Disease
    Huwentoxin I (HWTX-I) is a peptide toxin that inhibits voltage-gated sodium channels and N-type calcium channels. Huwentoxin I inhibits sodium channels in rat hippocampus and cockroach dorsal unpaired median (DUM) neurons with IC50 values of 66.1 and 4.80 nM, respectively .
    Huwentoxin I
  • HY-B1885
    Fenitrothion
    2 Publications Verification

    		 Insecticide Parasite Cholinesterase (ChE) AMPK PI3K Akt Apoptosis SOD Infection
    Fenitrothion is a broad-spectrum and orally active insecticide/acaricide. Fenitrothion inhibits cholinesterase, AMPKα and IRS1/PI3K/AKT. Fenitrothion causes Apoptosis, reduces SOD activity. Fenitrothion shows insecticidal effect against Rhyzopertha dominica and Tribolium castaneum adults. Fenitrothion is widely used in cotton crops, vegetable crops, fruit crops and field crops, especially rice. Fenitrothion can be used for brain and spleen toxicology studies .
    Fenitrothion
  • HY-B1885R
    Fenitrothion (Standard)

    		Reference Standards Insecticide Parasite Cholinesterase (ChE) AMPK PI3K Akt Apoptosis SOD Infection
    Fenitrothion (Standard) is the analytical standard of Fenitrothion (HY-B1885). This product is intended for research and analytical applications. Fenitrothion is a broad-spectrum and orally active insecticide/acaricide. Fenitrothion inhibits cholinesterase, AMPKα and IRS1/PI3K/AKT. Fenitrothion causes Apoptosis, reduces SOD activity. Fenitrothion shows insecticidal effect against Rhyzopertha dominica and Tribolium castaneum adults. Fenitrothion is widely used in cotton crops, vegetable crops, fruit crops and field crops, especially rice. Fenitrothion can be used for brain and spleen toxicology studies .
    Fenitrothion (Standard)
  • HY-B0827
    Dinotefuran
    4 Publications Verification

    MTI-446

    		 nAChR Parasite Infection Cardiovascular Disease
    Dinotefuran is an orally active and competitive inhibitor and insecticide targeting insect nicotinic acetylcholine receptors (nAChRs). Dinotefuran blocks neural signaling and induces neural dysfunction in insects. Dinotefuran binds to [ 3H]epibatidine in the neural cord membrane of American cockroach with an IC50 of 890 nM and to [ 3H]α-bungarotoxin with an IC50 of 36.1 μM. Dinotefuran exhibits knockdown activity (KD50=0.351 nmol/g) and lethal activity (LD50=0.173 nmol/g) against German cockroach. Dinotefuran is mainly used for agricultural pest control, such as field control of piercing-sucking and chewing insects (e.g., aphids, planthoppers), while its environmental toxicological effects (e.g., oxidative stress and reproductive neurotoxicity on earthworms) are also a research focus to assess ecological risks .
    Dinotefuran
  • HY-W587768R
    Metoxadiazone (Standard)

    S-21074 (Standard)

    		 Insecticide Reference Standards Others
    Metoxadiazone (Standard) is the analytical standard of Metoxadiazone. This product is intended for research and analytical applications. Metoxadiazone is a type of insecticide that effectively controls a wide range of insects, including cockroaches and ants. Metoxadiazone exerts its insecticidal effect by impacting the nervous system of insects. Metoxadiazone can be used for research into its potential toxicity to humans and other non-target organisms .
    Metoxadiazone (Standard)

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