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Results for "

chain termination

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

1

MCE Kits

1

Isotope-Labeled Compounds

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-108060A
    Valopicitabine dihydrochloride

    NM283 dihydrochloride

    		 HCV HCV Protease Nucleoside Antimetabolite/Analog Infection
    Valopicitabine (NM283) dihydrochloride is a nucleoside analog and the orally bioavailable proagent of the potent anti-HCV agent 2'-C-methylcytidine (NM107). NM107competitively inhibits NS5B polymerase, causing chain termination .
    Valopicitabine dihydrochloride
  • HY-17422S1
    Acyclovir-d4

    Aciclovir-d4; Acycloguanosine-d4

    		 Isotope-Labeled Compounds HSV Bacterial Apoptosis Antibiotic Infection Cancer
    Acyclovir-d4 is the deuterium labeled Acyclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. Acyclovir inhibits HSV-1 (IC50 of 0.85 μM), HSV-2 (IC50 of 0.86 μM) and varicella-zoster virus. Acyclovir can be phosphorylated by viral thymidine kinase (TK), and Acyclovir triphosphate interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate and obligatory chain termination[1][2][3]. Acyclovir prevents bacterial infections during induction therapy for acute leukaemia[4].
    Acyclovir-d4
  • HY-171587
    3′-Deoxy CTP

    		HCV Infection
    3′-Deoxy CTP is a nucleotide analogue and a mandatory chain terminator. 3′-Deoxy CTP can cause chain termination by lacking the 3′-hydroxyl group, inhibiting the RNA synthesis activity of HCV nonstructural protein (NS5B) polymerase and blocking viral replication. 3′-Deoxy CTP can be used to study the chain termination mechanism of HCV polymerase and the development of antiviral drugs .
    3′-Deoxy CTP
  • HY-171587A
    3′-Deoxy CTP trisodium

    		HCV Infection
    3′-Deoxy CTP (trisodium) is the sodium salt form of 3′-Deoxy CTP (HY-171587). 3′-Deoxy CTP (trisodium) is a nucleotide analogue and a mandatory chain terminator. 3′-Deoxy CTP (trisodium) can cause chain termination by lacking the 3′-hydroxyl group, inhibiting the RNA synthesis activity of HCV nonstructural protein (NS5B) polymerase and blocking viral replication. 3′-Deoxy CTP (trisodium) can be used to study the chain termination mechanism of HCV polymerase and the development of antiviral drugs .
    3′-Deoxy CTP trisodium
  • HY-108060
    Valopicitabine

    NM283

    		 HCV HCV Protease Nucleoside Antimetabolite/Analog Infection
    Valopicitabine (NM283) is a nucleoside analog and the orally bioavailable proagent of the potent anti-HCV agent 2'-C-methylcytidine (NM107). NM107competitively inhibits NS5B polymerase, causing chain termination .
    Valopicitabine
  • HY-172002
    3'-O-Methylguanosine-5'-O-triphosphate sodium

    3'-O-Methyl GTP sodium

    		 Drug Derivative Metabolic Disease
    3'-O-Methylguanosine-5'-O-triphosphate (3'-O-Methyl GTP) sodium is a methylated derivative of Guanosine 5'-triphosphate (HY-W010737). 3'-O-Methylguanosine-5'-O-triphosphate has been used as a chain termination reagent in the preparation of early RNA polymerase II elongation intermediates.
    3'-O-Methylguanosine-5'-O-triphosphate sodium
  • HY-131603
    Lamivudine triphosphate

    3TCTP

    		 Reverse Transcriptase HCV HBV SARS-CoV Infection
    Lamivudine triphosphate (3TCTP) is a phosphorylated Lamivudine (HY-B0250) (a nucleoside analogue). Lamivudine triphosphate inhibits the Reverse Transcriptase of HIV or HBV viruses to block viral replication by chain termination. Lamivudine triphosphate is also an inhibitor of the RdRp activity of the NS5B subunit of the HCV. Lamivudine triphosphate can be incorporated into the nascent RNA by the SARS-CoV-2 RdRp, thus halting mutations in the nascent SARS-CoV-2 RNA .
    Lamivudine triphosphate

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