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cardioprotective activity

" in MedChemExpress (MCE) Product Catalog:

57

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1

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3

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23

Natural
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7

Isotope-Labeled Compounds

2

Click Chemistry

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0596
    Panaxadiol
    3 Publications Verification

    20(R)-Panaxadiol

    		 PD-1/PD-L1 HIF/HIF Prolyl-Hydroxylase STAT Cancer
    Panaxadiol (20(R)-Panaxadiol) is an orally active HIF-1α/STAT3 inhibitor. Panaxadiol can suppress HIF-1α and STAT3 then lead to downregulation of programmed cell death-ligand 1 (PD-L1) expression. Panaxadiol shows anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities .
    Panaxadiol
  • HY-N6033
    Ferruginol

    (+)-Ferruginol

    		 EBV HSV Apoptosis Infection Cardiovascular Disease Neurological Disease Cancer
    Ferruginol ((+)-Ferruginol), a natural diterpenoid, is an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA). Ferruginol inhibits the growth of thyroid cancer cells through the induction of mitochondrial apoptosis. Ferruginol has antitumor, cardioprotective, antioxidant, gastroprotective, and neuroprotective activities .
    Ferruginol
  • HY-N0055
    Chlorogenic acid
    Maximum Cited Publications
    20 Publications Verification

    3-O-Caffeoylquinic acid; Heriguard; NSC-407296

    		 HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) Bacterial Influenza Virus Endogenous Metabolite Infection Cardiovascular Disease Inflammation/Immunology Cancer
    Chlorogenic acid is a major phenolic compound in Lonicera japonica Thunb. It is an orally active antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension compound .
    Chlorogenic acid
  • HY-N0055R
    Chlorogenic acid (Standard)

    3-O-Caffeoylquinic acid (Standard); Heriguard (Standard); NSC-407296 (Standard)

    		 Reference Standards HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) Bacterial Influenza Virus Endogenous Metabolite Infection Inflammation/Immunology Cancer
    Chlorogenic acid (Standard) is the analytical standard of Chlorogenic acid. This product is intended for research and analytical applications. Chlorogenic acid is a major phenolic compound in Lonicera japonica Thunb. It is an orally active antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension compound .
    Chlorogenic acid (Standard)
  • HY-157448
    CBR1-IN-6

    		Apoptosis Cancer
    CBR1-IN-6 (compound 1a) is a CBR1 inhibitor with chemosensitizing and cardioprotective activities .
    CBR1-IN-6
  • HY-N0596R
    Panaxadiol (Standard)

    20(R)-Panaxadiol (Standard)

    		 Reference Standards PD-1/PD-L1 HIF/HIF Prolyl-Hydroxylase STAT Cancer
    Panaxadiol (Standard) is the analytical standard of Panaxadiol. This product is intended for research and analytical applications. Panaxadiol (20(R)-Panaxadiol) is an orally active HIF-1α/STAT3 inhibitor. Panaxadiol can suppress HIF-1α and STAT3 then lead to downregulation of programmed cell death-ligand 1 (PD-L1) expression. Panaxadiol shows anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities .
    Panaxadiol (Standard)
  • HY-159169
    5-LOX/sEH-IN-1

    		COX Epoxide Hydrolase Lipoxygenase Inflammation/Immunology
    5-LOX/sEH-IN-1 (Compound 8o) is a dual 5-LOX/sEH-IN-1 inhibitor with cardioprotective effects, exhibiting IC50 values of 3.05 μM and 2.20 nM respectively, and 5-LOX/sEH-IN-1 can also inhibit the activity of COX-2 (IC50=10.50 μM). 5-LOX/sEH-IN-1 has analgesic and anti-inflammatory effects, while reducing ulcer pathogenicity, and can be used to develop anti-inflammatory agents with fewer gastrointestinal and cardiovascular side effects .
    5-LOX/sEH-IN-1
  • HY-U00354
    CP-060

    		Calcium Channel Cardiovascular Disease
    CP-​060 is a potent Ca 2+ antagonist, inhibits Ca 2+ overload and possesses antioxidant and cardioprotective activities.
    CP-060
  • HY-168120
    Carvacrol-C4-3-hydroxybenzoic acid

    		Others Cardiovascular Disease
    Carvacrol-C4-3-hydroxybenzoic acid (compund 6) has significant cardioprotective activity and good computational ADMET properties.
    Carvacrol-C4-3-hydroxybenzoic acid
  • HY-118397
    RB394

    		PPAR Others
    RB394 is a potent dual sEH/PPARγ modulator isoform that promotes adipocyte browning and exhibits cardioprotective activity, and can be used to suppress metabolic syndrome.
    RB394
  • HY-19396
    Ingliforib
    2 Publications Verification

    CP 368296; GPi 296

    		 Phosphorylase Cardiovascular Disease
    Ingliforib (CP 368296) is a glycogen phosphorylase inhibitor, with IC50s of 52, 352 and 150 nM for liver, muscle and brain glycogen phosphorylase, and has cardioprotective activity.
    Ingliforib
  • HY-N1214
    Squalene

    Super Squalene; trans-Squalene; AddaVax

    		 Endogenous Metabolite Reactive Oxygen Species (ROS) Fungal Infection Cardiovascular Disease Cancer
    Squalene (Super Squalene) is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumour activity .
    Squalene
  • HY-12184
    ONO-AE 248

    		Prostaglandin Receptor Endogenous Metabolite Cardiovascular Disease
    ONO-AE 248 is a selective EP3 receptor agonist with cardioprotective activity. ONO-AE 248 reduces myocardial infarction size by selectively binding to the EP3α receptor in mice. The cardioprotective effect of ONO-AE 248 is independent of hemodynamic effects. The mechanism of ONO-AE 248 may involve activation of protein kinase C and opening of K(ATP) channels .
    ONO-AE 248
  • HY-N7697D
    Chitoheptaose heptahydrochloride

    		Reactive Oxygen Species (ROS) Cardiovascular Disease Inflammation/Immunology
    Chitoheptaose heptahydrochloride is a chitosan oligosaccharide with antioxidant, anti-inflammatory, antiapoptotic and cardioprotective activities. Chitoheptaose heptahydrochloride significantly enhances the growth and photosynthesis parameters of wheat seedlings .
    Chitoheptaose heptahydrochloride
  • HY-N0524
    Propyl gallate
    1 Publications Verification

    		 Reactive Oxygen Species (ROS) Apoptosis Cardiovascular Disease Inflammation/Immunology Cancer
    Propyl gallate is a common food antioxidant. Propyl gallate can inhibit the production of acrolein, glyoxal and methylglyoxal. Propyl gallate exhibits anti-inflammatory, antitumor and cardioprotective activities .
    Propyl gallate
  • HY-W013075
    Rutin trihydrate
    15+ Cited Publications

    Rutoside trihydrate; Quercetin 3-O-rutinoside trihydrate

    		 Apoptosis Endogenous Metabolite Neurological Disease Cancer
    Rutin (Rutoside) trihydrate is a multifunctional natural flavonoid glycoside. Rutin trihydrate has been demonstrating excellent antioxidant, anti-inflammatory, anti-diabetic, and anti-carcinogenic properties. Cardioprotective and neuroprotective activities .
    Rutin trihydrate
  • HY-108502
    KC 12291 hydrochloride

    		Sodium Channel Cardiovascular Disease
    KC 12291 hydrochloride is an orally active blocker of voltage-gated sodium channel (VGSC). KC 12291 hydrochloride reduces the amplitude of sustained Na + current to exert antiischemic activity. KC 12291 hydrochloride has significant cardioprotective effect in vitro and in vivo .
    KC 12291 hydrochloride
  • HY-121710
    MonoHER

    7-Monohydroxyethylrutoside

    		 Carbonyl Reductase Cardiovascular Disease
    MonoHER (7-Monohydroxyethylrutoside) is a Carbonyl reductase 1 (CBR1) inhibitor and can be used as a cardioprotective agent. MonoHER inhibits the activity of CBR1 V88 and CBR1 I88 in a concentration-dependent manner .
    MonoHER
  • HY-N8754
    (7S)-Dalbergiphenol

    		Others Cardiovascular Disease Cancer
    (7S)-Dalbergiphenol is a cytotoxic compound that can be isolated from Brazilian red propoli. (7S)-Dalbergiphenol inhibits cancer cell viability. Brazilian red propoli has cardioprotective activity .
    (7S)-Dalbergiphenol
  • HY-108286
    Talinolol

    Cordanum

    		 Adrenergic Receptor Cardiovascular Disease
    Talinolol (Cordanum) is a long-acting, cardioselective β1-adrenergic receptor blocker. Talinolol exhibits cardioprotective and antihypertensive activities. Talinolol is also a well-known and frequently used probe substrate for P-glycoprotein (P-gp) activity .
    Talinolol
  • HY-135175
    Phenoprolamine hydrochloride

    		Adrenergic Receptor Cardiovascular Disease Neurological Disease
    Phenoprolamine hydrochloride is an adrenergic α1 receptor antagonist that exhibits potent antihypertensive effects. Phenoprolamine hydrochloride demonstrates neuroprotective and cardioprotective properties. Phenoprolamine hydrochloride inhibits CYP2D and CYP3A activities while down-regulating their mRNA transcription.
    Phenoprolamine hydrochloride
  • HY-N1214R
    Squalene (Standard)

    Super Squalene (Standard); trans-Squalene (Standard); AddaVax (Standard)

    		 Reference Standards Endogenous Metabolite Reactive Oxygen Species (ROS) Fungal Infection Cardiovascular Disease
    Squalene (Standard) is the analytical standard of Squalene. This product is intended for research and analytical applications. Squalene (Super Squalene) is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumour activity .
    Squalene (Standard)
  • HY-110075
    Dexrazoxane monohydrochloride

    		Others Cardiovascular Disease
    Dexrazoxane monohydrochloride is the hydrochloride of Dexrazoxane (HY-B0581). Dexrazoxane can prevent or reduce cardiac damage and is an iron chelator and apoptosis inducer. Dexrazoxane has cardioprotective, anti-inflammatory, antioxidant, anti-tumor and neuroprotective activities and inhibits ferroptosis .
    Dexrazoxane monohydrochloride
  • HY-N1214S
    Squalene-d6

    Super Squalene-d6; trans-Squalene-d6; AddaVax-d6

    		 Isotope-Labeled Compounds Others
    Squalene-d6 (Super Squalene-d6) is a deuterium labeled Squalene. Squalene (Super Squalene) is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumour activity .
    Squalene-d6
  • HY-19463A
    F15845

    		Sodium Channel Cardiovascular Disease
    F 15845 is a highly effective persistent sodium current blocker. F 15845 also is a cardioprotective agent, has anti-ischemic activity and exerts short- and long-term cardioprotection after myocardial infarction. F 15845 can be used for the research of myocardium functional impairment .
    F15845
  • HY-108286S
    (Rac)-Talinolol-d5

    		Isotope-Labeled Compounds Adrenergic Receptor Cardiovascular Disease
    (Rac)-Talinolol-d5 is the racemate of Talinolol. Talinolol (Cordanum) is a long-acting, cardioselective β1-adrenergic receptor blocker. Talinolol exhibits cardioprotective and antihypertensive activities. Talinolol is also a well-known and frequently used probe substrate for P-glycoprotein (P-gp) activity .
    (Rac)-Talinolol-d5
  • HY-N0368
    Linalool
    3 Publications Verification

    		 TNF Receptor Apoptosis iGluR Endogenous Metabolite Bacterial Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
    Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .
    Linalool
  • HY-N0524R
    Propyl gallate (Standard)

    		Reference Standards Reactive Oxygen Species (ROS) Apoptosis Cardiovascular Disease Inflammation/Immunology Cancer
    Propyl gallate (Standard) is the analytical standard of Propyl gallate. This product is intended for research and analytical applications. Propyl gallate is a common food antioxidant. Propyl gallate can inhibit the production of acrolein, glyoxal and methylglyoxal. Propyl gallate exhibits anti-inflammatory, antitumor and cardioprotective activities .
    Propyl gallate (Standard)
  • HY-B0655
    Zofenopril calcium

    SQ26991

    		 Angiotensin-converting Enzyme (ACE) Reactive Oxygen Species (ROS) Cardiovascular Disease
    Zofenopril Calcium (SQ26991) is an orally active angiotensin-converting enzyme (ACE) inhibitor with antioxidant activity and cardioprotective effects. Zofenopril Calcium reduces ROS production and GSH consumption and helps inhibit foam cell formation, thus slowing the progression of atherosclerosis. Zofenopril Calcium prevents cardiac damage caused by chronic Doxorubicin (HY-15142A).
    Zofenopril calcium
  • HY-108351
    IM-54

    		Necroptosis Cardiovascular Disease
    IM-54 is a selective inhibitor of oxidative stress-induced necrosis. IM-54 shows potent inhibitory activity against H2O2-induced necrosis. IM-54 acts as a potential cardioprotective agent and biological tool for investigating the molecular mechanisms of cell death .
    IM-54
  • HY-B0581
    Dexrazoxane
    15+ Cited Publications

    ICRF-187; ADR-529; NSC-169780

    		 Ferroptosis Apoptosis Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
    Dexrazoxane, as an intracellular iron chelating agent, reduces the formation of superoxide radicals and has cardioprotective, anti-inflammatory, antioxidant, anti-tumor and neuroprotective activities. Dexrazoxane inhibits ferroptosis of H9c2 cells by inhibiting HMGB1. Dexrazoxane induces DNA damage and apoptosis in human fibrosarcoma cells .
    Dexrazoxane
  • HY-W728451
    URB694

    		FAAH Cardiovascular Disease Neurological Disease
    URB694 is a carbamate FAAH inhibitor that irreversibly carbamoylate the nucleophile catalytic serine in FAAH active site. URB694 exhibits antidepressant-like activity and cardioprotective effects. URB694 can be used to prepare 11C-Carbonyl-URB694 for in vivo positron emission tomography (PET) imaging studies of the brain FAAH .
    URB694
  • HY-133829
    Zofenoprilat

    		Angiotensin-converting Enzyme (ACE) Cardiovascular Disease
    Zofenoprilat is an orally active inhibitor for angiotensin converting enzyme (ACE) with an IC50 of 1.7 nM. Zofenoprilat inhibits the expression of angiotensin II, reduces the blood pressure, exhibits thus cardioprotective and renalprotective activity. Zofenoprilat promotes the NO production, decreases endothelin-1 (ET-1) expression, exhibits protective effect on vascular endothelial function. Zofenoprilat regulates oxidative stress-related molecules, exhibits antioxidant activity .
    Zofenoprilat
  • HY-105064
    Zoniporide
    2 Publications Verification

    CP-597396

    		 Na+/H+ Exchanger (NHE) Cardiovascular Disease
    Zoniporide (CP-597396) is a potent and selective NHE-1 inhibitor with cardioprotective activity. Zoniporide inhibits 22Na + uptake by human NHE-1-expressing fibroblasts in a concentration-dependent manner (IC50=14 nM). Zoniporide inhibits platelet swelling in vitro with an IC50 of 0.059 μM. Zoniporide can be used in the study of cardiovascular disease .
    Zoniporide
  • HY-N0120
    (E/Z)-Polydatin
    1 Publications Verification

    (E/Z)-Piceid

    		 Others Inflammation/Immunology
    (E/Z)-Polydatin ((E/Z)-Piceid) is the E/Z mixture of Polydatin (HY-N0120A). Polydatin is a monocrystalline compound originally isolated from the root and rhizome of Polygonum cuspidatum. (E/Z)-Polydatin has anti-platelet aggregation, anti-oxidative action of low-density lipoprotein (LDL), cardioprotective activity, anti-inflammatory and immune-regulating functions .
    (E/Z)-Polydatin
  • HY-N0213
    Peiminine
    5+ Cited Publications

    Verticinone; Raddeanine

    		 Autophagy Caspase Bcl-2 Family PARP p38 MAPK ERK NF-κB Apoptosis Inflammation/Immunology Cancer
    Peiminine is a compound that can be isolated from Bolbostemma paniculatum (Maxim) Franquet (Cucurbitaceae family). Peiminine can induce apoptosis in human hepatocellular carcinoma HepG2 cells through both extrinsic and intrinsic apoptotic pathways. Peiminine has anti-inflammatory, anticancer, anti-osteoporosis, cardioprotective and other activities in many animal models .
    Peiminine
  • HY-N0368S1
    Linalool-13C3

    		Apoptosis Endogenous Metabolite iGluR Bacterial Isotope-Labeled Compounds Cancer
    Linalool- 13C3 is 13C labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .
    Linalool-13C3
  • HY-152052S
    Linalool-d5

    		Isotope-Labeled Compounds Others
    Linalool-d5 is the deuterium labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .
    Linalool-d5
  • HY-N0368S2
    Linalool-d6

    		Apoptosis Endogenous Metabolite iGluR Bacterial Isotope-Labeled Compounds Cancer
    Linalool-d6 is deuterated labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .
    Linalool-d6
  • HY-W001538
    S-Propargylcysteine

    SPRC

    		 STAT MDM-2/p53 Inflammation/Immunology
    S-Propargylcysteine (SPRC), a structural analog of S-allyl cysteine (SAC), is a slow H2S-releasing compound. S-Propargylcysteine reduces Ca 2+ accumulation and inflammatory cytokines, inhibits STAT3, and elevates p53 and Bax. S-Propargylcysteine has anti-inflammatory activity and protects mice against acute pancreatitis. S-Propargylcysteine also has cardioprotective, neuroprotective acitivties .
    S-Propargylcysteine
  • HY-B0581R
    Dexrazoxane (Standard)

    ICRF-187 (Standard); ADR-529 (Standard); NSC-169780 (Standard)

    		 Ferroptosis Apoptosis Reference Standards Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
    Dexrazoxane (Standard) is the analytical standard of Dexrazoxane. This product is intended for research and analytical applications. Dexrazoxane, as an intracellular iron chelating agent, reduces the formation of superoxide radicals and has cardioprotective, anti-inflammatory, antioxidant, anti-tumor and neuroprotective activities. Dexrazoxane inhibits ferroptosis of H9c2 cells by inhibiting HMGB1. Dexrazoxane induces DNA damage and apoptosis in human fibrosarcoma cells .
    Dexrazoxane (Standard)
  • HY-N0055S
    Chlorogenic acid-13C3

    3-O-Caffeoylquinic acid-13C3; Heriguard-13C3; NSC-407296-13C3

    		 Isotope-Labeled Compounds Cancer
    Chlorogenic acid- 13C3 (Heriguard- 13C3; NSC-407296- 13C3) is 13C- and 15N-labeled Chlorogenic acid (HY-N0055). Chlorogenic acid is a major phenolic compound in Lonicera japonica Thunb.. It plays several important and therapeutic roles such as antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension .
    Chlorogenic acid-13C3
  • HY-W145695
    Chitoheptaose

    		Biochemical Assay Reagents Inflammation/Immunology
    Chitoheptaose is a chitosan oligosaccharide. Chitoheptaose is capable of extracting exoskeletons from crustaceans, such as the shells of crabs, shrimp and lobsters. Chitoheptaose has antioxidant, anti-inflammatory and anti-apoptotic activities and can be used in the study of myocarditis. Chitoheptaose has cardioprotective effects and improves cardiac parameters (left ventricular internal size, end-systolic and end-diastolic, ejection fraction and shortening fraction), inflammatory cytokines (IL-1β) in vanishing models .
    Chitoheptaose
  • HY-105064R
    Zoniporide (Standard)

    CP-597396 (Standard)

    		 Reference Standards Na+/H+ Exchanger (NHE) Cardiovascular Disease
    Zoniporide (Standard) is the analytical standard of Zoniporide. This product is intended for research and analytical applications. Zoniporide (CP-597396) is a potent and selective NHE-1 inhibitor with cardioprotective activity. Zoniporide inhibits 22Na+ uptake by human NHE-1-expressing fibroblasts in a concentration-dependent manner (IC50=14 nM). Zoniporide inhibits platelet swelling in vitro with an IC50 of 0.059 μM. Zoniporide can be used in the study of cardiovascular disease .
    Zoniporide (Standard)
  • HY-W010410S
    Oct-1-en-3-ol-d3

    		Isotope-Labeled Compounds Metabolic Disease
    Oct-1-en-3-ol-d3 is deuterated labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .
    Oct-1-en-3-ol-d3
  • HY-N0213R
    Peiminine (Standard)

    Verticinone (Standard); Raddeanine (Standard)

    		 Reference Standards Autophagy Caspase Bcl-2 Family PARP p38 MAPK ERK NF-κB Apoptosis Inflammation/Immunology Cancer
    Peiminine (Standard) is the analytical standard of Peiminine. This product is intended for research and analytical applications. Peiminine is a compound that can be isolated from Bolbostemma paniculatum (Maxim) Franquet (Cucurbitaceae family). Peiminine can induce apoptosis in human hepatocellular carcinoma HepG2 cells through both extrinsic and intrinsic apoptotic pathways. Peiminine has anti-inflammatory, anticancer, anti-osteoporosis, cardioprotective and other activities in many animal models .
    Peiminine (Standard)
  • HY-12403A
    Talfirastide acetate
    10+ Cited Publications

    TXA127 acetate; Angiotensin (1-7) acetate; Ang-(1-7) acetate

    		 Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
    Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 acetate inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acetate acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 acetate blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium .
    Talfirastide acetate
  • HY-12403
    Talfirastide
    10+ Cited Publications

    TXA127; Angiotensin (1-7); Ang-(1-7)

    		 Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
    Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity .
    Talfirastide
  • HY-125959
    Ucf-101
    1 Publications Verification

    		 Apoptosis Cardiovascular Disease Neurological Disease
    Ucf-101 is a selective and competitive inhibitor of pro-apoptotic protease Omi/HtrA2, with an IC50 of 9.5 μM for His-Omi. Ucf-101 exhibits very little activity against various other serine proteases (IC50>200 μM). Ucf-101 has a natural red fluorescence at 543 nm that is used to monitor its ability to enter mammalian cells. Ucf-101 has a significant cardioprotective effect against MI/R injury and also has certain neuroprotective effect .
    Ucf-101
  • HY-N8380
    (-)-Latifolin

    		Apoptosis Autophagy PI3K Necroptosis Cardiovascular Disease Inflammation/Immunology Cancer
    (-)-Latifolin, a flavonoid, induces apoptotic cell death by targeting PI3K/AKT/mTOR/p70S6K signaling. (-)-Latifolin significantly inhibits the cell proliferation of oral squamous cell carcinoma (OSCC), and causes the anti-metastatic activities by effectively blocking cell migration, invasion, and adhesion via the inactivation of FAK/Src. (-)-Latifolin suppresses autophagic-related proteins and autophagosome formation. (-)-Latifolin inhibits necroptosis by dephosphorylating necroptosis-regulatory proteins (RIP1, RIP3, and MLKL). (-)-Latifolin has beneficial effects on anti-aging, anti-carcinogenic, anti-inflammatory, and cardio-protective activities .
    (-)-Latifolin

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