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Pathways Recommended:	Membrane Transporter/Ion Channel

Results for "

calcium ion concentration

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Calcium Channel (4) CaSR (2) Biochemical Assay Reagents (2) Endogenous Metabolite (1) Fluorescent Dye (6) Guanylate Cyclase (1) LDLR (1) P2Y Receptor (1) Platelet-activating Factor Receptor (PAFR) (1) Potassium Channel (1) TRP Channel (1)
By Research Areas:	Cardiovascular Disease (1) Metabolic Disease (5) Neurological Disease (2)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Targets Recommended: Calcium Channel CaSR Calmodulin CRAC Channel

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B2200

Calcium citrate tetrahydrate, 99% Tricalcium dicitrate tetrahydrate, 99%	Calcium Channel Biochemical Assay Reagents	Metabolic Disease
Calcium citrate tetrahydrate, 99% exhibits the ability to release more calcium ions in a short time therefore allowing a high activity, and a high concentration of calcium ions that can stimulate bone formation .

HY-101898

Indo-1 AM 1 Publications Verification Indo-1 Acetoxymethyl ester	Fluorescent Dye	Others
Calcium is an important part of the human body, usually in the form of calcium, a large number of bones and teeth of the human body, a small amount of blood and tissues. MCE calcium ion detection probe can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence, in addition, Mag-indo-1/AM and Mag-Fluo-4 AM at a certain concentration (usually 5 mM) can effectively identify intracellular magnesium ions .

HY-148129

Apecotrep TRPC6-IN-3	TRP Channel	Cardiovascular Disease
Apecotrep (TRPC6-IN-3) (compound 17) is a potent, orally active *transient receptor potential C6 ion* channel (TRPC6)** inhibitor. Apecotrep modulates not only intracellular calcium concentration, but also membrane potential by modulating the flux of cations including calcium and sodium ions. Apecotrep can be used in research of respiratory system .

HY-Y0537E

Potassium chloride, for cell culture	Biochemical Assay Reagents Potassium Channel Calcium Channel	Neurological Disease
Potassium chloride, for cell culture is potassium chloride that can be used for cell culture. Potassium chloride, for cell culture increases extracellular potassium ion concentration to induce cellular depolarization, thereby activating voltage-gated calcium channels and regulating intracellular calcium signaling. Potassium chloride, for cell culture upregulates Brn-5. Potassium chloride, for cell culture inhibits the proliferation of neurons and some plant cells .

HY-D1639

5,5'-Dibromo BAPTA tetrapotassium	Fluorescent Dye	Others
5,5'-Dibromo BAPTA tetrapotassium is a calcium chelator, can be formulated into a buffer with a defined calcium ion concentration. 5,5'-Dibromo BAPTA tetrapotassium can control the concentration of calcium ions inside and outside the cell and can be used in studies of calcium physiological activity .

HY-172627

Rhod-FF tripotassium	Fluorescent Dye Calcium Channel	Others
Rhod-FF tripotassium is a Rhod-2 derivative and low-affinity calcium indicator (K_d of 320 μM). Rhod-FF tripotassium indicates calcium concentration by fluorescence upon binding to calcium ions, with excitation at 552 nm and emission at 580 nm .

HY-158746

Fluo-2 AM Fluo-2 acetoxymethyl ester; Fluo-2 ha; Fluo-2 high affinity	Fluorescent Dye	Others
Fluo-2 AM (Fluo-2 acetoxymethyl ester) is a fluorescent dye, that can be used for detection of intracellular calcium ion concentration .

HY-D1701

Mag-Fura-2 AM	Fluorescent Dye	Others
Calcium is an important part of the human body, usually in the form of calcium, a large number of bones and teeth of the human body, a small amount of blood and tissues. MCE calcium ion detection probe can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence, in addition, Mag-indo-1/AM and Mag-Fluo-4 AM at a certain concentration (usually 5 mM) can effectively identify intracellular magnesium ions .

HY-120174

SU200	Endogenous Metabolite	Others
SU200 is a TRPV1 agonist with the activity of regulating intracellular calcium ion concentration. SU200 can induce different calcium ion response modes, showing significant reaction potential and maximum reaction effect. There is obvious response delay and variability in the effects of SU200 in different cells. The use of SU200 may provide pharmacological development opportunities .

HY-126551

Butenoyl-PAF	LDLR Platelet-activating Factor Receptor (PAFR) Calcium Channel	Metabolic Disease
Butenoyl-PAF is a phospholipid analog of platelet activating factor (PAF-like) that is generated in oxidized low-density lipoprotein (DLDR). Butenoyl-PAF can activate cells that express human PAF receptors, such as neutrophils, monocytes, and platelets, and it stimulates an increase in intracellular *calcium* ion concentration .

HY-137325

2-Chloro-ATP	Guanylate Cyclase	Others
2-Chloro-ATP is a soluble guanylate cyclase inhibitor that increases intracellular calcium concentration at low concentrations through a mechanism independent of inositol phosphate production .

HY-10171

NPS-2143 hydrochloride Maximum Cited Publications 24 Publications Verification SB-262470A hydrochloride	CaSR	Metabolic Disease
NPS-2143 hydrochloride (SB-262470A hydrochloride), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 hydrochloride (SB-262470A hydrochloride) blocks increases in cytoplasmic Ca ²⁺ concentrations (IC₅₀=43 nM) elicited by activating the Ca ²⁺ receptor in HEK 293 cells expressing the human Ca ²⁺ receptor .

HY-10007

NPS-2143 Maximum Cited Publications 24 Publications Verification SB-262470A	CaSR	Metabolic Disease
NPS-2143 (SB-262470A), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 (SB-262470A) blocks increases in cytoplasmic Ca ²⁺ concentrations (IC₅₀=43 nM) elicited by activating the Ca ²⁺ receptor in HEK 293 cells expressing the human Ca ²⁺ receptor .

HY-D0121B

INDO 1 pentasodium	Fluorescent Dye	Others
INDO 1 pentasodium is a ratiometric, free calcium ion (Ca ²⁺) fluorescent indicator that can quantitatively monitor dynamic changes in intracellular free Ca ²⁺ concentrations. When unbound to Ca ²⁺ (free state), INDO 1 pentasodium exhibits a peak emission wavelength of 485 nm under UV excitation (350 nm). Upon binding to Ca ²⁺ (bound state), the emission peak shifts to 405 nm. INDO 1 pentasodium is highly photolabile and susceptible to photobleaching, and its emission spectrum may overlap with the autofluorescence of NADH .

HY-108663

5-OMe-UDP 5-Methoxyuridine 5'-trihydrogen diphosphate	P2Y Receptor	Neurological Disease Metabolic Disease
5-OMe-UDP (5-methoxyuridine 5'-trihydrogen diphosphate) is a P2Y6 receptor agonist (EC₅₀=0.08 μM). 5-OMe-UDP activates the P2Y6 receptor by binding to it, which triggers signaling pathways within the cell. This activation can lead to an increase in intracellular calcium ion concentration, which in turn regulates cellular function. The methoxy groups of 5-OMe-UDP provide additional activity and selectivity, contributing to the binding of 5-OMe-UDP to the P2Y6 receptor. 5-OMe-UDP can be used to study diseases related to P2Y6 receptor function, such as diabetes, inflammatory bowel disease, Alzheimer's disease, etc .

Cat. No.	Product Name

HY-L166

Ion Channel Compound Library	1,450 compounds
Ion channel is a membrane-binding enzyme whose catalytic site is an ion conduction pore, which is opened and closed in response to specific environmental stimuli (voltage, ligand concentration, membrane tension, temperature, etc.). Ion channel provide pores for the passive diffusion of ions on the biofilm. Due to their high selectivity for ion, ion channel are generally classified as sodium (Na⁺ ), potassium (K⁺ ), calcium (Ca²⁺ ), chloride (Cl^- ), and non-specific cation channel. Ion channel is an important contributor to cell signal transduction and homeostasis. In addition to electrical signal transduction, ion channel also have many functions: regulating vascular smooth muscle contraction, maintaining normal cell volume, regulating glandular secretion, protein kinase activation, etc. Therefore, dysfunction of ion channel can lead to many diseases, and its mechanism research is particularly important. MCE designs a unique collection of 1,450 small molecules related to ion channel, mainly targeting Na⁺ channel, K⁺ channel, Ca²⁺ channel, GABA receptor, iGluR, etc. It is an essential tool for research of cardiovascular diseases, Nervous system diseases and other diseases.

Ion Channel Compound Library

1,450 compounds

Ion channel is a membrane-binding enzyme whose catalytic site is an ion conduction pore, which is opened and closed in response to specific environmental stimuli (voltage, ligand concentration, membrane tension, temperature, etc.). Ion channel provide pores for the passive diffusion of ions on the biofilm. Due to their high selectivity for ion, ion channel are generally classified as sodium (Na⁺ ), potassium (K⁺ ), calcium (Ca²⁺ ), chloride (Cl^- ), and non-specific cation channel. Ion channel is an important contributor to cell signal transduction and homeostasis. In addition to electrical signal transduction, ion channel also have many functions: regulating vascular smooth muscle contraction, maintaining normal cell volume, regulating glandular secretion, protein kinase activation, etc. Therefore, dysfunction of ion channel can lead to many diseases, and its mechanism research is particularly important.

MCE designs a unique collection of 1,450 small molecules related to ion channel, mainly targeting Na⁺ channel, K⁺ channel, Ca²⁺ channel, GABA receptor, iGluR, etc. It is an essential tool for research of cardiovascular diseases, Nervous system diseases and other diseases.

Cat. No.	Product Name	Type

HY-101898

Indo-1 AM 1 Publications Verification Indo-1 Acetoxymethyl ester	Fluorescent Dyes/Probes
Calcium is an important part of the human body, usually in the form of calcium, a large number of bones and teeth of the human body, a small amount of blood and tissues. MCE calcium ion detection probe can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence, in addition, Mag-indo-1/AM and Mag-Fluo-4 AM at a certain concentration (usually 5 mM) can effectively identify intracellular magnesium ions .

Indo-1 AM

1 Publications Verification

Indo-1 Acetoxymethyl ester

Fluorescent Dyes/Probes

Calcium is an important part of the human body, usually in the form of calcium, a large number of bones and teeth of the human body, a small amount of blood and tissues. MCE calcium ion detection probe can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence, in addition, Mag-indo-1/AM and Mag-Fluo-4 AM at a certain concentration (usually 5 mM) can effectively identify intracellular magnesium ions .

HY-D1639

5,5'-Dibromo BAPTA tetrapotassium	Fluorescent Dyes/Probes
5,5'-Dibromo BAPTA tetrapotassium is a calcium chelator, can be formulated into a buffer with a defined calcium ion concentration. 5,5'-Dibromo BAPTA tetrapotassium can control the concentration of calcium ions inside and outside the cell and can be used in studies of calcium physiological activity .

HY-158746

Fluo-2 AM Fluo-2 acetoxymethyl ester; Fluo-2 ha; Fluo-2 high affinity	Fluorescent Dyes/Probes
Fluo-2 AM (Fluo-2 acetoxymethyl ester) is a fluorescent dye, that can be used for detection of intracellular calcium ion concentration .

HY-D1701

Mag-Fura-2 AM	Fluorescent Dyes/Probes
Calcium is an important part of the human body, usually in the form of calcium, a large number of bones and teeth of the human body, a small amount of blood and tissues. MCE calcium ion detection probe can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence, in addition, Mag-indo-1/AM and Mag-Fluo-4 AM at a certain concentration (usually 5 mM) can effectively identify intracellular magnesium ions .

Mag-Fura-2 AM

Fluorescent Dyes/Probes

HY-D0121B

INDO 1 pentasodium	Fluorescent Dyes/Probes
INDO 1 pentasodium is a ratiometric, free calcium ion (Ca ²⁺) fluorescent indicator that can quantitatively monitor dynamic changes in intracellular free Ca ²⁺ concentrations. When unbound to Ca ²⁺ (free state), INDO 1 pentasodium exhibits a peak emission wavelength of 485 nm under UV excitation (350 nm). Upon binding to Ca ²⁺ (bound state), the emission peak shifts to 405 nm. INDO 1 pentasodium is highly photolabile and susceptible to photobleaching, and its emission spectrum may overlap with the autofluorescence of NADH .

INDO 1 pentasodium

Fluorescent Dyes/Probes

INDO 1 pentasodium is a ratiometric, free calcium ion (Ca ²⁺) fluorescent indicator that can quantitatively monitor dynamic changes in intracellular free Ca ²⁺ concentrations. When unbound to Ca ²⁺ (free state), INDO 1 pentasodium exhibits a peak emission wavelength of 485 nm under UV excitation (350 nm). Upon binding to Ca ²⁺ (bound state), the emission peak shifts to 405 nm. INDO 1 pentasodium is highly photolabile and susceptible to photobleaching, and its emission spectrum may overlap with the autofluorescence of NADH .

Cat. No.	Product Name	Type

HY-B2200

Calcium citrate tetrahydrate, 99% Tricalcium dicitrate tetrahydrate, 99%	Buffer Reagents
Calcium citrate tetrahydrate, 99% exhibits the ability to release more calcium ions in a short time therefore allowing a high activity, and a high concentration of calcium ions that can stimulate bone formation .

HY-Y0537E

Potassium chloride, for cell culture	Buffer Reagents
Potassium chloride, for cell culture is potassium chloride that can be used for cell culture. Potassium chloride, for cell culture increases extracellular potassium ion concentration to induce cellular depolarization, thereby activating voltage-gated calcium channels and regulating intracellular calcium signaling. Potassium chloride, for cell culture upregulates Brn-5. Potassium chloride, for cell culture inhibits the proliferation of neurons and some plant cells .

Potassium chloride, for cell culture

Buffer Reagents

Potassium chloride, for cell culture is potassium chloride that can be used for cell culture. Potassium chloride, for cell culture increases extracellular potassium ion concentration to induce cellular depolarization, thereby activating voltage-gated calcium channels and regulating intracellular calcium signaling. Potassium chloride, for cell culture upregulates Brn-5. Potassium chloride, for cell culture inhibits the proliferation of neurons and some plant cells .

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