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PF-07328948 is an orally effective BDK (branchchain ketoacid dehydrogenase kinase) inhibitor, with IC50 of 110 nM. PF-07328948 acts as a BCKDH (branchchain ketoacid dehydrogenase) enzyme complex degrader to enhance BCAA (branchchainamino acid) catabolism. PF-07328948 improves metabolic and heart failure end points in rats .
L-Leucine-d10 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chainamino acid (BCAA), which activates the mTOR signaling pathway .
L-Leucine-d2 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chainamino acid (BCAA), which activates the mTOR signaling pathway .
L-Leucine-d3 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chainamino acid (BCAA), which activates the mTOR signaling pathway .
Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde that acts as a highly selective and potent proteasomal inhibitor (Ki = 1.5 µM for branchedchainamino acid preferring, 2.3 µM for small neutral amino acid preferring, and 40.5 µM for chymotrypsin-like activities; IC50 = 3.1 µM for peptidyl-glutamyl peptide hydrolyzing activity) .
L-Leucine-d is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chainamino acid (BCAA), which activates the mTOR signaling pathway .
L-Leucine-d7 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chainamino acid (BCAA), which activates the mTOR signaling pathway .
ERG240 is an oral active branched-chainamino acid aminotransferase 1 (BCAT1) inhibitor. ERG240 can be used for the research of cancer, rheumatoid arthritis, and bone disease .
L-Leucine (Standard) is the analytical standard of L-Leucine. This product is intended for research and analytical applications. L-Leucine is an essential branched-chainamino acid (BCAA), which activates the mTOR signaling pathway .
Triafamone (AE 1887196) is a paddy field pre-emergence and post-emergence sulfonamide herbicide. Triafamone weeds by
inhibiting the acetolactate synthase (ALS) enzyme, thereby blocking the biosynthesis of branched-chainaminoacids .
L-Alloisoleucine-d10 is the deuterium labeled L-Alloisoleucine. L-Alloisoleucine is a branchedchainamino acid and is a stereo-isomer of L-isoleucine. L-Alloisoleucine is a common constituent of human plasma (albeit at low levels).
L-Leucine- 13C6, 15N is the 13C- and 15N-labeled L-Leucine. L-Leucine is an essential branched-chainamino acid (BCAA), which activates the mTOR signaling pathway .
L-Leucine-2- 13C, 15N is the 13C- and 15N-labeled L-Leucine. L-Leucine is an essential branched-chainamino acid (BCAA), which activates the mTOR signaling pathway .
2,3-Dihydroxyisovaleric acid (2,3-Dihydroxy-3-methylbutanoic acid) is a natural metabolite of the branched-chainamino acid leucine that has been found present in the urine of a patient with 2-hydroxyglutaric aciduria .
L-Leucine-1- 13C, 15N is the 13C- and 15N-labeled L-Leucine. L-Leucine is an essential branched-chainamino acid (BCAA), which activates the mTOR signaling pathway .
PF-07208254 is a selective, orally active allosteric inhibitor of branched-chain ketoacid dehydrogenase kinase (BDK) (IC50=110 nM, Ki=54 nM, KD=84 nM). PF-07208254 inhibits BDK-mediated BCKDH phosphorylation and enhances the catabolism of branched-chainaminoacids (BCAAs) and branched-chain keto acids (BCKAs) by binding to the allosteric pocket of BDK, reducing BDK binding to BCKDH-E2 and promoting BDK degradation. PF-07208254 inhibits BDK activity in human skeletal muscle cells (IC50=540 nM) and has activity to improve cardiac function and metabolism. PF-07208254 can be used in the study of cardiometabolic diseases (e.g., heart failure, type 2 diabetes) .
L-Cycloserine ((S)-4-Amino-3-isoxazolidone) is an oral inhibitor of the enzyme gamma-aminobutyric acid (GABA) transaminase (GABA-t) and branched-chain transaminases in Mycobacterium tuberculosis. L-Cycloserine has anticonvulsant properties and inhibits the synthesis of neurotensin in mouse brains .
Foramsulfuron is a postemergence herbicide used for selective control of grass and some broadleaved weeds in maize (Zea mays L.). Foramsulfuron is a sulfonylurea herbicide that exerts its herbicidal activity by inhibiting acetolactate synthase (ALS), a key enzyme in the biosynthesis of branchedchainaminoacids .
LAGIPRA peptide is a long-acting GIP1R agonist. LAGIPRA peptide enhances insulin sensitivity by augmenting glucose disposal and reduces branched-chainaminoacids (BCAAs) and ketoacids. LAGIPRA peptide has the potential for the research of type 2 diabetes .
BAY-069 is a potent branched-chainamino acid transaminases 1 (BCAT1) and BCAT2 inhibitor with IC50 values of 31 nM and 153 nM, respectively. BAY-069 also can be used as a chemical probe. BAY-069 can be used tor research anticancer .
2-Methylvaleric acid is a branched short-chain fatty acid (SCFA) produced by the metabolism of branched-chainaminoacids by gut microbes. 2-Methylvaleric acid can be used as a potential biomarker for metabolic diseases such as type 2 diabetes, and its content is significantly reduced in the feces of diabetic mice. 2-Methylvaleric acid may regulate host energy metabolism and inflammatory response through G protein-coupled receptors (GPCRs) or histone deacetylase (HDAC) inhibition. 2-Methylvaleric acid can be used to study gut microbe-host interactions and metabolic diseases as a fecal biomarker[1][2].
Harzianic acid, a tetramic acid derivative, with activity of antimicrobial, antibiofilm formation and biofilm disaggregation. Harzianic acid interferes with biofilm formation by limiting bacterial iron availability. Harzianic acid is also a selective inhibitor of Acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chainamino acid biosynthetic pathway. Harzianic acid can used for herbicide and fungicide .
BAY-252 is a potent branched-chainamino acid transaminases 1 (BCAT1) and BCAT2 inhibitor with IC50s of 2 μM and 2 μM, respectively. BAY-069 also can be used as a chemical probe. BAY-069 can be used for the research of cancer .
L-Isoleucine is an orally active branchedchainamino acid, which is the L-enantiomer of isoleucine. L-Isoleucine has a role as a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a plant metabolite, a human metabolite, an algal metabolite and a mouse metabolite. L-Isoleucine regulates the inflammatory response to protect against pathogens in vivo and in vitro .
Florasulam is a targeted post-emergent herbicide belonging to the triazolopyrimidine sulfonanilide class, which functions by inhibiting acetolactate synthase (ALS) in plants. Located in the chloroplasts, ALS plays a crucial role in the biosynthesis of branched-chainaminoacids. When Florasulam inhibits ALS, it disrupts plant cell division, reduces growth, and ultimately leads to plant death.
L-Cycloserine (Standard) is the analytical standard of L-Cycloserine. This product is intended for research and analytical applications. L-Cycloserine ((S)-4-Amino-3-isoxazolidone) is an oral inhibitor of the enzyme gamma-aminobutyric acid (GABA) transaminase (GABA-t) and branched-chain transaminases in Mycobacterium tuberculosis. L-Cycloserine has anticonvulsant properties and inhibits the synthesis of neurotensin in mouse brains[1][2][3][4].
Foramsulfuron (Standard) is the analytical standard of Foramsulfuron. This product is intended for research and analytical applications. Foramsulfuron is a postemergence herbicide used for selective control of grass and some broadleaved weeds in maize (Zea mays L.). Foramsulfuron is a sulfonylurea herbicide that exerts its herbicidal activity by inhibiting acetolactate synthase (ALS), a key enzyme in the biosynthesis of branchedchainaminoacids .
Foramsulfuron-d6-1 is the deuterium labeled Foramsulfuron (HY-W422402). Foramsulfuron is a postemergence herbicide used for selective control of grass and some broadleaved weeds in maize (Zea mays L.). Foramsulfuron is a sulfonylurea herbicide that exerts its herbicidal activity by inhibiting acetolactate synthase (ALS), a key enzyme in the biosynthesis of branchedchainaminoacids .
2-Methylvaleric acid (Standard) is the analytical standard of 2-Methylvaleric acid. This product is intended for research and analytical applications. 2-Methylvaleric acid is a branched short-chain fatty acid (SCFA) produced by the metabolism of branched-chainaminoacids by gut microbes. 2-Methylvaleric acid can be used as a potential biomarker for metabolic diseases such as type 2 diabetes, and its content is significantly reduced in the feces of diabetic mice. 2-Methylvaleric acid may regulate host energy metabolism and inflammatory response through G protein-coupled receptors (GPCRs) or histone deacetylase (HDAC) inhibition. 2-Methylvaleric acid can be used to study gut microbe-host interactions and metabolic diseases as a fecal biomarker[1][2].
Bispyribac sodium is a selective, orally active, systemic and post-emergence herbicide. Bispyribac sodium reduces SOD levels and inhibits ALS activity. Bispyribac sodium blocks the biosynthesis of branched-chainaminoacids, resulting in growth retardation, chlorosis and necrosis of weeds. Bispyribac sodium exerts herbicidal activity against grass, sedge and broadleaf weeds in rice fields. Bispyribac sodium is hepatotoxic and genotoxic .
PF-07238025 is a BCKDC kinase (BDK) inhibitor (EC50=19 nM). PF-07238025 stabilizes the interaction between BDK and BCKDH core subunit E2 and prevents phosphorylation of E1. While BDK mediates branched-chain ketoacid dehydrogenase (BCKDH) phosphorylation, and inhibition of BCKDH is involved in controlling the rate-limiting step of branched-chainamino acid (BCAA) degradation. Impaired BCAA catabolism has been associated with several diseases, particularly cardiometabolic diseases, including heart failure (HF), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and obesity. PF-07238025 improved cardiometabolic endpoints and improves glucose tolerance in mice .
PF-07247685 is a BCKDC kinase (BDK) inhibitor (EC50=2.2 nM). PF-07247685 stabilizes the interaction between BDK and BCKDH core subunit E2 and prevents phosphorylation of E1. While BDK mediates branched-chain ketoacid dehydrogenase (BCKDH) phosphorylation, and inhibition of BCKDH is involved in controlling the rate-limiting step of branched-chainamino acid (BCAA) degradation. Impaired BCAA catabolism has been associated with several diseases, particularly cardiometabolic diseases, including heart failure (HF), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and obesity. PF-07247685 improved cardiometabolic endpoints and improves glucose tolerance in mice .
L-Isoleucine (Standard) is the analytical standard of L-Isoleucine. This product is intended for research and analytical applications. L-Isoleucine is an orally active branchedchainamino acid, which is the L-enantiomer of isoleucine. L-Isoleucine has a role as a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a plant metabolite, a human metabolite, an algal metabolite and a mouse metabolite. L-Isoleucine regulates the inflammatory response to protect against pathogens in vivo and in vitro .
Florasulam (Standard) is the analytical standard of Florasulam. This product is intended for research and analytical applications. Florasulam is a targeted post-emergent herbicide belonging to the triazolopyrimidine sulfonanilide class, which functions by inhibiting acetolactate synthase (ALS) in plants. Located in the chloroplasts, ALS plays a crucial role in the biosynthesis of branched-chainaminoacids. When Florasulam inhibits ALS, it disrupts plant cell division, reduces growth, and ultimately leads to plant death.
L-Isoleucine (Standard) is the analytical standard of L-Isoleucine. This product is intended for research and analytical applications. L-Isoleucine is an orally active branchedchainamino acid, which is the L-enantiomer of isoleucine. L-Isoleucine has a role as a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a plant metabolite, a human metabolite, an algal metabolite and a mouse metabolite. L-Isoleucine regulates the inflammatory response to protect against pathogens in vivo and in vitro .
(rac)-Isoleucine is the racemic form of Isoleucine. Isoleucine is a mixture of the diastereomers L-isoleucine, L-alloisoleucine, D-isoleucine, and D-alloisoleucine. L-isoleucine is a branched-chainamino acid that acts as a nitrogen donor, and has roles in glucose consumption, fatty acid metabolism, as well as immune function. L-Alloisoleucine is generated by transamination of L-isoleucine. D-Isoleucine and D-alloisoleucine are enantiomers of L-isoleucine and L-alloisoleucine, respectively .
Nicosulfuron is efficient, harmless, antifungal and selective herbicide belonging to the sulfonylurea family. Nicosulfuron is also a photosynthetic system inhibitor and inhibits acetolactate synthase (ALS) enzyme activity. Nicosulfuron degradation by Plectosphaerella cucumerina AR1 is glucose concentration dependent in planktonic lifestyle. Nicosulfuron enhances the glycolysis pathway and tricarboxylic acid cycle to improve the adaptability of sweet maize. Nicosulfuron reduces the synthesis of branched-chainaminoacids (BCAAs), which is proming for maize cultivation .
Bispyribac (sodium) (Standard) is the analytical standard of Bispyribac sodium (HY-B0869A). This product is intended for research and analytical applications. Bispyribac sodium is a selective, orally active, systemic and post-emergence herbicide. Bispyribac sodium reduces SOD levels and inhibits ALS activity. Bispyribac sodium blocks the biosynthesis of branched-chainaminoacids, resulting in growth retardation, chlorosis and necrosis of weeds. Bispyribac sodium exerts herbicidal activity against grass, sedge and broadleaf weeds in rice fields. Bispyribac sodium is hepatotoxic and genotoxic .
Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde that acts as a highly selective and potent proteasomal inhibitor (Ki = 1.5 µM for branchedchainamino acid preferring, 2.3 µM for small neutral amino acid preferring, and 40.5 µM for chymotrypsin-like activities; IC50 = 3.1 µM for peptidyl-glutamyl peptide hydrolyzing activity) .
LAGIPRA peptide is a long-acting GIP1R agonist. LAGIPRA peptide enhances insulin sensitivity by augmenting glucose disposal and reduces branched-chainaminoacids (BCAAs) and ketoacids. LAGIPRA peptide has the potential for the research of type 2 diabetes .
L-Isoleucine (Standard) is the analytical standard of L-Isoleucine. This product is intended for research and analytical applications. L-Isoleucine is an orally active branchedchainamino acid, which is the L-enantiomer of isoleucine. L-Isoleucine has a role as a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a plant metabolite, a human metabolite, an algal metabolite and a mouse metabolite. L-Isoleucine regulates the inflammatory response to protect against pathogens in vivo and in vitro .
L-Leucine (Standard) is the analytical standard of L-Leucine. This product is intended for research and analytical applications. L-Leucine is an essential branched-chainamino acid (BCAA), which activates the mTOR signaling pathway .
PF-07208254 is a selective, orally active allosteric inhibitor of branched-chain ketoacid dehydrogenase kinase (BDK) (IC50=110 nM, Ki=54 nM, KD=84 nM). PF-07208254 inhibits BDK-mediated BCKDH phosphorylation and enhances the catabolism of branched-chainaminoacids (BCAAs) and branched-chain keto acids (BCKAs) by binding to the allosteric pocket of BDK, reducing BDK binding to BCKDH-E2 and promoting BDK degradation. PF-07208254 inhibits BDK activity in human skeletal muscle cells (IC50=540 nM) and has activity to improve cardiac function and metabolism. PF-07208254 can be used in the study of cardiometabolic diseases (e.g., heart failure, type 2 diabetes) .
L-Cycloserine ((S)-4-Amino-3-isoxazolidone) is an oral inhibitor of the enzyme gamma-aminobutyric acid (GABA) transaminase (GABA-t) and branched-chain transaminases in Mycobacterium tuberculosis. L-Cycloserine has anticonvulsant properties and inhibits the synthesis of neurotensin in mouse brains .
2-Methylvaleric acid is a branched short-chain fatty acid (SCFA) produced by the metabolism of branched-chainaminoacids by gut microbes. 2-Methylvaleric acid can be used as a potential biomarker for metabolic diseases such as type 2 diabetes, and its content is significantly reduced in the feces of diabetic mice. 2-Methylvaleric acid may regulate host energy metabolism and inflammatory response through G protein-coupled receptors (GPCRs) or histone deacetylase (HDAC) inhibition. 2-Methylvaleric acid can be used to study gut microbe-host interactions and metabolic diseases as a fecal biomarker[1][2].
L-Isoleucine is an orally active branchedchainamino acid, which is the L-enantiomer of isoleucine. L-Isoleucine has a role as a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a plant metabolite, a human metabolite, an algal metabolite and a mouse metabolite. L-Isoleucine regulates the inflammatory response to protect against pathogens in vivo and in vitro .
PF-07238025 is a BCKDC kinase (BDK) inhibitor (EC50=19 nM). PF-07238025 stabilizes the interaction between BDK and BCKDH core subunit E2 and prevents phosphorylation of E1. While BDK mediates branched-chain ketoacid dehydrogenase (BCKDH) phosphorylation, and inhibition of BCKDH is involved in controlling the rate-limiting step of branched-chainamino acid (BCAA) degradation. Impaired BCAA catabolism has been associated with several diseases, particularly cardiometabolic diseases, including heart failure (HF), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and obesity. PF-07238025 improved cardiometabolic endpoints and improves glucose tolerance in mice .
PF-07247685 is a BCKDC kinase (BDK) inhibitor (EC50=2.2 nM). PF-07247685 stabilizes the interaction between BDK and BCKDH core subunit E2 and prevents phosphorylation of E1. While BDK mediates branched-chain ketoacid dehydrogenase (BCKDH) phosphorylation, and inhibition of BCKDH is involved in controlling the rate-limiting step of branched-chainamino acid (BCAA) degradation. Impaired BCAA catabolism has been associated with several diseases, particularly cardiometabolic diseases, including heart failure (HF), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and obesity. PF-07247685 improved cardiometabolic endpoints and improves glucose tolerance in mice .
L-Cycloserine (Standard) is the analytical standard of L-Cycloserine. This product is intended for research and analytical applications. L-Cycloserine ((S)-4-Amino-3-isoxazolidone) is an oral inhibitor of the enzyme gamma-aminobutyric acid (GABA) transaminase (GABA-t) and branched-chain transaminases in Mycobacterium tuberculosis. L-Cycloserine has anticonvulsant properties and inhibits the synthesis of neurotensin in mouse brains[1][2][3][4].
2-Methylvaleric acid (Standard) is the analytical standard of 2-Methylvaleric acid. This product is intended for research and analytical applications. 2-Methylvaleric acid is a branched short-chain fatty acid (SCFA) produced by the metabolism of branched-chainaminoacids by gut microbes. 2-Methylvaleric acid can be used as a potential biomarker for metabolic diseases such as type 2 diabetes, and its content is significantly reduced in the feces of diabetic mice. 2-Methylvaleric acid may regulate host energy metabolism and inflammatory response through G protein-coupled receptors (GPCRs) or histone deacetylase (HDAC) inhibition. 2-Methylvaleric acid can be used to study gut microbe-host interactions and metabolic diseases as a fecal biomarker[1][2].
L-Isoleucine (Standard) is the analytical standard of L-Isoleucine. This product is intended for research and analytical applications. L-Isoleucine is an orally active branchedchainamino acid, which is the L-enantiomer of isoleucine. L-Isoleucine has a role as a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a plant metabolite, a human metabolite, an algal metabolite and a mouse metabolite. L-Isoleucine regulates the inflammatory response to protect against pathogens in vivo and in vitro .
Various studies have demonstrated that the BCAT2 protein plays a critical role in cellular processes as it catalyzes the initial reactions in the catabolism of the essential branched-chain amino acids leucine, isoleucine, and valine. This enzyme activity is essential for the breakdown of these amino acids, contributing to metabolic processes necessary for energy production and nitrogen balance. BCAT2 Protein, Human is the recombinant human-derived BCAT2 protein, expressed by E. coli , with tag free.
Various studies have demonstrated that the BCAT2 protein plays a critical role in cellular processes as it catalyzes the initial reactions in the catabolism of the essential branched-chain amino acids leucine, isoleucine, and valine. This enzyme activity is essential for the breakdown of these amino acids, contributing to metabolic processes necessary for energy production and nitrogen balance. BCAT2 Protein, Human (His, Strep) is the recombinant human-derived BCAT2 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag.
The BCAT1 protein plays a key role in cellular processes as it catalyzes the initial reactions in the catabolism of the essential branched-chain amino acids leucine, isoleucine, and valine. This enzyme activity is essential for the breakdown of these amino acids, contributing to metabolic pathways necessary for energy production and nitrogen balance. BCAT1 Protein, Human is the recombinant human-derived BCAT1 protein, expressed by E. coli , with tag free.
The BCAT1 protein plays a key role in cellular processes as it catalyzes the initial reactions in the catabolism of the essential branched-chain amino acids leucine, isoleucine, and valine. This enzyme activity is essential for the breakdown of these amino acids, contributing to metabolic pathways necessary for energy production and nitrogen balance. BCAT1 Protein, Human (His, Strep) is the recombinant human-derived BCAT1 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag.
L-Leucine-d10 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chainamino acid (BCAA), which activates the mTOR signaling pathway .
L-Leucine-d2 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chainamino acid (BCAA), which activates the mTOR signaling pathway .
L-Leucine-d3 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chainamino acid (BCAA), which activates the mTOR signaling pathway .
L-Leucine-d is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chainamino acid (BCAA), which activates the mTOR signaling pathway .
L-Leucine-d7 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chainamino acid (BCAA), which activates the mTOR signaling pathway .
L-Alloisoleucine-d10 is the deuterium labeled L-Alloisoleucine. L-Alloisoleucine is a branchedchainamino acid and is a stereo-isomer of L-isoleucine. L-Alloisoleucine is a common constituent of human plasma (albeit at low levels).
L-Leucine- 13C6, 15N is the 13C- and 15N-labeled L-Leucine. L-Leucine is an essential branched-chainamino acid (BCAA), which activates the mTOR signaling pathway .
L-Leucine-2- 13C, 15N is the 13C- and 15N-labeled L-Leucine. L-Leucine is an essential branched-chainamino acid (BCAA), which activates the mTOR signaling pathway .
L-Leucine-1- 13C, 15N is the 13C- and 15N-labeled L-Leucine. L-Leucine is an essential branched-chainamino acid (BCAA), which activates the mTOR signaling pathway .
Foramsulfuron-d6-1 is the deuterium labeled Foramsulfuron (HY-W422402). Foramsulfuron is a postemergence herbicide used for selective control of grass and some broadleaved weeds in maize (Zea mays L.). Foramsulfuron is a sulfonylurea herbicide that exerts its herbicidal activity by inhibiting acetolactate synthase (ALS), a key enzyme in the biosynthesis of branchedchainaminoacids .
