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ataxia telangiectasia mutated kinase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ATM/ATR (5) Checkpoint Kinase (Chk) (1) Choline Kinase (1) Isotope-Labeled Compounds (1) PD-1/PD-L1 (1) STING (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Inflammation/Immunology (1) Neurological Disease (1)

7

Inhibitors & Agonists

1

Isotope-Labeled Compounds

3

Antibodies

Targets Recommended: ATM/ATR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

ART0380	ATM/ATR	Cancer
ART0380 is a potent and selective ATR kinase inhibitor. ART0380 has selective antitumor activity that can be used for the research of Ataxia-Telangiectasia Mutated (ATM) aberrant cancers .

ATR-IN-4	ATM/ATR	Cancer
ATR-IN-4 is a potent ATR (Ataxia telangiectasia mutated gene Rad 3-associated kinase) inhibitor. ATR-IN-4 inhibits growth of human prostate cancer cells DU145 and human lung cancer cells NCI-H460 with IC₅₀s of 130.9 nM and 41 .33 nM, respectively. (Patent CN112142744A, compound 13) .

ATR-IN-10	ATM/ATR	Cancer
ATR-IN-10 is a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase with an IC₅₀ value of 2.978 μM.

Neurofilament, U-15N	Isotope-Labeled Compounds	Neurological Disease
Neurofilament, U- ¹⁵N is the ¹⁵N-labeled Neurofilament.

Antitumor agent-28	ATM/ATR	Cancer
Antitumor agent-28 selectively inhibits ataxia telangiectasia mutated (ATM) kinase. Antitumor agent-28 prevents ATM mediated disease and has potent anti-cancer activity .

(Rac)-Lartesertib (Rac)-M4076; (Rac)-ATM Inhibitor-5	ATM/ATR STING PD-1/PD-L1	Cardiovascular Disease Inflammation/Immunology Cancer
(Rac)-Lartesertib ((Rac)-M4076) is an isoform of Lartesertib (HY-150617). Lartesertib (M4076) is an inhibitor of the serine/threonine protein kinase ATM with high potency. Lartesertib can inhibit the growth of multiple hematopoietic cell lines. Additionally, when combined with the ATR inhibitor Tuvusertib (HY-111451), Lartesertib can promote the death of tumor cells, activate the immune signaling pathway, and exhibit anti-tumor activity .

Chk2-IN-1	Checkpoint Kinase (Chk) Choline Kinase	Cancer
Chk2-IN-1 (compound 1) is a potent and selective inhibitor of *checkpoint kinase* 2 (Chk2), with IC₅₀s of 13.5 nM and 220.4 nM for Chk2 and Chk1*, respectively. Chk2-IN-1 can elicit a strong ataxia* telangiectasia mutated (ATM)-dependent Chk2-mediated radioprotection effect .

Cat. No.	Compare	Product Name	Application	Reactivity

	Phospho-ATM (Ser1981) Antibody (YA3181) ATM; Serine-protein kinase ATM; ataxia telangiectasia mutated; A-T mutated	WB, IHC-P, ICC/IF, IP	Human
	Phospho-ATM (Ser1981) Antibody (YA3181) is a non-conjugated IgG antibody, targeting Phospho-ATM (Ser1981), with a predicted molecular weight of 351 kDa. Phospho-ATM (Ser1981) Antibody (YA3181) can be used for WB, IHC-P, ICC/IF, IP experiment in human background.

	ATM Antibody (YA4741) ATM; Serine-protein kinase ATM; ataxia telangiectasia mutated; A-T mutated	WB, ELISA	Human
	ATM Antibody (YA4741) is a mouse-derived and non-conjugated monoclonal antibody, targeting to Atm. It can be applicated for WB, ELISA assays, in the background of human.

	ATM Antibody (YA5801) ATM; Serine-protein kinase ATM; ataxia telangiectasia mutated; A-T mutated	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	ATM Antibody (YA5801) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATM. It can be applicated for WB, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

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