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astragalus

" in MedChemExpress (MCE) Product Catalog:

32

Inhibitors & Agonists

1

Biochemical Assay Reagents

31

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-159066
    Polysachoride of astragalus mongholicus

    		Biochemical Assay Reagents Inflammation/Immunology
    Polysachoride of astragalus mongholicus is a large molecular weight polysaccharide that can be isolated from Astragalus Mongholicus. Polysachoride of astragalus mongholicus, 95% may possess anti-fibrosis properties .
    Polysachoride of astragalus mongholicus
  • HY-N0424
    Cyclogalegenin

    Cyclogalegigenin

    		 Others Others
    Cyclogalegenin (Cyclogalegigenin) is an isoprenoid. Cyclogalegenin can be isolated from Astragalus galegiformis. Cyclogalegenin is an isomer of cycloastragenol.
    Cyclogalegenin
  • HY-N0434
    Astragaloside III
    2 Publications Verification

    		 Others Others
    Astragaloside III is a natural product isolated from Astragalus.
    Astragaloside III
  • HY-N9989
    Brachyoside B

    		Others Others
    Brachyoside B is a triterpenoid saponin from Astragalus wiedemannianus .
    Brachyoside B
  • HY-N10048
    Agroastragaloside I

    		Others Others
    Agroastragaloside I is a astragaloside, and can be isolated from the hairy root cultures of Astragalus membranaceus .
    Agroastragaloside I
  • HY-N0424R
    Cyclogalegenin (Standard)

    Cyclogalegigenin (Standard)

    		 Others Others
    Cyclogalegenin (Standard) is the analytical standard of Cyclogalegenin. This product is intended for research and analytical applications. Cyclogalegenin (Cyclogalegigenin) is an isoprenoid. Cyclogalegenin can be isolated from Astragalus galegiformis. Cyclogalegenin is an isomer of cycloastragenol .
    Cyclogalegenin (Standard)
  • HY-N10597
    5'''-O-Feruloyl complanatoside B

    		Others Cardiovascular Disease Metabolic Disease Cancer
    5'''-O-Feruloyl complanatoside B is isolated from Astragali Semen, the seeds of Astragalus Complanatus. Semen Astragali Complanati (SAC) include fatty acids, amino acids, polysaccharides, flavonoids, triterpene glycosides and trace elements; have been reported to involve in chronic diseases such as cardiovascular diseases, diabetes mellitus and cancers .
    5'''-O-Feruloyl complanatoside B
  • HY-N10644
    Complanatin

    		Others Others
    Complanatin is an acylated flavonol glycoside, it can be isolated from Astragalus complanatus R. Br .
    Complanatin
  • HY-N1985
    Acetylastragaloside I

    		Parasite Infection
    Acetylastragaloside I is a glycoside that can be isolated from the roots of Astragalus baibutensis. Acetylastragaloside I is the first cycloartane-type triterpene with remarkable trypanocidal activity with IC50 values of 9.5 and 5.0 μg/mL for T. brucei rhodesiense and T. cruzi, respectively. Acetylastragaloside I can be used for the research of trypanosome infection .
    Acetylastragaloside I
  • HY-108268
    Cyclocephaloside II

    		Biochemical Assay Reagents Others
    Cyclocephaloside II is a natural product that can be obtained from the roots of Astragalus brachypterus and Astragalus microcephalus .
    Cyclocephaloside II
  • HY-N11450
    Complanatin I

    		Others Others
    Complanatin I is a natural product that can be isolated from Astragalus complanatus .
    Complanatin I
  • HY-N4212
    Astraganoside

    		Others Others
    Astraganoside, an isoflavane compound, isolated from the roots of Astragalus membranaceus (known as ‘‘Huangqi’’) .
    Astraganoside
  • HY-N0888
    Isoastragaloside II

    Astrasieversianin-VII

    		 Others Others
    Isoastragaloside II is an astragaloside, which is isolated from the hairy root culture of Astragalus membranaceus.
    Isoastragaloside II
  • HY-N9880
    Tamarixin

    		Bacterial Infection Inflammation/Immunology Cancer
    Tamarixin is flavonoid that isolated from Astragalus tanae Sosn that has hepatoprotective, antioxidant, anticancer, and antimicrobial activities .
    Tamarixin
  • HY-N0624
    Complanatoside A

    		Others Cancer
    Complanatoside A is a flavonol glycoside isolated from Astragalus complanatus, and currently it is used as a quality control index for A. complanatus in the 2010 edition of the Chinese Pharmacopoeia.
    Complanatoside A
  • HY-W009713R
    3,4,5-Trimethoxyphenylacetic acid (Standard)

    		Drug Metabolite Neurological Disease
    Cyclogalegenin (Standard) is the analytical standard of Cyclogalegenin. This product is intended for research and analytical applications. Cyclogalegenin (Cyclogalegigenin) is a isoprenoid that can be isolated from Astragalus galegiformis. Cyclogalegenin is the enantiomer of Cycloastragenol .
    3,4,5-Trimethoxyphenylacetic acid (Standard)
  • HY-N2473
    Methylnissolin-3-O-glucoside

    		Others Inflammation/Immunology
    Methylnissolin-3-O-glucoside (Methylnissolin-3-O-β-D-glucoside) is a flavonoid from the roots of Astragalus membranaceus with anti-inflammatory effects .
    Methylnissolin-3-O-glucoside
  • HY-N0432
    Astragaloside I

    Astrasieversianin IV; Cyclosieversioside B

    		 Wnt β-catenin Metabolic Disease
    Astragaloside I, one of the main active ingredients in Astragalus membranaceus, has osteogenic properties. Astragaloside I stimulates osteoblast differentiation through the Wnt/β-catenin signaling pathway .
    Astragaloside I
  • HY-N11472
    Rhamnocitrin 3-glucoside

    Rhamnocitrin-3-O-β-D-glucopyranoside

    		 Others Others
    Rhamnocitrin 3-glucoside (Rhamnocitrin-3-O-β-D-glucopyranoside) is a natural product that can be isolated from Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao (AM) .
    Rhamnocitrin 3-glucoside
  • HY-N0431
    Astragaloside IV
    Maximum Cited Publications
    23 Publications Verification

    		 MMP ERK JNK Cancer
    Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.
    Astragaloside IV
  • HY-N0432R
    Astragaloside I (Standard)

    		Wnt β-catenin Metabolic Disease
    Astragaloside I (Standard) is the analytical standard of Astragaloside I. This product is intended for research and analytical applications. Astragaloside I, one of the main active ingredients in Astragalus membranaceus, has osteogenic properties. Astragaloside I stimulates osteoblast differentiation through the Wnt/β-catenin signaling pathway .
    Astragaloside I (Standard)
  • HY-N12954
    (R)-Mucronulatol

    		Bacterial Infection
    (R)-Mucronulatol is a flavonoid that can be isolated from Astragalus adsurgens. (R)-Mucronulatol shows antibacterial activity against Escherichia coli, Bacillus cereus, Staphylococcus aureus, Erwinia carotovora and Bacillus subtili, with MICs of 15.5, 15.5, 7.8, 7.8, 15.5 μg/mL respectively .
    (R)-Mucronulatol
  • HY-N4005
    Isoastilbin

    		Bacterial Tyrosinase Infection Neurological Disease
    Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC50 value of 54.3 μg/mL, and also inhibits tyrosinase activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research .
    Isoastilbin
  • HY-N2473R
    Methylnissolin-3-O-glucoside (Standard)

    		Others Inflammation/Immunology
    Methylnissolin-3-O-glucoside (Standard) is the analytical standard of Methylnissolin-3-O-glucoside. This product is intended for research and analytical applications. Methylnissolin-3-O-glucoside (Methylnissolin-3-O-β-D-glucoside) is a flavonoid from the roots of Astragalus membranaceus with anti-inflammatory effects .
    Methylnissolin-3-O-glucoside (Standard)
  • HY-N0431R
    Astragaloside IV (Standard)

    		MMP ERK JNK Cancer
    Astragaloside IV (Standard) is the analytical standard of Astragaloside IV. This product is intended for research and analytical applications. Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.
    Astragaloside IV (Standard)
  • HY-N12742
    Tamarixetin 3-O-β-d-apiofuranosyl-(1 → 2)-β-d-galactopyranoside

    		Others Inflammation/Immunology
    Tamarixetin 3-O-β-d-apiofuranosyl-(1 → 2)-β-d-galactopyranoside (compound 4) is an inhibitor of collagenase and elastase with potential anti-inflammatory activity. Tamarixetin 3-O-β-d-apiofuranosyl-(1 → 2)-β-d-galactopyranoside can be isolated from the methanol extract of the Balkan endemic species Astragalus thracicus Griseb .
    Tamarixetin 3-O-β-d-apiofuranosyl-(1 → 2)-β-d-galactopyranoside
  • HY-N1353
    Rhamnocitrin
    1 Publications Verification

    		 p38 MAPK Cardiovascular Disease Inflammation/Immunology
    Rhamnocitrin is an anti-inflammatory and antioxidant agent that targets STIM-1, NFATc3 and MAPK pathways and can scavenge DPPH (IC50=28.38 mM). Rhamnocitrin selectively inhibits oxidative stress and inflammatory responses in vascular endothelial cells and neurons. Rhamnocitrin up-regulates miR-185 to inhibit STIM-1-mediated store-operated calcium entry (SOCE), thereby blocking NFATc3 nuclear translocation and downstream inflammatory factor expression, while inducing heme oxygenase HO-1 expression and regulating the ERK/p38 MAPK pathway, inhibiting antioxidant and pro-inflammatory cytokines (such as IL-6, IL-8) and adhesion molecules (such as ICAM-1, VCAM-1). Rhamnocitrin can be used in the study of endothelial-related inflammatory diseases (such as sepsis, acute lung injury, atherosclerosis) and neuroprotection (such as oxidative damage of PC12 cells) .
    Rhamnocitrin
  • HY-N1353R
    Rhamnocitrin (Standard)

    		Others p38 MAPK Cardiovascular Disease Inflammation/Immunology
    Rhamnocitrin (Standard) is the analytical standard of Rhamnocitrin. This product is intended for research and analytical applications. Rhamnocitrin is an anti-inflammatory and antioxidant agent that targets STIM-1, NFATc3 and MAPK pathways and can scavenge DPPH (IC50=28.38 mM). Rhamnocitrin selectively inhibits oxidative stress and inflammatory responses in vascular endothelial cells and neurons. Rhamnocitrin up-regulates miR-185 to inhibit STIM-1-mediated store-operated calcium entry (SOCE), thereby blocking NFATc3 nuclear translocation and downstream inflammatory factor expression, while inducing heme oxygenase HO-1 expression and regulating the ERK/p38 MAPK pathway, inhibiting antioxidant and pro-inflammatory cytokines (such as IL-6, IL-8) and adhesion molecules (such as ICAM-1, VCAM-1). Rhamnocitrin can be used in the study of endothelial-related inflammatory diseases (such as sepsis, acute lung injury, atherosclerosis) and neuroprotection (such as oxidative damage of PC12 cells) .
    Rhamnocitrin (Standard)
  • HY-N2484
    Methylnissolin

    Astrapterocarpan

    		 PDGFR ERK Cardiovascular Disease
    Methylnissolin (Astrapterocarpan), isolated from Astragalus membranaceus, inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC50 of 10 μM. Methylnissolin inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinase. Methylnissolin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibition of the ERK1/2 MAP kinase cascade .
    Methylnissolin
  • HY-N0433
    Astragaloside II
    1 Publications Verification

    Astrasieversianin VIII

    		 Autophagy Interleukin Related HIF/HIF Prolyl-Hydroxylase SOD NF-κB Inflammation/Immunology Endocrinology Cancer
    Astragaloside II is an orally active Cycloartane-type triterpene glycoside. Astragaloside II can be extracted from Astragalus membranaceus. Astragaloside II inhibits Autophagy, decreases pro-inflammatory cytokines (IL-6, IL-1β), HIF-α, p-p65, p-IκB and increases SOD. Astragaloside II regulates immunity and reduces inflammatory responses. Astragaloside II can be used in the research of diseases such as liver cancer, osteoporosis, immunosuppressive diseases, and ulcerative colitis .
    Astragaloside II
  • HY-N0433R
    Astragaloside II (Standard)

    Astrasieversianin VIII (Standard)

    		 Autophagy Interleukin Related HIF/HIF Prolyl-Hydroxylase SOD NF-κB Inflammation/Immunology Endocrinology Cancer
    Astragaloside II (Standard) is the analytical standard of Astragaloside II (HY-N0433). This product is intended for research and analytical applications. Astragaloside II is an orally active Cycloartane-type triterpene glycoside. Astragaloside II can be extracted from Astragalus membranaceus. Astragaloside II inhibits Autophagy, decreases pro-inflammatory cytokines (IL-6, IL-1β), HIF-α, p-p65, p-IκB and increases SOD. Astragaloside II regulates immunity and reduces inflammatory responses. Astragaloside II can be used in the research of diseases such as liver cancer, osteoporosis, immunosuppressive diseases, and ulcerative colitis .
    Astragaloside II (Standard)
  • HY-N10645
    Rhamnocitrin 3-O-β-D-apiofuranosyl(1→2)-β-D-glucopyranoside

    		Others Others
    Rhamnocitrin 3-O-β-D-apiofuranosyl(1→2)-β-D-glucopyranoside is a flavonol O-glycoside, isolated from Astragali semen of leguminous plants .
    Rhamnocitrin 3-O-β-D-apiofuranosyl(1→2)-β-D-glucopyranoside

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