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Results for "

antiprion

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Apoptosis (3) Bacterial (2) Bcr-Abl (2) Flavivirus (3) Fluorescent Dye (1) Isotope-Labeled Compounds (1) JAK (2) PAI-1 (1) Parasite (1) Phosphatase (2) Prion Protein (9) STAT (2) Transmembrane Glycoprotein (1)
By Research Areas:	Cancer (3) Infection (19) Inflammation/Immunology (1) Neurological Disease (7)

Inhibitors & Agonists

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153756

GFP16	Prion Protein	Infection
GFP16 is a low affinity antiprion compound. GFP16 can be used for research of antiprion drug discovery .

HY-117856

IND24	Prion Protein	Infection
IND24 is a potent *antiprion* agent with an EC₅₀ value of 1.27 µM. IND24 decreases abnormal, misfolded, pathogenic forms of benign normally occurring prion protein on the cell surface or inside the cell .

HY-138865

BiCAPPA	Prion Protein	Infection
BiCAPPA is the first bivalent *antiprion* ligand. BiCAPPA can decrease infectious conformational form of prion protein (PrP ^Sc) from scrapie-infected cells, with an EC₅₀ of 0.32 μM .

HY-W081348

1-(4-Methoxyphenyl)-3-methyl-1H-pyrazol-5(4H)-one	Prion Protein Transmembrane Glycoprotein	Neurological Disease
1-(4-Methoxyphenyl)-3-methyl-1H-pyrazol-5(4H)-one (Compound 2) has antiprion activity in ScN2a and F3 cells with IC₅₀ values of 13 nM and 25 nM, respectively .

HY-107662

TCS PrP Inhibitor 13	Apoptosis	Infection Cancer
TCS PrP Inhibitor 13, an antiprion agent, is a cellular prion protein (PrP ^C) inhibitor. TCS PrP Inhibitor 13, as a protease-resistant form of prion protein (PrP-res) accumulation inhibitor, shows an IC₅₀ value of 3 nM in both ScN2a and F3 cell lines. TCS PrP Inhibitor 13 induces Schwannoma cells apoptosis .

HY-13735D

d-Atabrine dihydrochloride	Bacterial	Infection
d-Atabrine dihydrochloride is an active enantiomer of quinacrine which displays antiprion activity.

HY-13735C

l-Atabrine dihydrochloride	Bacterial	Infection
l-Atabrine dihydrochloride is a less active enantiomer of quinacrine which displays antiprion activity.

HY-114621

DB772 1 Publications Verification	Flavivirus	Infection
DB772 hydrate is a bovine viral diarrhoea virus (BVDV) inhibitor. DB772 also has anti-prion activity .

HY-124375

IND81	Prion Protein	Infection
IND81 is an orally active antiprion with IC₅₀ value of 1.95 μM. IND81 reduces abnormal, misfolded, disease-causing forms of benign prion proteins that are normally present on or within cells .

HY-147371

Quinoprazine	Parasite	Infection Neurological Disease
Quinoprazine is a potent inhibitor of Vaccinia virus DNA synthesis with an IC₅₀ value of 10 μM. Quinoprazine has antimalarial activity against Plasmodium berghei and also displays antiprion potency, significantly decreases PrP ^{S ^c} levels ^- .

HY-114621A

DB772 hydrate 1 Publications Verification	Flavivirus	Infection
DB772 hydrate is a bovine viral diarrhoea virus (BVDV) inhibitor. DB772 also has anti-prion activity .

HY-114621B

DB772 free base	Flavivirus	Infection
DB772 free base is a bovine viral diarrhoea virus (BVDV) inhibitor. DB772 free base also has anti-prion activity .

HY-100857

PrPSc-IN-1	Fluorescent Dye	Neurological Disease
PrPSc-IN-1 is a fluorescent probe, binds to the misfolded protein PrP ^Sc, inhibits its accumulation, with an IC₅₀ of 1.6 μM. Anti-prion activity .

HY-111022

Icerguastat 2 Publications Verification Sephin1; IFB-088	Phosphatase	Infection Inflammation/Immunology
Icerguastat (Sephin1), a derivative of Guanabenz lacking the α2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). Icerguastat inhibits eIF2α dephosphorylation, thereby prolonging the protective response. Anti-prion effect .

HY-110365

Icerguastat Carbonate Sephin1 Carbonate; IFB-088 Carbonate	Phosphatase	Infection
Icerguastat (Sephin1) Carbonate, a derivative of Guanabenz lacking the α2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). Icerguastat Carbonate inhibits eIF2α dephosphorylation, thereby prolonging the protective response. Anti-prion effect .

HY-147702

BB 0305179	Prion Protein	Infection Neurological Disease
BB 0305179 (compound 59) is a potent anti-prion agent, with an IC₅₀ of 4.7 μM. BB 0305179 inhibits the toxicity of a specific PrP mutant carrying a deletion in the hydrophobic domain . BB 0305179 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-175136

Chloroguanabenz acetate GAh acetate	Adrenergic Receptor	Infection Neurological Disease
Chloroguanabenz (acetate) is an antiprion agent and a derivative of the α₂-adrenergic receptor agonist guanabenz. Chloroguanabenz (acetate) can inhibit the formation of prion in yeast and mammalian in vitro assays. Chloroguanabenz (acetate) can reduce the levels of truncated Huntingtin derivative Htt48 in HEK293T cells. Chloroguanabenz (acetate) can be studied in research on Huntington’s disease .

HY-134561

6-Amino-8-trifluoromethylphenanthridine 6A-8tFP	Prion Protein	Infection
6-Amino-8-trifluoromethylphenanthridine (6A-8tFP) is an antiprion agent and a derivative of 6-aminophenanthridine (HY-135189). It inhibits protein folding activity of the ribosome (PFAR) when used at a concentration of 150 μM.2 6A-8tFP directly competes with protein substrates for the ribosomal active site.

HY-15728

Radotinib IY-5511	Bcr-Abl Apoptosis STAT JAK Prion Protein	Infection Neurological Disease Cancer
Radotinib (IY-5511) is an orally active and BBB-permeable selective tyrosine kinase Bcr-Abl1 inhibitor with an IC₅₀ of 34 nM. Radotinib has anti-prion and anti-tumor activities. Radotinib can inhibit the proliferation, induce cell cycle arrest and apoptosis of tumor cells . Radotinib can be used in the research of cancer such as chronic myeloid leukemia and multiple myeloma, as well as neurodegenerative diseases such as prion diseases .

HY-150514

ARN1468	PAI-1	Infection
ARN1468 (compound 5) is an orally active and potent serpins inhibitor. ARN1468 can inhibit serpins activity would set the protease free to further reduce *prion* accumulation. ARN1468 shows anti-prion effect in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC₅₀ values of 8.64, 19.3, 11.2, and 6.27 μM .

HY-15728S

Radotinib-d6 IY-5511-d₆	Isotope-Labeled Compounds Bcr-Abl Apoptosis STAT JAK Prion Protein	Infection Neurological Disease Cancer
Radotinib-d₆ is deuterium labeled Radotinib (HY-15728). Radotinib (IY-5511) is an orally active and BBB-permeable selective tyrosine kinase Bcr-Abl1 inhibitor with an IC₅₀ of 34 nM. Radotinib has anti-prion and anti-tumor activities. Radotinib can inhibit the proliferation, induce cell cycle arrest and apoptosis of tumor cells . Radotinib can be used in the research of cancer such as chronic myeloid leukemia and multiple myeloma, as well as neurodegenerative diseases such as prion diseases .

Cat. No.	Product Name	Chemical Structure

HY-15728S

Radotinib-d6
Radotinib-d₆ is deuterium labeled Radotinib (HY-15728). Radotinib (IY-5511) is an orally active and BBB-permeable selective tyrosine kinase Bcr-Abl1 inhibitor with an IC₅₀ of 34 nM. Radotinib has anti-prion and anti-tumor activities. Radotinib can inhibit the proliferation, induce cell cycle arrest and apoptosis of tumor cells . Radotinib can be used in the research of cancer such as chronic myeloid leukemia and multiple myeloma, as well as neurodegenerative diseases such as prion diseases .

Radotinib-d6

Radotinib-d₆ is deuterium labeled Radotinib (HY-15728). Radotinib (IY-5511) is an orally active and BBB-permeable selective tyrosine kinase Bcr-Abl1 inhibitor with an IC₅₀ of 34 nM. Radotinib has anti-prion and anti-tumor activities. Radotinib can inhibit the proliferation, induce cell cycle arrest and apoptosis of tumor cells . Radotinib can be used in the research of cancer such as chronic myeloid leukemia and multiple myeloma, as well as neurodegenerative diseases such as prion diseases .

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