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Results for "

antimetabolite

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Nucleoside Antimetabolite/Analog (21) ADC Payload (6) Antifolate (11) Apoptosis (35) Autophagy (5) Bacterial (9) Biochemical Assay Reagents (1) CMV (3) DNA Alkylator/Crosslinker (9) DNA Methyltransferase (3) DNA/RNA Synthesis (19) Drug Metabolite (7) Drug-Linker Conjugates for ADC (1) Endogenous Metabolite (6) Fluorescent Dye (1) Herbicide (1) HSV (3) Isotope-Labeled Compounds (10) JNK (1) LXR (1) NADPH Oxidase (2) NO Synthase (1) PPAR (1) Reference Standards (8) Thymidylate Synthase (2)
By Research Areas:	Cancer (59) Infection (4) Inflammation/Immunology (11) Metabolic Disease (7)
Oligonucleotides:	Nucleoside Analogs (2) Inosine (1) Cytidine (1)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Nucleoside Antimetabolite/Analog

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0077

Bendamustine hydrochloride 5 Publications Verification SDX-105	DNA Alkylator/Crosslinker Apoptosis	Cancer
Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties .

HY-13567

Bendamustine 5 Publications Verification SDX-105 free base	DNA Alkylator/Crosslinker Apoptosis	Cancer
Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties .

HY-130569

7-Hydroxymethotrexate	Drug Metabolite	Inflammation/Immunology Cancer
7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .

HY-130812

Gemcitabine-O-Si(di-iso)-O-Mc	Drug-Linker Conjugates for ADC	Cancer
Gemcitabine-O-Si(di-iso)-O-Mc is a agent-linker conjugate for ADC with potent antitumor activity by using Gemcitabine (a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent; HY-17026), linked via the ADC linker .

HY-N14253

cis-2-Amino-1-hydroxycyclobutane-1-acetic acid	Herbicide	Others
cis-2-Amino-1-hydroxycyclobutane-1-acetic acid is a herbicidal antimetabolite that can cause L-cysteineor L-methionine-reversible chlorosis in Arabidopsis thaliana .

HY-121207

Denopterin Pteroylglutamic acid	Antifolate Nucleoside Antimetabolite/Analog	Cancer
Denopterin is a dihydrofolate reductase (DHFR) inhibitor and an antifolate agent. Denopterin is an *antimetabolite* that has toxic effects on cells and can be used for cancer .

HY-B0077R

Bendamustine hydrochloride (Standard) SDX-105 (Standard)	Reference Standards DNA Alkylator/Crosslinker Apoptosis	Cancer
Bendamustine (hydrochloride) (Standard) is the analytical standard of Bendamustine (hydrochloride). This product is intended for research and analytical applications. Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties .

HY-13567R

Bendamustine (Standard)	DNA Alkylator/Crosslinker Apoptosis	Cancer
Bendamustine (Standard) is the analytical standard of Bendamustine. This product is intended for research and analytical applications. Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties .

HY-121151

(±)-Methotrexate (±)-Amethopterin; (±)-CL14377; (±)-WR19039	Antifolate	Others
(±)-Methotrexate ((±)-Amethopterin) is a racemate of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of Folic acid into Tetrahydrofolate, and inhibiting DNA synthesis .

HY-117058

LY243246 (6S)-DDATHF	Antifolate	Cancer
LY243246 ((6S)-DDATHF), the 6S diastereomer of DDATHF, is a potent competitive inhibitor of 5’-phosphoribosylglycinamide formyltransferase (GAR transformylase). 6R- and 6S-diastereomers of DDATHF are remarkably similar and equiactive antimetabolites inhibitory to de novo purine synthesis .

HY-112732

Sparfosic acid 3 Publications Verification	Apoptosis	Metabolic Disease Cancer
Sparfosic acid, a DNA antimetabolite agent, is a potent inhibitor of aspartate transcarbamoyl transferase, the enzyme catalyzing the second step of de novo pyrimidine biosynthesis. Sparfosic acid synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines .

HY-W010342

6-Aminonicotinamide 5+ Cited Publications	NADPH Oxidase	Cancer
6-Aminonicotinamide, a potent antimetabolite of nicotinamide, is competitive NADP ⁺-dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) inhibitor (K_i=0.46 μM). 6-Aminonicotinamide resultis ATP depletion and synergizes with DNA-crosslinking chemotherapy agents, such as Cisplatin (HY-17394), in killing cancer cells .

HY-W010342R

6-Aminonicotinamide (Standard)	NADPH Oxidase	Cancer
6-Aminonicotinamide, a potent antimetabolite of nicotinamide, is competitive NADP+-dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) inhibitor (Ki=0.46 μM). 6-Aminonicotinamide resultis ATP depletion and synergizes with DNA-crosslinking chemotherapy agents, such as Cisplatin (HY-17394), in killing cancer cells .

HY-106014

Tezacitabine	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Apoptosis	Cancer
Tezacitabine is a cytostatic and cytotoxic antimetabolite and a nucleoside analogue. Tezacitabine irreversibly inhibits the ribonucleotide reductase and interferes with DNA replication and repair. Tezacitabine effectively induces cells apoptotic. Tezacitabine has the potential for leukemias and solid tumors (carcinomas) treatment .

HY-112732B

Sparfosic acid trisodium 3 Publications Verification	Apoptosis	Metabolic Disease Cancer
Sparfosic acid trisodium is a DNA antimetabolite agent and a potent inhibitor of aspartate transcarbamoyl transferase. Aspartate transcarbamoyl transferase catalyzes the second step of de novo pyrimidine biosynthesis. Sparfosic acid trisodium synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines .

HY-115528

FF-10502	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Cancer
FF-10502, a structural analog of Gemcitabine, is a pyrimidine nucleoside antimetabolite. FF-10502 inhibits DNA polymerase α and β. FF-10502 shows beneficial anticancer activity via a mechanism of action on dormant cells .

HY-123032

Sorivudine BV-araU	DNA/RNA Synthesis	Infection
Sorivudine (BV-araU) is an orally active synthetic pyrimidine nucleoside antimetabolite agent. Sorivudine derives its antiviral activity from selective conversion by a specific thymidine kinase present in certain DNA viruses to nucleotides, which can in turn interfere with viral DNA synthesis .

HY-B0097

Floxuridine 10+ Cited Publications 5-Fluorouracil 2'-deoxyriboside	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Bacterial CMV HSV Apoptosis	Infection Cancer
Floxuridine (5-Fluorouracil 2'-deoxyriboside) is a pyrimidine analog and known as an oncology antimetabolite. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage by activating the ATM and ATR checkpoint signaling pathways in vitro. Floxuridine is a extreamly potent inhibitor for S. aureus infection and induces cell apoptosis . Floxuridine has antiviral effects against HSV and CMV .

HY-B0097R

Floxuridine (Standard) 5-Fluorouracil 2'-deoxyriboside (Standard)	Reference Standards Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Bacterial CMV HSV Apoptosis	Infection Cancer
Floxuridine (Standard) is the analytical standard of Floxuridine. This product is intended for research and analytical applications. Floxuridine (5-Fluorouracil 2'-deoxyriboside) is a pyrimidine analog and known as an oncology antimetabolite. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage by activating the ATM and ATR checkpoint signaling pathways in vitro. Floxuridine is a extreamly potent inhibitor for S. aureus infection and induces cell apoptosis . Floxuridine has antiviral effects against HSV and CMV .

HY-10821

Raltitrexed 10+ Cited Publications ZD1694; D1694; ICI-D1694	Thymidylate Synthase Nucleoside Antimetabolite/Analog	Cancer
Raltitrexed is an antimetabolite agent used in chemotherapy, acting by inhibiting thymidylate synthase.

HY-121295

Roseoflavin	Bacterial	Infection
Roseoflavin, a natural pigment originally isolated from Streptomyces davawensis, is an antimetabolite analog of Riboflavin and flavin mononucleotide that has antimicrobial properties .

HY-13567S

Bendamustine-d4 SDX-105-d₄ free base	Isotope-Labeled Compounds DNA Alkylator/Crosslinker	Cancer
Bendamustine-d₄ is the deuterium labeled Bendamustine. Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties.

HY-17026

Gemcitabine Maximum Cited Publications 225 Publications Verification LY 188011	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Autophagy Apoptosis	Cancer
Gemcitabine (LY 188011) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine inhibits DNA synthesis and repair, resulting in autophagyand apoptosis .

HY-B0003

Gemcitabine hydrochloride Maximum Cited Publications 225 Publications Verification LY 188011 hydrochloride	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Autophagy Apoptosis	Cancer
Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis .

HY-10821R

Raltitrexed (Standard)	Thymidylate Synthase Nucleoside Antimetabolite/Analog	Cancer
Raltitrexed (Standard) is the analytical standard of Raltitrexed. This product is intended for research and analytical applications. Raltitrexed is an antimetabolite agent used in chemotherapy, acting by inhibiting thymidylate synthase.

HY-B1468

8-Azaguanine 2 Publications Verification	Nucleoside Antimetabolite/Analog Endogenous Metabolite	Cancer
8-Azaguanine is a purine analogue that shows antineoplastic activity. 8-Azaguanine functions as an antimetabolite and easily incorporates into ribonucleic acids, interfering with normal biosynthetic pathways, thus inhibiting cellular growth .

HY-133624

1,1,3-Tribromoacetone 1 Publications Verification	Drug Metabolite	Cancer
1,1,3-Tribromoacetone is an impurity of Methotrexate (HY-14519) . Methotrexate, an *antimetabolite* and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .

HY-107093

MBC-11	Apoptosis	Cancer
MBC-11 is a first-in-class conjugate of the bone-targeting bisphosphonate etidronate covalently linked to the antimetabolite cytarabine (araC). MBC-11 has the potential for tumor-induced bone disease (TIBD) research .

HY-133887

Methotrexate α-tert-butyl ester	Antifolate DNA/RNA Synthesis	Cancer
Methotrexate α-tert-butyl ester, capped by OtBu, significantly reduces tumor growth in HT1080 tumor bearing mice. Methotrexate is an antimetabolite and antifolate agent and is also an immunosuppressant and antineoplastic agent .

HY-B0003R

Gemcitabine hydrochloride (Standard) LY 188011 hydrochloride (Standard)	Reference Standards DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Autophagy Apoptosis	Cancer
Gemcitabine (hydrochloride) (Standard) is the analytical standard of Gemcitabine (hydrochloride). This product is intended for research and analytical applications. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis .

HY-17026R

Gemcitabine (Standard) LY 188011 (Standard)	Reference Standards Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Autophagy Apoptosis	Cancer
Gemcitabine (Standard) is the analytical standard of Gemcitabine. This product is intended for research and analytical applications. Gemcitabine (LY 188011) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine inhibits DNA synthesis and repair, resulting in autophagyand apoptosis .

HY-107093B

MBC-11 triethylamine	Apoptosis	Cancer
MBC-11 triethylamine is a first-in-class conjugate of the bone-targeting bisphosphonate etidronate covalently linked to the antimetabolite cytarabine (araC). MBC-11 triethylamine has the potential for tumor-induced bone disease (TIBD) research .

HY-107093A

MBC-11 trisodium	Apoptosis	Cancer
MBC-11 trisodium is a first-in-class conjugate of the bone-targeting bisphosphonate HEDP covalently linked to the antimetabolite Ara-C. MBC-11 trisodium has the potential for tumor-induced bone disease (TIBD) research .

HY-107430B

Oxythiamine chloride Hydroxythiamine chloride	Apoptosis	Cancer
Oxythiamine (Hydroxythiamine) chloride, an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine chloride inhibits cancer cell apoptosis and inhibits cell proliferation .

HY-107430

Oxythiamine 2 Publications Verification Hydroxythiamin	Apoptosis Endogenous Metabolite	Cancer
Oxythiamine (Hydroxythiamin), an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine inhibits cancer cell apoptosis and inhibits cell proliferation .

HY-107430A

Oxythiamine chloride hydrochloride 2 Publications Verification Hydroxythiamine chloride hydrochloride	Apoptosis Endogenous Metabolite	Cancer
Oxythiamine (Hydroxythiamine) chloride hydrochloride, an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine chloride hydrochloride is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine chloride hydrochloride inhibits cancer cell apoptosis and inhibits cell proliferation .

HY-W114787

N4-Benzoyl-2’-O-methylcytidine	Nucleoside Antimetabolite/Analog	Cancer
N4-Benzoyl-2’-O-methylcytidine is a natural cytidine nucleoside analog. Cytidine analogs have the mechanism of inhibiting DNA methyltransferase (such as Zebularine (HY-13420)) and have potential antimetabolite and antitumor activities .

HY-B0077S1

Bendamustine-d8 hydrochloride SDX-105-d₈	Isotope-Labeled Compounds DNA Alkylator/Crosslinker Apoptosis	Cancer
Bendamustine-d₈ (hydrochloride) is deuterium labeled Bendamustine (hydrochloride). Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties .

HY-B0003S

Gemcitabine-13C,15N2 hydrochloride LY 188011-¹³C,¹⁵N₂ hydrochloride	Apoptosis Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Autophagy	Cancer
Gemcitabine- ¹³C, ¹⁵N₂ (hydrochloride) is the ¹³C and ¹⁵N labeled Gemcitabine hydrochloride . Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis .

HY-B0003A

1'-epi Gemcitabine hydrochloride 1'-epi LY 188011 hydrochloride	Nucleoside Antimetabolite/Analog Apoptosis DNA/RNA Synthesis	Cancer
1'-epi Gemcitabine hydrochloride is the isomer of Gemcitabine hydrochloride (HY-B0003), and can be used as an experimental control. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis .

HY-14519

Methotrexate 60+ Cited Publications Amethopterin; CL14377; WR19039	Antifolate DNA/RNA Synthesis ADC Payload Apoptosis Bacterial	Inflammation/Immunology Cancer
Methotrexate (Amethopterin), an *antimetabolite* and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .

HY-14519D

Methotrexate monohydrate Amethopterin monohydrate; CL14377 monohydrate; WR19039 monohydrate	Antifolate DNA/RNA Synthesis ADC Payload Apoptosis Bacterial	Inflammation/Immunology Cancer
Methotrexate (Amethopterin) monohydrate, an *antimetabolite* and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate monohydrate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .

HY-13567S1

Bendamustine-d8 SDX-105-d₈ free base	DNA Alkylator/Crosslinker Apoptosis	Cancer
Bendamustine-d₈ is the deuterium labeled Bendamustine . Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties .

HY-14519A

Methotrexate disodium 60+ Cited Publications Amethopterin disodium; CL14377 disodium; WR19039 disodium	Antifolate DNA/RNA Synthesis ADC Payload Apoptosis Bacterial	Inflammation/Immunology Cancer
Methotrexate (Amethopterin) disodium, an *antimetabolite* and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate disodium, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .

HY-130569S1

7-Hydroxymethotrexate-d3	Isotope-Labeled Compounds Drug Metabolite	Metabolic Disease
7-Hydroxymethotrexate-d₃ is the deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .

HY-130569S

7-Hydroxymethotrexate-d3 sodium	Isotope-Labeled Compounds Drug Metabolite	Inflammation/Immunology Cancer
7-Hydroxymethotrexate-d₃ (sodium) is deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .

HY-145311

Bis-Pro-5FU	Nucleoside Antimetabolite/Analog	Cancer
Bis-Pro-5FU (Compound 4) is a 5-FU precursor that confers oral bioavailability and increase the safety profile of 5-Fluorouracil (5-FU) chemotherapy regimens. 5-FU is an antineoplastic antimetabolite that is widely used for the research of colorectal and pancreatic cancer .

HY-130569S2

7-Hydroxymethotrexate-d3 ammonium	Isotope-Labeled Compounds Drug Metabolite	Metabolic Disease
7-Hydroxymethotrexate-d₃ (ammonium) is the deuterium labeled 7-Hydroxymethotrexate ammonium. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .

HY-B1468R

8-Azaguanine (Standard)	Nucleoside Antimetabolite/Analog Endogenous Metabolite	Cancer
8-Azaguanine (Standard) is the analytical standard of 8-Azaguanine. This product is intended for research and analytical applications. 8-Azaguanine is a purine analogue that shows antineoplastic activity. 8-Azaguanine functions as an antimetabolite and easily incorporates into ribonucleic acids, interfering with normal biosynthetic pathways, thus inhibiting cellular growth .

HY-W654227

7-Hydroxy methotrexate-d3 ammonium salt	Isotope-Labeled Compounds Drug Metabolite	Inflammation/Immunology
7-Hydroxy methotrexate-d₃ (ammonium salt) is deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .

Cat. No.	Product Name

HY-L112

Chemotherapy Drug Library

155 compounds

Chemotherapy is one of the most common treatments for cancer. It can be used alone for some types of cancer or in combination with other treatments such as radiation or surgery. Chemotherapy drugs usually target cells at different phases of the cell cycle and inhibit tumor proliferation and avoid cancer cell invasion and metastasis. It is a cancer treatment method that kills cancer cells with drugs.

Chemotherapeutic agents can be classified into alkylating agents, antimetabolites, antimicrotubular agents, antibiotics, etc. according to the mechanism of action. MCE offers a unique collection of 155 chemotherapy drugs, which is a useful tool for cancer treatment research.

Cat. No.	Product Name	Type

HY-D2435

MTX-PEG-Cy3

Dyes

CDDP-PEG-Cy3 is a MTX-PEG conjugate labeled with Cy3 (HY-D0822). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. The maximum emission wavelength of Cy3 is approximately 562-570 nm. Methotrexate (Amethopterin; MTX) (HY-14519), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .

Cat. No.	Product Name	Type

HY-W015467

Pyridine-3-sulfonic acid Pyridine-3-sulphonic acid	Biochemical Assay Reagents
Pyridine-3-sulfonic acid (Pyridine-3-sulphonic acid) is an orally active structural analog of Nicotine acid (HY-B0143). Pyridine-3-sulfonic acid significantly reduces hepatic cholesterol synthesis in rats but lacks cholesterol-lowering activity. Pyridine-3-sulfonic acid does not interfere with the metabolism of Nicotine acid .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1468

8-Azaguanine 2 Publications Verification	Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Nucleoside Antimetabolite/Analog Endogenous Metabolite
8-Azaguanine is a purine analogue that shows antineoplastic activity. 8-Azaguanine functions as an antimetabolite and easily incorporates into ribonucleic acids, interfering with normal biosynthetic pathways, thus inhibiting cellular growth .

HY-107430

Oxythiamine 2 Publications Verification Hydroxythiamin	Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Apoptosis Endogenous Metabolite
Oxythiamine (Hydroxythiamin), an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine inhibits cancer cell apoptosis and inhibits cell proliferation .

HY-107430A

Oxythiamine chloride hydrochloride 2 Publications Verification Hydroxythiamine chloride hydrochloride	Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Apoptosis Endogenous Metabolite
Oxythiamine (Hydroxythiamine) chloride hydrochloride, an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine chloride hydrochloride is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine chloride hydrochloride inhibits cancer cell apoptosis and inhibits cell proliferation .

HY-N14253

cis-2-Amino-1-hydroxycyclobutane-1-acetic acid	Natural Products Microorganisms Source classification	Herbicide
cis-2-Amino-1-hydroxycyclobutane-1-acetic acid is a herbicidal antimetabolite that can cause L-cysteineor L-methionine-reversible chlorosis in Arabidopsis thaliana .

HY-B1468R

8-Azaguanine (Standard)	Natural Products Source classification Endogenous metabolite	Nucleoside Antimetabolite/Analog Endogenous Metabolite
8-Azaguanine (Standard) is the analytical standard of 8-Azaguanine. This product is intended for research and analytical applications. 8-Azaguanine is a purine analogue that shows antineoplastic activity. 8-Azaguanine functions as an antimetabolite and easily incorporates into ribonucleic acids, interfering with normal biosynthetic pathways, thus inhibiting cellular growth .

HY-107430R

Oxythiamine (Standard) Hydroxythiamin (Standard)	Natural Products Microorganisms Source classification Endogenous metabolite	Reference Standards Apoptosis Endogenous Metabolite
Oxythiamine (Standard) is the analytical standard of Oxythiamine. This product is intended for research and analytical applications. Oxythiamine (Hydroxythiamin), an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine inhibits cancer cell apoptosis and inhibits cell proliferation[1][2][3].

Cat. No.	Product Name	Chemical Structure

HY-14519S1

Methotrexate-d3 diammonium

Methotrexate-d₃ diammonium is the deuterium labeled Methotrexate diammonium. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .

HY-13567S

Bendamustine-d4
Bendamustine-d₄ is the deuterium labeled Bendamustine. Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties.

HY-B0077S1

Bendamustine-d8 hydrochloride
Bendamustine-d₈ (hydrochloride) is deuterium labeled Bendamustine (hydrochloride). Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties .

HY-B0003S

Gemcitabine-13C,15N2 hydrochloride
Gemcitabine- ¹³C, ¹⁵N₂ (hydrochloride) is the ¹³C and ¹⁵N labeled Gemcitabine hydrochloride . Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis .

HY-13567S1

Bendamustine-d8
Bendamustine-d₈ is the deuterium labeled Bendamustine . Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties .

HY-130569S1

7-Hydroxymethotrexate-d3
7-Hydroxymethotrexate-d₃ is the deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .

HY-130569S

7-Hydroxymethotrexate-d3 sodium
7-Hydroxymethotrexate-d₃ (sodium) is deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .

HY-130569S2

7-Hydroxymethotrexate-d3 ammonium
7-Hydroxymethotrexate-d₃ (ammonium) is the deuterium labeled 7-Hydroxymethotrexate ammonium. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .

HY-W654227

7-Hydroxy methotrexate-d3 ammonium salt
7-Hydroxy methotrexate-d₃ (ammonium salt) is deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .

HY-W738282

Bendamustine-d7 hydrochloride
Bendamustine-d₇ hydrochloride (SDX-105-d₇) is the deuterium labeled Bendamustine hydrochloride (HY-B0077). Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties .

HY-14519S

Methotrexate-d3

Methotrexate-d₃ (Amethopterin-d₃) is the deuterium labeled Methotrexate. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .

HY-A0004S

Decitabine-13C5

Decitabine- ¹³C₅ (5-Aza-2'-deoxycytidine- ¹³C₅) is ¹³C labeled Decitabine. Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and a DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell apoptosis. Decitabine has potent anticancer activity .

HY-W766548

Floxuridine-13C,15N2

Floxuridine- ¹³C, ¹⁵N₂ (5-Fluorouracil 2'-deoxyriboside- ¹³C, ¹⁵N₂) is the ¹³C- and ¹⁵N-labeled labeled Floxuridine (HY-B0097). Floxuridine (5-Fluorouracil 2'-deoxyriboside) is a pyrimidine analog and known as an oncology antimetabolite. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage by activating the ATM and ATR checkpoint signaling pathways in vitro. Floxuridine is a extreamly potent inhibitor for S. aureus infection and induces cell apoptosis . Floxuridine has antiviral effects against HSV and CMV .

Cat. No.	Product Name		Classification

HY-W114787

N4-Benzoyl-2’-O-methylcytidine		Nucleoside Analogs Cytidine
N4-Benzoyl-2’-O-methylcytidine is a natural cytidine nucleoside analog. Cytidine analogs have the mechanism of inhibiting DNA methyltransferase (such as Zebularine (HY-13420)) and have potential antimetabolite and antitumor activities .

HY-128671

6-Thioinosine 6TI; 6-Mercaptopurine riboside		Nucleoside Analogs Inosine
6-Thioinosine (6TI) is a purine antimetabolite and an anti-adipogenic agent. 6-Thioinosine reduces the mRNA levels of PPARγ and C/EBPα and downregulates the mRNA levels of PPARγ target genes (LPL, CD36, aP2, and LXRα). 6-Thioinosine exerts its anti-adipogenic effects by downregulating PPARγ through JNK-dependent iNOS upregulation. 6-Thioinosine can be used to study adipocyte dysfunction .

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