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anti-melanogenesis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) AMPK (1) Apoptosis (1) Caspase (1) GSK-3 (1) Interleukin Related (1) Isotope-Labeled Compounds (1) Keap1-Nrf2 (1) MCHR1 (GPR24) (3) Melatonin Receptor (1) NF-κB (2) NO Synthase (1) PARP (1) PERK (1) SOD (1) Tyrosinase (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (3) Endocrinology (1) Inflammation/Immunology (4) Metabolic Disease (2) Neurological Disease (1)

9

Inhibitors & Agonists

8

Natural
Products

1

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Methyl linolenate 1 Publications Verification Linolenic acid methyl ester	Melatonin Receptor	Metabolic Disease
Methyl linolenate is a polyunsaturated fattly acid (PUFA). Methyl linolenate has an anti-melanogenesis activity with an IC₅₀ of 60 μM. Methyl linolenate can also be used for studies of the mechanisms and prevention of oxidation/peroxidation of unsaturated fatty acids .

Ethyl linolenate	MCHR1 (GPR24)	Cardiovascular Disease
Ethyl linolenate is a fatty acid ethyl ester (FAEE). Ethyl linolenate plays an active role in inhibition of the cellular production on melanin with an IC₅₀ of 70 μM. Anti-melanogenesis Effects .

Gomisin N	Apoptosis AMPK Akt PERK Keap1-Nrf2 Caspase PARP GSK-3 NO Synthase Interleukin Related	Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology Cancer
Gomisin N is an orally active lignan compound. Gomisin N can be isolated from Schisandra chinensis. Gomisin N induces Apoptosis in a variety of cells. Gomisin N activates AMPK, Akt, MAPK/ERK, Nrf2, caspase-3 and PARP-1. Gomisin N inhibits GSK3β, nitric oxide (NO), and proinflammatory cytokines (IL-1β, IL-6, TNF-α). Gomisin N has anti-inflammatory, antioxidant, anti-obesity, anti-diabetic, and anti-melanogenesis activities. Gomisin N has anti-tumor activity against cervical cancer and liver cancer. Gomisin N improves Alzheimer's disease .

Valencene 1 Publications Verification	NF-κB	Inflammation/Immunology
Valencene is a sesquiterpene isolated from Cyperus rotundus, possesses antiallergic, antimelanogenesis, anti-infammatory, and antioxidant activitivies. Valencene inhibits the exaggerated expression of Th2 chemokines and proinflammatory chemokines through blockade of the NF-κB pathway. Valencene is used to flavor foods and drinks .

Apovincamine cis-Apovincamine; (+)-Apovincamine	Tyrosinase	Cancer
Apovincamine (cis-Apovincamine) is an indole alkaloid isolated from the Malaysian Alstonia pneumatophora (Apocynaceae). Apovincamine shows anti-melanogenesis activity .

Ethyl linolenate-d5	Isotope-Labeled Compounds MCHR1 (GPR24)	Cardiovascular Disease
Ethyl linolenate-d₅ is the deuterium labeled Ethyl linolenate. Ethyl linolenate is a fatty acid ethyl ester (FAEE). Ethyl linolenate plays an active role in inhibition of the cellular production on melanin with an IC₅₀ of 70 μM. Anti-melanogenesis Effects .

Ethyl linolenate (Standard)	MCHR1 (GPR24)	Cardiovascular Disease
Ethyl linolenate (Standard) is the analytical standard of Ethyl linolenate. This product is intended for research and analytical applications. Ethyl linolenate is a fatty acid ethyl ester (FAEE). Ethyl linolenate plays an active role in inhibition of the cellular production on melanin with an IC50 of 70 μM. Anti-melanogenesis Effects .

1,2,4,6-Tetra-O-galloyl-β-D-glucose	SOD	Inflammation/Immunology
1,2,4,6-Tetra-O-galloyl-β-D-glucose is an antioxidant found in Eucalyptus globulus. 1,2,4,6-Tetra-O-galloyl-β-D-glucose has significant superoxide dismutase (SOD)-like antioxidant activity (EC₅₀: 1.55 μM). 1,2,4,6-Tetra-O-galloyl-β-D-glucose can inhibit tyrosinase (IC₅₀: 0.59 mM) and hyaluronidase (IC₅₀: 0.68 mM). 1,2,4,6-Tetra-O-galloyl-β-D-glucose can be used in food antioxidants, cosmetics anti-melanogenesis and anti-allergy/anti-inflammatory research .

Valencene (Standard)	NF-κB	Inflammation/Immunology
Valencene (Standard) is the analytical standard of Valencene. This product is intended for research and analytical applications. Valencene is a sesquiterpene isolated from Cyperus rotundus, possesses antiallergic, antimelanogenesis, anti-infammatory, and antioxidant activitivies. Valencene inhibits the exaggerated expression of Th2 chemokines and proinflammatory chemokines through blockade of the NF-κB pathway. Valencene is used to flavor foods and drinks .

Cat. No.	Product Name	Category	Target	Chemical Structure

Methyl linolenate 1 Publications Verification Linolenic acid methyl ester	Structural Classification Natural Products other families Classification of Application Fields Source classification Other Diseases Plants Disease Research Fields	Melatonin Receptor
Methyl linolenate is a polyunsaturated fattly acid (PUFA). Methyl linolenate has an anti-melanogenesis activity with an IC₅₀ of 60 μM. Methyl linolenate can also be used for studies of the mechanisms and prevention of oxidation/peroxidation of unsaturated fatty acids .

Ethyl linolenate	Cardiovascular Disease Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields	MCHR1 (GPR24)
Ethyl linolenate is a fatty acid ethyl ester (FAEE). Ethyl linolenate plays an active role in inhibition of the cellular production on melanin with an IC₅₀ of 70 μM. Anti-melanogenesis Effects .

Gomisin N	Structural Classification Neurological Disease Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Inflammation/Immunology Disease Research Fields Cancer	Apoptosis AMPK Akt PERK Keap1-Nrf2 Caspase PARP GSK-3 NO Synthase Interleukin Related
Gomisin N is an orally active lignan compound. Gomisin N can be isolated from Schisandra chinensis. Gomisin N induces Apoptosis in a variety of cells. Gomisin N activates AMPK, Akt, MAPK/ERK, Nrf2, caspase-3 and PARP-1. Gomisin N inhibits GSK3β, nitric oxide (NO), and proinflammatory cytokines (IL-1β, IL-6, TNF-α). Gomisin N has anti-inflammatory, antioxidant, anti-obesity, anti-diabetic, and anti-melanogenesis activities. Gomisin N has anti-tumor activity against cervical cancer and liver cancer. Gomisin N improves Alzheimer's disease .

Valencene 1 Publications Verification	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Cyperaceae Cyperus rotundus L. Plants Inflammation/Immunology Disease Research Fields	NF-κB
Valencene is a sesquiterpene isolated from Cyperus rotundus, possesses antiallergic, antimelanogenesis, anti-infammatory, and antioxidant activitivies. Valencene inhibits the exaggerated expression of Th2 chemokines and proinflammatory chemokines through blockade of the NF-κB pathway. Valencene is used to flavor foods and drinks .

Apovincamine cis-Apovincamine; (+)-Apovincamine	Apocynaceae Alkaloids Structural Classification Alstonia yunnanensis Diels Classification of Application Fields Source classification Plants Disease Research Fields Indole Alkaloids Cancer	Tyrosinase
Apovincamine (cis-Apovincamine) is an indole alkaloid isolated from the Malaysian Alstonia pneumatophora (Apocynaceae). Apovincamine shows anti-melanogenesis activity .

Ethyl linolenate (Standard)	Structural Classification Natural Products other families Source classification Plants	MCHR1 (GPR24)
Ethyl linolenate (Standard) is the analytical standard of Ethyl linolenate. This product is intended for research and analytical applications. Ethyl linolenate is a fatty acid ethyl ester (FAEE). Ethyl linolenate plays an active role in inhibition of the cellular production on melanin with an IC50 of 70 μM. Anti-melanogenesis Effects .

1,2,4,6-Tetra-O-galloyl-β-D-glucose	Structural Classification Source classification Phenols Polyphenols Myrtaceae Plants Eucalyptus globulus Labill.	SOD
1,2,4,6-Tetra-O-galloyl-β-D-glucose is an antioxidant found in Eucalyptus globulus. 1,2,4,6-Tetra-O-galloyl-β-D-glucose has significant superoxide dismutase (SOD)-like antioxidant activity (EC₅₀: 1.55 μM). 1,2,4,6-Tetra-O-galloyl-β-D-glucose can inhibit tyrosinase (IC₅₀: 0.59 mM) and hyaluronidase (IC₅₀: 0.68 mM). 1,2,4,6-Tetra-O-galloyl-β-D-glucose can be used in food antioxidants, cosmetics anti-melanogenesis and anti-allergy/anti-inflammatory research .

Valencene (Standard)	Structural Classification Classification of Application Fields Terpenoids Source classification Cyperaceae Cyperus rotundus L. Plants Inflammation/Immunology Disease Research Fields	NF-κB
Valencene (Standard) is the analytical standard of Valencene. This product is intended for research and analytical applications. Valencene is a sesquiterpene isolated from Cyperus rotundus, possesses antiallergic, antimelanogenesis, anti-infammatory, and antioxidant activitivies. Valencene inhibits the exaggerated expression of Th2 chemokines and proinflammatory chemokines through blockade of the NF-κB pathway. Valencene is used to flavor foods and drinks .

Cat. No.	Product Name	Chemical Structure

Ethyl linolenate-d5
Ethyl linolenate-d₅ is the deuterium labeled Ethyl linolenate. Ethyl linolenate is a fatty acid ethyl ester (FAEE). Ethyl linolenate plays an active role in inhibition of the cellular production on melanin with an IC₅₀ of 70 μM. Anti-melanogenesis Effects .

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