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Results for "

anti-CD3

" in MedChemExpress (MCE) Product Catalog:

24

Inhibitors & Agonists

22

Inhibitory Antibodies

2

Natural
Products

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P990864
    Anti-CD3 Antibody (OKT-3)

    		CD3 Inflammation/Immunology
    Anti-CD3 Antibody (OKT-3) is a kind of mouse IgG2a κ antibody inhibitor, targeting to human CD3. Anti-CD3 Antibody (OKT-3) decreases T cells. Anti-CD3 Antibody (OKT-3) can be used for the research of immunology, such as graft-versus-host disease [3].
    Anti-CD3 Antibody (OKT-3)
  • HY-P99592
    Solitomab

    AMG 110

    		 CD3 Cancer
    Solitomab (AMG 110) is a bispecific anti-CD3 and anti-epithelial-cell-adhesion-molecule (EpCAM) antibody. Solitomab can be used for the research of primary uterine and ovarian carcinosarcoma cancer .
    Solitomab
  • HY-P99332
    Visilizumab

    anti-Human CD3E Recombinant antibody; HuM291

    		 Apoptosis Inflammation/Immunology Cancer
    Visilizumab (Anti-Human CD3E Recombinant Antibody) is a humanized low-Fc receptor binding anti-CD3 monoclonal IgG2 antibody. Visilizumab can be used for ulcerative colitis and Crohn's disease research .
    Visilizumab
  • HY-P99814
    Pavurutamab

    AMG-701

    		 CD3 Inflammation/Immunology Cancer
    Pavurutamab (AMG-701) is a bispecific T cell engager molecule that anti-CD3 and anti-B cell maturation antigens (BCMA). Pavurutamab has an extended half-life based on Pacanalotamab (HY-P99798). The Fc of Pavurutamab is coupled to molecules to improve pharmacokinetic parameters. Pavurutamab has potential applications in immune regulation and multiple myeloma (MM) [3] .
    Pavurutamab
  • HY-103316
    trans-Ned 19

    		Calcium Channel Cardiovascular Disease Inflammation/Immunology
    trans-Ned 19 is a NAADP antagonist and TPC blocker. trans-Ned 19 suppresses the calcium signal and the rat aorta relaxation in response to low histamine concentrations. trans-Ned 19 increases the spontaneous acrosome reaction rate, alleviates anti-CD3 mAb-induced intestinal inflammation, and improves kidney damage in mice with nephrotoxic serum nephritis [3] .
    trans-Ned 19
  • HY-P99339
    Tebentafusp

    IMCgp100

    		 Interleukin Related TNF Receptor Cancer
    Tebentafusp (IMCgp100) is a bispecific fusion protein to target gp100 peptide-HLA-A*02:01 (a melanoma-associated antigen). Tebentafusp guides T cells to kill gp100-expressing tumor cells via a high affinity T-cell receptor (TCR) binding domain and an anti-CD3 T-cell engaging domain. Tebentafusp leads to inflammatory cytokines and cytolytic proteins production, resulting in the direct lysis of tumour cells .
    Tebentafusp
  • HY-P991406
    MK-1248

    		TNF Receptor Cancer
    MK-1248 is a human IgG4 monoclonal antibody (mAb) targeting TNFSF18. MK-1248 enhances the proliferative response of tumor-infiltrating lymphocytes to anti-CD3 stimulation and promotes the production of anti-tumor-associated regulatory cytokines. MK-1248 can be used in solid tumors research .
    MK-1248
  • HY-P99837
    Dafsolimab

    SPV-T3a

    		 CD3 Infection
    Dafsolimab (SPV-T3a) is a Mouse IgG2b monoclonal antibody (anti-CD3). Dafsolimab can induce cell death through modulation and activation of the CD3/T cell receptor complex. Dafsolimab can be used for the research of graft-versus-host disease (GVHD) .
    Dafsolimab
  • HY-156520
    Immunosuppressant-1

    		Apoptosis Inflammation/Immunology
    Immunosuppressant-1 (Compound 31) inhibits anti-CD3/anti-CD28 co-stimulated T-cell proliferation. Immunosuppressant-1 has immunosuppressive activity, and induces apoptosis by activating caspase-3 and PARP in activated lymph node cells .
    Immunosuppressant-1
  • HY-120622
    BMS-243117

    		Src Cancer
    BMS-243117 is a potent, and selective benzothiazole based p56 Lck inhibitor with an IC50 of 4 nM. BMS-243117 inhibits anti-CD3/anti-CD28 induced PBL (human peripheral blood T-cells) proliferation with an IC50 of 1.1 μM. BMS-243117 binds in an extended conformation to the ATP-binding site of Lck .
    BMS-243117
  • HY-149917
    ITK degrader 1

    		PROTACs Itk Cancer
    ITK degrader 1 is a highly selective degrader of interleukin-2-inducible T-cell kinase (ITK; DC50=3.6 nM in vivo in mice), with good plasma exposure levels. ITK degrader 1 induces rapid, and prolonged ITK degradation and suppresses IL-2 secretion (EC50=35.2 nM, Jurkat cells) stimulated by anti-CD3 antibodyin vivo. ITK degrader 1 consists of target protein ligand (red part) ITK ligand 1 (HY-168387), PROTAC linker (black part) Piperidine-C2-piperazine-Boc (HY-168388) and E3 ubiquitinase ligand (blue part) Thalidomide 5-fluoride (HY-W087383). E3 ubiquitinase and PROTAC linker can form Thalidomide-piperidine-C2-piperazine-Boc (HY-168389) .
    ITK degrader 1
  • HY-P990717
    Brenetafusp

    		CD3 Inflammation/Immunology
    Brenetafusp is an anti-CD3E/PRAME monoclonal antibody .
    Brenetafusp
  • HY-P99948
    Etevritamab

    AMG-596

    		 EGFR Inflammation/Immunology
    Etevritamab is an anti-CD3E/EGFR monoclonal antibody .
    Etevritamab
  • HY-P99916
    Emirodatamab

    AMG-427

    		 FLT3 Inflammation/Immunology
    Emirodatamab is an anti-CD3E/FLT3 monoclonal antibody .
    Emirodatamab
  • HY-P990688
    Xaluritamig

    AMG-509

    		 CD3 Inflammation/Immunology
    Xaluritamig is an anti-CD3E/STEAP1 monoclonal antibody .
    Xaluritamig
  • HY-P990759
    Rezetamig

    		CD22 Inflammation/Immunology
    Rezetamig is an anti-CD3E/CD22 monoclonal antibody .
    Rezetamig
  • HY-N10445
    Maydispenoid A

    		CD28 CD3 Inflammation/Immunology
    Maydispenoid A is a potent immunosuppressor. Maydispenoid A can inhibit anti-CD3/anti-CD28 mAbs activated and lipopolysaccharide activated murine splenocyte proliferation .
    Maydispenoid A
  • HY-P990698
    Umizortamig

    		PD-1/PD-L1 EGFR Inflammation/Immunology
    Umizortamig is an anti-CD3E/EGFR/TNFRSF9/PD-L1/CD3G monoclonal antibody .
    Umizortamig
  • HY-N10446
    Maydispenoid B

    		CD28 CD3 Inflammation/Immunology
    Maydispenoid B is a potent immunosuppressor. Maydispenoid B can inhibit anti-CD3/anti-CD28 mAbs activated and lipopolysaccharide activated murine splenocyte proliferation .
    Maydispenoid B
  • HY-P99909
    Elranatamab

    PF-06863135

    		 TNF Receptor Inflammation/Immunology
    Elranatamab (PF-06863135) is an anti-CD3E/TNFRSF17 human IgG2κ monoclonal antibody . Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002).
    Elranatamab
  • HY-P990692
    Ciduvectamig

    		CD3 Inflammation/Immunology
    Ciduvectamig is an anti-CD3E/TMEFF2 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
    Ciduvectamig
  • HY-P991209
    Nebratamig

    GNC-035

    		 ROR CD3 PD-1/PD-L1 Inflammation/Immunology Cancer
    Nebratamig (GNC-035) is an anti-ROR1/anti-CD3/anti-PD-L1/anti-4-1BB tetra-specific antibody with potential immunostimulatory and antineoplastic activities .
    Nebratamig
  • HY-P990714
    Obertamig

    		CD3 Inflammation/Immunology
    Obertamig is an engineered, humanized, anti-CD3E/HLA-G monoclonal antibody with humanized CH2-CH3 modifications and consists of half immunoglobulin IgG1 λ2 and a single-chain variable fragment (scFv) .
    Obertamig
  • HY-P99199
    Foralumab

    NI-0401

    		 CD3 Inflammation/Immunology
    Foralumab (NI-0401) is a potent, orally active human monoclonal antibody targeting the CD3. Foralumab modulates immune responses by human cells in NSG mice that were reconstituted with human hematopoietic stem cells .
    Foralumab

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