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aneurysm

" in MedChemExpress (MCE) Product Catalog:

30

Inhibitors & Agonists

1

Fluorescent Dye

2

Biochemical Assay Reagents

7

Peptides

2

Inhibitory Antibodies

6

Natural
Products

6

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-162387
    UK4b

    		PGE synthase Cardiovascular Disease Inflammation/Immunology Cancer
    UK4b is a highly selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. UK4b possesses anti-inflammatory and analgesic effects. UK4b can block the growth of abdominal aortic aneurysms in mice .
    UK4b
  • HY-B0661
    Tamsulosin
    2 Publications Verification

    (R)-(-)-YM12617 free base; LY253351 free base

    		 Adrenergic Receptor Apoptosis Neurological Disease Endocrinology Cancer
    Tamsulosin ((R)-(-)-YM12617 free base) is an orally active antagonist of α1-adrenergic receptor. Tamsulosin induces Apoptosis. Tamsulosin is used for the research of prostatic hyperplasia. Tamsulosin attenuates abdominal aortic aneurysm growth and inhibits inflammation in animal models .
    Tamsulosin
  • HY-B0661A
    Tamsulosin hydrochloride
    2 Publications Verification

    (R)-(-)-YM12617; LY253351

    		 Adrenergic Receptor Apoptosis Neurological Disease Endocrinology Cancer
    Tamsulosin hydrochloride ((R)-(-)-YM12617 free base) is an orally active antagonist of α1-adrenergic receptor. Tamsulosin hydrochloride induces Apoptosis. Tamsulosin hydrochloride is used for the research of prostatic hyperplasia. Tamsulosin hydrochloride attenuates abdominal aortic aneurysm growth and inhibits inflammation in animal models .
    Tamsulosin hydrochloride
  • HY-24504
    MBA-m1

    		Mixed Lineage Kinase Inflammation/Immunology Cancer
    MBA-m1 is a MLKL inhibitor. MBA-m1 inhibits necroptosis in Mlkl −/− NIH-3T3 cells. MBA-m1 ameliorates disease in MLKL-induced dermatitis and abdominal aortic aneurysm mouse model .
    MBA-m1
  • HY-P99112
    Satralizumab

    RG-6168; SA-237

    		 Interleukin Related Inflammation/Immunology Cancer
    Satralizumab is a humanized monoclonal antibody that targets IL-6R. Satralizumab prevents dTAA formation and progression in rattus norvegicus. Satralizumab can be used for neuromyelitis optica spectrum disorder (NMOSD) and descending thoracic aorta aneurysm (dTAA) research .
    Satralizumab
  • HY-19307
    SB-273005

    		Integrin Interleukin Related Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
    SB-273005 is an orally active non-peptide αvβ3 integrin antagonist with Ki values of 1.2 nM and 0.3 nM for αvβ3 and αvβ5, respectively. SB-273005 blocks the binding of integrins to the RGD sequence in the extracellular matrix. SB-273005 inhibits Rictor phosphorylation and reduces IL-10 secretion. SB-273005 inhibits inflammation, prevents bone loss, regulates vascular smooth muscle function, and reverses pregnancy-induced immune deviation. SB-273005 can be used in the study of rheumatoid arthritis, osteoporosis, and aneurysms. .
    SB-273005
  • HY-N6660
    Trisdecanoin

    Tricaprin; Glyceryl tridecanoate

    		 Endogenous Metabolite Androgen Receptor Cardiovascular Disease Metabolic Disease
    Trisdecanoin (Tricaprin; Glyceryl tridecanoate) is an orally available precursor of decanoic acid (DA precursor) that can be hydrolyzed to decanoic acid. Trisdecanoin and its metabolite capric acid not only provide the body with a quick source of energy, but can also affect lipid metabolism. Trisdecanoin is a major component of medium chain triglycerides (MCT), which has preventive or inhibitory properties for abdominal aortic aneurysms (AAA), inhibition of cardiovascular disease, and anti-androgen (NSAA) and anti-hyperglycemic properties. Trisdecanoin can be used as an additive in food, medicine and cosmetics .
    Trisdecanoin
  • HY-D2376
    BH-Vis

    		Fluorescent Dye Cancer
    BH-Vis is a two-photon fluorescent probe that inhibits cell plasma membrane (CPM). BH-Vis has great potential to accurately identify pyroptosis at the cellular level during AAA development in the mouse abdominal aortic aneurysm AAA model .
    BH-Vis
  • HY-175599
    Z6466608628

    		Molecular Glues Cardiovascular Disease Cancer
    Z6466608628 is a selective PPIL4 molecular glue degrader with an EC50 of 0.34  μM. PPIL4 is a regulator of the B ACR spliceosome and it is essential for brain angiogenesis. Z6466608628 can be used for intracranial aneurysm (IA) research .
    Z6466608628
  • HY-B0661R
    Tamsulosin (Standard)

    (R)-(-)-YM12617 free base (Standard); LY253351 free base (Standard)

    		 Reference Standards Adrenergic Receptor Endogenous Metabolite Neurological Disease Endocrinology Cancer
    Tamsulosin (Standard) is the analytical standard of Tamsulosin. This product is intended for research and analytical applications. Tamsulosin ((R)-(-)-YM12617 free base) is an inhibitor of α1-adrenergic receptor. Tamsulosin is used for the research of prostatic hyperplasia. Tamsulosin attenuates abdominal aortic aneurysm growth in animal models .
    Tamsulosin (Standard)
  • HY-N6660R
    Trisdecanoin (Standard)

    Tricaprin (Standard); Glyceryl tridecanoate (Standard)

    		 Reference Standards Endogenous Metabolite Androgen Receptor Metabolic Disease
    Trisdecanoin (Standard) is the analytical standard of Trisdecanoin. This product is intended for research and analytical applications. Trisdecanoin (Tricaprin; Glyceryl tridecanoate) is an orally available precursor of decanoic acid (DA precursor) that can be hydrolyzed to decanoic acid. Trisdecanoin and its metabolite capric acid not only provide the body with a quick source of energy, but can also affect lipid metabolism. Trisdecanoin is a major component of medium chain triglycerides (MCT), which has preventive or inhibitory properties for abdominal aortic aneurysms (AAA), inhibition of cardiovascular disease, and anti-androgen (NSAA) and anti-hyperglycemic properties. Trisdecanoin can be used as an additive in food, medicine and cosmetics .
    Trisdecanoin (Standard)
  • HY-P990209
    Anti-Mouse IL-7Rα/CD127 Antibody (A7R34)
    1 Publications Verification

    		 Interleukin Related Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
    Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse IL-7Rα/CD127. Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) blocks IL-7 signaling. Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) can be used for the researches of cancer,infection, inflammation, immunology, cardiovascular and metabolic disease, such as abdominal aortic aneurysms, helicobacter felis-induced gastritis and diabetes .
    Anti-Mouse IL-7Rα/CD127 Antibody (A7R34)
  • HY-Y0406E
    Calcium chloride anhydrous, for cell culture
    1 Publications Verification

    Calcium dichloride anhydrous, for cell culture

    		 Biochemical Assay Reagents Cancer
    Calcium chloride anhydrous, for cell culture is an inorganic salt for the preparation of various buffers . Calcium chloride anhydrous, for cell culture can be used for animal modeling, to construct abdominal aortic aneurysm models .
    Calcium chloride anhydrous, for cell culture
  • HY-173383
    DOPE-DOTA sodium

    1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N- tetraazacyclododecane-N-tetraacetic acid, sodium salt

    		 Biochemical Assay Reagents Inflammation/Immunology Cancer
    DOPE-DOTA sodium is a chelated lipid that serves as a key contrast agent in magnetic resonance imaging (MRI). DOPE-DOTA sodium can be used for cancer, blood-brain barrier disruption, abnormalities such as aneurysms or plaque buildup, inflammation in arthritis, and liver function and lesions study
    DOPE-DOTA sodium
  • HY-B0661AS1
    Tamsulosin-d4 hydrochloride

    (R)-(-)-YM12617-d4; LY253351-d4

    		 Isotope-Labeled Compounds Adrenergic Receptor Endogenous Metabolite Neurological Disease Endocrinology
    Tamsulosin-d4 (hydrochloride) is deuterium labeled Tamsulosin (hydrochloride). Tamsulosin hydrochloride ((R)-(-)-YM12617) is an inhibitor of α1-adrenergic receptor. Tamsulosin hydrochloride is used for the research of prostatic hyperplasia. Tamsulosin hydrochloride attenuates abdominal aortic aneurysm growth in animal models .
    Tamsulosin-d4 hydrochloride
  • HY-B0661AS
    Tamsulosin-d5 hydrochloride

    (R)-(-)-YM12617-d5; LY253351-d5

    		 Isotope-Labeled Compounds Adrenergic Receptor Endogenous Metabolite Neurological Disease Endocrinology
    Tamsulosin-d5 (hydrochloride) is the deuterium labeled Tamsulosin hydrochloride. Tamsulosin hydrochloride ((R)-(-)-YM12617) is an inhibitor of α1-adrenergic receptor. Tamsulosin hydrochloride is used for the research of prostatic hyperplasia. Tamsulosin hydrochloride attenuates abdominal aortic aneurysm growth in animal models .
    Tamsulosin-d5 hydrochloride
  • HY-P1949
    Cyclic MKEY

    		CXCR Cardiovascular Disease Cancer
    Cyclic MKEY is a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, which protects against atherosclerosis and aortic aneurysm formation by mediating inflammation. Cyclic MKEY also protects against stroke-induced brain injury in mice .
    Cyclic MKEY
  • HY-P1949A
    Cyclic MKEY TFA

    		CXCR Cardiovascular Disease Cancer
    Cyclic MKEY TFA is a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, which protects against atherosclerosis and aortic aneurysm formation by mediating inflammation. Cyclic MKEY TFA also protects against stroke-induced brain injury in mice .
    Cyclic MKEY TFA
  • HY-125171
    IAXO-102
    5 Publications Verification

    		 Toll-like Receptor (TLR) Inflammation/Immunology
    IAXO-102 is a TLR4 antagonist which negatively regulates TLR4 signalling. IAXO-102 inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdominal aortic aneurysm development .
    IAXO-102
  • HY-B0661S
    Tamsulosin-d4

    (R)-(-)-YM12617 (free base)-d4; LY253351 (free base)-d4

    		 Isotope-Labeled Compounds Endogenous Metabolite Adrenergic Receptor Neurological Disease Endocrinology Cancer
    Tamsulosin-d4 ((R)-(-)-YM12617 (free base)-d4) is deuterium labeled Tamsulosin. Tamsulosin ((R)-(-)-YM12617 free base) is an inhibitor of α1-adrenergic receptor. Tamsulosin is used for the research of prostatic hyperplasia. Tamsulosin attenuates abdominal aortic aneurysm growth in animal models .
    Tamsulosin-d4
  • HY-107867
    (±)-Clopidogrel bisulfate

    		P2Y Receptor Cardiovascular Disease Inflammation/Immunology
    (±)-Clopidogrel bisulfate is a platelet P2Y12 receptor inhibitor and an adenosine diphosphate (ADP) receptor antagonist. (±)-Clopidogrel bisulfate inhibits the binding of ADP to its receptors on the membranes of platelet cells, and blocks ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. (±)-Clopidogrel bisulfate reduces vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression. (±)-Clopidogrel bisulfate has anti-inflammatory effects .
    (±)-Clopidogrel bisulfate
  • HY-B0661AR
    Tamsulosin hydrochloride (Standard)

    (R)-(-)-YM12617 (Standard); LY253351 (Standard)

    		 Reference Standards Adrenergic Receptor Apoptosis Neurological Disease Endocrinology Cancer
    Tamsulosin (hydrochloride) (Standard) is the analytical standard of Tamsulosin hydrochloride (HY-B0661A). Tamsulosin hydrochloride ((R)-(-)-YM12617 free base) is an orally active antagonist of α1-adrenergic receptor. Tamsulosin hydrochloride induces Apoptosis. Tamsulosin hydrochloride is used for the research of prostatic hyperplasia. Tamsulosin hydrochloride attenuates abdominal aortic aneurysm growth and inhibits inflammation in animal models .
    Tamsulosin hydrochloride (Standard)
  • HY-B0130R
    Perindopril (Standard)

    		Angiotensin-converting Enzyme (ACE) NF-κB STAT Sirtuin Cardiovascular Disease Neurological Disease Cancer
    Perindopril (Standard) is the analytical standard of Perindopril. This product is intended for research and analytical applications. Perindopril (S-9490) is an orally available, long-acting angiotensin-converting enzyme (ACE) inhibitor. Perindopril inhibits inflammatory cell influx and intimal thickening, preserving elastin on the inside of the aorta. Perindopril effectively inhibits experimental abdominal aortic aneurysm (AAA) formation in a rat model and reduces pulmonary vasoconstriction in rats with pulmonary hypertension .
    Perindopril (Standard)
  • HY-B0130S1
    Perindopril-d5

    S-9490-d5

    		 Isotope-Labeled Compounds Sirtuin Angiotensin-converting Enzyme (ACE) NF-κB STAT Cardiovascular Disease Neurological Disease Cancer
    Perindopril-d5 (S-9490-d5) is deuterium labeled Perindopril. Perindopril (S-9490) is an orally available, long-acting angiotensin-converting enzyme (ACE) inhibitor. Perindopril inhibits inflammatory cell influx and intimal thickening, preserving elastin on the inside of the aorta. Perindopril effectively inhibits experimental abdominal aortic aneurysm (AAA) formation in a rat model and reduces pulmonary vasoconstriction in rats with pulmonary hypertension .
    Perindopril-d5
  • HY-107867S1
    (Rac)-Clopidogrel hydrogen-d9 sulfate

    		Isotope-Labeled Compounds P2Y Receptor Inflammation/Immunology
    (Rac)-Clopidogrel hydrogen-d9 sulfate is the deuterium labeled (±)-Clopidogrel (bisulfate) (HY-107867). (±)-Clopidogrel bisulfate is a platelet P2Y12 receptor inhibitor and an adenosine diphosphate (ADP) receptor antagonist. (±)-Clopidogrel bisulfate inhibits the binding of ADP to its receptors on the membranes of platelet cells, and blocks ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. (±)-Clopidogrel bisulfate reduces vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression. (±)-Clopidogrel bisulfate has anti-inflammatory effects .
    (Rac)-Clopidogrel hydrogen-d9 sulfate
  • HY-107867S2
    Clopidogrel-13C,d3 sulfate

    		Isotope-Labeled Compounds P2Y Receptor Cardiovascular Disease
    Clopidogrel- 13C,d3 sulfate is the deuterium and 13C-labeled (±)-Clopidogrel (bisulfate) (HY-107867). (±)-Clopidogrel bisulfate is a platelet P2Y12 receptor inhibitor and an adenosine diphosphate (ADP) receptor antagonist. (±)-Clopidogrel bisulfate inhibits the binding of ADP to its receptors on the membranes of platelet cells, and blocks ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. (±)-Clopidogrel bisulfate reduces vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression. (±)-Clopidogrel bisulfate has anti-inflammatory effects .
    Clopidogrel-13C,d3 sulfate
  • HY-120272
    SMAP-2

    DT-1154

    		 Phosphatase Cancer
    SMAP-2 (DT-1154) is an orally active protein phosphatase 2A (PP2A) activator, with anti-cancer activity .
    SMAP-2
  • HY-16768R
    Fevipiprant (Standard)

    		Prostaglandin Receptor Cardiovascular Disease
    Fevipiprant (Standard) is the analytical standard of Fevipiprant. This product is intended for research and analytical applications. Fevipiprant (QAW039, NVP-QAW039) is s an orally active, selective, reversible prostaglandin D2 (DP2) receptor antagonist with an Kd value of 1.14 nM. Fevipiprant has the potential for the research of bronchial asthma .
    Fevipiprant (Standard)
  • HY-16768
    Fevipiprant
    1 Publications Verification

    QAW039; NVP-QAW039

    		 Prostaglandin Receptor Cardiovascular Disease
    Fevipiprant (QAW039, NVP-QAW039) is s an orally active, selective, reversible prostaglandin D2 (DP2) receptor antagonist with an Kd value of 1.14 nM. Fevipiprant has the potential for the research of bronchial asthma .
    Fevipiprant
  • HY-W342441
    Monosialoganglioside GM3 (bovine)

    		VEGFR Akt Ferroptosis Insulin Receptor Metabolic Disease Cancer
    Monosialoganglioside GM3 (bovine) is a monosialoganglioside and an inhibitor of VEGFR2 and Akt. At a concentration of 20 μM, Monosialoganglioside GM3 inhibits angiogenesis and reduces the proliferation and migration of human umbilical vein endothelial cells (HUVECs) by inhibiting VEGFR2 and Akt phosphorylation. Ganglioside GM3 also inhibits ferroptosis, providing protective effects during the formation of abdominal aortic aneurysms. Additionally, Monosialoganglioside GM3 (bovine) acts as an inhibitor of insulin signaling, inducing the dissociation of the insulin receptor (IR)-Caveolin-1 complex from lipid microdomains and causing insulin resistance in adipocytes. Monosialoganglioside GM3 (bovine) can be used in cancer and metabolic disease research .
    Monosialoganglioside GM3 (bovine)

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