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amastigote

" in MedChemExpress (MCE) Product Catalog:

36

Inhibitors & Agonists

1

Peptides

7

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-156427
    Antileishmanial agent-25

    		Parasite Infection
    Antileishmanial agent-25 (compound 24) is selective antileishmanial activity on intracellular amastigotes, with the IC50 of 6.63 μM .
    Antileishmanial agent-25
  • HY-149078
    Antiparasitic agent-14

    		Parasite Infection
    Antiparasitic agent-14 is a potent antiparasitic agent. Antiparasitic agent-14 shows cytotoxicity and antiparasitic activity. Antiparasitic agent-14 inhibits the growth of trypomastigote and amastigote .
    Antiparasitic agent-14
  • HY-149956
    Antileishmanial agent-15

    		Parasite Infection
    Antileishmanial agent-15 (compound 13c) is a potent antileishmanial agent. Antileishmanial agent-15 shows antileishmanial and cytotoxic activity against L. major promastigotes and amastigotes, with IC50 values of 0.78 and 0.99 μM, respectively .
    Antileishmanial agent-15
  • HY-149957
    Antileishmanial agent-16

    		Parasite Infection
    Antileishmanial agent-16 (compound 14c) is an anti-Leishmania agent. Antileishmanial agent-16 has superior anti-Leishmania major promastigotes activity (IC50 = 0.59 µM) and anti-Leishmania major amastigotes activity (IC50 = 0.81 µM). Antileishmanial agent-16 has good safety to mammalian cells (VERO cells) .
    Antileishmanial agent-16
  • HY-149093
    Antileishmanial agent-14

    		Parasite Infection
    Antileishmanial agent-14 is a sulfuretin analog with potential activity against the parasite Leishmania donovani promastigotes (IC50=4.1 μM). Antileishmanial agent-14 also inhibits infection by L. donovani amastigotes (IC50=11.1 μM) .
    Antileishmanial agent-14
  • HY-149079
    Antiparasitic agent-15

    		Parasite Necroptosis Infection
    Antiparasitic agent-15, a pyridine-thiazolidinone, has anti-Trypanosoma cruzi and leishmanicidal activities. Antiparasitic agent-15 has IC50s of 0.9 μM and 0.64 μM against trypomastigote and amastigote forms of T. cruzi. Antiparasitic agent-15 has IC50s of 42.2 μM and 9.58 μM against trypomastigote and amastigote forms of L. amazonensis. Antiparasitic agent-15 induces parasite cell death through necrosis induction. Antiparasitic agent-15 induces morphological changes such as shortening, retraction and curvature of the parasite body and leakage of internal content with T. cruzi trypomastigotes .
    Antiparasitic agent-15
  • HY-149080
    Antiparasitic agent-16

    		Parasite Necroptosis Infection
    Antiparasitic agent-16, a pyridine-thiazolidinone, has anti-Trypanosoma cruzi and leishmanicidal activities. Antiparasitic agent-16 has IC50s of 1.0 μM and 0.6 μM against trypomastigote and amastigote forms of T. cruzi. Antiparasitic agent-16 has IC50s of 150.2 μM and 16.75 μM against trypomastigote and amastigote forms of L. amazonensis. Antiparasitic agent-16 induces parasite cell death through necrosis induction. Antiparasitic agent-16 induces morphological changes such as shortening, retraction and curvature of the parasite body and leakage of internal content with T. cruzi trypomastigotes .
    Antiparasitic agent-16
  • HY-151935
    Antileishmanial agent-13

    		Parasite Infection
    Antileishmanial agent-13 is a quinoline-isatin hybrid, acts as an antileishmanial agent against L. Major Leishmania strain. Antileishmanial agent-13 acquires the antileishmanial activity via the anti-folate mechanism. Antileishmanial agent-13 has potent inhibition against both promastigote and amastigote forms with IC50s of 0.604 μM and 0.508 μM, respectively .
    Antileishmanial agent-13
  • HY-155301
    Antileishmanial agent-24

    		Parasite Infection
    Antileishmanial agent-24 (compound 33) is an antileishmanial agent with an IC50 of 5.39 μM against amastigote .
    Antileishmanial agent-24
  • HY-P1957
    Dihydrocyclosporin A

    		Parasite Infection
    Dihydrocyclosporin A is a derivative of Cyclosporine A (HY-B0579). Dihydrocyclosporin A significantly inhibites promastigotes and intracellular amastigotes. Dihydrocyclosporin A is highly cytotoxic .
    Dihydrocyclosporin A
  • HY-115725
    Antileishmanial agent-1

    		Parasite Infection
    Antileishmanial agent-1 exhibits the activity against L. amazonensis promastigotes (IC50 = 15.52 μM) and intracellular amastigotes (IC50 = 4.10 μM).
    Antileishmanial agent-1
  • HY-158690
    DDD00057570

    		Parasite Antibiotic Infection
    DDD00057570 is a selective M17 leucyl-aminopeptidase (LAP) inhibitor. DDD00057570 inhibits L. major and L. donovani intracellular amastigotes in vitro growth .
    DDD00057570
  • HY-159097
    T.cruzi-IN-4

    		Parasite Infection
    T.cruzi-IN-4 (Compound 21) is an anti-parasitic agent. T.cruzi-IN-4 inhibits the trypomastigote and amastigote form of Trypanosoma cruzi with IC50 of 0.033 μM (120 h), T.cruzi-IN-4 inhibits the promastigote and amastigote form of Leishmania infantum with IC50 of 28.74 and 61.82 μM. T.cruzi-IN-4 inhibits Leishmania amazonensis promastigote form with IC50 of 18.38 μM .
    T.cruzi-IN-4
  • HY-149980
    DCN-83

    		Parasite Infection
    DCN-83, an anti-leishmania agent, is most potent against the amastigote form with an IC50 of 0.71 μM. DCN-83 has the potential to cross the blood-brain barrier and central nervous system .
    DCN-83
  • HY-168342
    Anti-Trypanosoma cruzi agent-6

    		Parasite Infection
    Anti-Trypanosoma cruzi agent-6 (Compound 8) exhibits inhibitory activity against Trypanosoma cruzi, that inhibits the epimastigote, trypomastigote and amastigote form of T. cruzi with IC50s of 24.7 µM, 1.8 µM and 1.6 µM, respectively .
    Anti-Trypanosoma cruzi agent-6
  • HY-N7489
    β-Hederin

    		Parasite Infection Inflammation/Immunology
    β-Hederin, a saponin isolated from Hedera helix L.(Araliaceae), possesses antileishmanial activity. β-Hederin exhibits IC50 values of 1.5 μM, 68 nM and 4.57 μM in L. Mexicana promastigotes, L. mexicana amastigotes and THP1 cells, respectively .
    β-Hederin
  • HY-N8181
    1,3-Linolein-2-Olein

    		Parasite Infection
    1,3-Linolein-2-Olein, a triglyceride, is an antileishmanial agent. 1,3-Linolein-2-Olein inhibits promatigotes of the parasite (IC50=0.079 ug/ml) and inhibits the growth of amastigotes (IC50= 40.03 ug/ml) .
    1,3-Linolein-2-Olein
  • HY-N7926
    Pentadecane

    		Parasite Inflammation/Immunology
    Pentadecane is a floral volatile antimalarial agent that can inhibit the growth of parasites such as Leishmania and avoid infection of macrophages. The IC50s of Pentadecane against promastigotes and amastigotes are 65.3 μM and 60.5 μM, respectively. Pentadecane also has anti-inflammatory, analgesic, and antipyretic activities .
    Pentadecane
  • HY-168918
    Insecticidal agent 19

    		Parasite Dihydrofolate reductase (DHFR) Infection
    Insecticidal agent 19 (Compound 7b) exhibits antimalarial activity by inhibiting dihydrofolate reductase-thymidylate synthase (DHFR-TS) and pteridine reductase 1 (PTR1) through the folic acid metabolic pathway. Insecticidal agent 19 inhibits Leishmania major promastigote and amastigote with IC50 of 1.43 μM and 3.78 μM .
    Insecticidal agent 19
  • HY-146043
    Antiparasitic agent-5

    		Parasite Infection
    Antiparasitic agent-5 (compound 8h) has selectively antiparasitic activity against Leishmania infantum (L. infantum) with an IC50 value of 2.50 μM. Antiparasitic agent-5 also has certain cytotoxicity against HepG2 (CC50 = 6.78 μM) .
    Antiparasitic agent-5
  • HY-W159102
    8CN

    		Parasite Infection
    8CN, a 2-amino-thiophene derivative, has anti-leishmanial activity. 8CN can be used in research of Leishmaniasis .
    8CN
  • HY-146044
    Antiparasitic agent-6

    		Parasite Infection
    Antiparasitic agent-6 (compound 5b) has selectively antiparasitic activity against Leishmania infantum (L. infantum) with an IC50 value of 3.89 μM. Antiparasitic agent-6 also has certain cytotoxicity against HepG2 (CC50 = 13.64 μM) .
    Antiparasitic agent-6
  • HY-146045
    Antiparasitic agent-7

    		Parasite Infection
    Antiparasitic agent-7 (compound 5d) has selectively antiparasitic activity against Leishmania infantum (L. infantum) with an IC50 value of 2.85 μM. Antiparasitic agent-7 also has certain cytotoxicity against HepG2 (CC50 = 10.61 μM) .
    Antiparasitic agent-7
  • HY-N7926R
    Pentadecane (Standard)

    		Parasite Inflammation/Immunology
    Pentadecane (Standard) is the analytical standard of Pentadecane. This product is intended for research and analytical applications. Pentadecane is a floral volatile antimalarial agent that can inhibit the growth of parasites such as Leishmania and avoid infection of macrophages. The IC50s of Pentadecane against promastigotes and amastigotes are 65.3 μM and 60.5 μM, respectively. Pentadecane also has anti-inflammatory, analgesic, and antipyretic activities .
    Pentadecane (Standard)
  • HY-N12788
    T-Cadinol

    		Parasite Infection
    T-Cadinol is a sesquiterpene isolated from C. sylvestris that exhibits anti-Trypanosoma cruzi activity, with IC50 values of 18.2 μM and 15.8 μM against trypomastigote and amastigote forms, respectively. T-Cadinol can induce mitochondrial damage in parasites, leading to membrane hyperpolarization and decreased levels of reactive oxygen species. T-Cadinol can be used for the research of Chagas disease .
    T-Cadinol
  • HY-149958
    Antileishmanial agent-17

    		Parasite Infection
    Antileishmanial agent-17 is a coumarin hybrid compound with antileishmanial effects (IC50 <0.78 μM). Antileishmanial agent-17 is safe to normal VERO cells. Antileishmanial agent-17 binds to folate pathway enzymes pteridine reductase and DHFR-TS. And Antileishmanial agent-17 shows the most potent with IC50 value of 0.40 μM against promastigote and 0.68 μM against amastigote, respectivley.
    Antileishmanial agent-17
  • HY-130484
    2,3-Dehydro-3,4-dihydro ivermectin

    		Parasite Infection
    2,3-Dehydro-3,4-dihydro ivermectin is an analog of ivermectin (HY-15310) and an anthelmintic. 2,3-Dehydro-3,4-dihydro ivermectin has activity against L. amazonensis promastigotes and amastigotes (IC50s=13.8 and 3.6 µM, respectively) without inducing cytotoxicity to macrophages (IC50= 65.5 µM).
    2,3-Dehydro-3,4-dihydro ivermectin
  • HY-158379
    Antiparasitic agent-22

    		Parasite Infection
    Antiparasitic agent-22 (Compound 24) is a pan antiparasitic agent, that inhibits T. Brucei, L. infantum, L. tropica promastigotes (IC50 of 2.41, 5.95, 8.98 μM), L. infantum amastigotes (IC50 of 8.18 μM) and P. falciparum W2 strain (IC50 of 0.155 μM). Antiparasitic agent-22 exhibits low cytotoxicity against THP1, with CC50 of 64.16 μM .
    Antiparasitic agent-22
  • HY-146042
    Antiparasitic agent-4

    		Parasite Infection
    Antiparasitic agent-4 (compound 4q) has highly antiparasitic activity against Leishmania infantum (L. infantum) and Trypanosoma cruzi (T. cruzi) with IC50s of 8.51 μM and 2.20 μM, respectively. Antiparasitic agent-4 also has certain cytotoxicity against HepG2 (CC50 = 18.97 μM) .
    Antiparasitic agent-4
  • HY-146041
    Antiparasitic agent-2

    		Parasite Infection
    Antiparasitic agent-2 (compound 8a) has highly antiparasitic activity against Leishmania infantum (L. infantum) and Trypanosoma cruzi (T. cruzi) with IC50s of 7.28 μM and 2.30 μM, respectively. Antiparasitic agent-2 also has certain cytotoxicity against HepG2 (CC50 = 26.79 μM) .
    Antiparasitic agent-2
  • HY-151151
    Trypanothione synthetase-IN-3

    		Parasite Infection
    Trypanothione synthetase-IN-3 is a noncompetitive mixed hyperbolic Trypanothione synthetase (TryS) inhibitor (Ki: 0.8 μM). Trypanothione synthetase-IN-3 can be used in the study of parasites, such as L. infantum .
    Trypanothione synthetase-IN-3
  • HY-159915
    Se2h

    		Parasite Infection
    Se2h is a cruzain inhibitor that exhibits strong activity against the intracellular amastigotes of Trypanosoma cruzi (EC50 < 1 μM, SI > 10), with an inhibitory activity against cruzain of IC50 < 100 nM (SI > 5.55). Compared to Benznidazole (HY-B1548) and the cruzain inhibitor K777 (HY-119293), Se2h shows superior selectivity and inhibition, while its selenazole structure reduces selenium-related toxicity. Se2h exhibits antiparasitic activity and holds promise for research in Chagas disease .
    Se2h
  • HY-N3980
    Guaiol

    Champacol; Guaiac alcohol

    		 Autophagy RAD51 Infection Cardiovascular Disease Inflammation/Immunology Cancer
    Guaiol is a sesquiterpenoid alcohol with oral activity found in various traditional Chinese medicines, exhibiting biological activities such as anti-proliferative, autophagy-promoting, insecticidal, anti-anxiety, anti-inflammatory, diuretic, and blood pressure-lowering effects. Guaiol induces apoptosis in non-small cell lung cancer cells by regulating the stability of RAD51 through autophagy modulation. Guaiol can also act directly on parasites, inhibiting their growth by affecting the kinetoplast, mitochondrial matrix and plasma membrane of the promastigotes. Guaiol kills amastigotes at an IC50 of 0.01 µg/mL. Guaiol can be used in research related to cancer, infections, cardiovascular diseases, and inflammatory conditions [4]
    Guaiol
  • HY-N3980R
    Guaiol (Standard)

    		Autophagy RAD51 Infection Cardiovascular Disease Inflammation/Immunology Cancer
    Guaiol (Standard) is the analytical standard of Guaiol. This product is intended for research and analytical applications. Guaiol is a sesquiterpenoid alcohol with oral activity found in various traditional Chinese medicines, exhibiting biological activities such as anti-proliferative, autophagy-promoting, insecticidal, anti-anxiety, anti-inflammatory, diuretic, and blood pressure-lowering effects. Guaiol induces apoptosis in non-small cell lung cancer cells by regulating the stability of RAD51 through autophagy modulation. Guaiol can also act directly on parasites, inhibiting their growth by affecting the kinetoplast, mitochondrial matrix and plasma membrane of the promastigotes. Guaiol kills amastigotes at an IC50 of 0.01 µg/mL. Guaiol can be used in research related to cancer, infections, cardiovascular diseases, and inflammatory conditions [4]
    Guaiol (Standard)
  • HY-130743
    Dieugenol

    Bis-eugenol; Dehydrodieugenol

    		 Parasite Infection
    Dieugenol is a neolignan that has been found in N. leucantha and has antioxidative and antiprotozoal activities. It inhibits the formation of thiobarbituric acid reactive substances (TBARS) and scavenges superoxide anions, but not hydroxyl radicals, in cell-free assays. It has anti-trypanosomal activity against T. cruzi amastigotes and trypomastigotes (IC50s=15.1 and 11.5 μM, respectively) but is cytotoxic to NCTC L-929 fibroblasts with a 50% cytotoxic concentration (CC50) value of 58.2 μM.2 Dieugenol (15 μM) disrupts the integrity of the T. cruzi trypomastigote plasma membrane but does not induce the production of reactive oxygen species (ROS) in trypomastigotes or LPS-stimulated and unstimulated isolated mouse peritoneal macrophages.
    Dieugenol
  • HY-139090
    3-Oxobetulin acetate

    28-O-Acetyl-3-Oxobetulin; 3-oxo-28-O-Acetylbetulin

    		 Bacterial HIV Drug Derivative Cancer
    3-Oxobetulin acetate (28-O-Acetyl-3-Oxobetulin; 3-oxo-28-O-Acetylbetulin) is a derivative of betulin (HY-N0083), a cholesterol biosynthesis inhibitor. 3-Oxobetulin acetate inhibits the growth of P388 murine lymphocytic leukemia cells (EC50=0.12 μg/mL) and human MCF-7 breast cancer, SF-268 CNS cancer, H460 lung cancer, and KM20L2 colon cancer cells (GI50s=8, 10.6, 5.2, and 12.7 μg/mL), but not BxPC-3 pancreatic cancer cells or DU145 prostate cancer cells (GI50s=>10 μg/mL for both). 3-Oxobetulin acetate inhibits the replication of X4-tropic recombinant HIV (NL4.3-Ren) in MT-2 lymphoblastoid cells (IC50=13.4 μM). 3-Oxobetulin acetate is also effective against Listeria donovani amastigotes.
    3-Oxobetulin acetate

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