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adenosine uptake

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Deaminase (1) Adenosine Receptor (2) Endogenous Metabolite (1) Isotope-Labeled Compounds (1) Nucleoside Transporters (2) Phosphodiesterase (PDE) (4) Reference Standards (1) TNF Receptor (1)
By Research Areas:	Cardiovascular Disease (5) Inflammation/Immunology (3) Neurological Disease (5)
Oligonucleotides:	A (1) Nucleosides and their Analogs (1)

12

Inhibitors & Agonists

1

Natural
Products

3

Isotope-Labeled Compounds

1

Oligonucleotides

Targets Recommended: Adenosine Kinase Adenosine Receptor Adenosine Deaminase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

L-Adenosine	Adenosine Deaminase	Neurological Disease
L-Adenosine is a metabolically stable enantiomeric analog and also is a potential probe. L-Adenosine has weakly inhibitory adenosine deaminase (ADA) activity with an K_i value of 385 μM. L-Adenosine can be used for the research of adenosine uptake and accumulation .

Dilazep dihydrochloride	Nucleoside Transporters	Cardiovascular Disease
Dilazep dihydrochloride is an inhibitor of **adenosine uptake*. Dilazep dihydrochloride has cerebral and coronary vasodilating action through enhancement of effect of adenosine*. Dilazep dihydrochloride also inhibits the ischemic damage, platelet aggregation, and membrane transport of nucleosides .

NBTGR	Others	Cardiovascular Disease
NBTGR (p-Nitrobenzylthioguanosine) is a potent inhibitor of nucleoside transport; inhibits adenosine uptake with a K_i of 70 nM.

AICA-riboside, 5′-phosphate AICAR-5'-MP	Endogenous Metabolite	Others
AICA-riboside, 5′-phosphate is AICA riboside with a phosphate group. The functions of AICA riboside include: 1) conversion into AMP mimetic to selectively activate AMPK; 2) competition with adenosine for the uptake of nucleoside transporters, reversible blocking of adenosine reuptake, increasing extracellular adenosine concentration, and indirectly activating adenosine A1 receptors. AICA riboside is involved in metabolic regulation (promoting catabolism and inhibiting anabolism) and adenosine-dependent neuroprotection (inhibiting excitatory synaptic transmission). AICA riboside can be used in the study of metabolic diseases (such as diabetes and obesity) and neurological diseases (such as ischemia and epilepsy), and has central nervous system protective activity .

Propentofylline HWA 285	Phosphodiesterase (PDE)	Neurological Disease Inflammation/Immunology
Propentofylline is a xanthine-derivative that inhibits adenosine uptake and blocks phosphodiesterase activity. Propentofylline has neuroprotective, antiproliferative, and anti-inflammatory effects that improve cognition and dementia severity in patients with Alzheimer's disease or vascular dementia.

KF24345 free base	TNF Receptor	Inflammation/Immunology
KF24345 free base is an orally active adenosine uptake inhibitor. KF24345 free base inhibits adenosine uptake by human, mouse, rabbit and hamster erythrocytes with IC₅₀ values of 59.5, 130.1, 104.2 and 30.9 nM, respectively. KF24345 free base has anti-inflammatory activity and can inhibit LPS-induced TNF-α production and leukopenia in mice .

Dilazep dihydrochloride (Standard)	Nucleoside Transporters Reference Standards	Cardiovascular Disease
Dilazep (dihydrochloride) (Standard) is the analytical standard of Dilazep (dihydrochloride). This product is intended for research and analytical applications. Dilazep dihydrochloride is an inhibitor of adenosine uptake. Dilazep dihydrochloride has cerebral and coronary vasodilating action through enhancement of effect of adenosine. Dilazep dihydrochloride also inhibits the ischemic damage, platelet aggregation, and membrane transport of nucleosides .

(-)-N6-Phenylisopropyl adenosine L-Phenylisopropyladenosine; L-PIA	Adenosine Receptor	Neurological Disease
(-)-N6-phenylisopropyl adenosine (D-phenylisopropyladenosine) is a adenosine receptor agonist. (-)-N6-phenylisopropyl adenosine inhibits K ⁺-evoked Ca ²⁺ uptake with an IC₅₀ value of 0.5 µM .

Dipyridamole-d16	Phosphodiesterase (PDE)	Cardiovascular Disease
Dipyridamole-d₁₆ is the deuterium labeled Dipyridamole. Dipyridamole (Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.

Dipyridamole-d20	Phosphodiesterase (PDE)	Cardiovascular Disease
Dipyridamole-d₂₀ is the deuterium labeled Dipyridamole. Dipyridamole is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells .

Nitrobenzylthioinosine NBMPR	Adenosine Receptor	Neurological Disease
Nitrobenzylthioinosine is an ENT1 transporter inhibitor that binds to ENT1 transporter with high affinity. Nitrobenzylthioinosine is a photoaffinity probe for adenosine uptake sites in brain. Nitrobenzylthioinosine can cross the blood-brain barrier .

Propentofylline-d6 HWA 285-d6	Isotope-Labeled Compounds Phosphodiesterase (PDE)	Neurological Disease Inflammation/Immunology
Propentofylline-d₆ (HWA 285-d₆) is the deuterium labeled Propentofylline. Propentofylline is a xanthine-derivative that inhibits adenosine uptake and blocks phosphodiesterase activity. Propentofylline has neuroprotective, antiproliferative, and anti-inflammatory effects that improve cognition and dementia severity in patients with Alzheimer's disease or vascular dementia .

Cat. No.	Product Name	Category	Target	Chemical Structure

AICA-riboside, 5′-phosphate AICAR-5'-MP	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
AICA-riboside, 5′-phosphate is AICA riboside with a phosphate group. The functions of AICA riboside include: 1) conversion into AMP mimetic to selectively activate AMPK; 2) competition with adenosine for the uptake of nucleoside transporters, reversible blocking of adenosine reuptake, increasing extracellular adenosine concentration, and indirectly activating adenosine A1 receptors. AICA riboside is involved in metabolic regulation (promoting catabolism and inhibiting anabolism) and adenosine-dependent neuroprotection (inhibiting excitatory synaptic transmission). AICA riboside can be used in the study of metabolic diseases (such as diabetes and obesity) and neurological diseases (such as ischemia and epilepsy), and has central nervous system protective activity .

Cat. No.	Product Name	Chemical Structure

Dipyridamole-d16
Dipyridamole-d₁₆ is the deuterium labeled Dipyridamole. Dipyridamole (Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.

Dipyridamole-d20
Dipyridamole-d₂₀ is the deuterium labeled Dipyridamole. Dipyridamole is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells .

Propentofylline-d6
Propentofylline-d₆ (HWA 285-d₆) is the deuterium labeled Propentofylline. Propentofylline is a xanthine-derivative that inhibits adenosine uptake and blocks phosphodiesterase activity. Propentofylline has neuroprotective, antiproliferative, and anti-inflammatory effects that improve cognition and dementia severity in patients with Alzheimer's disease or vascular dementia .

Cat. No.	Product Name		Classification

L-Adenosine		Nucleosides and their Analogs A
L-Adenosine is a metabolically stable enantiomeric analog and also is a potential probe. L-Adenosine has weakly inhibitory adenosine deaminase (ADA) activity with an K_i value of 385 μM. L-Adenosine can be used for the research of adenosine uptake and accumulation .

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