YTHDF2

Isoforms Recommended:	YTHDF2

By Targets:	Apoptosis (1) Endogenous Metabolite (1) Epigenetic Reader Domain (1) FOXO (1) Influenza Virus (1) Interleukin Related (1) MMP (1) PROTACs (1) Pyroptosis (1) Reference Standards (1) Small Interfering RNA (siRNA) (3) YTHDF (5)
By Research Areas:	Cancer (4) Endocrinology (1) Infection (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-173008

YTHDF2-IN-1	Apoptosis YTHDF	Cancer
YTHDF2-IN-1 (Compound CK-75) is the inhibitor for YT521-B homology domain family 2 *YTHDF2* (K_d=26.2 μM), that blocks the interaction between YTHDF2 and m6A RNA. YTHDF2-IN-1 inhibits the colony formation of JAR cells, exhibits antiproliferative activity in a variety of cancer cells (IC₅₀ in micromolar levels), arrests the cell cycle at G0/G1 phase, induces apoptosis in K562 .

HY-154919

DC-Y13-27 4 Publications Verification	YTHDF FOXO MMP Pyroptosis Interleukin Related	Endocrinology Cancer
DC-Y13-27 is a DC-Y13 derivative and *YTHDF2* inhibitor (K_D: 37.9 μM). DC-Y13-27 inhibits *YTHDF2, restores FOXO3* and TIMP1 protein levels, and reduces MMP1/3/7/9 expression. DC-Y13-27 induces Pyroptosis and increases IL-1β secretion. DC-Y13-27 reduces intervertebral disc degeneration and enhances the response to radiotherapy in colon cancer and melanoma. DC-Y13-27 has antitumor activity against breast cancer ^[2] .

HY-168610

YTH-IN-1	Epigenetic Reader Domain YTHDF	Cancer
YTH-IN-1 (compound N-7) is a pan-YTH domain inhibitor with the IC₅₀ values of 39 μM, 34 μM, 35 μM, 48 μM and 30 μM for human YTH ^YTHDF1, YTH ^YTHDF2, YTH ^YTHDF3, YTH ^YTHDC1, and YTH ^YTHDC2, respectively .

HY-137341

SK-3-91	PROTACs YTHDF	Cancer
SK-3-91 is a PROTAC-type multi-kinase degrader that can jointly induce the degradation of the largest number of unique kinases (more than 125 unique kinases). SK-3-91 induces protein degradation through the ubiquitin biotinylation (E-STUB) pathway. SK-3-91 degrades *YTHDF2*. SK-3-91 inhibits cell proliferation and induces morphological changes. (Pink: TAE648 ligand (HY-169396); Blue: E3 ligase ligand (HY-131717); Black: Linker (HY-140819). The E3 ligase ligand and linker can form a conjugate (HY-169397)) ^[2].

HY-N0086R

N6-Methyladenosine (Standard) 6-Methyladenosine (Standard); N-Methyladenosine (Standard)	Endogenous Metabolite Influenza Virus Reference Standards	Infection
N6-Methyladenosine (Standard) is the analytical standard of N6-Methyladenosine. This product is intended for research and analytical applications. N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities. In Vitro: N6-methyladenosine (m6A) is selectively recognized by the human YTH domain family 2 (YTHDF2) protein to regulate mRNA degradation. N6-methyladenosine (m6A), a prevalent internal modification in the messenger RNA of all eukaryotes, is post-transcriptionally installed by m6A methyltransferase (e.g., MT-A70) within the consensus sequence of G(m6A)C (70%) or A(m6A)C (30%). N6-methyladenosine (m6A)-containing RNAs are greatly enriched in the YTHDF-bound portion and diminished in the flow-through portion . N6-methyladenosine (m6A), the most abundant internal RNA modification, functions in diverse biological processes, including regulation of embryonic stem cell self-renewal and differentiation. N6-methyladenosine (m6A) is a large protein complex, consisting in part of methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) catalytic subunits ^[2].

HY-RS23390

Ythdf2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ythdf2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ythdf2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ythdf2 Rat Pre-designed siRNA Set A Ythdf2 Rat Pre-designed siRNA Set A

HY-RS15938

YTHDF2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) YTHDF	Others
YTHDF2 Human Pre-designed siRNA Set A contains three designed siRNAs for YTHDF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

YTHDF2 Human Pre-designed siRNA Set A YTHDF2 Human Pre-designed siRNA Set A

HY-RS16947

Ythdf2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ythdf2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ythdf2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ythdf2 Mouse Pre-designed siRNA Set A Ythdf2 Mouse Pre-designed siRNA Set A

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0086R

N6-Methyladenosine (Standard) 6-Methyladenosine (Standard); N-Methyladenosine (Standard)	Structural Classification Natural Products Microorganisms Source classification Endogenous metabolite	Endogenous Metabolite Influenza Virus Reference Standards
N6-Methyladenosine (Standard) is the analytical standard of N6-Methyladenosine. This product is intended for research and analytical applications. N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities. In Vitro: N6-methyladenosine (m6A) is selectively recognized by the human YTH domain family 2 (YTHDF2) protein to regulate mRNA degradation. N6-methyladenosine (m6A), a prevalent internal modification in the messenger RNA of all eukaryotes, is post-transcriptionally installed by m6A methyltransferase (e.g., MT-A70) within the consensus sequence of G(m6A)C (70%) or A(m6A)C (30%). N6-methyladenosine (m6A)-containing RNAs are greatly enriched in the YTHDF-bound portion and diminished in the flow-through portion . N6-methyladenosine (m6A), the most abundant internal RNA modification, functions in diverse biological processes, including regulation of embryonic stem cell self-renewal and differentiation. N6-methyladenosine (m6A) is a large protein complex, consisting in part of methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) catalytic subunits ^[2].

Cat. No.	Compare	Product Name	Species	Source

HY-P702576

	YTHDF2 Protein, Human (His) DF2; CLL-associated antigen KW-14; High-glucose-regulated protein 8; Renal carcinoma antigen NY-REN-2	Human	E. coli
	YTHDF2 Protein, Human (His) is the recombinant human-derived YTHDF2, expressed by E. coli , with C-6*His labeled tag. ,

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HY-P86454

	YTHDF2 Antibody (YA6146)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat,
	YTHDF2 Antibody (YA6146) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to YTHDF2. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

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Cat. No.	Product Name		Classification

HY-RS23390

Ythdf2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Ythdf2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ythdf2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS15938

YTHDF2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
YTHDF2 Human Pre-designed siRNA Set A contains three designed siRNAs for YTHDF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16947

Ythdf2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ythdf2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ythdf2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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