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Results for "

Vandetanib

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

4

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-10260
    Vandetanib
    Maximum Cited Publications
    26 Publications Verification

    ZD6474

    		 VEGFR Autophagy Apoptosis Cancer
    Vandetanib (D6474) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity (IC50=40 nM). Vandetanib also has activity versus the tyrosine kinase activity of VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM) .
    Vandetanib
  • HY-10260S1
    Vandetanib-d4

    		Isotope-Labeled Compounds VEGFR Autophagy Apoptosis Cancer
    Vandetanib-d4 is the deuterium labeled Vandetanib. Vandetanib (ZD6474) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity (IC50=40 nM). Vandetanib also has activity versus the tyrosine kinase activity of VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM) .
    Vandetanib-d4
  • HY-10260R
    Vandetanib (Standard)

    ZD6474 (Standard)

    		 Reference Standards VEGFR Autophagy Apoptosis Cancer
    Vandetanib (Standard) is the analytical standard of Vandetanib. This product is intended for research and analytical applications. Vandetanib (D6474) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity (IC50=40 nM). Vandetanib also has activity versus the tyrosine kinase activity of VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM) .
    Vandetanib (Standard)
  • HY-10260B
    Vandetanib hydrochloride

    ZD6474 hydrochloride

    		 VEGFR Autophagy Apoptosis Cancer
    Vandetanib hydrochloride (D6474 hydrochloride) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity (IC50=40 nM). Vandetanib hydrochloride also has activity versus the tyrosine kinase activity of VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM) .
    Vandetanib hydrochloride
  • HY-10260A
    Vandetanib trifluoroacetate

    ZD6474 trifluoroacetate

    		 VEGFR Autophagy Apoptosis Cancer
    Vandetanib trifluoroacetate (D6474 trifluoroacetate) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity (IC50=40 nM). Vandetanib trifluoroacetate also has activity versus the tyrosine kinase activity of VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM) .
    Vandetanib trifluoroacetate
  • HY-10260S
    Vandetanib-d6

    ZD6474-d6

    		 Isotope-Labeled Compounds VEGFR Autophagy Apoptosis Cancer
    Vandetanib-d6 is the deuterium labeled Vandetanib. Vandetanib (D6474) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity (IC50=40 nM). Vandetanib also has activity versus the tyrosine kinase activity of VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM) .
    Vandetanib-d6
  • HY-10260S2
    Vandetanib-13C6

    ZD6474-13C6

    		 Isotope-Labeled Compounds VEGFR Autophagy Apoptosis Cancer
    Vandetanib- 13C6 is a 13C labeled Vandetanib (HY-10260) . Vandetanib (D6474) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity (IC50=40 nM). Vandetanib also has activity versus the tyrosine kinase activity of VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM) .
    Vandetanib-13C6
  • HY-131414S5
    N-Demethyl vandetanib-d5

    		Isotope-Labeled Compounds Others
    N-Demethyl vandetanib-d5 is the deuterium labeled N-Demethyl Vandetanib (HY-131414).
    N-Demethyl vandetanib-d5
  • HY-178942
    EGFR/VEGFR2-IN-9

    		VEGFR EGFR Apoptosis Bcl-2 Family Caspase MDM-2/p53 Cancer
    EGFR/VEGFR2-IN-9 (Compound 9b) is an inhibitor of VEGFR-2 (IC50 = 1.325 μM) and EGFR (IC50 = 1.891 μM). EGFR/VEGFR2-IN-9 significantly inhibits the proliferation of multiple cancer cell lines, particularly leukemia cells. EGFR/VEGFR2-IN-9 upregulates the expression levels of Bax, caspase-3, and p53, while downregulating the expression of Bcl-2. EGFR/VEGFR2-IN-9 induces apoptosis and arrests the cell cycle in the G1 phase. EGFR/VEGFR2-IN-9 can be used to investigate anti-tumor angiogenesis and multi-drug resistant cancers .
    EGFR/VEGFR2-IN-9

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