VEGFC

By Targets:	Akt (1) Apoptosis (1) Bacterial (1) HIF/HIF Prolyl-Hydroxylase (1) Interleukin Related (1) mRNA (2) PI3K (1) Small Interfering RNA (siRNA) (3) Tie (1) TNF Receptor (1) VEGFR (4)
By Research Areas:	Cancer (5) Cardiovascular Disease (3) Infection (1) Inflammation/Immunology (3) Metabolic Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) mRNA (2) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P990675

VGX-100	VEGFR	Inflammation/Immunology
VGX-100 is a humanized antibody expressed in CHO cells, targeting *VEGFC*. VGX-100 is composed of huIgG1 heavy chains and huλ light chains, with a predicted molecular weight (MW) of 143.6 kDa. The isotype control for VGX-100 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P9920A

Ramucirumab (anti-VEGFR) 1 Publications Verification	VEGFR	Cancer
Ramucirumab (anti-VEGFR) is a human VEGFR-2 antagonist for the treatment of solid tumors. Ramucirumab (anti-VEGFR) is a recombinant human immunoglobulin G1 monoclonal antibody that binds to the extracellular binding domain of VEGFR-2 and prevents the binding of VEGFR ligands: VEGF-A, VEGF-C, and VEGF-D. Ramucirumab (anti-VEGFR) is also an angiogenesis inhibitor .

HY-P3369

Gersizangitide AXT-107	VEGFR Tie Akt	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Gersizangitide (AXT107) is an anti-angiogenic peptide consisting of 20 amino acids, derived from collagen IV. Gersizangitide is an inhibitor of *VEGF-A* and *VEGF-C* and an activator of Tie2. Gersizangitide can block *VEGF* receptor signaling, inhibit vascular leakage, neovascularization and inflammation. Gersizangitide can be used in the research of diseases related to ocular neovascularization and angiogenesis .

HY-N2187

Deoxyshikonin 2 Publications Verification	Bacterial HIF/HIF Prolyl-Hydroxylase PI3K Apoptosis	Infection Cardiovascular Disease Cancer
Deoxyshikonin increases the expression of *VEGF-C* and *VEGF-A* mRNA in HMVEC-dLy, promotes HIF-1α and HIF-1β subunit interaction and binds to specific DNA sequences targeted by HIF. Deoxyshikonin inhibited colorectal cancer (CRC) through the PI3K/Akt/mTOR pathway. Deoxyshikonin has proangiogenesis effect and antitumor activity. Deoxyshikonin is an antibacterial agent against methicillin-resistant S. aureus (MRSA) and S. pneumonia (MIC=17 μg/mL) .

HY-P99830

Conbercept KH902	VEGFR TNF Receptor Interleukin Related	Cardiovascular Disease Inflammation/Immunology Cancer
Conbercept (KH902) is a recombinant fusion protein composed of VEGFR-1 (second domain) and VEGFR-2 (third and fourth domains) regions fused to human IgG1 Fc. Conbercept is a *VEGF* inhibitor (IC₅₀ = 8.8 pM) and is a soluble receptor decoy that blocks all isoforms of *VEGF-A* (K_d = 0.5 pM), *VEGF-B* (K_d = 8 pM), *VEGF-C, and PlGF* (K_d = 5 pM). Conbercept has anti-inflammatory effects, can lower the levels of *VEGF, TNF-α* and IL-6, and reduce the infiltration of inflammatory cells. Conbercept decreases tumor growth in several oncology studies. Conbercept can be used for various eye diseases such as polypoidal choroidal vasculopathy (PCV), diabetic macular edema (DME) and pathologic myopia choroidal neovascularization (pmCNV) .

HY-RS16674

Vegfc Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Vegfc Mouse Pre-designed siRNA Set A contains three designed siRNAs for Vegfc gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Vegfc Mouse Pre-designed siRNA Set A Vegfc Mouse Pre-designed siRNA Set A

HY-RS15637

VEGFC Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
VEGFC Human Pre-designed siRNA Set A contains three designed siRNAs for VEGFC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

VEGFC Human Pre-designed siRNA Set A VEGFC Human Pre-designed siRNA Set A

HY-RS23109

Vegfc Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Vegfc Rat Pre-designed siRNA Set A contains three designed siRNAs for Vegfc gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Vegfc Rat Pre-designed siRNA Set A Vegfc Rat Pre-designed siRNA Set A

HY-174508

*Human VEGFC* mRNA**	mRNA	Cancer
Human VEGFC mRNA encodes the human vascular endothelial growth factor C (VEGFC) protein, a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. VEGFC promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels.

HY-174507

Human VEGFD mRNA	mRNA	Cancer
Human VEGFD mRNA encodes the human vascular endothelial growth factor D (VEGFD) protein, a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. VEGFD is structurally and functionally similar to vascular endothelial growth factor C (VEGFC).

Cat. No.	Product Name	Target	Research Area

HY-P3369

Gersizangitide AXT-107	VEGFR Tie Akt	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Gersizangitide (AXT107) is an anti-angiogenic peptide consisting of 20 amino acids, derived from collagen IV. Gersizangitide is an inhibitor of *VEGF-A* and *VEGF-C* and an activator of Tie2. Gersizangitide can block *VEGF* receptor signaling, inhibit vascular leakage, neovascularization and inflammation. Gersizangitide can be used in the research of diseases related to ocular neovascularization and angiogenesis .

Cat. No.	Product Name	Target	Research Area

HY-P990675

VGX-100	VEGFR	Inflammation/Immunology
VGX-100 is a humanized antibody expressed in CHO cells, targeting *VEGFC*. VGX-100 is composed of huIgG1 heavy chains and huλ light chains, with a predicted molecular weight (MW) of 143.6 kDa. The isotype control for VGX-100 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P9920A

Ramucirumab (anti-VEGFR) 1 Publications Verification	VEGFR	Cancer
Ramucirumab (anti-VEGFR) is a human VEGFR-2 antagonist for the treatment of solid tumors. Ramucirumab (anti-VEGFR) is a recombinant human immunoglobulin G1 monoclonal antibody that binds to the extracellular binding domain of VEGFR-2 and prevents the binding of VEGFR ligands: VEGF-A, VEGF-C, and VEGF-D. Ramucirumab (anti-VEGFR) is also an angiogenesis inhibitor .

HY-P99830

Conbercept KH902	VEGFR TNF Receptor Interleukin Related	Cardiovascular Disease Inflammation/Immunology Cancer
Conbercept (KH902) is a recombinant fusion protein composed of VEGFR-1 (second domain) and VEGFR-2 (third and fourth domains) regions fused to human IgG1 Fc. Conbercept is a *VEGF* inhibitor (IC₅₀ = 8.8 pM) and is a soluble receptor decoy that blocks all isoforms of *VEGF-A* (K_d = 0.5 pM), *VEGF-B* (K_d = 8 pM), *VEGF-C, and PlGF* (K_d = 5 pM). Conbercept has anti-inflammatory effects, can lower the levels of *VEGF, TNF-α* and IL-6, and reduce the infiltration of inflammatory cells. Conbercept decreases tumor growth in several oncology studies. Conbercept can be used for various eye diseases such as polypoidal choroidal vasculopathy (PCV), diabetic macular edema (DME) and pathologic myopia choroidal neovascularization (pmCNV) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2187

Deoxyshikonin 2 Publications Verification	Infection Cardiovascular Disease Quinones Structural Classification Classification of Application Fields Plants Naphthalene Quinones Boraginaceae Disease Research Fields Arnebia euchroma (Royle) Johnst.	Bacterial HIF/HIF Prolyl-Hydroxylase PI3K Apoptosis
Deoxyshikonin increases the expression of *VEGF-C* and *VEGF-A* mRNA in HMVEC-dLy, promotes HIF-1α and HIF-1β subunit interaction and binds to specific DNA sequences targeted by HIF. Deoxyshikonin inhibited colorectal cancer (CRC) through the PI3K/Akt/mTOR pathway. Deoxyshikonin has proangiogenesis effect and antitumor activity. Deoxyshikonin is an antibacterial agent against methicillin-resistant S. aureus (MRSA) and S. pneumonia (MIC=17 μg/mL) .

Recombinant Proteins Recommended:

VEGF-C

Species:	Human (6) Mouse (2) Rat (2)
Tag:	His (6) Tag Free (1) Avi (2) Fc (1)
Source:	HEK293 (8)

Cat. No.	Compare	Product Name	Species	Source

HY-P74474

	VEGF-C Protein, Mouse/Rat (HEK293, His) 3 Publications Verification Flt4-L; vascular endothelial growth factor C; VEGFC; VRP	Mouse;Rat	HEK293
	VEGF-C protein stimulates cell proliferation, migration, and vascular permeability, which are critical for angiogenesis and endothelial cell dynamics. It plays a crucial role in the development of the venous and lymphatic vasculature during embryogenesis and in the maintenance of adult lymphatic endothelium. VEGF-C Protein, Mouse/Rat (HEK293, His) is the recombinant mouse, rat-derived VEGF-C protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P74475

	VEGF-C Protein, Mouse/Rat (HEK293, Fc) Flt4-L; vascular endothelial growth factor C; VEGFC; VRP	Rat;Mouse	HEK293
	VEGF-C protein stimulates cell proliferation, migration, and vascular permeability, which are critical for angiogenesis and endothelial cell dynamics. It plays a crucial role in the development of the venous and lymphatic vasculature during embryogenesis and in the maintenance of adult lymphatic endothelium. VEGF-C Protein, Mouse/Rat (HEK293, Fc) is the recombinant rat, mouse-derived VEGF-C protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P70501

	VEGF-C Protein, Human (196a.a, HEK293, His) Vascular Endothelial Growth Factor C; VEGF-C; Flt4 Ligand; Flt4-L; Vascular Endothelial Growth Factor-Related Protein; VRP; VEGFC	Human	HEK293
	The VEGF-C protein is a potent growth factor in angiogenesis and endothelial cell growth, stimulating cell proliferation and migration while affecting vascular permeability. It plays a critical role in embryonic vein and lymphangiogenesis and maintains adult differentiated lymphatic endothelium. VEGF-C Protein, Human (196a.a, HEK293, His) is the recombinant human-derived VEGF-C protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P73529

	VEGF-C Protein, Human (125a.a, HEK293, His) Flt4-L; vascular endothelial growth factor C; VEGFC; VRP	Human	HEK293
	The VEGF-C protein is a potent growth factor in angiogenesis and endothelial cell growth, stimulating cell proliferation and migration while affecting vascular permeability. It plays a critical role in embryonic vein and lymphangiogenesis and maintains adult differentiated lymphatic endothelium. VEGF-C Protein, Human (125a.a, HEK293, His) is the recombinant human-derived VEGF-C protein, expressed by HEK293 , with C-His labeled tag.

HY-P7313

	VEGF-C Protein, Human (116a.a, HEK293) 1 Publications Verification rHuVEGF-C; Vascular endothelial growth factor C; Flt4-L; VRP	Human	HEK293
	VEGF-C Protein, Human (116a.a, HEK293) functions in lymphangiogenesis, where it acts on lymphatic endothelial cells (LECs) primarily via its receptor VEGFR-3 promoting survival, growth and migration.

HY-P77864

	VEGF-C Protein, Human (HEK293, His-Avi) VEGFC; VEGF-CC; VEGFC; Flt4-L; VRP;	Human	HEK293
	VEGF-C protein is an important member of the PDGF/VEGF growth factor family and plays a role in important cell signaling pathways. As part of this family, VEGF-C may share features with related proteins that promote cell growth, angiogenesis, and lymphangiogenesis. VEGF-C Protein, Human (HEK293, His-Avi) is the recombinant human-derived VEGF-C protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P77865

	VEGF-C Protein, Human (Biotinylated, HEK293, His-Avi) VEGFC; VEGF-CC; VEGFC; Flt4-L; VRP;	Human	HEK293
	VEGF-C protein is an important member of the PDGF/VEGF growth factor family and plays a role in important cell signaling pathways. As part of this family, VEGF-C may share features with related proteins that promote cell growth, angiogenesis, and lymphangiogenesis. VEGF-C Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived VEGF-C protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P7313A

	VEGF-C Protein, Human (116a.a, HEK293, His) rHuVEGF-C; Vascular endothelial growth factor C; Flt4-L; VRP	Human	HEK293
	The VEGF-C protein is a potent growth factor in angiogenesis and endothelial cell growth, stimulating cell proliferation and migration while affecting vascular permeability. It plays a critical role in embryonic vein and lymphangiogenesis and maintains adult differentiated lymphatic endothelium. VEGF-C Protein, Human (116a.a, HEK293, His) is the recombinant human-derived VEGF-C protein, expressed by HEK293 , with C-6*His labeled tag.

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Cat. No.	Product Name		Classification

HY-RS16674

Vegfc Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Vegfc Mouse Pre-designed siRNA Set A contains three designed siRNAs for Vegfc gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS15637

VEGFC Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
VEGFC Human Pre-designed siRNA Set A contains three designed siRNAs for VEGFC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23109

Vegfc Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Vegfc Rat Pre-designed siRNA Set A contains three designed siRNAs for Vegfc gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-174508

*Human VEGFC* mRNA**		mRNA
Human VEGFC mRNA encodes the human vascular endothelial growth factor C (VEGFC) protein, a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. VEGFC promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels.

HY-174507

Human VEGFD mRNA		mRNA
Human VEGFD mRNA encodes the human vascular endothelial growth factor D (VEGFD) protein, a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. VEGFD is structurally and functionally similar to vascular endothelial growth factor C (VEGFC).

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