Search Result

Results for "

UGT

" in MedChemExpress (MCE) Product Catalog:

By Targets:	UGT (8) Apoptosis (6) Autophagy (10) Biochemical Assay Reagents (1) Carboxylesterase (CES) (2) Cytochrome P450 (2) Drug Metabolite (1) Endogenous Metabolite (4) Estrogen Receptor/ERR (5) GABA Receptor (1) Glutathione S-transferase (1) Glycosidase (2) HBV (1) HIV (3) HIV Integrase (3) Isotope-Labeled Compounds (6) Keap1-Nrf2 (2) Methionine Adenosyltransferase (MAT) (1) mTOR (1) NO Synthase (1) OAT (3) p38 MAPK (8) RAR/RXR (1) Small Interfering RNA (siRNA) (27)
By Research Areas:	Cancer (16) Cardiovascular Disease (3) Endocrinology (5) Infection (8) Inflammation/Immunology (3) Metabolic Disease (13) Neurological Disease (9)
Oligonucleotides:	Rat Pre-designed siRNA Sets (5) Mouse Pre-designed siRNA Sets (3) Human Pre-designed siRNA Sets (19) siRNAs (27)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: UGT

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-131703

UGT8-IN-1	UGT	Metabolic Disease
UGT8-IN-1 is a brain penetrable and orally active inhibitor of ceramide galactosyltransferase enzyme (UGT8). UGT8-IN-1 can be used in the study for lysosomal storage disorders .

HY-160250

UGT1A1-IN-1	UGT	Metabolic Disease
UGT1A1-IN-1 (compound 2) is a non-competitive inhibitor of *UGT1A1, which can inhibit the 1-O-glucuronidation process mediated by UGT1A1* with a K_i value of 5.02 μM. UGT1A1-IN-1 (compound 2) can bind on *UGT1A1* at the same ligand-binding site as bilirubin (HY-N0323). UGT1A1-IN-1 can serve as a ‘turn-on’ fluorescent probe substrate for UGT1A1 .

HY-137083

Trifluoperazine N-Glucuronide UGT1A4	UGT	Metabolic Disease
Trifluoperazine N-Glucuronide (UGT1A4), as one of the human UGT1A isoforms, is expressed in the liver. Trifluoperazine N-Glucuronide catalyzes the imipramine and trifluoperazine Nglucuronide formation .

HY-137083A

Trifluoperazine N-glucuronide chloride UGT1A4 chloride	Drug Metabolite	Neurological Disease
Trifluoperazine N-glucuronide (UGT1A4) chloride is a metabolite of the antipsychotic agent trifluoperazine. Trifluoperazine N-glucuronide (UGT1A4) chloridecatalyzes the imipramine and trifluoperazine Nglucuronide formation .

HY-RS15443

UGT8 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UGT8 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UGT8 Human Pre-designed siRNA Set A UGT8 Human Pre-designed siRNA Set A

HY-RS27017

Ugt1a Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ugt1a Rat Pre-designed siRNA Set A contains three designed siRNAs for Ugt1a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ugt1a Rat Pre-designed siRNA Set A Ugt1a Rat Pre-designed siRNA Set A

HY-RS16380

UGT1A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UGT1A Human Pre-designed siRNA Set A contains three designed siRNAs for UGT1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UGT1A Human Pre-designed siRNA Set A UGT1A Human Pre-designed siRNA Set A

HY-RS26323

Ugt1a3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ugt1a3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ugt1a3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ugt1a3 Rat Pre-designed siRNA Set A Ugt1a3 Rat Pre-designed siRNA Set A

HY-RS15436

UGT2A3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UGT2A3 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT2A3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UGT2A3 Human Pre-designed siRNA Set A UGT2A3 Human Pre-designed siRNA Set A

HY-RS15442

UGT3A2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UGT3A2 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT3A2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UGT3A2 Human Pre-designed siRNA Set A UGT3A2 Human Pre-designed siRNA Set A

HY-RS23238

Ugt1a1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ugt1a1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ugt1a1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ugt1a1 Rat Pre-designed siRNA Set A Ugt1a1 Rat Pre-designed siRNA Set A

HY-RS15426

UGT1A1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UGT1A1 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT1A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UGT1A1 Human Pre-designed siRNA Set A UGT1A1 Human Pre-designed siRNA Set A

HY-RS15433

UGT1A9 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UGT1A9 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT1A9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UGT1A9 Human Pre-designed siRNA Set A UGT1A9 Human Pre-designed siRNA Set A

HY-RS15430

UGT1A6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UGT1A6 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT1A6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UGT1A6 Human Pre-designed siRNA Set A UGT1A6 Human Pre-designed siRNA Set A

HY-RS15427

UGT1A10 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UGT1A10 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT1A10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UGT1A10 Human Pre-designed siRNA Set A UGT1A10 Human Pre-designed siRNA Set A

HY-RS15434

UGT2A1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UGT2A1 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT2A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UGT2A1 Human Pre-designed siRNA Set A UGT2A1 Human Pre-designed siRNA Set A

HY-RS19083

Ugt1a8 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ugt1a8 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ugt1a8 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ugt1a8 Mouse Pre-designed siRNA Set A Ugt1a8 Mouse Pre-designed siRNA Set A

HY-RS15428

UGT1A3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UGT1A3 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT1A3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UGT1A3 Human Pre-designed siRNA Set A UGT1A3 Human Pre-designed siRNA Set A

HY-RS15432

UGT1A8 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UGT1A8 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT1A8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UGT1A8 Human Pre-designed siRNA Set A UGT1A8 Human Pre-designed siRNA Set A

HY-RS16797

Ugt1a1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ugt1a1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ugt1a1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ugt1a1 Mouse Pre-designed siRNA Set A Ugt1a1 Mouse Pre-designed siRNA Set A

HY-RS28491

Ugt1a4 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ugt1a4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ugt1a4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ugt1a4 Rat Pre-designed siRNA Set A Ugt1a4 Rat Pre-designed siRNA Set A

HY-RS15431

UGT1A7 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UGT1A7 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT1A7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UGT1A7 Human Pre-designed siRNA Set A UGT1A7 Human Pre-designed siRNA Set A

HY-RS15435

UGT2A2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UGT2A2 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT2A2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UGT2A2 Human Pre-designed siRNA Set A UGT2A2 Human Pre-designed siRNA Set A

HY-RS21974

Ugt1a4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ugt1a4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ugt1a4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ugt1a4 Mouse Pre-designed siRNA Set A Ugt1a4 Mouse Pre-designed siRNA Set A

HY-RS15429

UGT1A4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UGT1A4 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT1A4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UGT1A4 Human Pre-designed siRNA Set A UGT1A4 Human Pre-designed siRNA Set A

HY-RS26709

Ugt2b7 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ugt2b7 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ugt2b7 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ugt2b7 Rat Pre-designed siRNA Set A Ugt2b7 Rat Pre-designed siRNA Set A

HY-RS15437

UGT2B10 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UGT2B10 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT2B10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UGT2B10 Human Pre-designed siRNA Set A UGT2B10 Human Pre-designed siRNA Set A

HY-RS15441

UGT2B7 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UGT2B7 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT2B7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UGT2B7 Human Pre-designed siRNA Set A UGT2B7 Human Pre-designed siRNA Set A

HY-RS15440

UGT2B4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UGT2B4 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT2B4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UGT2B4 Human Pre-designed siRNA Set A UGT2B4 Human Pre-designed siRNA Set A

HY-RS15439

UGT2B17 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UGT2B17 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT2B17 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UGT2B17 Human Pre-designed siRNA Set A UGT2B17 Human Pre-designed siRNA Set A

HY-RS15438

UGT2B15 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UGT2B15 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT2B15 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UGT2B15 Human Pre-designed siRNA Set A UGT2B15 Human Pre-designed siRNA Set A

HY-137083S

Trifluoperazine N-glucuronide-d3 UGT1A4-d₃	Isotope-Labeled Compounds	Metabolic Disease
Trifluoperazine N-glucuronide-d₃ is deuterium labeled Trifluoperazine N-Glucuronide. Trifluoperazine N-Glucuronide (UGT1A4), as one of the human UGT1A isoforms, is expressed in the liver. Trifluoperazine N-Glucuronide catalyzes the imipramine and trifluoperazine Nglucuronide formation .

HY-135581

Raloxifene 6-glucuronide	Estrogen Receptor/ERR	Endocrinology
Raloxifene 6-glucuronide is a primary metabolite of Raloxifene. Raloxifene 6-glucuronide is mediated mostly by UGT1A1 and UGT1A8. Raloxifene 6-glucuronide binds to estrogen receptor with an IC₅₀ of 290 μM. Raloxifene is a selective and nonsteroidal estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .

HY-135582

Raloxifene 4'-glucuronide	Estrogen Receptor/ERR	Endocrinology
Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC₅₀ of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .

HY-135582S

Raloxifene 4'-glucuronide-d4	Estrogen Receptor/ERR Isotope-Labeled Compounds	Endocrinology
Raloxifene 4'-glucuronide-d₄ is deuterated labeled Raloxifene 4'-glucuronide (HY-135582). Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC₅₀ of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .

HY-N0548

α-Angelica lactone 2 Publications Verification	Glutathione S-transferase	Cancer
α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and *UDP-glucononosyltransferase (UGT) detoxification enzymes* .

HY-124364

RO6889678	HBV Cytochrome P450	Infection Metabolic Disease
RO6889678 is a highly potent HBV capsid formation inhibitor with a complex absorption, distribution, metabolism, and excretion (ADME) profile. RO6889678 is a potent inducer of CYP3A4 and coregulated proteins in human hepatocytes. RO6889678 is metabolized by a combination of CYP3A4-mediated oxidation and UDP-glucuronosyltransferase UGT1A3- and UGT1A1-mediated direct glucuronidation .

HY-111832

1,2,3,6-Tetragalloylglucose TeGG	UGT	Infection Metabolic Disease
1,2,3,6-Tetragalloylglucose (TEgG) is a competitive inhibitor of UDP-glucuronyltransferase *UGT1A1, targeting the competitive substrate binding site of UGT1A1. 1,2,3,6-Tetragalloylglucose inhibits UGT1A1-mediated β-estradiol 3-glucuronidation and SN-38 glucuronidation with IC₅₀* of 6.01 μM and 4.31 μM, respectively, and binds to UGT1A1 with K_i of 3.55 μM. 1,2,3,6-Tetragalloylglucose also induces tumor cell apoptosis, inhibit cell proliferation, activates caspase-3 and induces DNA fragmentation in HL-60 cells. 1,2,3,6-Tetragalloylglucose also inhibits HIV integrase and reverse transcriptase, and inhibits HCV protease .

HY-100319

UK-157147	UGT	Metabolic Disease
UK-157147 is a substrate for UDP-glucuronosyltransferases (UGT1A1) with a K_m value of 105 μM.

HY-N0859

Schisanhenol Schizanhenol; Gomisin-K3	UGT	Cancer
Schisanhenol is a natural compound solated from Schisandra rubriflora; UGT2B7 UDP-glucuronosyltransferases inhibitor.

HY-N0168

Hesperetin Maximum Cited Publications 15 Publications Verification	p38 MAPK Autophagy Apoptosis	Neurological Disease Cancer
Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human *UGT* activity. Hesperetin regulates apoptosis.

HY-W278777

Monohexyl phthalate	Biochemical Assay Reagents	Others
Monohexyl phthalate is a competitive inhibitor towards *UGT1A9, with an IC₅₀* of 12.46 μM and a K_i of 7.47 μM .

HY-135541

Darexaban maleate YM150 maleate	Endogenous Metabolite	Cardiovascular Disease
Darexaban maleate (YM150 maleate) is a direct factor Xa inhibitor with activity in preventing venous thromboembolism. The major metabolite of Darexaban maleate in humans is Darexaban glucitol, which acts pharmacologically. The glucitolation reaction of Darexaban maleate is mainly catalyzed by UGT1A9 and UGT1A10 in the human liver and intestine. The K(m) value of Darexaban maleate glucitolation in the liver is greater than 250 μM, while in the intestine it exhibits substrate inhibition kinetics with a K(m) value of 27.3 μM. The unbound K(m) value of Darexaban maleate is significantly reduced by the influence of fatty acid-free bovine serum albumin in both HLM and UGT1A9 .

HY-N0372

Licochalcone A 10+ Cited Publications Licochalcone-A	Autophagy	Cancer
Licochalcone A (LCA), a flavonoid isolated, presents obvious anti-cancer effects, displays broad-spectrum inhibition against UDP-glucuronosyltransferases (UGTs) . Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC₅₀ and K_i values lower than 5 μM) .

HY-N0372R

Licochalcone A (Standard)	Autophagy	Cancer
Licochalcone A (Standard) is the analytical standard of Licochalcone A. This product is intended for research and analytical applications. Licochalcone A (LCA), a flavonoid isolated, presents obvious anti-cancer effects, displays broad-spectrum inhibition against UDP-glucuronosyltransferases (UGTs) . Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC₅₀ and Ki values lower than 5 μM) .

HY-Y1683

DL-Menthol Racementhol	GABA Receptor	Neurological Disease
DL-Menthol (Racementhol) is an orally active, GABA_aR positive allosteric modulator and UDP-glucuronosyltransferase (UGT) inhibitor that can cross the blood-brain barrier. DL-Menthol binds to GABA_AR and exhibits an allosteric activation effect, enhancing GABA-mediated chloride influx and inhibiting neuronal excitability. DL-Menthol can induce surgical anesthesia in fish and inhibit the metabolic detoxification of tobacco carcinogens by human liver and intestinal UGT enzymes, resulting in reduced NNAL-N-Gluc production .

HY-N0168A

(Rac)-Hesperetin	p38 MAPK Apoptosis Autophagy	Neurological Disease Cancer
(Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human *UGT* activity. Hesperetin induces apoptosis via p38 MAPK activation.

HY-N0168S

Hesperetin-d3	p38 MAPK Apoptosis Autophagy	Neurological Disease
Hesperetin-d₃ is the deuterium labeled Hesperetin . Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin regulates apoptosis .

HY-113216R

Asymmetric dimethylarginine (Standard)	Endogenous Metabolite NO Synthase	Cardiovascular Disease Cancer
Hesperetin (Standard) is the analytical standard of Hesperetin. This product is intended for research and analytical applications. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin regulates apoptosis.

HY-135581S1

Raloxifene 6-glucuronide-d4 lithium	Isotope-Labeled Compounds Estrogen Receptor/ERR	Endocrinology
Raloxifene 6-glucuronide-d₄ (lithium) is deuterium labeled Raloxifene 6-glucuronide. Raloxifene 6-glucuronide is a primary metabolite of Raloxifene. Raloxifene 6-glucuronide is mediated mostly by UGT1A1 and UGT1A8. Raloxifene 6-glucuronide binds to estrogen receptor with an IC₅₀ of 290 μM. Raloxifene is a selective and nonsteroidal estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0548

α-Angelica lactone 2 Publications Verification	Natural Products Classification of Application Fields Source classification Dicerothamnus rhinocerotis Plants Umbelliferae Disease Research Fields Cancer	Glutathione S-transferase
α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and *UDP-glucononosyltransferase (UGT) detoxification enzymes* .

HY-111832

1,2,3,6-Tetragalloylglucose TeGG	Structural Classification other families Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	UGT
1,2,3,6-Tetragalloylglucose (TEgG) is a competitive inhibitor of UDP-glucuronyltransferase *UGT1A1, targeting the competitive substrate binding site of UGT1A1. 1,2,3,6-Tetragalloylglucose inhibits UGT1A1-mediated β-estradiol 3-glucuronidation and SN-38 glucuronidation with IC₅₀* of 6.01 μM and 4.31 μM, respectively, and binds to UGT1A1 with K_i of 3.55 μM. 1,2,3,6-Tetragalloylglucose also induces tumor cell apoptosis, inhibit cell proliferation, activates caspase-3 and induces DNA fragmentation in HL-60 cells. 1,2,3,6-Tetragalloylglucose also inhibits HIV integrase and reverse transcriptase, and inhibits HCV protease .

HY-N0859

Schisanhenol Schizanhenol; Gomisin-K3	Structural Classification Monophenols Classification of Application Fields Source classification Lignans Phenols Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer	UGT
Schisanhenol is a natural compound solated from Schisandra rubriflora; UGT2B7 UDP-glucuronosyltransferases inhibitor.

HY-N0168

Hesperetin Maximum Cited Publications 15 Publications Verification	Structural Classification Neurological Disease Classification of Application Fields Source classification Plants Flavonoids Microorganisms other families Sunscreen Flavonones Cosmetic Research Disease Research Fields Cancer	p38 MAPK Autophagy Apoptosis
Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human *UGT* activity. Hesperetin regulates apoptosis.

HY-N0372

Licochalcone A 10+ Cited Publications Licochalcone-A	Structural Classification Chalcones Flavonoids Classification of Application Fields Leguminosae Source classification Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Cancer	Autophagy
Licochalcone A (LCA), a flavonoid isolated, presents obvious anti-cancer effects, displays broad-spectrum inhibition against UDP-glucuronosyltransferases (UGTs) . Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC₅₀ and K_i values lower than 5 μM) .

HY-Y1683

DL-Menthol Racementhol	Structural Classification Natural Products Classification of Application Fields Leguminosae Labiatae Source classification Other Diseases Erythrina poeppigiana Plants Glycyrrhiza uralensis Fisch. Disease Research Fields	GABA Receptor
DL-Menthol (Racementhol) is an orally active, GABA_aR positive allosteric modulator and UDP-glucuronosyltransferase (UGT) inhibitor that can cross the blood-brain barrier. DL-Menthol binds to GABA_AR and exhibits an allosteric activation effect, enhancing GABA-mediated chloride influx and inhibiting neuronal excitability. DL-Menthol can induce surgical anesthesia in fish and inhibit the metabolic detoxification of tobacco carcinogens by human liver and intestinal UGT enzymes, resulting in reduced NNAL-N-Gluc production .

HY-N0168A

(Rac)-Hesperetin	Structural Classification Flavonoids other families Flavonones Source classification Phenols Polyphenols Plants	p38 MAPK Apoptosis Autophagy
(Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human *UGT* activity. Hesperetin induces apoptosis via p38 MAPK activation.

HY-N0372R

Licochalcone A (Standard)	Structural Classification Chalcones Flavonoids Leguminosae Source classification Plants Glycyrrhiza uralensis Fisch.	Autophagy
Licochalcone A (Standard) is the analytical standard of Licochalcone A. This product is intended for research and analytical applications. Licochalcone A (LCA), a flavonoid isolated, presents obvious anti-cancer effects, displays broad-spectrum inhibition against UDP-glucuronosyltransferases (UGTs) . Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC₅₀ and Ki values lower than 5 μM) .

HY-113216R

Asymmetric dimethylarginine (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite NO Synthase
Hesperetin (Standard) is the analytical standard of Hesperetin. This product is intended for research and analytical applications. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin regulates apoptosis.

HY-125129

Carlinoside	Structural Classification Flavonoids Classification of Application Fields Flavones Cymbopogon citratus Gramineae Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields	Keap1-Nrf2
Carlinoside is a flavone glycoside with hepatoprotective efficiency. Carlinoside reduces hepatic bilirubin accumulation by stimulating bilirubin-UGT activity through Nrf2 gene expression. Carlinoside has the potential to intervene hyperbilirubinemia due to liver dysfunction .

HY-N10754

Aschantin	Structural Classification Natural Products Source classification Magnoliaceae Yulania biondii (Pamp.) D. L. Fu Plants	mTOR Cytochrome P450
Aschantin, a bisepoxylignan, can be isolated from Magnolia biondii. Aschantin has antiplasmodial, Ca ²⁺-antagonistic, platelet activating factor-antagonistic, and chemopreventive activities. Aschantin is a mTOR kinase inhibitor. Aschantin is also an inhibitor of Cytochrome P450 and *UGT* enzyme .

HY-N0168AR

(Rac)-Hesperetin (Standard)	Structural Classification Flavonoids other families Flavonones Source classification Phenols Polyphenols Plants	p38 MAPK Apoptosis Autophagy
(Rac)-Hesperetin (Standard) is the analytical standard of (Rac)-Hesperetin. This product is intended for research and analytical applications. (Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation.

HY-N2574

Gitogenin 2 Publications Verification	Tribulus terrester Linn. Structural Classification Classification of Application Fields Zygophyllaceae Source classification Metabolic Disease Plants Disease Research Fields Steroids	Glycosidase
Gitogenin is a natural steroid isolated from the whole plant of Tribulus longipetalus. Gitogenin is a selective inhibitor of UDP-glucuronosyltransferase 1A4 (UGT1A4) and enzyme α-glucosidase with IC₅₀ values of 0.69 μM (use trifluoperazine as a substrate) and 37.2 μM, respectively, and does not inhibit the activities of major human cytochrome P450 isoforms .

HY-N1902R

4-Hydroxyphenylacetic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Monophenols Source classification Phenols Plants Compositae Endogenous metabolite Erythrina latissima E. Mey.	Keap1-Nrf2 Endogenous Metabolite
4-Hydroxyphenylacetic acid (Standard) is the analytical standard of 4-Hydroxyphenylacetic acid. This product is intended for research and analytical applications. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2 . IC₅₀ & Target:Nrf2 In Vivo: 4-Hydroxyphenylacetic acid (6, 12, or 25 mg/kg) increases Nrf2 translocation to the nucleus and enhances the activity of phase II and antioxidant enzymes. The protein levels of nuclear Nrf2 are increased by 170% and 230% in pre-treated 12 and 25 mg/kg 4-Hydroxyphenylacetic acid groups, respectively, compared with the control group.The 4-Hydroxyphenylacetic acid pretreatment at a final dose of 25 mg/kg markedly and selectively up-regulated the target genes of phase II enzymes and resulted in higher up-regulation than that of the control group by 270%, 400%, and 500% or UGT1A1, UGT1A9, and SULT2A1, respectively. 4-Hydroxyphenylacetic acid also suppresses the expression of CYP2E1 .

HY-N2574R

Gitogenin (Standard)	Tribulus terrester Linn. Structural Classification Zygophyllaceae Source classification Plants Steroids	Glycosidase
Gitogenin (Standard) is the analytical standard of Gitogenin. This product is intended for research and analytical applications. Gitogenin is a natural steroid isolated from the whole plant of Tribulus longipetalus. Gitogenin is a selective inhibitor of UDP-glucuronosyltransferase 1A4 (UGT1A4) and enzyme α-glucosidase with IC₅₀ values of 0.69 μM (use trifluoperazine as a substrate) and 37.2 μM, respectively, and does not inhibit the activities of major human cytochrome P450 isoforms .

HY-N0235

Bakuchiol 2 Publications Verification (S)-(+)-Bakuchiol	Structural Classification Monophenols Classification of Application Fields Leguminosae Source classification Phenols Psoralea corylifolia L. Plants Disease Research Fields Cancer	Carboxylesterase (CES) p38 MAPK Autophagy UGT
Bakuchiol is a phytoestrogen that can be obtained from psoralen seeds. Bakuchiol has been proven to be a non-competitive inhibitor of multiple enzymes, including UDP-glucuronosyltransferase 2B7 (UGT2B7) and human carboxylesterase 2 (hCE2) , with IC₅₀s values of 40.9 μM and 7.28 μM, respectively. Bakuchiol exhibits significant research and application potential in areas such as anti-inflammatory , antibacterial , antitumor therapies, as well as drug metabolism regulation.

HY-N0235R

Bakuchiol (Standard)	Structural Classification Monophenols Leguminosae Source classification Phenols Psoralea corylifolia L. Plants	Carboxylesterase (CES) p38 MAPK Autophagy UGT
Bakuchiol (Standard) is the analytical standard of Bakuchiol. This product is intended for research and analytical applications. Bakuchiol is a phytoestrogen that can be obtained from psoralen seeds. Bakuchiol has been proven to be a non-competitive inhibitor of multiple enzymes, including UDP-glucuronosyltransferase 2B7 (UGT2B7) and human carboxylesterase 2 (hCE2) , with IC₅₀s values of 40.9 μM and 7.28 μM, respectively. Bakuchiol exhibits significant research and application potential in areas such as anti-inflammatory , antibacterial , antitumor therapies, as well as drug metabolism regulation.

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HY-P702034

	SLC35A2 Protein, Human (Sf9, His, MBP, FLAG) SLC35A2; UDP-galactose translocator; Solute carrier family 35 member A2; UDP-galactose transporter; UDP-Gal-Tr; UGT	Human	Sf9 insect cells
	SLC35A2 is a key transmembrane protein that acts as an antiporter to transport uridine diphosphate galactose (UDP-galactose) into the Golgi apparatus. The process involves the exchange of UDP-galactose with UMP and exhibits versatility through exchange with AMP and CMP. SLC35A2 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC35A2 protein, expressed by Sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-137083S

Trifluoperazine N-glucuronide-d3
Trifluoperazine N-glucuronide-d₃ is deuterium labeled Trifluoperazine N-Glucuronide. Trifluoperazine N-Glucuronide (UGT1A4), as one of the human UGT1A isoforms, is expressed in the liver. Trifluoperazine N-Glucuronide catalyzes the imipramine and trifluoperazine Nglucuronide formation .

HY-135582S

Raloxifene 4'-glucuronide-d4

Raloxifene 4'-glucuronide-d₄ is deuterated labeled Raloxifene 4'-glucuronide (HY-135582). Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC₅₀ of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .

HY-N0168S

Hesperetin-d3
Hesperetin-d₃ is the deuterium labeled Hesperetin . Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin regulates apoptosis .

HY-135581S1

Raloxifene 6-glucuronide-d4 lithium

Raloxifene 6-glucuronide-d₄ (lithium) is deuterium labeled Raloxifene 6-glucuronide. Raloxifene 6-glucuronide is a primary metabolite of Raloxifene. Raloxifene 6-glucuronide is mediated mostly by UGT1A1 and UGT1A8. Raloxifene 6-glucuronide binds to estrogen receptor with an IC₅₀ of 290 μM. Raloxifene is a selective and nonsteroidal estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .

HY-135582S1

Raloxifene 4'-glucuronide-d4 lithium

Raloxifene 4'-glucuronide-d₄ (lithium) is deuterium labeled Raloxifene 4'-glucuronide. Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC₅₀ of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .

HY-N0168AS

(Rac)-Hesperetin-d3
(Rac)-Hesperetin-d₃ is the deuterium labeled (Rac)-Hesperetin. (Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation.

HY-N0168AS1

(Rac)-Hesperetin-13C,d3
(Rac)-Hesperetin- ¹³C,d₃ is the ¹³C- and deuterium labeled (Rac)-Hesperetin. (Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation.

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