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Ten-eleven-translocation (TET) protein

" in MedChemExpress (MCE) Product Catalog:

By Targets:	TET Protein (10) ADC Linker (19) Apoptosis (1) Bacterial (4) Biochemical Assay Reagents (1) DNA Methyltransferase (3) DNA Stain (2) Endogenous Metabolite (7) Fluorescent Dye (6) GABA Receptor (2) Histone Demethylase (5) Isotope-Labeled Compounds (2) Oct3/4 (1) Potassium Channel (1) PROTAC Linkers (1) Small Interfering RNA (siRNA) (9) STAT (2) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (34) Cardiovascular Disease (1) Endocrinology (1) Infection (3) Inflammation/Immunology (5) Metabolic Disease (2) Neurological Disease (7)
Click Chemistry:	ADC Synthesis (17) Labeling and Fluorescence Imaging (5) PROTAC Synthesis (1) Tetrazine (23)
Oligonucleotides:	Rat Pre-designed siRNA Sets (3) Mouse Pre-designed siRNA Sets (3) Human Pre-designed siRNA Sets (3) siRNAs (9)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: TET Protein MALT1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-122258

NSC-370284	STAT TET Protein	Cancer
NSC-370284 is a selective inhibitor of ten-eleven translocation 1 (TET1) and 5-hydroxymethylcytosine (5hmC). NSC-370284 significantly inhibits the level of TET1 expression via targets STAT3/5 .

HY-W018324

5-Hydroxymethylcytosine 5hmC	Endogenous Metabolite	Neurological Disease Metabolic Disease Cancer
5-Hydroxymethylcytosine (5hmC) is an oxidized forms of 5-methylcytosine (5mC) in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET)1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development. 5-Hydroxymethylcytosine can be used for the study of non-small cell lung cancer (NSCLC), neurodegenerative diseases (Alzheimer’s, Parkinson’s) and hematological malignancies (acute myeloid leukemia, myelodysplastic syndromes) .

HY-P3459A

Tet-213 TFA	Bacterial	Infection
Tet-213 TFA is a antimicrobial peptide. Tet-213 TFA has broad spectrum antibacterial activity. Tet-213 TFA can promote infected wound repair .

HY-W396714

Succinic acid sodium Wormwood acid sodium	Potassium Channel TET Protein	Cardiovascular Disease Neurological Disease
Succinic acid sodium is a potent and orally active anxiolytic agent. Succinic acid sodium shows inhibitory effects on colonic epithelial cell proliferation in vivo. Succinic acid sodium can down-regulate the expression of KCNMB1 (potassium channel subunit β1) and *TET1* (ten?eleven translocation 1). Succinic acid sodium can be used for gestational hypertension research .

HY-P3459

Tet-213	Bacterial	Infection
Tet-213 is a antimicrobial peptide. Tet-213 has broad spectrum antibacterial activity. Tet-213 can promote infected wound repair .

HY-P5486

Tet-20	Bacterial	Others
Tet-20 is a biological active peptide. (Tet-20, is a synthetic cathelicidin-derived peptide. It was tested as infection-resistant coating for medical devices. When tethered on an implant surface Tet-20 exhibited broad antimicrobial activities both in vivo and in vitro. It can stop biofilm formation and appears to be non-toxic to eukaryotic cells)

HY-131461

*6-TET* Dipivaloate**	Fluorescent Dye	Inflammation/Immunology
6-TET Dipivaloate is a nucleic acid sequencing probe.

HY-169432

TET-13	GABA Receptor	Neurological Disease
TET-13 is a positive allosteric modulator of GABA_A receptor with an EC₅₀ of 5.65 μM, lower than that of Etomidate (EC₅₀: 9.29 μM). TET-13 shows potent anesthetic effects in both mice and rats (ED₅₀: 0.48 mg/kg and 0.69 mg/kg, respectively) .

HY-P11094

Tet1	TET Protein	Neurological Disease
Tet1 is a peptide with the sequence of HLNILSTLWKYRC. Tet1 can specifically bind to the neuronal ganglioside receptor GT1b and possesses neuronal targeting ability. Tet1 can be used in research related to drug delivery .

HY-D1898

*6-TET* Azide**	Fluorescent Dye	Others
6-TET Azide is a fluorescent probe that can be used for the preparation of fluorescent contrast agent and nucleic acid sequencing .

HY-W018324S

5-Hydroxymethylcytosine-13C,d2 5hmC-¹³C,d₂	Isotope-Labeled Compounds	Neurological Disease
5-Hydroxymethylcytosine- ¹³C,d₂ is the ¹³C and deuterium labeled 5-Hydroxymethylcytosine (HY-W018324). 5-Hydroxymethylcytosine (5hmC) is an oxidized forms of 5-methylcytosine (5mC) in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET)1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development. 5-Hydroxymethylcytosine can be used for the study of non-small cell lung cancer (NSCLC), neurodegenerative diseases (Alzheimer’s, Parkinson’s) and hematological malignancies (acute myeloid leukemia, myelodysplastic syndromes) .

HY-P10998

Tet1 peptide	TET Protein	Neurological Disease
Tet1 peptide is neuron-specific ligand for GT1B gangliosides. Tet1 peptide can be used as a ligand for targeted delivery of functionalized polymersomes .

HY-D1897

*6-TET* phosphoramidite** 5′-Tetrachlorofluorescein phosphoramidite	Fluorescent Dye	Others
6-TET phosphoramidite (5′-Tetrachlorofluorescein phosphoramidite) is a fluorescent dye that can be used for labeling an oligonucleotide with fluorescein .

HY-156497

Biotin-PEG8-Me-Tet	Endogenous Metabolite	Others
Biotin-PEG8-Me-Tet is a biotin labeling .

HY-156494

*Me-Tet-PEG9-COOH*	ADC Linker	Cancer
Me-Tet-PEG9-COOH is an ADC Linker containing 9 PEG units. Me-Tet-PEG9-COOH can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156491

*Me-Tet-PEG9-NHS*	ADC Linker	Cancer
Me-Tet-PEG9-NHS is an ADC Linker containing 9 PEG units. Me-Tet-PEG9-NHS can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156475

*Me-Tet-PEG2-COOH*	ADC Linker	Cancer
Me-Tet-PEG2-COOH is an ADC Linker containing 2 PEG units. Me-Tet-PEG2-COOH can use its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156495

Biotin-PEG3-Me-Tet	ADC Linker	Cancer
Biotin-PEG3-Me-Tet is an ADC Linker containing 3 PEG units. Biotin-PEG3-Me-Tet can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156479

*Me-Tet-PEG3-NHBoc*	ADC Linker	Cancer
Me-Tet-PEG3-NHBoc is an ADC Linker containing 3 PEG units. Me-Tet-PEG3-NHBoc can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156476

*Me-Tet-PEG2-NHS*	ADC Linker	Cancer
Me-Tet-PEG2-NHS is an ADC Linker containing 2 PEG units. Me-Tet-PEG2-NHS can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156478

*Me-Tet-PEG4-NHBoc*	ADC Linker	Cancer
Me-Tet-PEG4-NHBoc is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-NHBoc can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156313

*Me-Tet-PEG4-NHS*	ADC Linker	Cancer
Me-Tet-PEG4-NHS is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-NHS can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156477

*Me-Tet-PEG8-NHBoc*	ADC Linker	Cancer
Me-Tet-PEG8-NHBoc is an ADC Linker containing 8 PEG units. Me-Tet-PEG8-NHBoc can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156490

*Me-Tet-PEG5-NHS*	ADC Linker	Cancer
Me-Tet-PEG5-NHS is an ADC Linker containing 5 PEG units. Me-Tet-PEG5-NHS can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156492

*Me-Tet-PEG4-COOH*	ADC Linker	Cancer
Me-Tet-PEG4-COOH is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-COOH can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156493

*Me-Tet-PEG5-COOH*	ADC Linker	Cancer
Me-Tet-PEG5-COOH is an ADC Linker containing 5 PEG units. Me-Tet-PEG5-COOH can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-RS14384

TET1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TET1 Human Pre-designed siRNA Set A contains three designed siRNAs for TET1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TET1 Human Pre-designed siRNA Set A TET1 Human Pre-designed siRNA Set A

HY-RS18373

Tet3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tet3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tet3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tet3 Mouse Pre-designed siRNA Set A Tet3 Mouse Pre-designed siRNA Set A

HY-RS23091

Tet2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tet2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tet2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tet2 Rat Pre-designed siRNA Set A Tet2 Rat Pre-designed siRNA Set A

HY-RS23219

Tet1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tet1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tet1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tet1 Rat Pre-designed siRNA Set A Tet1 Rat Pre-designed siRNA Set A

HY-RS16779

Tet1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tet1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tet1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tet1 Mouse Pre-designed siRNA Set A Tet1 Mouse Pre-designed siRNA Set A

HY-RS14385

TET2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TET2 Human Pre-designed siRNA Set A contains three designed siRNAs for TET2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TET2 Human Pre-designed siRNA Set A TET2 Human Pre-designed siRNA Set A

HY-RS24852

Tet3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tet3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tet3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tet3 Rat Pre-designed siRNA Set A Tet3 Rat Pre-designed siRNA Set A

HY-RS14386

TET3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TET3 Human Pre-designed siRNA Set A contains three designed siRNAs for TET3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TET3 Human Pre-designed siRNA Set A TET3 Human Pre-designed siRNA Set A

HY-RS16656

Tet2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tet2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tet2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tet2 Mouse Pre-designed siRNA Set A Tet2 Mouse Pre-designed siRNA Set A

HY-D2116

TAMRA-PEG8-Me-Tet	Fluorescent Dye	Others
TAMRA-PEG8-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 8 PEG units. TAMRA-PEG8-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-D2117

TAMRA-PEG4-Me-Tet	Fluorescent Dye	Others
TAMRA-PEG4-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG8-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-D2118

TAMRA-PEG3-Me-Tet	Fluorescent Dye	Others
TAMRA-PEG3-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 3 PEG units. TAMRA-PEG3-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-156301A

*Me-Tet-PEG8-NH2 hydrochloride*	ADC Linker	Cancer
Me-Tet-PEG8-NH2 (hydrochloride) is an ADC Linker containing 2 PEG units. Me-Tet-PEG8-NH2 (hydrochloride) can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-W591272

*Me-Tet-PEG3-NH2*	ADC Linker	Cancer
Me-Tet-PEG3-NH2 is an ADC Linker containing 3 PEG units. Me-Tet-PEG3-NH2 can use its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups .

HY-W591272A

*Me-Tet-PEG3-NH2 hydrochloride*	ADC Linker	Cancer
Me-Tet-PEG3-NH2 hydrochloride is an ADC Linker containing 3 PEG units. Me-Tet-PEG3-NH2 hydrochloride can use its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups .

HY-156300

*Me-Tet-PEG4-NH2*	ADC Linker	Cancer
Me-Tet-PEG4-NH2 is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-NH2 can use its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156307

*Me-Tet-PEG3-Maleimide*	ADC Linker	Cancer
Me-Tet-PEG3-Maleimide is an ADC Linker containing 3 PEG units. Me-Tet-PEG3-Maleimide can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.

HY-156312

*Me-Tet-PEG8-Maleimide*	ADC Linker	Cancer
Me-Tet-PEG8-Maleimide is an ADC Linker containing 8 PEG units. Me-Tet-PEG8-Maleimide can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.

HY-156308

*Me-Tet-PEG4-Maleimide*	ADC Linker	Cancer
Me-Tet-PEG4-Maleimide is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-Maleimide can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.

HY-133505

*Me-Tet-PEG4-NH2 hydrochloride*	PROTAC Linkers	Cancer
Me-Tet-PEG4-NH2 (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Me-Tet-PEG4-NH2 (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-155498

TETS-4-Methylaniline	GABA Receptor	Neurological Disease
TETS-4-Methylaniline (compound 2k) is a hapten. TETS-4-Methylaniline conjugates to the carrier protein via using either diazotization or glutaraldehyde methods .

HY-402410

TETi76 1 Publications Verification	TET Protein	Cancer
TETi76 is an orally active *TET* family inhibitor with IC₅₀ values ??of 1.5, 9.4 and 8.8 μM for *TET1, TET2* and *TET3, respectively. TETi76 competitively binds to the active site of TET* enzymes, reduces cytosine hydroxymethylation and restricts clonal growth of *TET2* mutants in vitro and in vivo, but does not affect the growth of normal hematopoietic precursor cells. TETi76 can be used for leukemia research .

HY-161006

TETS-C4-acid	Biochemical Assay Reagents	Inflammation/Immunology
TETS-C4-acid (Compound 2d) is a hapten coupled directly to a carrier protein through a carboxylic acid functionality. TETS-C4-acid (Compound 2d) can be used to detect tetramethylenedisulfotetramine (TETS) .

HY-160638

NSC-311068	TET Protein	Cancer
NSC-311068 is *TET1* inhibitor. NSC-311068 selectively suppress TET1 transcription and 5-hydroxymethylcytosine (5hmC) modification. NSC-311068 represses the level of TET1 expression and the global 5hmC level. NSC-311068 effectively inhibits cell viability in AML cells with high expression of TET1 .

Cat. No.	Product Name	Type

HY-D0828

3,6-Dichlorotrimellitic acid	Chromogenic Assays
3,6-Dichlorotrimellitic acid is the key precursor that is used for preparing a variety of dichlorinated fluoresceins and rhodamines such as TET and HEX.

HY-D0829

3,6-Dichlorotrimellitic anhydride	Chromogenic Substrates
3,6-Dichlorotrimellitic anhydride is the key precursor that is used for preparing a variety of dichlorinated fluoresceins and rhodamines such as TET and HEX.

HY-131461

*6-TET* Dipivaloate**	Fluorescent Dyes/Probes
6-TET Dipivaloate is a nucleic acid sequencing probe.

HY-D1898

*6-TET* Azide**	Fluorescent Dyes/Probes
6-TET Azide is a fluorescent probe that can be used for the preparation of fluorescent contrast agent and nucleic acid sequencing .

HY-D1897

*6-TET* phosphoramidite** 5′-Tetrachlorofluorescein phosphoramidite	Fluorescent Dyes/Probes
6-TET phosphoramidite (5′-Tetrachlorofluorescein phosphoramidite) is a fluorescent dye that can be used for labeling an oligonucleotide with fluorescein .

HY-D2116

TAMRA-PEG8-Me-Tet	Fluorescent Dyes/Probes
TAMRA-PEG8-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 8 PEG units. TAMRA-PEG8-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-D2117

TAMRA-PEG4-Me-Tet	Fluorescent Dyes/Probes
TAMRA-PEG4-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG8-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-D2118

TAMRA-PEG3-Me-Tet	Fluorescent Dyes/Probes
TAMRA-PEG3-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 3 PEG units. TAMRA-PEG3-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

Cat. No.	Product Name	Target	Research Area

HY-P3459A

Tet-213 TFA	Bacterial	Infection
Tet-213 TFA is a antimicrobial peptide. Tet-213 TFA has broad spectrum antibacterial activity. Tet-213 TFA can promote infected wound repair .

HY-P2514

TET 830 modified/T-helper epitope from tetanus toxoid	Peptides	Inflammation/Immunology
TET 830 modified/T-helper epitope from tetanus toxoid is a modified T-helper epitope from tetanus toxoid. TET 830 modified/T-helper epitope from tetanus toxoid induces T-cells responses and is used as a helper peptide in vaccinations .

HY-P3459

Tet-213	Bacterial	Infection
Tet-213 is a antimicrobial peptide. Tet-213 has broad spectrum antibacterial activity. Tet-213 can promote infected wound repair .

HY-P5486

Tet-20	Bacterial	Others
Tet-20 is a biological active peptide. (Tet-20, is a synthetic cathelicidin-derived peptide. It was tested as infection-resistant coating for medical devices. When tethered on an implant surface Tet-20 exhibited broad antimicrobial activities both in vivo and in vitro. It can stop biofilm formation and appears to be non-toxic to eukaryotic cells)

HY-P11094

Tet1	TET Protein	Neurological Disease
Tet1 is a peptide with the sequence of HLNILSTLWKYRC. Tet1 can specifically bind to the neuronal ganglioside receptor GT1b and possesses neuronal targeting ability. Tet1 can be used in research related to drug delivery .

HY-P10998

Tet1 peptide	TET Protein	Neurological Disease
Tet1 peptide is neuron-specific ligand for GT1B gangliosides. Tet1 peptide can be used as a ligand for targeted delivery of functionalized polymersomes .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W018324

5-Hydroxymethylcytosine 5hmC	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
5-Hydroxymethylcytosine (5hmC) is an oxidized forms of 5-methylcytosine (5mC) in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET)1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development. 5-Hydroxymethylcytosine can be used for the study of non-small cell lung cancer (NSCLC), neurodegenerative diseases (Alzheimer’s, Parkinson’s) and hematological malignancies (acute myeloid leukemia, myelodysplastic syndromes) .

HY-113038B

α-Hydroxyglutaric acid 2-Hydroxyglutarate; 2-Hydroxyglutaric acid; 2-Hydroxypentanedioic acid	Structural Classification Immune System Disorder Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields Cancer	Histone Demethylase Endogenous Metabolite
α-Hydroxyglutaric acid (2-Hydroxyglutarate) is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-113038A

α-Hydroxyglutaric acid disodium 2-Hydroxyglutarate disodium; 2-Hydroxyglutaric acid disodium; 2-Hydroxypentanedioic acid disodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Histone Demethylase Endogenous Metabolite
α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

Cat. No.	Compare	Product Name	Species	Source

HY-P702914

	TET1 Protein, Human (sf9, FLAG) CXXC6; KIAA1676; LCX	Human	Sf9 insect cells
	TET1 Protein, Human (sf9, FLAG) is the recombinant human-derived TET1, expressed by Sf9 insect cells , with N-Flag labeled tag. ,

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HY-113038AS

α-Hydroxyglutaric acid-13C5 disodium
α-Hydroxyglutaric acid- ¹³C₅ (sodium) is the ¹³C labeled α-Hydroxyglutaric acid sodium . α-Hydroxyglutaric acid (2-Hydroxyglutarate) sodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid sodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-113038AS1

α-Hydroxyglutaric acid-d4 disodium

α-Hydroxyglutaric acid-d₄ (disodium) is the deuterium labeled α-Hydroxyglutaric acid disodium . α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

HY-W018324S

5-Hydroxymethylcytosine-13C,d2

5-Hydroxymethylcytosine- ¹³C,d₂ is the ¹³C and deuterium labeled 5-Hydroxymethylcytosine (HY-W018324). 5-Hydroxymethylcytosine (5hmC) is an oxidized forms of 5-methylcytosine (5mC) in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET)1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development. 5-Hydroxymethylcytosine can be used for the study of non-small cell lung cancer (NSCLC), neurodegenerative diseases (Alzheimer’s, Parkinson’s) and hematological malignancies (acute myeloid leukemia, myelodysplastic syndromes) .

HY-W704805

Sodium 2-hydroxypentanedioate-2,3,3-d3

Sodium 2-hydroxypentanedioate-2,3,3-d₃ is the deuterium labeled α-Hydroxyglutaric acid disodium (HY-113038A). α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P84639

	TET2 Antibody (YA4336) MDS; KIAA1546	WB, IHC-P, ICC/IF, FC, ELISA	Human
	TET2 Antibody (YA4336) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TET2.

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Cat. No.	Product Name		Classification

HY-156497

Biotin-PEG8-Me-Tet		Labeling and Fluorescence Imaging Tetrazine
Biotin-PEG8-Me-Tet is a biotin labeling .

HY-156494

*Me-Tet-PEG9-COOH*		ADC Synthesis Tetrazine
Me-Tet-PEG9-COOH is an ADC Linker containing 9 PEG units. Me-Tet-PEG9-COOH can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156491

*Me-Tet-PEG9-NHS*		ADC Synthesis Tetrazine
Me-Tet-PEG9-NHS is an ADC Linker containing 9 PEG units. Me-Tet-PEG9-NHS can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156475

*Me-Tet-PEG2-COOH*		Tetrazine ADC Synthesis
Me-Tet-PEG2-COOH is an ADC Linker containing 2 PEG units. Me-Tet-PEG2-COOH can use its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156495

Biotin-PEG3-Me-Tet		Labeling and Fluorescence Imaging Tetrazine
Biotin-PEG3-Me-Tet is an ADC Linker containing 3 PEG units. Biotin-PEG3-Me-Tet can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156479

*Me-Tet-PEG3-NHBoc*		ADC Synthesis Tetrazine
Me-Tet-PEG3-NHBoc is an ADC Linker containing 3 PEG units. Me-Tet-PEG3-NHBoc can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156476

*Me-Tet-PEG2-NHS*		Tetrazine ADC Synthesis
Me-Tet-PEG2-NHS is an ADC Linker containing 2 PEG units. Me-Tet-PEG2-NHS can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156478

*Me-Tet-PEG4-NHBoc*		Tetrazine ADC Synthesis
Me-Tet-PEG4-NHBoc is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-NHBoc can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156313

*Me-Tet-PEG4-NHS*		ADC Synthesis Tetrazine
Me-Tet-PEG4-NHS is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-NHS can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156477

*Me-Tet-PEG8-NHBoc*		ADC Synthesis Tetrazine
Me-Tet-PEG8-NHBoc is an ADC Linker containing 8 PEG units. Me-Tet-PEG8-NHBoc can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156490

*Me-Tet-PEG5-NHS*		Tetrazine ADC Synthesis
Me-Tet-PEG5-NHS is an ADC Linker containing 5 PEG units. Me-Tet-PEG5-NHS can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156492

*Me-Tet-PEG4-COOH*		ADC Synthesis Tetrazine
Me-Tet-PEG4-COOH is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-COOH can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156493

*Me-Tet-PEG5-COOH*		ADC Synthesis Tetrazine
Me-Tet-PEG5-COOH is an ADC Linker containing 5 PEG units. Me-Tet-PEG5-COOH can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-D2116

TAMRA-PEG8-Me-Tet		Labeling and Fluorescence Imaging Tetrazine
TAMRA-PEG8-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 8 PEG units. TAMRA-PEG8-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-D2117

TAMRA-PEG4-Me-Tet		Labeling and Fluorescence Imaging Tetrazine
TAMRA-PEG4-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG8-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-D2118

TAMRA-PEG3-Me-Tet		Tetrazine Labeling and Fluorescence Imaging
TAMRA-PEG3-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 3 PEG units. TAMRA-PEG3-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-156301A

*Me-Tet-PEG8-NH2 hydrochloride*		ADC Synthesis Tetrazine
Me-Tet-PEG8-NH2 (hydrochloride) is an ADC Linker containing 2 PEG units. Me-Tet-PEG8-NH2 (hydrochloride) can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-W591272

*Me-Tet-PEG3-NH2*		Tetrazine ADC Synthesis
Me-Tet-PEG3-NH2 is an ADC Linker containing 3 PEG units. Me-Tet-PEG3-NH2 can use its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups .

HY-156300

*Me-Tet-PEG4-NH2*		Tetrazine ADC Synthesis
Me-Tet-PEG4-NH2 is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-NH2 can use its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.

HY-156307

*Me-Tet-PEG3-Maleimide*		ADC Synthesis Tetrazine
Me-Tet-PEG3-Maleimide is an ADC Linker containing 3 PEG units. Me-Tet-PEG3-Maleimide can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.

HY-156312

*Me-Tet-PEG8-Maleimide*		ADC Synthesis Tetrazine
Me-Tet-PEG8-Maleimide is an ADC Linker containing 8 PEG units. Me-Tet-PEG8-Maleimide can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.

HY-156308

*Me-Tet-PEG4-Maleimide*		ADC Synthesis Tetrazine
Me-Tet-PEG4-Maleimide is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-Maleimide can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.

HY-133505

*Me-Tet-PEG4-NH2 hydrochloride*		Tetrazine PROTAC Synthesis
Me-Tet-PEG4-NH2 (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Me-Tet-PEG4-NH2 (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

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Ten-eleven-translocation (TET) protein

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Fluorescent Dye

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Isotope-Labeled Compounds

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Click Chemistry

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